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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                 --------------

                                   FORM 10-Q

(Mark One)

|X|      Quarterly Report Pursuant to Section 13 or 15(d) of
         the Securities Exchange Act of 1934

         For the Quarter Ended March 31, 2006

                                       OR

|_|      Transition Report Pursuant To Section 13 Or 15(d) Of
         the Securities Exchange Act of 1934

         For the Transition Period from ___________ to _____________

                           Commission File No. 0-23047

                          ----------------------------

                             SIGA Technologies, Inc.
             (Exact name of registrant as specified in its charter)

       A Delaware Corporation                     IRS Employer No. 13-3864870

               420 Lexington Avenue, Suite 408, New York, NY 10170
                         Telephone Number (212) 672-9100

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days. Yes |X| No |_|.

Indicate by check mark whether the registrant is a large  accelerated  filer, an
accelerated  filer, or a  non-accelerated  filer. See definition of "accelerated
filer and large  accelerated  filer" in Rule 12b-2 of the Exchange  Act.  (Check
one):

Large Accelerated Filer |_|   Accelerated Filer |_|   Non-Accelerated Filer |X|.

Indicate by check mark whether the  registrant is a shell company (as defined in
rule 12b-2 of the Exchange Act). Yes |_| No|X|.

As of May 10,  2005  the  registrant  had  26,500,648  shares  of  common  stock
outstanding.

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                             SIGA Technologies, Inc.

                                    Form 10-Q

                                Table of Contents



                                                                                                Page No.
                                                                                               
PART I FINANCIAL INFORMATION

Item 1.  Financial Statements........................................................................2

Item 2.  Management's Discussion and Analysis of Financial Condition and Results of Operations......12

Item 3.  Quantitative and Qualitative Disclosure About Market Risk..................................17

Item 4.  Controls and Procedures....................................................................17

PART II OTHER INFORMATION

Item 1.  Legal Proceedings..........................................................................18

Item 1A. Risk Factors...............................................................................18

Item 2.  Changes in Securities, Use of Proceeds and Issuer Purchases of Equity Securities...........18

Item 3.  Defaults Upon Senior Securities............................................................18

Item 4.  Submission of Matters to a Vote of Security Holders........................................18

Item 5.  Other Information..........................................................................18

Item 6.  Exhibits...................................................................................18

SIGNATURES..........................................................................................19



                                       1


Part I - Financial Information

Item 1 - Financial Statements

                             SIGA TECHNOLOGIES, INC.

                                 BALANCE SHEETS



                                                                                          Unaudited
                                                                                           March 31,       December 31,
                                                                                             2006              2005
                                                                                         ------------      ------------
                                                                                                     
ASSETS
Current assets
   Cash and cash equivalents .......................................................     $  2,478,102      $  1,772,489
   Accounts receivable .............................................................          258,182           883,054
   Prepaid expenses ................................................................           97,878           160,144
                                                                                         ------------      ------------
    Total current assets ...........................................................        2,834,162         2,815,687

   Property, plant and equipment, net ..............................................        1,492,392         1,224,147
   Goodwill ........................................................................          898,334           898,334
   Intangible assets, net ..........................................................          658,386           932,735
   Other assets ....................................................................          244,284           234,126
                                                                                         ------------      ------------
    Total assets ...................................................................     $  6,127,558      $  6,105,029
                                                                                         ============      ============

LIABILITIES AND STOCKHOLDERS' EQUITY
   Current liabilities
   Accounts payable ................................................................     $    581,103      $  1,251,854
   Accrued expenses and other ......................................................          441,805           452,082
   Deferred revenue ................................................................        1,264,356           347,319
   Common stock rights .............................................................        1,007,722            73,400
   Notes payable ...................................................................        1,107,520           107,520
                                                                                         ------------      ------------
    Total current liabilities ......................................................        4,402,506         2,232,175

Non-current portion of notes payable ...............................................           79,825           106,705
Common stock warrants ..............................................................        1,126,432           535,119
                                                                                         ------------      ------------
    Total liabilities ..............................................................        5,608,763         2,873,999

Commitments and contingencies ......................................................               --                --

Stockholders' equity
   Series A convertible preferred stock ($.0001 par value, 10,000,000 shares
     authorized, 68,038 issued and outstanding at March 31, 2006
     and December 31, 2005) ........................................................           58,672            58,672
   Common stock ($.0001 par value, 50,000,000 shares authorized,
     26,500,648 issued and outstanding at March 31, 2006
     and December 31, 2005) ........................................................            2,650             2,650
   Additional paid-in capital ......................................................       49,760,044        49,638,619
   Accumulated deficit .............................................................      (49,302,571)      (46,468,911)
                                                                                         ------------      ------------
    Total stockholders' equity .....................................................          518,795         3,231,030
                                                                                         ------------      ------------
    Total liabilities and stockholders' equity .....................................     $  6,127,558      $  6,105,029
                                                                                         ============      ============

   The accompanying notes are an integral part of these financial statements.



                                       2


                             SIGA TECHNOLOGIES, INC.

                      STATEMENTS OF OPERATIONS (UNAUDITED)



                                                                                        Three Months Ended
                                                                                              March 31,
                                                                                       2006               2005
                                                                                   ------------       ------------
                                                                                                
Revenues
     Research and development .............................................        $  1,394,454       $  1,458,565
                                                                                   ------------       ------------

Operating expenses
     Selling, general and administrative (includes $92,172 of non-cash
                  share based compensation) ...............................             941,540            844,709
     Research and development (includes $29,253 of non-cash share
                  based compensation) .....................................           1,657,670          1,551,640
     Patent preparation fees ..............................................             109,537            175,038

                                                                                   ------------       ------------
      Total operating expenses ............................................           2,708,747          2,571,387
                                                                                   ------------       ------------

      Operating loss ......................................................          (1,314,293)        (1,112,822)

Increase in fair market value of common stock rights
     and common stock warrants ............................................          (1,525,635)                --
Other income, net .........................................................               6,268              5,397

                                                                                   ------------       ------------
      Net loss ............................................................        $ (2,833,660)      $ (1,107,425)
                                                                                   ============       ============

Weighted average shares outstanding: basic and diluted ....................          26,500,648         24,500,648
                                                                                   ============       ============
Net loss per share: basic and diluted .....................................        $      (0.11)      $      (0.05)
                                                                                   ============       ============


   The accompanying notes are an integral part of these financial statements.


                                       3


                             SIGA TECHNOLOGIES, INC.

                       STATEMENT OF CASH FLOWS (UNAUDITED)



                                                                                         Three Months Ended
                                                                                               March 31,
                                                                                        2006              2005
                                                                                    -----------        -----------
                                                                                                 
Cash flows from operating activities:
Net loss ...............................................................            $(2,833,660)       $(1,107,425)
Adjustments to reconcile net loss to net
cash provided by (used in) operating activities:
Depreciation ...........................................................                 39,172             39,497
Amortization of intangible assets ......................................                274,349            324,848
Increase in fair market value of common stock rights and warrants ......              1,525,635                 --
Stock based compensation ...............................................                121,425                 --
Changes in assets and liabilities:
   Accounts receivable .................................................                624,872             46,174
   Prepaid expenses ....................................................                 62,266             44,178
   Other assets ........................................................                (10,158)           (61,651)
   Deferred revenue ....................................................                917,037                 --
   Accounts payable and accrued expenses ...............................               (681,028)            88,007
                                                                                    -----------        -----------
   Net cash provided by (used in) operating activities .................                 39,910           (626,372)
                                                                                    -----------        -----------

Cash flows from investing activities:
Capital expenditures ...................................................               (307,417)          (363,465)
                                                                                    -----------        -----------
   Net cash used in investing activities ...............................               (307,417)          (363,465)
                                                                                    -----------        -----------

Cash flows from financing activities:
Proceeds from note payable .............................................              1,000,000                 --
Repayment of note payable ..............................................                (26,880)                --
                                                                                    -----------        -----------
   Net cash provided by financing activities ...........................                973,120                 --
                                                                                    -----------        -----------

Net increase (decrease) in cash and cash equivalents ...................                705,613           (989,837)
Cash and cash equivalents at beginning of period .......................              1,772,489          2,020,938
                                                                                    -----------        -----------
Cash and cash equivalents at end of period .............................            $ 2,478,102        $ 1,031,101
                                                                                    ===========        ===========


   The accompanying notes are an integral part of these financial statements.


