Exhibit 31.1


                            CERTIFICATION PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Eric A. Rose, M.D., certify that:

            1.    I have  reviewed  this  quarterly  report on Form 10-Q of SIGA
                  Technologies, Inc.;

            2.    Based on my knowledge, this report does not contain any untrue
                  statement of a material  fact or omit to state a material fact
                  necessary  to  make  the  statements  made,  in  light  of the
                  circumstances  under  which such  statements  were  made,  not
                  misleading   with  respect  to  the  period  covered  by  this
                  quarterly report;

            3.    Based on my  knowledge,  the financial  statements,  and other
                  financial  information  included  in  this  quarterly  report,
                  fairly   present  in  all  material   respects  the  financial
                  condition,  results  of  operations  and  cash  flows  of  the
                  registrant  as of,  and for,  the  periods  presented  in this
                  report;

            4.    The   registrant's   other   certifying   officer  and  I  are
                  responsible  for  establishing   and  maintaining   disclosure
                  controls  and  procedures  (as defined in  Exchange  Act Rules
                  13a-15(e) and 15d-15(e)) for the registrant and have:

                  (a)   Designed such  disclosure  controls and  procedures,  or
                        caused such  disclosure  controls and  procedures  to be
                        designed under our supervision,  to ensure that material
                        information  relating to the  registrant,  including its
                        consolidated subsidiaries, is made known to us by others
                        within those entities, particularly during the period in
                        which this quarterly report is being prepared;

                  (b)   Evaluated   the   effectiveness   of  the   registrant's
                        disclosure controls and procedures and presented in this
                        report our conclusions  about the  effectiveness  of the
                        disclosure controls and procedures, as of the end of the
                        period covered by this report based on such  evaluation;
                        and

                  (c)   Disclosed in this report any change in the  registrant's
                        internal control over financial  reporting that occurred
                        during the registrant's  most recent fiscal quarter that
                        has  materially  affected,  or is  reasonably  likely to
                        materially  affect,  the  registrant's  internal control
                        over financial reporting; and

            5.    The  registrant's   other   certifying   officer  and  I  have
                  disclosed,  based on our most  recent  evaluation  of internal
                  control over financial reporting, to the registrant's auditors
                  and the audit committee of registrant's board of directors (or
                  persons performing the equivalent functions);

                  (a)   All significant  deficiencies and material weaknesses in
                        the  design  or  operation  of  internal   control  over
                        financial  reporting  which  are  reasonably  likely  to
                        adversely  affect  the  registrant's  ability to record,
                        process, summarize and report financial information; and

                  (b)   Any  fraud,  whether  or  not  material,  that  involves
                        management  or other  employees  who have a  significant
                        role in the registrant's internal control over financial
                        reporting.

Date: August 14, 2007                                By: /s/ Eric A. Rose
                                                         ----------------------
                                                         Eric A. Rose, M.D.
                                                         Chief Executive Officer


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