Exhibit 99.1



September 2009


Dear Fellow Ore Shareholders,


I acknowledge  that being an owner of Ore shares over the past several years has
not been profitable. The company's poor stock performance has no doubt left many
of you  with  meaningful  losses  on your  Ore  investment.  You may  also  have
developed a more  general  lack of faith in the ability of the company to create
value over the long term. Ore has likely not lived up to the potential that many
of you hoped for at the time you became a shareholder.

I was appointed Ore CEO in March 2009. I fully  appreciate these difficult facts
and the need for Ore to address  them.  In the few months  I've been CEO,  we've
completed an extraordinary  effort to cut unnecessary  expenses and place Ore on
firmer financial  ground.  We have made sweeping changes to the management team,
such that as of today only one  employee  of Ore has been with the  company  for
more than one year.  We have shrunk the size of the Board of  Directors  to five
members, including one distinguished new Director who just recently joined. Most
importantly,  we are in the process of implementing a new business strategy that
we believe makes the best use of Ore's strengths as well as capitalizes  upon an
emerging opportunity in the marketplace.

Ore's new strategy is to be a pharmaceutical  asset management  company,  and no
longer a traditional  biopharmaceutical  operating company. We intend to acquire
or  in-license  drug  programs  from  research-focused  companies.  We intend to
increase the value of drug  candidates  by  conducting  targeted and  outsourced
development   studies,  and  then  monetize  those  assets.  To  pay  for  those
activities,  we plan to use  subsidiary  financing  structures  that we  believe
better align the risks and rewards of drug development  with investor  interests
as well  as  attenuate  Ore  shareholder  dilution.  We  intend  for Ore to earn
management  advisory and other fees for our operational  contributions  to these
programs, as well as to retain a significant economic interest in their enhanced
value.  We already have a portfolio of four clinical stage assets  acquired from
large  pharmaceutical  companies,  that we believe  are  attractive  development
opportunities.  We are also engaged in continual efforts to identify  additional
programs and are working to attract subsidiary investors to finance them.

However,  in order to advance  this new Ore  strategy we need your  support.  In
addition to several  routine  matters,  the enclosed proxy  statement/prospectus
lays out two proposals that we believe are critical to the future success of the
company, and we are asking for your vote "FOR" each of them.



The first proposal is to reorganize the current Ore  Pharmaceuticals  into a new
company,  Ore  Pharmaceutical  Holdings.  One of  our  largest  assets  is a net
operating tax loss carryforward (or "NOL") of approximately  $324 million.  This
asset  may  permit  us  (subject  to tax  laws  and  certain  circumstances)  to
significantly  reduce taxes due on Ore income.  This has  significant  potential
value.  However, in order to maximize our ability to protect that value, we need
to reorganize Ore into a company that will have  restrictions  on ownership that
we believe are necessary to prevent the  inadvertent  loss of our NOLs. You will
find significantly more information in the enclosed document,  which we urge you
to read prior to voting on this proposal.

The second  proposal is to approve a new Omnibus  Equity  Incentive Plan for the
Company.  Our  current  plan is 10 years  old and may soon run out of  shares to
grant to employees,  board members and others. As you will appreciate,  in order
to attract the high quality employees, directors, consultants and others we need
to  support  and  drive  this  turnaround  of Ore,  as well as to  better  align
management's  economic interests with yours, we need to be able to motivate them
with equity in the form of incentive stock options. This is particularly true at
a time when we are trying to control our cash expenses,  including salaries.  We
believe  that your support of this new plan will enhance our ability to continue
to get the people we need to be able to execute our new strategy.

Again, we urge you to vote "FOR" both of these proposals.

I took this role at Ore because I believe that the company has  valuable  assets
and that we have a strategy  that will  reveal and grow this value over time.  I
and my team are committed to making this  strategy  work and creating  value for
you, the owners of Ore. Your approval of the proposals in the enclosed  proxy is
a critical component of our ability to execute on that strategy.  I look forward
to updating you  periodically  on our progress,  and I urge you to contact me or
any other member of our  executive  team if you have any questions or desire any
more information about our activities. I thank you for your continued support of
Ore.


