PRESS RELEASE                            LIFE SCIENCES RESEARCH, INC.
                                         (OTCBB: LSRI)

                                         PO Box 2360
                                         Mettlers Road
                                         East Millstone, NJ 08875-2360

                                         For Further Information:
                                         Richard Michaelson
                                         Phone:   US: (732) 649-9961
                                         e-mail: LifeSciencesResearch@LSRinc.net


November 3, 2005

                       LSR ANNOUNCES THIRD QUARTER RESULTS


East  Millstone,  New Jersey,  November 3, 2005 - Life Sciences  Research,  Inc.
(OTCBB:  LSRI) announced today that revenues for the quarter ended September 30,
2005  were  $43.8  million,  operating  income  was  $5.7  million,  or 13.0% of
revenues,  and EBITDA,  excluding Other Expenses,  was $8.1 million, or 18.5% of
revenues.

Revenues for the quarter  ended  September  30, 2005 of $43.8  million were 7.1%
above the  revenues  for the same  period in the  prior  year of $40.9  million.
Excluding  the  effect  of  exchange  rate  movements,  the  increase  was 8.6%.
Operating  Income for the quarter ended September 30, 2005 was $5.7 million,  or
13.0% of revenues, compared with $4.5 million, or 11.1% of revenues for the same
period in the prior year. The Company  reported net income for the quarter ended
September 30, 2005 of $1.1 million, compared with net income of $1.8 million for
the same period in the prior year.  Net income per common  share for the quarter
ended  September 30, 2005 was $0.09 compared with net income per common share of
$0.15 for the same period in the prior year.  Net income per fully diluted share
was $0.08 for the quarter ended  September 30, 2005 compared with net income per
fully diluted share of $0.13 for the same period in the prior year.

The net income in the quarter ended September 30, 2005 included Other Expense of
$1.8  million   reflecting  a  non-cash  foreign  exchange   remeasurement  loss
pertaining  to the  Convertible  Capital  Bonds  of  $0.6  million  and  finance
arrangement  fees of Alconbury,  our landlord,  of $1.2 million  associated with
FIN46R  consolidation  of their  financing  expenses.  In the same period in the
prior year, Other Expense of $0.1 million  comprised a non-cash foreign exchange
remeasurement loss pertaining to the Convertible Capital Bonds.  Excluding these
Other Expense items and related tax effect,  non-GAAP net income for the quarter
ended  September  30, 2005 was $3.2 million,  or $0.22 per fully diluted  share,
compared with $1.9 million, or $0.13 per fully diluted share for the same period
in the prior year.

Earnings  before  Interest,  Taxes,  Depreciation  and  Amortization  and  Other
Income/(Expense) ("EBITDA") was $8.1 million for the quarter ended September 30,
2005, or 18.5% of revenues,  compared  with $7.0 million,  or 17.0% of revenues,
for the same period in the prior year.

Net days sales  outstanding  at September  30, 2005 were 21 (20 at September 30,
2004 and 4 at December 31, 2004) and capital  expenditures  totaled $5.1 million
in the quarter ended September 30, 2005, compared with $2.4 million for the same
period in the prior year.  As a result net cash used totaled $3.3 million in the
quarter  ended  September  30,  2005  compared  with  $5.7  million  of net cash
generated for the same period in the prior year.

Cash on hand at September 30, 2005 was $12.2 million compared with $33.3 million
at December 31, 2004.  Long-term  debt was $29.6  million at September 30, 2005,
compared with $89.7 million at December 31, 2004.  This  reduction was primarily
due to the  reclassification to short-term debt of the $46.2 million outstanding
amount of  Convertible  Capital  Bonds,  which mature in  September  2006; a net
repayment of $10.7 million of our non-bank debt  concurrently with completion of
the sale and leaseback transaction; and exchange rate movements.

Net new business  signings totaled $42.0 million for the quarter ended September
30, 2005.  This  represented  a decrease of 7% from the same period in the prior
year. At September 30, 2005,  backlog (booked on work) amounted to approximately
$115 million.

Revenues for the nine months  ended  September  30, 2005 of $132.0  million were
13.4% above  revenues  for the same period in the prior year of $116.4  million.
Excluding  the  effect of  exchange  rate  movements,  the  increase  was 12.3%.
Operating Income for the nine months ended September 30, 2005 was $16.3 million,
or 12.3% of revenues,  compared with $10.8 million,  or 9.3% of revenues for the
same period in the prior  year.  The  Company  reported  net income for the nine
months ended September 30, 2005 of $2.0 million,  compared with $4.4 million for
the same  period in the prior  year.  Net income  per common  share for the nine
months  ended  September  30,  2005 was $0.16  compared  with $0.36 for the same
period in the prior year.

