EXHIBIT 32.1

                             CERTIFICATION PURSUANT
                           TO 18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Hydron Technologies, Inc. (the
"Registrant") on Form 10-QSB for the period ended March 31, 2006 as filed with
the Securities and Exchange Commission on May 15, 2006, hereof (the "Report"),
the undersigned officer certifies, pursuant to 18 U.S.C. Section 1350, as
adopted pursuant to section 906 of the Sarbanes-Oxley Act of 2002, that:

The Report fully complies with the requirements of Section 13(a) or 15(d) of the
Securities Exchange Act of 1934, and

The information contained in the Report fairly presents, in all material
respects, the financial condition, and results of operations of the Registrant.



                            HYDRON TECHNOLOGIES, INC.
                                /s/ David Pollock
                                -----------------
                                  David Pollock
       Chief Executive Officer, Principal Financial and Accounting Officer
                                  May 15, 2006