                                       4


                             SIGA TECHNOLOGIES, INC.

          Notes to the March 31, 2006 Financial Statements (Unaudited)

1. Basis of Presentation

SIGA  Technologies,  Inc.  ("SIGA" or the  "Company") is a  bio-defense  company
engaged in the discovery,  development and commercialization of products for use
in defense against  biological warfare agents such as Smallpox and Arenaviruses.
In December 2005, the FDA accepted the SIGA's IND  application for the Company's
lead product,  SIGA-246, an orally administered anti-viral drug that targets the
smallpox virus.  The Company is also engaged in the discovery and development of
other novel  anti-infectives,  vaccines,  and antibiotics for the prevention and
treatment of serious infectious diseases.  The Company's anti-viral programs are
designed  to  prevent  or  limit  the  replication  of viral  pathogens.  SIGA's
anti-infectives  programs are aimed at the increasingly  serious problem of drug
resistant bacteria and emerging pathogens.

The financial  statements  of the Company have been prepared in accordance  with
accounting  principles  generally  accepted in the United  States of America for
interim  financial  information  and the rules and regulations of the Securities
and  Exchange  Commission  (the "SEC") for  quarterly  reports on Forms 10-Q and
should be read in conjunction with the Company's  audited  financial  statements
and notes  thereto for the year ended  December 31,  2005,  included in the 2005
Form 10-K.  All terms used but not  defined  elsewhere  herein  have the meaning
ascribed  to them in the  Company's  2005  annual  report and Form 10-K.  In the
opinion of  management,  all  adjustments  (consisting  of normal and  recurring
adjustments)  considered necessary for a fair presentation of the results of the
interim periods presented have been included.  The results of operations for the
three months ended March 31, 2006 are not necessarily  indicative of the results
expected for the full year.

The  accompanying  financial  statements  have been  prepared  on a basis  which
assumes that the Company will continue as a going concern and which contemplates
the realization of assets and the satisfaction of liabilities and commitments in
the normal course of business.  The Company has incurred  cumulative  net losses
and  expects  to  incur  additional  losses  to  perform  further  research  and
development  activities.  The Company does not have commercial  products and has
limited  capital  resources.  Management's  plans with  regard to these  matters
include  continued  development  of its  products as well as seeking  additional
research support funds and financial arrangements. Although management continues
to pursue these plans, there is no assurance that the Company will be successful
in obtaining sufficient  financing on commercially  reasonable terms or that the
Company will be able to secure funding from anticipated government contracts and
grants.

On April 19, 2006,  the Company  received  the second $1.0 million  under a $3.0
million Bridge Note Purchase Agreement between the Company and PharmAthene, Inc.
(see Note 6).  Management  believes that existing cash combined with anticipated
cash flows,  including  receipt of future funding from government  contracts and
grants and receipt of the remaining  $1.0 million  funding under the Bridge Note
Purchase  Agreement will be sufficient to support its operations beyond June 30,
2007,  and that  sufficient  cash flows will be available to meet the  Company's
business  objectives.  Management  has  developed  a plan to further  reduce the
Company's  operating  expenses  in the  event  that  sufficient  funds  are  not
available,  or if the Company is not able to obtain the additional  $1.0 million
funding from the Bridge Note Purchase  Agreement or the  anticipated  government
contracts and grants, which would be sufficient to enable the Company to operate
beyond  June 30,  2007.  If the Company is unable to raise  adequate  capital or
achieve  profitability,  future  operations  will  need  to be  scaled  back  or
discontinued.  Continuance of the Company as a going concern is dependent  upon,
among  other  things,  the success of the  Company's  research  and  development
programs and the Company's ability to obtain adequate  financing.  The financial
statements do not include any adjustments  relating to the recoverability of the
carrying amount of recorded  assets and  liabilities  that might result from the
outcome of these uncertainties.

2. Significant Accounting Policies

Share-based Compensation

On January 1, 2006,  the  Company  adopted  Statement  of  Financial  Accounting
Standards No. 123 (revised 2004),  "Share-Based  Payment," ("SFAS 123(R)") which
requires  the  measurement  and  recognition  of  compensation  expense  for all
share-based  payment awards made to employees and directors  including  employee
stock  options  and  employee  stock  purchases  related to the  Employee  Stock
Purchase Plan ("employee stock purchases") based on estimated fair values.  SFAS
123(R) supersedes the Company's previous accounting under Accounting  Principles
Board Opinion No. 25,  "Accounting for Stock Issued to Employees" ("APB 25") for
periods  beginning  on January  1, 2006.  In March  2005,  the SEC issued  Staff
Accounting Bulletin No. 107 ("SAB 107") relating to SFAS 123(R). The Company has
applied the  provisions  of SAB 107 in its adoption of SFAS 123(R).


                                       5


The  Company  adopted  SFAS 123(R)  using the  modified  prospective  transition
method,  which requires the application of the accounting standard as of January
1,  2006,  the  first day of the  Company's  fiscal  year  2006.  The  Company's
Financial Statements as of and for the three months ended March 31, 2006 reflect
the  impact  of  SFAS  123(R).  In  accordance  with  the  modified  prospective
transition method, the Company's Financial Statements for prior periods have not
been  restated  to  reflect,  and do not  include,  the  impact of SFAS  123(R).
Share-based  compensation related to stock options expense recognized under SFAS
123(R) for the three months ended March 31, 2006 was  $121,425.  No  share-based
compensation expense related to employee stock options was recognized during the
three months ended March 31, 2005.

SFAS 123(R) requires companies to estimate the fair value of share-based payment
awards on the grant-date using an option-pricing model. The value of the portion
of the award that is  ultimately  expected to vest is recognized as expense over
the requisite service periods in the Company's  Statements of Operations.  Prior
to the adoption of SFAS 123(R),  the Company accounted for share-based awards to
employees and directors  using the intrinsic value method in accordance with APB
25 as allowed  under  Statement  of  Financial  Accounting  Standards  No.  123,
"Accounting  for  Stock-Based  Compensation"  ("SFAS 123").  Under the intrinsic
value method, no share-based  compensation  expense related to stock options had
been  recognized  in the Company's  Statements  of Operations  when the exercise
price of the Company's stock options granted to employees and directors  equaled
the fair market value of the underlying stock at the grant-date.

