As filed with the Securities and Exchange Commission on July 10, 2002 Registration No. 333-______ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NASTECH PHARMACEUTICAL COMPANY INC. (Exact Name of Registrant as Specified in Charter) DELAWARE 11-2658569 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification No.) 45 Davids Drive Hauppauge, NY 11788 (Address of Principal Executive Offices)(Zip Code) STOCK OPTIONS AWARDED PURSUANT TO EMPLOYMENT AGREEMENTS WITH CERTAIN NAMED EXECUTIVES OF THE CORPORATION (Full title of the plan) Dr. Steven C. Quay Chairman, Chief Executive Officer and President NASTECH PHARMACEUTICAL COMPANY INC. 45 Adams Avenue Hauppauge, NY 11788 (631) 273-0101 (Name, address and telephone number of agent for service) Copies to: Bruce R. Thaw, Esq. 45 Banfi Plaza Farmingdale, NY 11735 (631) 752-1760 CALCULATION OF REGISTRATION FEE Proposed Maximum Proposed Maximum Title of Securities Amount to be Offering Price Aggregate Amount of to be Registered Registered Per Share (1) Offering Price (1) Registration Fee (1) ---------------- ----------- ------------- ------------------ -------------------- Shares of Common Stock $.006 par value, reserved for Steven C. Quay and Gregory L. Weaver 561,719 15.455 8,681,367.15 $2,074.84 (1) Pursuant to paragraphs (c) and (h) of Rule 457 of the Securities Act of 1933, the proposed maximum offering price per share of such shares is estimated solely for the purpose of determining the registration fee and is based upon the average of the high and low sale prices per share of the Registrant's shares as reported on the Nasdaq National Market System on July 5, 2002. PART 1 INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS The documents containing the information specified in Part I of Form S-8 will be sent or given to Dr. Steven C. Quay and Gregory L. Weaver as specified by Rule 428(b)(1). Such documents need not be filed with the Commission either as part of this registration statement or as prospectuses or prospectus supplements pursuant to Rule 424. These documents and the documents incorporated by reference in the registration statement pursuant to Item 3 of Part II of this form, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE. The following documents filed with the Securities and Exchange Commission ("SEC") are incorporated by reference in this registration statement: o Annual Report on Form 10-K for the fiscal year ended December 31, 2001; o Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2002; o Definitive and Revised Proxy Statement dated May 1, 2002 and May 7, 2002, respectively, for the Annual Meeting of stockholders held on June 6, 2002, including any documents incorporated by reference therein; o The description of our common stock contained in the Form 8-A Registration Statement filed with the SEC on October 6, 1985, and any amendment or report filed for the purpose of updating those descriptions. All reports and other documents subsequently filed with the SEC pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be a part of this registration statement from the date of filing of such documents. Any statement contained herein or in a document incorporated by reference herein shall be deemed to be modified or superseded for purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement. ITEM 4. DESCRIPTION OF SECURITIES. Not Applicable. ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL. The validity of the issuance of securities being registered hereby has been passed upon for the Company by the Law Offices of Bruce R. Thaw, 45 Banfi Plaza, Farmingdale, NY 11735. Bruce R. Thaw is the General Counsel and a Director of the Company and owns 198,041 shares of the Company's Common Stock including options to acquire 120,000 shares of the Company's Common Stock. ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS. Our Certificate of Incorporation provides that the indemnification provisions of Sections 102(b)(7) and 145 of the Delaware General Corporation Law shall be utilized to the fullest extent possible. Further, the Certificate of Incorporation contains provisions to eliminate the liability of our directors to the Company or its stockholders to the fullest extent permitted by Section 102(b)(7) of the Delaware General Corporation Law, as amended from time to time. Section 145 of the Delaware General Corporation Law provides that a corporation may indemnify directors and officers as well as other employees and individuals against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with any threatened, pending or completed actions, suits or proceedings in which such person is made a party by reason of such person being or having been a director, officer, employee or agent of the corporation. The Delaware General Corporation Law provides that Section 145 is not exclusive of other rights to which those seeking indemnification may be entitled under any bylaw, agreement, vote of stockholders