Exhibit 3.1

ROSS MILLER
Secretary of State                                        Document Number
254 North Carson Street, Suite 1                          20120818095-36
Carson City, Nevada 89701-4520                            Filing Date and Time
(776) 684 5708                                            12/04/2012 2:40 PM
Website: www.nvsos.gov                                    Entity Number
                                                          C6818-2002

                                                          Filed in the office of
                                                          /s/ Ross Miller
CERTIFICATE OF CHANGE PURSUANT                            Ross Miller
      TO NRS 78.209                                       Secretary of State
                                                          State of Nevada

                                              ABOVE SPACE IS FOR OFFICE USE ONLY

               CERTIFICATE OF CHANGE FILED PURSUANT TO NRS 78.209
                         FOR NEVADA PROFIT CORPORATIONS

1.   Name of corporation:

     UPSTREAM BIOSCIENCES INC.

2.   The board of directors have adopted a resolution pursuant to NRS 78.209 and
     have obtained any required approval of the stockholders.

3.   The current number of authorized shares at the par value, if any, of each
     class or series, if any, of shares before the change:

     100,000,000  common shares with a par value of $0.001

4.   The number of authorized shares and the par value, if any, of each class or
     series, if any, of shares after the change:

     100,000,000  common shares with a par value of $0.001

5.   The number of shares of each affected class or series, if any, to be issued
     after the change in exchange for each issued share of the same class or
     series:

     The Corporation shall issue one (1) share of stock for each thirty-five
     (35) shares of common stock issued and outstanding immediately prior to the
     effective date of the reverse split.

6.   The provisions, if any, for the issuance of fractional shares, or for the
     payment of money or the issuance of scrip to stockholders otherwise
     entitled to a fraction of a share and the percentage of outstanding shares
     affected thereby:

     No fractional shares shall be issued

7.   Effective date of filing (optional):
                 (must not be later than 90 days after the certificate is filed)

8.   Signature: (required)

     X /s/ Charles El-Moussa                                   President
     Signature of Officer                                         Title

IMPORTANT: Failure to include any of the above information and submit the proper
fees may cause this filing to be rejected.