Share-based  compensation  expense recognized during the current period is based
on the value of the portion of  share-based  payment  awards that is  ultimately
expected to vest. SFAS 123(R)  requires  forfeitures to be estimated at the time
of grant in order to  estimate  the  amount  of  share-based  awards  that  will
ultimately vest. The forfeiture rate is based on historical  rates.  Share-based
compensation  expense  recognized in the Company's  Statements of Operations for
the first  quarter of 2006  includes (i)  compensation  expense for  share-based
payment  awards  granted  prior to, but not yet vested as of December  31, 2005,
based on the grant-date  fair value  estimated in accordance  with the pro forma
provisions of SFAS 123 and (ii) compensation expense for the share-based payment
awards granted  subsequent to December 31, 2005,  based on the  grant-date  fair
value  estimated in accordance  with the provisions of SFAS 123(R).  The Company
utilizes the Black-Scholes option pricing model for the valuation of share-based
awards.

Share-based compensation expense reduced the Company's results of operations for
the three  months ended March 31, 2006 by $121,425 or $0.00 per share and had no
impact on the Company's cash flow.

The following table illustrates the effect on net loss and net loss per share as
if the Company had applied  the fair value  recognition  provisions  of SFAS No.
123, as amended by SFAS No. 148,  "Accounting  for  Stock-Based  Compensation  -
Transition and Disclosures" ("SFAS 148").



                                                                      Three months ended
                                                                        March 31, 2005
                                                                      ------------------
                                                                       
      Net loss available to common stockholders, as reported              $(1,107,425)
      Add: Stock-based employee compensation expense included
            in reported net income                                                 --
      Deduct: Total stock based compensation expense determined
            under the fair value based method                                (211,136)
                                                                          -----------
      Net loss available to common stockholders, pro forma                $(1,318,561)
                                                                          ===========

      Loss per common share - basic and diluted:
            As reported                                                   $     (0.05)
            Pro forma                                                     $     (0.05)


Use of Estimates

The financial statements and related disclosures are prepared in conformity with
accounting  principles  generally  accepted  in the  United  States of  America.
Management  is  required  to make  estimates  and  assumptions  that  affect the
reported amounts of assets and liabilities,  the disclosure of contingent assets
and liabilities at the date of the financial statements and revenue and expenses
during the period reported.  These estimates include the realization of deferred
tax assets,  useful lives and impairment of tangible and intangible  assets, and
the  value of  options  and  warrants  granted  by the  Company.  Estimates  and
assumptions are reviewed periodically and the effects of revisions are reflected
in the financial  statements in the period they are  determined to be necessary.
Actual results could differ from these estimates.


                                       6


Cash and cash equivalents

Cash and cash equivalents consist of short term, highly liquid investments, with
original  maturities of less than three months when  purchased and are stated at
cost. Interest income is accrued as earned.

Property, Plant and Equipment

Property, plant and equipment are stated at cost less accumulated  depreciation.
Depreciation is provided on the  straight-line  method over the estimated useful
lives of the various asset classes.  Estimated  lives are 5 years for laboratory
equipment;  3 years for computer equipment;  7 years for furniture and fixtures;
and the shorter of the  estimated  lives or the life of the lease for  leasehold
improvements. Maintenance, repairs and minor replacements are charged to expense
as  incurred.  Upon  retirement  or  disposal  of assets,  the cost and  related
accumulated depreciation are removed from the Balance Sheet and any gain or loss
is reflected in the Statement of Operations.

Revenue Recognition

The Company  recognizes  revenue  from  contract  research and  development  and
research  payments in  accordance  with SEC Staff  Accounting  Bulletin No. 104,
Revenue  Recognition,  ("SAB  104").  In  accordance  with SAB 104,  revenue  is
recognized  when  persuasive  evidence of an  arrangement  exists,  delivery has
occurred,  the  fee is  fixed  or  determinable,  collectibility  is  reasonably
assured,  contractual obligations have been satisfied and title and risk of loss
have been  transferred  to the  customer.  The Company  recognizes  revenue from
non-refundable  up-front payments,  not tied to achieving a specific performance
milestone, over the period which the Company is obligated to perform services or
based on the percentage of costs incurred to date,  estimated  costs to complete
and total expected  contract  revenue.  Payments for development  activities are
recognized as revenue as earned, over the period of effort.  Substantive at-risk
milestone  payments,  which  are  based  on  achieving  a  specific  performance
milestone,  are  recognized  as revenue  when the  milestone is achieved and the
related  payment  is  due,  providing  there  is no  future  service  obligation
associated with that milestone. In situations where the Company receives payment
in advance of the  performance  of  services,  such  amounts  are  deferred  and
recognized as revenue as the related services are performed.

For the three  month  periods  ended  March 31,  2006 and  2005,  revenues  from
National  Institutes  of  Health  ("NIH")  Small  Business  Innovation  Research
("SBIR")  grants  approximated  52% and 94%,  respectively,  of  total  revenues
recognized by the Company.

Accounts Receivable

Accounts  receivable  are recorded net of provisions for doubtful  accounts.  An
allowance  for  doubtful   accounts  is  based  on  specific   analysis  of  the
receivables.  At March  31,  2006 and  December  31,  2005  the  Company  had no
allowance for doubtful accounts.

Research and development

Research and  development  expenses  include costs directly  attributable to the
conduct of research and development programs,  including employee related costs,
materials, supplies,  depreciation on and maintenance of research equipment, the
cost of services  provided by outside  contractors,  and facility costs, such as
rent,  utilities,  and  general  support  services.  All costs  associated  with
research  and  development  are  expensed  as  incurred.  Costs  related  to the
acquisition  of  technology  rights,  for  which  development  work is  still in
process, and that have no alternative future uses, are expensed as incurred.

Goodwill

Goodwill is recorded when the purchase price paid for an acquisition exceeds the
estimated  fair  value of the net  identified  tangible  and  intangible  assets
acquired.

The Company  performs an annual  review in the fourth  quarter of each year,  or
more frequently if indicators of potential impairment exist, to determine if the
carrying  value of the recorded  goodwill is impaired.  Goodwill  impairment  is
determined  using a two-step  approach in accordance with Statement of Financial
Accounting  Standards  No. 142  "Goodwill and Other  Intangible  Assets"  ("SFAS
142").  The impairment  review process  compares the fair value of the reporting
unit in which goodwill resides to its carrying value.

Identified Intangible Assets

Acquisition-related  intangible  assets include  acquired  technology,  customer
contracts,  grants and covenants not to compete, and are amortized on a straight
line basis over periods ranging from 2 to 4 years.

In  accordance  with  Statement  of  Financial   Accounting  Standards  No.  144
"Accounting  for the Impairment or Disposal of Long-Lived  Assets" ("SFAS 144"),
the Company performs a review of its identified  intangible  assets to determine
if


                                       7


facts and  circumstances  exist which  indicate  that the useful life is shorter
than  originally  estimated  or that the  carrying  amount of assets  may not be
recoverable.  If such facts and circumstances do exist, the Company assesses the
recoverability  of  identified  intangible  assets by  comparing  the  projected
undiscounted net cash flows associated with the related asset or group of assets
over  their  remaining  lives  against  their   respective   carrying   amounts.
Impairment,  if any, is based on the excess of the carrying amount over the fair
value of those  assets.  Changes  in events  or  circumstances  that may  affect
long-lived assets include, but are not limited to, cancellations or terminations
of research contracts or pending government grants.

