EXHIBIT 31.1


                  CERTIFICATION PURSUANT TO SECTION 302 OF THE
                           SARBANES-OXLEY ACT OF 2002

I, Laurence P. Birch, certify that:

1.    I have reviewed this quarterly report on Form 10-Q of NeoPharm, Inc.;

2.    Based on my knowledge, this report does not contain any untrue statement
      of a material fact or omit to state a material fact necessary to make the
      statements made, in light of the circumstances under which such statements
      were made, not misleading with respect to the period covered by this
      report;

3.    Based on my knowledge, the financial statements, and other financial
      information included in this report, fairly present in all material
      respects the financial condition, results of operations and cash flows of
      the registrant as of, and for, the periods presented in this report;

4.    I am responsible for establishing and maintaining disclosure controls and
      procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
      internal control over financial reporting (as defined in Exchange Act
      Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
      (a) Designed such disclosure controls and procedures, or caused such
         disclosure controls and procedures to be designed under my supervision,
         to ensure that material information relating to the registrant,
         including its consolidated subsidiary, is made known to me by others
         within those entities, particularly during the period in which this
         quarterly report is being prepared;
      (b) Designed such internal control over financial reporting, or caused
         such internal control over financial reporting to be designed under my
         supervision, to provide reasonable assurance regarding the reliability
         of financial reporting and the preparation of financial statements for
         external purposes in accordance with generally accepted accounting
         principles;
      (c) Evaluated the effectiveness of the registrant's disclosure controls
         and procedures and presented in this report my conclusions about the
         effectiveness of the disclosure controls and procedures, as of the end
         of the period covered by this report based on such evaluation; and
      (d) Disclosed in this report any change in the registrant's internal
         control over financial reporting that occurred during the registrant's
         most recent fiscal quarter (the registrant's fourth fiscal quarter in
         the case of an annual report) that has materially affected, or is
         reasonably likely to materially affect, the registrant's internal
         control over financial reporting; and

5.    I have disclosed, based on my most recent evaluation of internal control
      over financial reporting, to the registrant's auditors and the audit
      committee of registrant's board of directors (or persons performing the
      equivalent function): (a) All significant deficiencies and material
      weaknesses in the design or operation
         of internal control over financial reporting which are reasonably
         likely to adversely affect the registrant's ability to record, process,
         summarize and report financial information; and
      (b) Any fraud, whether or not material, that involves management or other
         employees who have a significant role in the registrant's internal
         controls over financial reporting.



Dated:  August 14, 2008        /s/  Laurence P. Birch
                               -----------------------
                               Laurence P. Birch
                               President and Chief Executive Officer (Principal
                               Executive Officer) and Acting Chief Financial
                               Officer (Principal Financial Officer)