Sincerely,

/s/ Mark J. Gabrielson
- ----------------------
Mark J. Gabrielson
President & CEO



Where to Find Additional Information

On September 2, 2009, the Company filed a registration statement with the SEC on
Form S-4 that  includes  the  definitive  proxy  statement/prospectus  and other
relevant materials regarding the proposed reorganization. Stockholders are urged
to  read  the  definitive  proxy  statement/prospectus  filed  with  the  SEC on
September 2, 2009, and any other relevant materials filed with the SEC when they
become available because they contain,  or will contain,  important  information
about  the  Company  and  the  proposed  reorganization.  The  definitive  proxy
statement/prospectus  seeking  stockholder  approval  of the  reorganization  is
enclosed with this letter. Stockholders may obtain a free copy of the definitive
proxy  statement/prospectus  filed on September 2, 2009 with the SEC, as well as
other  documents  filed by the  Company  with the SEC at the  SEC's  web site at
www.sec.gov  or  through  the  Company's  web  site  as  www.orepharma.com.  The
definitive proxy  statement/prospectus  and the Company's other SEC filings also
may be  obtained  for free from the  Company  by  directing  a request  to:  Ore
Pharmaceuticals Inc., 610 Professional Drive, Suite 101, Gaithersburg,  Maryland
20879, Attention: Corporate Secretary, telephone: 240-361-4400. Stockholders are
urged to read the  definitive  proxy  statement/prospectus  and  other  relevant
materials  relating  to the  reorganization  when they become  available  before
voting or making any investment decision with respect to the reorganization.

The Company, its directors, executive officers and certain members of management
and employees may be considered  "participants  in the  solicitation" of proxies
from the Company's stockholders in connection with the transaction.  Information
regarding such persons and a description of their  interests in the  transaction
is contained in the proxy  statement/prospectus and the Company's Annual Reports
on Form  10-K and  Form  10-K/A  filed  with  the  SEC.  Additional  information
regarding  the  interests  of those  persons  may be  obtained  by  reading  the
definitive proxy statement/prospectus.

Safe Harbor Statement

This letter contains  "forward-looking  statements," as such term is used in the
Securities  Exchange Act of 1934, as amended.  Such  forward-looking  statements
include our ability to identify strategies for making our businesses  successful
and the impact of such strategies on our business and financial  performance and
on shareholder  value.  Forward-looking  statements  typically include the words
"expect,"  "anticipate,"  "believe,"  "estimate,"  "intend,"  "may," "will," and
similar  expressions as they relate to Ore  Pharmaceuticals  or its  management.
Forward-looking   statements   are  based  on  our  current   expectations   and
assumptions,  which  are  subject  to  risks  and  uncertainties.  They  are not
guarantees of our future  performance  or results.  Our actual  performance  and
results  could  differ  materially  from  what  we  project  in  forward-looking
statements for a variety of reasons and  circumstances,  including  particularly
risks and  uncertainties  that may affect the  Company's  operations,  financial
condition and  financial  results and that are discussed in detail in our Annual
Report on Form 10-K and our other  subsequent  filings with the  Securities  and
Exchange Commission. They include, but are not limited to: whether the compounds
we  develop  will be  commercially  viable;  whether we will be able to begin to
generate  sufficient  new revenue  from  licensing or other  transactions  early
enough to support our operations and continuing  compound  development;  whether
there will be valid claims for  indemnification  from the buyers of our Genomics
Assets; whether there will be claims from the landlords of the leased properties
we have assigned,  the buyer of our Preclinical  Division or the assignee of our
Cambridge facility lease, that we would be required to pay as guarantors of such
leases;  whether  we will be able to  collect  amounts  due  under  the terms of
promissory notes from the buyers of our Genomics Assets and molecular diagnostic
business;  whether we will be able to manage our existing  cash  adequately  and
whether we will have access to  financing  on  sufficiently  favorable  terms to
maintain our  businesses and effect our  strategies;  whether we will be able to
maintain  our NASDAQ  listing;  whether  we will be able to  attract  and retain
qualified  personnel for our business;  and  potential  negative  effects on our
operations   and   financial   results  from   workforce   reductions   and  the
transformation  of  our  business.   Ore  Pharmaceuticals   Inc.  undertakes  no
obligation  to update or revise  any  forward-looking  statements,  whether as a
result of new information, future events or otherwise.