UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                            ------------------------

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

         Date of report (Date of earliest event reported): July 31, 2007

                            ------------------------

                            Opexa Therapeutics, Inc.
                            ------------------------
             (Exact Name of Registrant as Specified in Its Charter)

                                      Texas
                                      -----
                 (State or Other Jurisdiction of Incorporation)

        001-33004                                          76-0333165
        ---------                                          ----------
 (Commission File Number)                   (I.R.S. Employer Identification No.)

    2635 N. Crescent Ridge Drive
       The Woodlands, Texas                                   77381
       --------------------                                   -----
(Address of Principal Executive Offices)                    (Zip Code)

                                 Not Applicable
                            ------------------------
         (Former name or former address, if changed since last report.)

       Registrant's telephone number, including area code: (281) 272-9331

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17
    CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
    CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the
    Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the
    Exchange Act (17 CFR 240.13e-4(c))




ITEM 1.01 ENTRY INTO A MATERIAL DEFENITIVE AGREEMENT

     In  February  2004,  Opexa  entered  into  a  license  agreement  with  the
University of Chicago  ("University")  for the  worldwide  license to technology
developed at Argonne National Laboratory, a U.S. Department of Energy Laboratory
Operated by the University.  In December 2004, Opexa entered into an amended and
restated  license  agreement,  which was  attached  as an  exhibit to its annual
report on Form 10-KSB filed on April 15, 2005.  On July 31, 2007,  Opexa entered
into a second amended and restated license  agreement.  In consideration for the
second amended and restated  license  agreement,  Opexa is not obligated to make
any  further  payments  upon  executing  the second  amendment  and is no longer
obligated to make a $1.5 million  milestone  payment that was due July 31, 2007.
Opexa also is no longer obligated to issue any further shares of Common Stock or
any other securities to the University.  The second amended and restated license
agreement includes payments to be made by Opexa to the University upon achieving
certain clinical development milestones.

ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS

     (c)  Exhibits

The following exhibits are to be filed as part of this 8-K:

EXHIBIT NO.                IDENTIFICATION OF EXHIBIT
- -----------                -------------------------

10.1 (1) (2)   Second Amended and Restated License Agreement with University of
               Chicago

- ----------------
(1)  Filed herewith.
(2)  Portions of this exhibit have been omitted based on a request for
     confidential treatment pursuant to the Rule 24b-2 of the Exchange Act.


                                   SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                         OPEXA THERAPEUTICS, INC.


                                         By: /s/ Lynne Hohlfeld
                                         ----------------------
                                         Lynne Hohlfeld, Chief Financial Officer


     DATE: August 3, 2007