Income taxes

Income taxes are accounted for under the asset and liability  method  prescribed
by Statement of Financial  Accounting  Standards No. 109, "Accounting for Income
Taxes."  Deferred  income taxes are recorded for temporary  differences  between
financial   statement   carrying  amounts  and  the  tax  basis  of  assets  and
liabilities.  Deferred tax assets and liabilities reflect the tax rates expected
to be in effect for the years in which the  differences are expected to reverse.
A valuation allowance is provided if it is more likely than not that some or all
of the deferred tax asset will not be realized.

Net income (loss) per common share

The Company  computes,  presents and discloses  earnings per share in accordance
with SFAS 128 "Earnings  Per Share"  ("EPS")  which  specifies the  computation,
presentation and disclosure requirements for earnings per share of entities with
publicly held common stock or potential common stock. The statement  defines two
earnings per share calculations,  basic and diluted.  The objective of basic EPS
is to measure the performance of an entity over the reporting period by dividing
income  (loss) by the weighted  average  shares  outstanding.  The  objective of
diluted  EPS is  consistent  with  that of basic  EPS,  that is to  measure  the
performance of an entity over the reporting  period,  while giving effect to all
dilutive  potential common shares that were outstanding  during the period.  The
calculation  of diluted  EPS is similar to basic EPS except the  denominator  is
increased for the conversion of potential common shares.

The Company  incurred losses for the three months ended March 31, 2006 and 2005,
and as a result, certain equity instruments are excluded from the calculation of
diluted  loss per  share.  At March  31,  2006 and  2005,  68,038  shares of the
Company's  Series A  convertible  preferred  stock have been  excluded  from the
computation  of diluted loss per share as they are  anti-dilutive.  At March 31,
2006 and 2005,  outstanding options to purchase 8,488,727 and 10,012,061 shares,
respectively,  of the Company's  common stock with exercise  prices ranging from
$0.94 to $5.50 have been excluded from the computation of diluted loss per share
as they are anti-dilutive.  At March 31, 2006 and 2005,  outstanding warrants to
purchase 9,478,794 and 8,469,594 shares,  respectively,  of the Company's common
stock,  with exercise prices ranging from $1.18 to $3.60 have been excluded from
the computation of diluted loss per share as they are anti-dilutive.

Fair value of financial instruments

The carrying value of cash and cash  equivalents,  accounts  payable and accrued
expenses  approximates  fair value due to the relatively short maturity of these
instruments.

Concentration of credit risk

The Company has cash in bank accounts that exceed the Federal Deposit  Insurance
Corporation  insured  limits.  The Company has not experienced any losses on its
cash  accounts.  No allowance  has been  provided for  potential  credit  losses
because management believes that any such losses would be minimal.

Segment information

The Company is managed  and  operated as one  business.  The entire  business is
managed by a single management team that reports to the Chief Executive Officer.
The Company  does not operate  separate  lines of business or separate  business
entities with respect to any of its product candidates. Accordingly, the Company
does not prepare discrete financial information with respect to separate product
areas or by location and only has one reportable  segment as defined by SFAS No.
131, "Disclosures about Segments of an Enterprise and Related Information".


                                       8


3. Intangible Assets

Amortization expense recorded for the three months ended March 31, 2006 and 2005
was as follows:

                                                           Three Months Ended
                                                                March 31,
                                                          2006           2005
                                                       ----------     ----------

Amortization of acquired grants                        $  245,337     $  245,336
Amortization of customer contract and grants                8,357          8,357
Amortization of covenants not to compete                       --         50,500
Amortization of acquired technology                        20,655         20,655
                                                       ----------     ----------
                                                       $  274,349     $  324,848
                                                       ----------     ----------

4. Stockholders' Equity

At  March  31,  2006,  the  Company's  authorized  share  capital  consisted  of
60,000,000  shares,  of  which  50,000,000  are  designated  common  shares  and
10,000,000 are designated  preferred shares. The Company's Board of Directors is
authorized  to issue  preferred  shares in series with  rights,  privileges  and
qualifications of each series determined by the Board.

Holders  of the  Series  A  Convertible  Preferred  Stock  are  entitled  to (i)
cumulative dividends at an annual rate of 6% payable when and if declared by the
Company's  board of directors;  (ii) in the event of liquidation of the Company,
each  holder is  entitled  to  receive  $1.4375  per share  (subject  to certain
adjustments) plus all accrued but unpaid dividends;  (iii) convert each share of
Series A to a number of fully paid and non-assessable  shares of common stock as
calculated by dividing $1.4375 by the Series A Conversion Price (shall initially
be  $1.4375);  and (iv) vote with the  holders of other  classes of shares on an
as-converted basis.

In November  2005,  the Company sold  2,000,000  shares of the Company's  common
stock at $1.00 per share, warrants to purchase 1,000,000 shares of the Company's
common stock with an initial  exercise  price of $1.18 per share,  and rights to
purchase  2,000,000  additional  shares  of the  Company's  common  stock for an
initial price of $1.10 per share.  The warrants are  exercisable at any time and
from time to time  through and  including  the seventh  anniversary  of the sale
closing  date and the rights  are  exercisable  for a period of 90 trading  days
following the effectiveness of a registration statement. An initial registration
statement  relating  to the  common  stock  sold and the  stock  underlying  the
warrants became effective on December 2, 2005. A registration statement relating
to the common stock underlying the rights became effective on April 17, 2006.

The Company  accounted for the  transaction  under the  provisions of EITF 00-19
which requires that free standing derivative financial  instruments that require
net cash  settlement be classified as assets or  liabilities  at the time of the
transaction, and recorded at their fair value. EITF 00-19 also requires that any
changes in the fair value of the derivative  instruments be reported in earnings
as long as the derivative contracts are classified as assets or liabilities.  At
March 31, 2006,  the fair value of the warrants to acquire  common stock and the
option  to  acquire  additional  shares  of  common  stock  was  $1,123,000  and
$1,008,000,  respectively.  At December 31,  2005,  the fair market value of the
warrants to acquire common stock and the option to acquire  additional shares of
common stock was $535,000 and  $73,000,  respectively.  The Company  applied the
Black-Scholes  model to calculate the fair values of the  respective  derivative
instruments using the contracted term of the instruments.  Management  estimates
the  expected  volatility  using  a  combination  of  the  Company's  historical
volatility and the volatility of a group of comparable companies.  SIGA recorded
a loss of  $1,526,000  for the  increase  in the  instruments'  fair  value from
December 31, 2005 to March 31, 2006.

5. Related Parties

During the three  months  ended March 31, 2006,  the Company  incurred  costs of
$38,900  related to work performed by Transtech  Pharma,  Inc., a related party,
and  its  affiliates  in  connection  with  one of the  Company's  lead  product
programs.  On March  31,  2006,  the  Company's  outstanding  payables  included
$157,000 payable to the related party and its affiliates. Revenues for the three
months ended March 31, 2006 included $21,500 related to services provided by the
Company to  Transtech  Pharma,  Inc.  The balance is  included in the  Company's
accounts receivable on March 31, 2006.


                                       9


6. Notes Payable

On May 20, 2005, the Company borrowed  approximately $276,000 under a Promissory
Note payable to General Electric Capital Corporation.  The note is payable in 36
monthly  installments of principal and interest of 10.31% per annum. The note is
secured  by a  master  security  agreement  dated as of  April  29,  2005 and by
specific property listed under the master security agreement.

