Exhibit 10.1

                                                   Amendment to Credit Agreement

This agreement is dated as of February 5, 2007, by and between SHARPS COMPLIANCE
CORP. (the "Borrower") and JPMorgan Chase Bank, N.A. (the "Bank"), and its
successors and assigns. The provisions of this agreement are effective on the
date that this agreement has been executed by all of the signers and delivered
to the Bank (the "Effective Date").

WHEREAS, the Borrower and the Bank entered into a Credit Agreement dated March
27, 2006, as amended (if applicable) (the "Credit Agreement"); and

WHEREAS, the Borrower has requested and the Bank has agreed to amend the
Credit Agreement as set forth below;

NOW, THEREFORE, in mutual consideration of the agreements contained herein and
for other good and valuable consideration, the parties agree as follows:

1.   DEFINED TERMS. Capitalized terms not defined herein shall have the meaning
     ascribed in the Credit Agreement.

2.   MODIFICATION OF CREDIT AGREEMENT. The Credit Agreement is hereby amended as
     follows:

     2.1  From and after the Effective Date, the section caption "Facility A
          (Line of Credit)" under section 1.2 of the Credit Agreement is hereby
          amended and restated to read as follows:

          Facility A (Line of Credit). The Bank has approved a credit
          facility to the Borrower in the principal sum not to exceed
          $2,500,000.00 in the aggregate at any one time outstanding
          ("Facility A"). Credit under Facility A shall be repayable as
          set forth in a Line of Credit Note executed concurrently with
          this agreement, and any renewals, modifications, extensions,
          rearrangements, restatements thereof and replacements or
          substitutions thereof. The proceeds of Facility A shall be
          used for the following purpose: support working capital needs,
          small acquisitions and general corporate purposes.

3.   RATIFICATION. The Borrower ratifies and reaffirms the Credit Agreement and
     the Credit Agreement shall remain in full force and effect as modified
     herein.

4.   BORROWER REPRESENTATIONS AND WARRANTIES. The Borrower represents and
     warrants that (a) the representations and warranties contained in the
     Credit Agreement are true and correct in all material respects as of the
     date of this agreement, (b) no condition, act or event which could
     constitute an event of default under the Credit Agreement or any promissory
     note or credit facility executed in reference to the Credit Agreement
     exists, and (c) no condition, event, act or omission has occurred, which,
     with the giving of notice or passage of time, would constitute an event of
     default under the Credit Agreement or any promissory note or credit
     facility executed in reference to the Credit Agreement.

5.   FEES AND EXPENSES. The Borrower agrees to pay all fees and out-of-pocket
     disbursements incurred by the Bank in connection with this agreement,
     including legal fees incurred by the Bank in the preparation, consummation,
     administration and enforcement of this agreement.

6.   EXECUTION AND DELIVERY. This agreement shall become effective only after it
     is fully executed by the Borrower and the Bank, and the Bank shall have
     received from the Borrower the following documents: Note Modification
     Agreement.

7.   ACKNOWLEDGEMENTS OF BORROWER. The Borrower acknowledges that as of the date
     of this agreement it has no offsets with respect to all amounts owed by the
     Borrower to the Bank arising under or related to the Credit Agreement on or
     prior to the date of this agreement. The Borrower fully, finally and
     forever releases and discharges the Bank and its successors, assigns,
     directors, officers, employees, agents and representatives from any and all
     claims, causes of action, debts and liabilities, of whatever kind or
     nature, in law or in equity, of the Borrower, whether now known or unknown
     to the Borrower, which may have arisen in connection with the Credit
     Agreement or the actions or omissions of the Bank related to the Credit
     Agreement on or prior to the date hereof. The Borrower acknowledges and
     agrees that this agreement is limited to the terms outlined above, and
     shall not be construed as an agreement to change any other terms or
     provisions of the Credit Agreement. This agreement shall not establish a
     course of dealing or be construed as evidence of any willingness on the
     Bank's part to grant other or future agreements, should any be requested.



8.   NOT A NOVATION. This agreement is a modification only and not a novation.
     Except for the above-quoted modification(s), the Credit Agreement, any loan
     agreements, credit agreements, reimbursement agreements, security
     agreements, mortgages, deeds of trust, pledge agreements, assignments,
     guaranties, instruments or documents executed in connection with the Credit
     Agreement, and all the terms and conditions thereof, shall be and remain in
     full force and effect with the changes herein deemed to be incorporated
     therein. This agreement is to be considered attached to the Credit
     Agreement and made a part thereof. This agreement shall not release or
     affect the liability of any guarantor of any promissory note or credit
     facility executed in reference to the Credit Agreement or release any owner
     of collateral granted as security for the Credit Agreement. The validity,
     priority and enforceability of the Credit Agreement shall not be impaired
     hereby. To the extent that any provision of this agreement conflicts with
     any term or condition set forth in the Credit Agreement, or any document
     executed in conjunction therewith, the provisions of this agreement shall
     supersede and control. The Bank expressly reserves all rights against all
     parties to the Credit Agreement.

THIS AGREEMENT REPRESENTS THE FINAL AGREEMENT OF THE PARTIES AND MAY NOT BE
CONTRADICTED BY EVIDENCE OR PRIOR, CONTEMPORANEOUS, OR SUBSEQUENT ORAL
AGREEMENTS OF THE PARTIES.

THERE ARE NO UNWRITTEN ORAL AGREEMENTS BETWEEN THE PARTIES.


                       Borrower:

                       SHARPS COMPLIANCE CORP.

                       By:
                            ----------------------------------------------------

                            David P. Tusa                  Executive Vice
                                                           President and CFO
                            ----------------------------------------------------
                            Printed Name                                   Title

                       Date Signed:
                                    --------------------------------------------


                       Bank:

                       JPMorgan Chase Bank, N.A.

                       By:
                            ----------------------------------------------------

                            ----------------------------------------------------
                            Printed Name                                   Title

                       Date Signed:
                                    --------------------------------------------


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