or disinterested directors or otherwise. Section 102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except for liability (i) for any breach of the director's duty of loyalty to the corporation or its stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) for unlawful payments of dividends or unlawful stock repurchases, redemptions or other distributions, or (iv) for any transaction from which the director derived an improper personal benefit. Our Certificate of Incorporation provides for such limitation of liability. At present, there is no pending litigation or proceeding involving any of our directors, officers or employees as to which indemnification is sought, nor are we aware of any threatened litigation or proceeding that may result in claims for indemnification. Insofar as indemnification for liabilities arising under the Securities Act of 1933, as amended, is permitted to directors, officers or controlling persons of the Registrant, pursuant to any charter provision, by-law contract, arrangement, statute, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act, and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue. ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED. Not Applicable. ITEM 8. EXHIBITS. 4.1 Specimen of Common Stock Certificate of Registrant (1) 4.2 Articles of Incorporation of Registrant, as amended and filed with the Secretary of State of Delaware on November 8, 1993 (1) 4.3 By-laws of Registrant (1) 4.4 Employment Agreement, dated as of August 8, 2000, between Nastech Pharmaceutical Company Inc. and Steven C. Quay, M.D., Ph.D.(2) 4.5 Employment Agreement, dated as of April 30, 2002, between Nastech Pharmaceutical Company Inc. and Gregory L. Weaver. 5 Opinion of Counsel Bruce R. Thaw, Counsel to the Company, as to the legality of securities being registered 15 None 23A Consent of Counsel Bruce R. Thaw, Counsel to the Company (included in Exhibit 5) 23B Consent of KPMG LLP, Independent Auditors 24 Power of Attorney - See signature page - ---------- (1) Filed as an exhibit to the Registration Statement on Form SB-2 (File No. 33-70180) of the Registrant, filed on October 12, 1993, and incorporated herein by reference. (2) Filed as an exhibit to the Current Report on Form 8-K (File No. 000-13789) of the Registrant and incorporated herein by reference. ITEM 9. UNDERTAKINGS The undersigned Registrant hereby undertakes: (1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement to include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement. (2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. (3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering. (4) The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to section 13(a) or section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. (5) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to any charter provision, by-law, contract, arrangement, statute, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it against public policy as expressed in the Act and will be governed by the final adjudication of such issue. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of Hauppauge, New York on the 10th day of July, 2002. NASTECH PHARMACEUTICAL COMPANY INC. By: /s/ Dr. Steven C. Quay --------------------------------------- DR. STEVEN C. QUAY, M.D., Chairman, President and Chief Executive Officer KNOW ALL MEN BY THESE PRESENT, that each of the undersigned whose signature appears below constitutes and appoints Dr. Steven C. Quay and Bruce R. Thaw, Esq., and each of them (with full power of each of them to act alone), his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution for him and on his behalf, and in his name, place and stead, in any and all capacities to execute and sign any and all amendments or post-effective amendments to this registration statement, or subsequent registration statements related to the shares registered hereby and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agents or any of them or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof and the Registrant hereby confers like authority on its behalf. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on July 10, 2002: Signature Title --------- ----- /s/ Steven C. Quay - ----------------------------- President, Chief Executive Officer and Chairman Dr. Steven C. Quay of the Board (Principal Executive Officer) /s/ Gregory L. Weaver - ----------------------------- Chief Financial Officer Gregory Weaver (Principal Financial and Accounting Officer) /s/ Grant W. Denison - ----------------------------- Director Grant W. Denison /s/ Ian R. Ferrier - ----------------------------- Director Dr. Ian R. Ferrier /s/ Alvin Katz - ----------------------------- Director Alvin Katz /s/ John V. Pollock - ----------------------------- Director John V. Pollock /s/ Bruce R. Thaw - ----------------------------- Director Bruce R. Thaw /s/ Devin N. Wenig - ----------------------------- Director Devin N. Wenig