On March 20, 2006,  SIGA entered into a Bridge Note  Purchase  Agreement  ("Note
Purchase  Agreement") with  PharmAthene,  Inc. for the sale of three 8% Notes by
SIGA, for  $1,000,000  each. The first and second Notes were issued on March 20,
2006  and  April  19,  2006,  respectively.  The  subsequent  remaining  Note is
contemplated  to be issued on May 19,  2006.  The  proceeds of the Notes will be
used by the Company for (i)  expenses  directly  related to the  development  of
SIGA's lead product,  SIGA-246,  (ii) expenses related to the Company's  planned
merger with  PharmAthene  and (iii) corporate  overhead.  Pursuant to a Security
Agreement  between the Company and  PharmAthene,  also entered into on March 20,
2006,  the  Notes are  secured  by a first  priority  security  interest  in the
Company's assets (other than assets subject to the security  interest granted to
General Electric Capital Corporation).

The first and second Notes for a principal  amount of $1,000,000  each,  will be
payable on the earliest of (x) March 20, 2008 and April 19, 2008,  respectively,
(the "Maturity Dates"),  (y) the closing of a Qualified Financing (as defined in
the  Purchase  Agreement)  or (z) a  Sale  Event  (as  defined  in the  Purchase
Agreement).  In the event of default under the Notes,  payment of the Notes will
be accelerated such that the entire unpaid principal amount of the Notes and all
accrued and unpaid interest shall become immediately due and payable in full.

7. Stock Compensation Plans

In January 1996, the Company  implemented  its 1996 Incentive and  Non-Qualified
Stock Option Plan (the "Plan"). The Plan as amended provides for the granting of
up to 11,000,000 shares of the Company's common stock to employees,  consultants
and outside  directors of the Company.  The exercise  period for options granted
under the Plan,  except those granted to outside  directors,  is determined by a
committee of the Board of Directors.  Stock options granted to outside directors
pursuant  to the Plan must have an  exercise  price equal to or in excess of the
fair market value of the Company's common stock at the date of grant.

For the three  months ended March 31, 2006,  the Company  recorded  compensation
expense of approximately $121,000 related to stock options. The total fair value
of options vested during the three months ended March 31, 2006 was $222,000. The
total compensation cost not yet recognized related to non-vested awards at March
31,  2006  was  $1,634,000.   The  weighted  average  period  over  which  total
compensation cost is expected to be recognized is 2.5 years.

SIGA  calculated  the fair value of each option  grant  using the  Black-Scholes
model with the following weighted average assumptions:

                                                        Three months ended
     Weighted Average Assumptions                         March 31, 2006
                                                        ------------------
        Expected volatility                                    54.35%
        Dividend Yield                                          0.00%
        Risk-free interest rate                                 4.29%
        Forfeitures rate                                        2.50%
        Expected holding period                                 3.00

The Company  calculates  the expected  volatility  using a combination of SIGA's
historical volatility and the volatility of a group of comparable companies. The
risk-free  interest  rate  assumption  is  based  upon  observed  interest  rate
appropriate for the term of the Company's  employee stock options.  The dividend
yield assumption is based on the Company's intent not to issue a dividend in the
foreseeable  future.  The expected holding period assumption was estimated based
on historical experience.


                                       10


Stock option activity of the Company is summarized as follows:



                                                                   Number of      Average Exercise
                                                                    Shares            Price ($)
                                                                               
Options outstanding at December 31, 2005                           9,399,561               2.00
   Granted                                                           122,500               0.94
   Forfeited                                                      (1,250,000)              1.30
   Expired                                                           (33,334)              1.50
   Exercised                                                              --                 --
                                                                  ----------         ----------
Options outstanding at March 31, 2006                              8,238,727               2.09


                                                                                      Weighted
                                                                   Number of     Average Intrinsic
                                                                    Shares            Value ($)
                                                                               
Nonvested options at December 31, 2005                             1,987,500                 --
 Nonvested options at March 31, 2006                                 524,974               0.18
 Options vested during 2006                                          212,526               0.21

 Options available for future grant at March 31, 2006              2,546,232
 Weighted average fair value of options granted during 2006       $     0.38
 Weighted average fair value of options forfeited during 2006     $     1.02


The following table summarizes information about options outstanding at March
31, 2006:



                                        Weighted
                                         Average                         Number Fully                        Aggregate
                Number of Options       Remaining         Weighted         Vested &          Weighted        Intrinsic
   Range of       Outstanding at    Contractual Life      Average       Exercisable at       Average          Value at
Exercise Price    March 31, 2006         (Years)       Exercise Price   March 31, 2006    Exercise Price   March 31, 2006
     ($)                                                     ($)                                ($)
                                                                                          
1.00 - 1.85          3,063,250              7.70            1.38             2,415,776          1.40        $     493,100
2.00 - 2.75          4,837,250              4.94            2.38             4,837,250          2.38                   --
3.94 - 5.50            338,227              2.91            4.36               338,227          4.36                   --
                 -------------                                           -------------                      -------------
                     8,238,727                                               7,591,253                      $     493,100
                 =============                                           =============                      =============


8. Commitments and Contingencies

As of March 31,  2006,  our  purchase  obligations  are not  material.  We lease
certain  facilities  and office space under  operating  leases.  Minimum  future
rental commitments under operating leases having  non-cancelable  lease terms in
excess of one year are as follows:

            Year ended December 31,

                2006                                 $ 255,400
                2007                                   261,800
                2008                                   133,200
                2009                                   135,900
                2010                                    22,700
                                                     ---------
            Total                                    $ 809,000
                                                     ---------


                                       11


                             SIGA TECHNOLOGIES, INC.

Item 2. Management's  Discussion and Analysis of Financial Condition and Results
of Operations

      The following  discussion should be read in conjunction with our financial
statements  and  notes to  those  statements  and  other  financial  information
appearing  elsewhere  in  this  Quarterly  Report.  In  addition  to  historical
information,  the following  discussion and other parts of this Quarterly Report
contain forward-looking information that involves risks and uncertainties.

Overview

      Since our inception in December 1995, we have been principally  engaged in
the research and  development of novel products for the prevention and treatment
of  serious  infectious  diseases,  including  products  for use in the  defense
against biological warfare agents such as Smallpox and Arenaviruses.  The effort
to  develop  a drug for  Smallpox  is being  aided by SBIR  grants  from the NIH
totaling  approximately  $5.8 million that were awarded in the third  quarter of
2004,  an  agreement  with Saint  Louis  University,  funded by the NIH that was
signed in September  2005, and a $1.6 million  contract with the U.S. Army which
began in January 2003. The Arenavirus  program is being supported by SBIR grants
from the NIH totaling  approximately $6.3 million that were awarded in the third
quarter of 2004.

      Our anti-viral  programs are designed to prevent or limit the  replication
of  the  viral  pathogen.   Our  anti-infectives   programs  are  aimed  at  the
increasingly serious problem of drug resistance.  These programs are designed to
block the ability of bacteria to attach to human  tissue,  the first step in the
infection process.  We are also developing a technology for the mucosal delivery
of our vaccines  which may allow the  vaccines to activate the immune  system at
the mucus lined  surfaces of the body -- the mouth,  the nose, the lungs and the
gastrointestinal and urogenital tracts -- the sites of entry for most infectious
agents.

      We do not have  commercial  biomedical  products,  and we do not expect to
have such  products for one to three  years,  if at all. We believe that we will
need additional  funds to complete the  development of our biomedical  products.
Our plans with regard to these  matters  include  continued  development  of our
products as well as seeking  additional  research  support  funds and  financial
arrangements.  Although we continue to pursue these plans, there is no assurance
that we will be successful in obtaining sufficient financing on terms acceptable
to us. The financial statements do not include any adjustments that might result
from the outcome of this  uncertainty.  Management  believes  it has  sufficient
funds and projected cash flows to support operations beyond June 30, 2007.