The net income in the nine  months  ended  September  30,  2005  included  Other
Expense of $5.2 million  reflecting a non-cash  foreign  exchange  remeasurement
loss  pertaining  to the  Convertible  Capital Bonds of $3.8 million and finance
arrangement  fees of $1.4 million.  In the same period in the prior year,  Other
Income of $0.6 million comprised a non-cash foreign exchange  remeasurement gain
pertaining to the Convertible  Capital Bonds. The net income for the nine months
ended September 30, 2005 also included $2.4 million of taxes associated with the
sale and leaseback transaction announced on June 14, 2005. Excluding these Other
Expense items and related tax effect,  and the transaction  related tax charges,
non-GAAP  net income  for the nine  months  ended  September  30,  2005 was $9.4
million or $0.65 per fully  diluted  share,  compared with $3.9 million or $0.29
per fully diluted share for the same period in the prior year.

EBITDA in the nine months ended September 30, 2005 was $23.5 million or 17.8% of
revenues, compared with $17.9 million, or 15.4% of revenues, for the same period
in the prior year.

Capital  expenditures  in the nine months ended September 30, 2005 totaled $12.1
million  compared  with $7.0  million in the same period in the prior year.  Net
cash used in the nine months ended September 30, 2005 was $21.2 million compared
with $3.3 million of net cash generated for the same period in the prior year.

Andrew Baker the  Company's  Chairman and CEO said,  "These last few months have
seen both exciting and frustrating developments in LSR's fortunes. In August, we
announced  the  approval  for  listing on the New York Stock  Exchange  of LSR's
common stock, only to be followed the morning of that scheduled listing with the
unprecedented  postponement by the Exchange. The NYSE's decision to postpone our
trading,  which  continues  today,  has  been  met  with  condemnation  by  many
organizations and the world's financial media, and provoked  questions in the US
Senate  last week.  The  Senate's  examination  of the animal  rights  extremist
campaign  that has  targeted  our company and the world of medical  research has
resulted in their  introduction  of new  legislation to address the challenge of
controlling  this form of  domestic  terrorism.  This  progress,  along with the
continuing commitment we've seen from the UK government and law enforcement,  is
welcomed not only by LSR, but by the medical  research  community and others who
recognize  that this issue is far broader than the symptoms  that have  affected
our company and your stock".

Brian Cass,  LSR's  President  and Managing  Director  said,  "This  progress in
providing support for the whole research  community is very promising and we are
proud of the part we have been able to play in  encouraging  it.  However,  as a
company,  we remain focussed on pursuing our financial  success.  In this regard
the steady  growth in  revenues  has been  maintained  this  quarter and we have
increased our operating  income by 25% over last year to come in at a new record
level of 13% of revenues."

LSR will hold an investor  conference  call to discuss the quarter's  results on
Friday  morning,  November 4, 2005 at 9:00 a.m.  Eastern Time.  That call can be
listened to by dialing (212) 547-0201;  pass code 39138. We suggest calling five
minutes prior to the scheduled call.

This announcement  contains non-GAAP  financial  measures,  including EBITDA and
non-GAAP  earnings per share which exclude,  among other items,  gains or losses
associated with the non-cash foreign exchange  remeasurement  loss pertaining to
the Company's  Convertible  Capital Bonds and one time charges. We exclude these
items from the non-GAAP  financial  measures because they are outside our normal
operations. We believe that the inclusion of non-GAAP financial measures in this
announcement  helps  investors  to gain a meaningful  understanding  of our core
operating  results and future  prospects,  and is consistent with how management
measures and forecasts the Company's  performance and debt service capabilities,
especially  when comparing such results to prior periods or forecasts.  Non-GAAP
results also allow  investors to compare the  Company's  operations  against the
financial  results of other  companies  in the industry  who  similarly  provide
non-GAAP results.  The non-GAAP financial measures included in this announcement
are not meant to be  considered  superior  to or a  substitute  for  results  of
operations  prepared in accordance  with GAAP.  Reconciliations  of the non-GAAP
financial  measures used in this  announcement  to the most directly  comparable
GAAP financial measures are set forth in the text of this announcement and other
public   filings,   and  can  also  be  found  on  the   Company's   website  at
www.lsrinc.net.

Life  Sciences  Research,  Inc.  is  a  global  contract  research  organization
providing product development  services to the pharmaceutical,  agrochemical and
biotechnology  industries.  LSR brings  leading  technology  and  capability  to
support its clients in  non-clinical  safety  testing of new  compounds in early
stage development and assessment.  The purpose of this work is to identify risks
to humans, animals or the environment resulting from the use or manufacture of a
wide  range of  chemicals  which  are  essential  components  of LSR's  clients'
products.   The  Company's   services  are  designed  to  meet  the   regulatory
requirements of governments  around the world. LSR operates research  facilities
in the United States (the Princeton  Research Center, New Jersey) and the United
Kingdom (Huntingdon and Eye, England).

