SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   ----------

                                    FORM 8-K

                                 CURRENT REPORT

                         Pursuant to Section 13 or 15(d)
                     of the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): April 14, 2004

                                  VAXGEN, INC.
             (Exact name of Registrant as Specified in its Charter)

           DELAWARE                      0-26483                 94-3236309
(State or other jurisdiction of  (Commission File Number)    (I.R.S. Employer
incorporation or organization)                            Identification Number)

            1000 MARINA BLVD., SUITE 200, BRISBANE, CALIFORNIA 94005
                  (Address of Principal Administrative Offices)

       Registrant's Telephone Number, Including Area Code: (650) 624-1000



Item 5. Other Events and Regulation FD Disclosure.

      On April 14, 2004, VaxGen, Inc. issued a press release entitled, "VaxGen
Reports Positive Results of Animal Efficacy Studies of Smallpox Vaccine
Candidate".

      This press release is attached as Exhibit 99.1 to this report and is
incorporated herein by reference.

Item 7. Financial Statements, Pro Forma Financial Information and Exhibits.

      (a)   Financial Statements. Not applicable

      (b)   Financial Information. Not applicable

      (c)   Exhibits.

Exhibit No.       Description
- -----------       -----------

99.1              Press release dated April 14, 2004, entitled, "VaxGen Reports
                  Positive Results of Animal Efficacy Studies of Smallpox
                  Vaccine Candidate".



                                    SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                                  VaxGen, Inc.
                                                  (Registrant)


Dated: April 14, 2004                   By: /s/ Lance K. Gordon
                                            -----------------------------------
                                            Lance K. Gordon
                                            President & Chief Executive Officer