      Our  biotechnology  operations  are  based  in our  research  facility  in
Corvallis,  Oregon.  We continue to seek to fund a major  portion of our ongoing
antiviral,  antibiotic and vaccine  programs through a combination of government
grants and strategic alliances. While we have had success in obtaining strategic
alliances  and  grants,  there  is no  assurance  that  we will  continue  to be
successful in obtaining funds from these sources. Until additional relationships
are  established,  we expect  to  continue  to incur  significant  research  and
development costs and costs associated with the manufacturing of product for use
in clinical  trials and  pre-clinical  testing.  It is expected that general and
administrative  costs,  including  patent and  regulatory  costs,  necessary  to
support  clinical  trials and  research  and  development  will  continue  to be
significant in the future.

      To date, we have not marketed,  or generated  revenues from the commercial
sale of any products. Our biopharmaceutical  product candidates are not expected
to be  commercially  available for several  years,  if at all.  Accordingly,  we
expect to incur  operating  losses for the foreseeable  future.  There can be no
assurance that we will ever achieve profitable operations.

Critical Accounting Estimates

      The methods,  estimates  and  judgments we use in applying our  accounting
policies  have a  significant  impact on the results we report in our  financial
statements, which we discuss under the heading "Results of Operations" following
this section of our MD&A.  Some of our  accounting  policies  require us to make
difficult  and  subjective  judgments,  often  as a  result  of the need to make
estimates of matters that are inherently uncertain. Our most critical accounting
estimates  include the  assessment of  recoverability  of goodwill,  which could
impact  goodwill  impairments;  the assessment of  recoverability  of long-lived
assets, which primarily impacts operating income if impairment exists. Below, we
discuss these policies further, as well as the estimates and judgments involved.
Other  key  accounting  policies,   including  revenue  recognition,   are  less
subjective and involve a far lower degree of estimates and judgment.


                                       12


Significant Accounting Policies

      The  following is a brief  discussion of the more  significant  accounting
policies and methods used by us in the preparation of our financial  statements.
Note 2 of the Notes to the Financial Statements includes a summary of all of the
significant accounting policies.

      Share-based Compensation

      On January 1, 2006, the Company adopted Statement of Financial  Accounting
Standards No. 123 (revised 2004),  "Share-Based  Payment," ("SFAS 123(R)") which
requires  the  measurement  and  recognition  of  compensation  expense  for all
share-based  payment awards made to employees and directors  including  employee
stock  options  and  employee  stock  purchases  related to the  Employee  Stock
Purchase Plan ("employee stock purchases") based on estimated fair values.  SFAS
123(R) supersedes the Company's previous accounting under Accounting  Principles
Board Opinion No. 25,  "Accounting for Stock Issued to Employees" ("APB 25") for
periods  beginning  on January  1, 2006.  In March  2005,  the SEC issued  Staff
Accounting Bulletin No. 107 ("SAB 107") relating to SFAS 123(R). The Company has
applied the provisions of SAB 107 in its adoption of SFAS 123(R).

      The Company adopted SFAS 123(R) using the modified prospective  transition
method,  which requires the application of the accounting standard as of January
1,  2006,  the  first day of the  Company's  fiscal  year  2006.  The  Company's
Financial Statements as of and for the three months ended March 31, 2006 reflect
the  impact  of  SFAS  123(R).  In  accordance  with  the  modified  prospective
transition method, the Company's financial statements for prior periods have not
been  restated  to  reflect,  and do not  include,  the  impact of SFAS  123(R).
Share-based  compensation related to stock options expense recognized under SFAS
123(R) for the three months ended March 31, 2006 was  $121,000.  No  share-based
compensation expense related to employee stock options was recognized during the
three months ended March 31, 2005.

      SFAS 123(R)  requires  companies to estimate the fair value of share-based
payment awards on the grant-date using an option-pricing model. The value of the
portion  of the award  that is  ultimately  expected  to vest is  recognized  as
expense  over the  requisite  service  periods in the  Company's  Statements  of
Operations.  Prior to the adoption of SFAS  123(R),  the Company  accounted  for
share-based  awards to employees and directors  using the intrinsic value method
in  accordance  with APB 25 as allowed under  Statement of Financial  Accounting
Standards No. 123, "Accounting for Stock-Based Compensation" ("SFAS 123"). Under
the intrinsic value method, no share-based compensation expense related to stock
options had been  recognized in the Company's  Statements of Operations when the
exercise price of the Company's stock options granted to employees and directors
equaled the fair market value of the underlying stock at the grant-date.

      Share-based  compensation  expense recognized during the current period is
based  on the  value  of the  portion  of  share-based  payment  awards  that is
ultimately expected to vest. SFAS 123(R) requires forfeitures to be estimated at
the time of grant in order to  estimate  the amount of  share-based  awards that
will  ultimately  vest.  The  forfeiture  rate is  based  on  historical  rates.
Share-based  compensation  expense  recognized  in the  Company's  Statements of
Operations for the first quarter of 2006 includes (i)  compensation  expense for
share-based  payment  awards granted prior to, but not yet vested as of December
31, 2005,  based on the grant-date  fair value  estimated in accordance with the
pro  forma  provisions  of  SFAS  123  and  (ii)  compensation  expense  for the
share-based payment awards granted subsequent to December 31, 2005, based on the
grant-date  fair value  estimated  in  accordance  with the  provisions  of SFAS
123(R).  The Company  utilizes the  Black-Scholes  options pricing model for the
valuation of share-based awards.

      Revenue Recognition

      The Company  recognizes revenue from contract research and development and
research progress payments in accordance with SEC Staff Accounting  Bulletin No.
104,  Revenue  Recognition,  ("SAB 104"). In accordance with SAB 104, revenue is
recognized  when  persuasive  evidence of an  arrangement  exists,  delivery has
occurred,  the fee is  fixed  and  determinable,  collectibility  is  reasonably
assured,  contractual obligations have been satisfied and title and risk of loss
have been  transferred  to the  customer.  The Company  recognizes  revenue from
non-refundable  up-front payments,  not tied to achieving a specific performance
milestone, over the period which the Company is obligated to perform services or
based on the percentage of costs incurred to date,  estimated  costs to complete
and total expected  contract  revenue.  Payments for development  activities are
recognized as revenue is earned, over the period of effort.  Substantive at-risk
milestone  payments,  which  are  based  on  achieving  a  specific  performance
milestone,  are  recognized  as revenue  when the  milestone is achieved and the
related  payment  is  due,  providing  there  is no  future  service  obligation
associated with that milestone. In situations where the Company receives payment
in advance of the  performance  of  services,  such  amounts  are  deferred  and
recognized as revenue as the related services are performed.


                                       13


      Goodwill

      Goodwill  is  recorded  when the  purchase  price paid for an  acquisition
exceeds the estimated fair value of the net  identified  tangible and intangible
assets acquired.

      The Company  performs an annual review in the fourth quarter of each year,
or more frequently if indicators of potential  impairment exist, to determine if
the carrying value of the recorded goodwill is impaired.  Goodwill impairment is
determined  using a two-step  approach in accordance with Statement of Financial
Accounting  Standards  No. 142  "Goodwill and Other  Intangible  Assets"  ("SFAS
142").  The impairment  review process  compares the fair value of the reporting
unit in which  goodwill  resides to its  carrying  value.  In 2005,  the Company
operated  as one  business  and one  reporting  unit.  Therefore,  the  goodwill
impairment  analysis was  performed on the basis of the Company as a whole using
the market  capitalization  of the Company as an estimate of its fair value. The
estimated  fair values might produce  significantly  different  results if other
reasonable assumptions and estimates were to be used.