This announcement  contains statements that may be forward-looking as defined by
the Private Securities Litigation Reform Act of 1995. These statements are based
largely  on  LSR's  expectations  and are  subject  to a  number  of  risks  and
uncertainties,  certain  of  which  are  beyond  LSR's  control,  as more  fully
described in the Company's  SEC filings,  including its Form 10-K for the fiscal
year ended  December  31,  2004,  as filed with the US  Securities  and Exchange
Commission.


                              - tables to follow -






                           Life Sciences Research Inc.
                             Statement of Operations

                                    Unaudited



                                                          Three months ended             Nine months ended
                                                             September 30                   September 30

(Dollars in thousands, except per share data)               2005            2004           2005            2004
                                                                                           
Net revenues                                             $43,758         $40,855       $131,993        $116,406
Cost of revenues                                        (31,673)        (29,674)       (95,214)        (87,220)
                                                      -----------    ------------    -----------     -----------
Gross profit                                              12,085          11,181         36,779          29,186
Selling, general and administrative expenses             (6,410)         (6,659)       (20,496)        (18,345)
                                                      -----------    ------------    -----------     -----------
Operating income                                           5,675           4,522         16,283          10,841
Interest income                                               21              13             66              41
Interest expense                                         (2,138)         (1,689)        (5,855)         (4,858)
Other (expense)/income                                   (1,760)           (105)        (5,195)             625
                                                      -----------    ------------    -----------     -----------
Income before income taxes                                 1,798           2,741          5,299           6,649
Income tax expense                                         (649)           (945)        (3,288)         (2,261)
                                                      -----------    ------------    -----------     -----------
Net income                                                $1,149          $1,796         $2,011          $4,388
                                                      -----------    ------------    -----------     -----------
Income per common share
- - Basic                                                    $0.09           $0.15          $0.16           $0.36
- - Diluted                                                  $0.08           $0.13          $0.14           $0.33

Weighted average common shares outstanding
- - Basic     (000's)                                       12,542          12,166         12,506          12,085
- - Diluted  (000's)                                        14,601          13,914         14,521          13,369







                           Life Sciences Research Inc.
                                  Balance Sheet


(Dollars in thousands, except per share data)                      September 30, 2005   December 31,2004
                                                                       Unaudited                Audited

ASSETS
                                                                                        
Current assets:
Cash and cash equivalents                                                 $12,161              $33,341
Accounts receivable, net of allowance of $338 and $259
in 2005 and 2004, respectively                                             29,581               27,841
Unbilled receivables                                                       12,531               11,516
Inventories                                                                 1,733                2,024
Prepaid expenses and other current assets                                   8,712                2,929
                                                                   -------------------  --------------------
Total current assets                                                       64,718               77,651

Property and equipment, net                                               107,709              109,999
Goodwill                                                                    1,032                  901
Unamortized capital bonds issue costs                                         117                  271
Deferred income taxes                                                       7,450               11,253
                                                                   -------------------  --------------------
Total assets                                                             $181,026             $200,075
                                                                   -------------------  --------------------

LIABILITIES AND STOCKHOLDERS' EQUITY/(DEFICIT)
Current liabilities:
Accounts payable                                                          $15,855              $13,547
Accrued payroll and other benefits                                          3,948                4,024
Accrued expenses and other liabilities                                     16,928               19,987
Short-term debt                                                            46,499                  719
Fees invoiced in advance                                                   31,850               37,574
                                                                   -------------------  --------------------
Total current liabilities                                                 115,080               75,851

Long-term debt                                                             29,643               89,685
Pension liabilities                                                        33,760               36,603
                                                                   -------------------  --------------------
Total liabilities                                                         178,483              202,139
                                                                   -------------------  --------------------
Commitments and contingencies
Stockholders' equity/(deficit)
Preferred Stock, $0.01 par value. Authorized: 5,000,000
Issued and outstanding : None                                                   -                    -
Non-Voting Common Stock, $0.01 par value. Authorized: 5,000,000
Issued and outstanding: None                                                    -                    -
Voting Common Stock, $0.01 par value.  Authorized 50,000,000
Issued and outstanding at September 30, 2005:  12,548,251
(December 31, 2004: 12,441,281)                                              $125                 $125
Paid in capital                                                            75,841               75,671
Less: Promissory notes for the issuance of common stocks                     (238)                (697)
Accumulated comprehensive loss                                            (32,757)             (34,724)
Accumulated deficit                                                       (40,428)             (42,439)
                                                                   -------------------  --------------------
Total stockholders' equity/(deficit)                                        2,543               (2,064)
                                                                   -------------------  --------------------
Total liabilities and stockholders' equity/(deficit)                     $181,026             $200,075
                                                                   -------------------  --------------------