Issuer Free Writing Prospectus
                                                      Filed Pursuant to Rule 433
                                           Registration Statement No. 333-147167
                                                               February 12, 2008

                            Opexa Therapeutics, Inc.

                         Revised Series E Warrant Terms

     Opexa  Therapeutics,  Inc.  ("Opexa")  has  revised a term of its  Series E
warrants that it is offering. The revised term is described below.

1. The  exercise  price of the Series E  warrants  to be issued by Opexa will be
$____ (100% of offering price per share of common stock).

     Opexa Therapeutics,  Inc. has filed a registration  statement  (including a
prospectus) with the SEC for the offering to which this  communication  relates.
Before you invest, you should read the prospectus in that registration statement
and  other  documents  the  issuer  has  filed  with the SEC for  more  complete
information about the issuer and this offering.  You may get these documents for
free by visiting EDGAR on the SEC Web site at http://www.sec.gov. Alternatively,
Opexa  Therapeutics,  Inc., any underwriter or any dealer  participating  in the
offering  will arrange to send you the  prospectus  if you request it by calling
281-272-9331 or by e-mailing ir@opexatherapeutics.com.