      Identified Intangible Assets

      Acquisition-related  intangibles  include  acquired  technology,  customer
contracts,  grants and covenants not to compete, and are amortized on a straight
line basis over periods ranging from 1-4 years.

      In accordance  with  Statement of Financial  Accounting  Standards No. 144
"Accounting  for the Impairment or Disposal of Long-Lived  Assets" ("SFAS 144"),
the Company performs a review of its identified  intangible  assets to determine
if facts and circumstances  exist which indicate that the useful life is shorter
than  originally  estimated  or that the  carrying  amount of assets  may not be
recoverable.  If such facts and circumstances do exist, the Company assesses the
recoverability  of  identified  intangible  assets by  comparing  the  projected
undiscounted net cash flows associated with the related asset or group of assets
over  their  remaining  lives  against  their   respective   carrying   amounts.
Impairment,  if any, is based on the excess of the carrying amount over the fair
value of those assets.

Results of Operations

Three months ended March 31, 2006 and 2005

      Revenues  from  grants  and  research  and   development   contracts  were
approximately  $1.4 million for the three months ended March 31, 2006,  compared
to $1.5  million for the three  months  ended March 31,  2005.  During the first
quarters of 2006 and 2005 we  recorded  revenues  of  $504,000  and  $1,364,000,
respectively,  from our two  Phase I and two  Phase II SBIR  grants  which  were
awarded by the NIH during the third quarter of 2004. The Phase II grants are for
a two year period ending in the third quarter of 2006. Revenue from our contract
with the U.S. Army approximated $94,100 for the three month periods ending March
31, 2006 and 2005. On September 1, 2005, we entered into an agreement with Saint
Louis University for the continued  development of one of the Company's  leading
compounds.  The agreement was funded through the NIH and expired on February 28,
2006.  For the three  months  ended March 31, 2006,  we  recognized  revenues of
$226,000  from this  agreement.  On September  22, 2005,  we entered into a $3.2
million,  one  year  contract  with  USAMRMC.  The  agreement,   for  the  rapid
identification and treatment of anti-viral diseases,  is funded through the USAF
(the "USAF  Agreement").  For the three months ended March 31, 2006, the Company
recognized revenues of $550,000 from the USAF Agreement.

      Selling, general and administrative expenses ("SG&A") increased $97,000 or
11.00% to $942,000  from  $845,000 for the three months ended March 31, 2006 and
2005,  respectively.  On  January  1, 2006 the  Company  adopted  FAS 123(R) and
recorded a non-cash charge of $91,000 for share based compensation. On March 31,
2006, the Company  recorded  $115,000  reflecting  severance  payment due to Dr.
Kasten upon  termination  of his  employment  as the Company's  Chief  Executive
Officer.  In addition to such charges,  the Company's  legal expenses  increased
$92,000 as compared to the same period in 2005 mainly due to the  negotiation of
a merger of the Company with  PharmAthene,  Inc. and related  transactions.  The
increases  were partially  offset by a decline of $46,000 in investor  relations
expense,  a decline of $71,000  in payroll  expense  and a decline of $51,000 in
amortization expense.

      Research and  development  expenses were $1.7 million and $1.6 million for
the three  months ended March 31, 2006 and 2005,  respectively.  The increase of
approximately  $100,000 or 6.25% mainly reflects higher payroll expenses related
to the expansion of the Company's  research and  development  work force from 30
full time employees to 38 on March 31, 2005 and 2006, respectively.


                                       14


      Patent preparation expenses for the three months ended March 31, 2006 were
$110,000  compared to $175,000 for the three  months  ended March 31,  2005.  We
incurred  higher costs  during the 2005 three  months  period for the filings of
patents in connection with the ViroPharma assets acquisition.

      A loss from the increase in common stock rights and common stock  warrants
was recorded in connection with the sale of common stock, warrants and rights in
November  2005.  The warrants  and rights to purchase  common stock of SIGA were
recorded at fair market value and  classified as  liabilities at the time of the
transaction.  A loss of $1.5 million was recorded by us, reflecting the increase
in the fair value of the warrants and the rights to acquire additional shares of
our common stock, during the period December 31, 2005 to March 31, 2006.

      Other  income of $6,000 and $5,000 for the three  months  ended  March 31,
2006 and 2005, respectively, reflect interest income for the period.

      Our product programs are in the early stage of development.  At this stage
of development,  we cannot make  reasonable  estimates of the potential cost for
most of our  programs to be  completed  or the time it will take to complete the
project. Our lead product,  SIGA-246, is an orally administered  anti-viral drug
that  targets the  smallpox  virus.  In December  2005 the FDA  accepted our IND
application for SIGA-246 and granted it Fast-Track  status.  Fast Track programs
of the FDA are designed to facilitate the development and expedite the review of
new drugs that are intended to treat serious or life-threatening  conditions and
that demonstrate the potential to address unmet medical needs.

      We expect that costs to complete our SIGA-246 program will approximate $15
million to $20 million,  and that the project could be completed in 12 months to
36 months.  There is a high risk of  non-completion  of any  program,  including
SIGA-246,  because of the lead time to program completion and uncertainty of the
costs.  Net cash inflows from any  products  developed  from our programs are at
least one to three years away.  However,  we could  receive  additional  grants,
contracts or  technology  licenses in the  short-term.  The  potential  cash and
timing is not known and we cannot be certain if they will ever occur.

      The risk of failure to complete any program is high,  as each,  other than
our smallpox  program that entered  phase I clinical  trials in 2006,  is in the
relatively  early stage of  development.  Products  for the  biological  warfare
defense  market,  such  as the  SIGA-246  smallpox  anti-viral,  could  generate
revenues in one to three  years.  We believe the products  directed  toward this
market are on schedule.  We expect the future research and  development  cost of
our biological  warfare defense  programs to increase as the potential  products
enter animal studies and safety testing,  including  human safety trials.  Funds
for  future  development  will be  partially  paid for by NIH SBIR  grants,  the
contract  we have with the U.S.  Army,  additional  government  funding and from
future  financing.  If we are  unable to obtain  additional  federal  grants and
contracts or funding in the required amounts, the development timeline for these
products would slow or possibly be suspended.  Delay or suspension of any of our
programs  could have an  adverse  impact on our  ability  to raise  funds in the
future,  enter into  collaborations with corporate partners or obtain additional
federal funding from contracts or grants.

Liquidity and Capital Resources

      As of March 31, 2006 we had  approximately  $2.5  million in cash and cash
equivalents.  We  believe  that  these  funds and our  anticipated  cash  flows,
including  receipt of funding  from  government  contracts  and grants,  will be
sufficient to support our operations beyond June 30, 2007.

      On March 9,  2006,  SIGA  entered  into a term sheet for the merger of the
Company with PharmAthene, Inc. Under the provisions of the term sheet, the Chief
Executive  Officer of  PharmAthene  will serve as President and Chief  Executive
Officer of the combined  company and the Board of Directors  for the new company
will  reflect  the  new  proportionate   ownership.  It  is  expected  that  the
shareholders of SIGA will own approximately  32% of the combined company,  which
is anticipated to remain listed on the NASDAQ stock market.  The  transaction is
conditioned  on,  among other  things,  the  execution  of a  definitive  merger
agreement, approval of the shareholders of each company, regulatory approval and
other customary closing conditions.

