Exhibit 17.1 Burton C. Firtel 19533 Island Court Drive Boca Raton, Florida 33434 Dr. David Platt, CEO Pro-Pharmaceuticals, Inc. 7 Wells Avenue Newton, MA. 02459 Dear David, Effective immediately, I am resigning from the Board of Directors of Pro-Pharmaceuticals. This past September, it was suggested that I think about resigning from the board but remain a "friend" of the company. I found that idea to be a contradiction. My recent offer to become an employee and organize a marketing department in the anticipation of an FDA approval for Davanat was denied. That along with unfulfilled promises made to me, led me to this decision. It is my sincere hope that Pro succeeds in its' quest for a drug approval. Sincerely, /s/ Burt Burton C. Firtel 1-11-07