UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                               ------------------

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

      Date of report (Date of earliest event reported): September 19, 2007


                            Opexa Therapeutics, Inc.
                            ------------------------
             (Exact Name of Registrant as Specified in Its Charter)


                                      Texas
                                      -----
                 (State or Other Jurisdiction of Incorporation)

                   001-33004                           76-0333165
                   ---------                           ----------
           (Commission File Number)                 (I.R.S. Employer
                                                   Identification No.)

         2635 N. Crescent Ridge Drive
             The Woodlands, Texas                        77381
             --------------------                        -----
   (Address of Principal Executive Offices)           (Zip Code)

       Registrant's telephone number, including area code: (281) 272-9331

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act
    (17 CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act
    (17 CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the
    Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the
    Exchange Act (17 CFR 240.13e-4(c))




Item  5.02.   Departure of Directors or Certain Officers; Election of Directors;
Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On September  19, 2007,  the board of directors  appointed  Lorin Jeffry  (Jeff)
Randall to the Board of Directors. Mr. Randall was also appointed to the board's
audit committee replacing Dr. David Hung, who resigned from the audit committee,
but remains a member of the board of directors.

From 2004 to 2006,  Mr.  Randall  was senior vice  president  - chief  financial
officer of Eximias Pharmaceutical  Corporation,  a development stage provider of
oncology  therapeutics.  From  2002-2004,  Mr. Randall held the same position at
i-STAT  Corporation,  a manufacturer of medical  diagnostic  devices,  which was
acquired  by Abbott  Laboratories  in 2004.  His  career  also  included  senior
management  positions  at  CFM  Technologies,   a  semiconductor   manufacturing
equipment company;  Greenwich  Pharmaceutical  Corporation,  a development stage
provider of immune system disease  therapeutics;  and  Surgilase,  a provider of
surgical  lasers to  hospitals  and  clinics.  Mr.  Randall  received a B.S.  in
accounting  from  The  Pennsylvania   State   University  and  an  M.B.A.   from
Northeastern University.

Mr. Randall has not been involved with a related  transaction or relationship as
defined by Item 404(a) of Regulation S-B with the Company.

A copy of the press release is attached as Exhibit 99.1.


Item 9.01 Financial Statements and Exhibits

(c) Exhibit 99.1

The following exhibit is to be filed as part of this 8-K:

Exhibit No.          Description
- -----------          -----------

99.1                 Press release issued September 20, 2007


                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                OPEXA THERAPEUTICS, INC.

                                By: /s/ David B. McWilliams
                                   ---------------------------------------------
                                   David B. McWilliams, Chief Executive Officer

DATE:  September 19, 2007




EXHIBIT INDEX

Exhibit No.          Description
- -----------          -----------

99.1                 Press release issued September 20, 2007