      On March 20, 2006, in connection with the  transaction,  we entered into a
Bridge Note Purchase Agreement ("Notes Purchase Agreement") with PharmAthene for
the sale of three 8% Notes by SIGA,  for  $1,000,000  each. The first and second
Notes  were  issued on March 20,  2006 and April  19,  2006,  respectively.  The
subsequent  remaining  Note is  contemplated  to be issued on May 19, 2006.  The
proceeds  of the Notes will be used by the  Company  for (i)  expenses


                                       15


directly  related to the  development  of SIGA's lead  product,  SIGA-246,  (ii)
expenses  related to the Company's  planned  merger with  PharmAthene  and (iii)
corporate   overhead.   Pursuant  to  a  Security  Agreement  between  SIGA  and
PharmAthene,  also entered  into on March 20,  2006,  the Notes are secured by a
first  priority  security  interest in the  Company's  assets (other than assets
subject  to  the  security   interest   granted  to  General   Electric  Capital
Corporation).

      We believe that our existing cash combined  with  anticipated  cash flows,
including  receipt of future  funding from  government  contracts and grants and
receipt of the  remaining  $1.0 million  funding  under the Bridge Note Purchase
Agreement will be sufficient to support our operations beyond June 30, 2007, and
that sufficient cash flows will be available to meet our business objectives. We
have developed a plan to further reduce the Company's  operating expenses in the
event that sufficient  funds are not available,  or if we are not able to obtain
funding from the Bridge Note Purchase  Agreement or the  anticipated  government
contracts and grants,  which would be sufficient to enable us to operate  beyond
June 30,  2007.  If we are not  unable  to raise  adequate  capital  or  achieve
profitability, future operations will need to be scaled back or discontinued.

Off-Balance Sheet Arrangements

      SIGA does not have any off-balance sheet arrangements.

Safe Harbor Statement

      This  report  contains  certain  "forward-looking  statements"  within the
meaning of the Private  Securities  Litigation  Reform Act of 1995,  as amended,
including statements regarding the efficacy of potential products, the timelines
for bringing such products to market and the availability of funding sources for
continued development of such products.  Forward-looking statements are based on
management's  estimates,   assumptions  and  projections,  and  are  subject  to
uncertainties,  many of which are beyond the control of SIGA. Actual results may
differ  materially  from those  anticipated  in any  forward-looking  statement.
Factors  that may cause such  differences  include the risks that (a)  potential
products that appear promising to SIGA or its  collaborators  cannot be shown to
be efficacious or safe in subsequent  pre-clinical or clinical trials,  (b) SIGA
or its  collaborators  will not obtain  appropriate  or  necessary  governmental
approvals to market these or other potential products,  (c) SIGA may not be able
to obtain  anticipated  funding for its  development  projects  or other  needed
funding, (d) SIGA may not be able to secure funding from anticipated  government
contracts  and  grants,  (e) SIGA may not be able to secure or enforce  adequate
legal  protection,  including  patent  protection,  for  its  products  and  (f)
unanticipated   internal  control  deficiencies  or  weaknesses  or  ineffective
disclosure  controls and procedures.  More detailed  information  about SIGA and
risk  factors that may affect the  realization  of  forward-looking  statements,
including the forward-looking  statements in this presentation,  is set forth in
SIGA's  filings with the Securities and Exchange  Commission,  including  SIGA's
Annual Report on Form 10-K for the fiscal year ended  December 31, 2005,  and in
other  documents that SIGA has filed with the  Commission.  SIGA urges investors
and security  holders to read those documents free of charge at the Commission's
Web  site at  http://www.sec.gov.  Interested  parties  may  also  obtain  those
documents free of charge from SIGA.  Forward-looking statements speak only as of
the date they are made,  and except for our ongoing  obligations  under the U.S.
federal  securities  laws,  we undertake no  obligation  to publicly  update any
forward-looking statements whether as a result of new information, future events
or otherwise.


                                       16


Item 3. Quantitative and Qualitative Disclosure About Market Risk

      None

Item 4. Controls and Procedures

      (a) Disclosure Controls and Procedures. The Company's management, with the
participation  of the  Company's  Chief  Financial  Officer,  has  evaluated the
effectiveness of the Company's disclosure controls and procedures (as defined in
Rules  13a-15(e)  and  15d-15(e)  under the  Exchange  Act) as of the end of the
fiscal period  covered by this  Quarterly  Report on Form 10-Q.  Based upon such
evaluation,  the Chief  Executive  Officer  and  Chief  Financial  Officer  have
concluded that, as of the end of such period, the Company's  disclosure controls
and procedures are effective.

      (b) Internal  Control Over  Financial  Reporting.  There have not been any
changes in the Company's internal control over financial reporting (as such term
is defined in Rules  13a-15(f) and 15d-15(f)  under the Exchange Act) during the
fiscal period covered by this Quarterly Report on Form 10-Q that have materially
affected,  or are reasonably likely to materially affect, the Company's internal
control over financial reporting.


                                       17


                                     Part II
                                Other information

Item 1.  Legal  Proceedings - On or about February 28, 2006,  Four Star Group, a
         Division  of  Executive  Intelligence  Network,  LLC filed  suit in the
         Supreme  Court of the  State  if New York  naming  as  defendants  SIGA
         Technologies,  Inc.,  Bernard  Kasten and "John Odgen  [sic]." In 2004,
         SIGA  renewed a contract  with Four Star  under  which Four Star was to
         assist  SIGA  in  identifying  and  obtaining   contracts  and  grants.
         Plaintiff  Four  Star  alleges  that  SIGA  breached  its  contract  by
         allegedly  failing to  compensate  Four Star within the time set by the
         contract and that SIGA breached the contract, and tortuously interfered
         with Four Star's  contractual  relationships,  by allegedly  soliciting
         and/or hiring certain  affiliates of Four Star.  Plaintiff asserts that
         it has not fully  calculated  its  damages,  but  states  that they are
         "believed to be" in excess of  approximately  $700,000.  Plaintiff also
         seeks relief preventing defendants from soliciting agents and employees
         of plaintiff. SIGA believes the claims are without merit and intends to
         contest them vigorously.

Item 1A. Risk Factors - there were no material changes to Risk Factors disclosed
         in SIGA's 2005 Form 10-K.

Item 2.  Unregistered Sale of Equity Securities and Use of Proceeds - None

Item 3.  Defaults upon Senior Securities - None

Item 4.  Submission of Matters to a Vote of Security Holders - None

Item 5.  Other Information - None

Item 6.  Exhibits

     *   31       Certification  of Chief  Financial  Officer  and Acting  Chief
                  Executive   Officer   Pursuant   to   Section   302   of   the
                  Sarbanes-Oxley Act of 2002.

     *   32       Certification  of Chief  Financial  Officer  and Acting  Chief
                  Executive   Officer   Pursuant   to   Section   906   of   the
                  Sarbanes-Oxley Act of 2002.

         * Filed herein


                                       18


                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, thereunto duly authorized.

                                        SIGA Technologies, Inc.
                                        (Registrant)


       Date: May 12, 2006               By: /s/ Thomas N. Konatich
                                           -----------------------
                                        Thomas N. Konatich
                                        Chief Financial Officer and Acting Chief
                                        Executive Officer


                                       19