UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


         Date of Report (Date of Earliest Event Reported): March 2, 2006


                            IRIS INTERNATIONAL, INC.
             (Exact name of registrant as specified in its charter)


          DELAWARE                     1-11181                   94-2579751
(State or other jurisdiction    (Commission File Number)      (I.R.S. Employer
     of incorporation)                                       Identification No.)


                                9172 ETON AVENUE
                              CHATSWORTH, CA 91311
                (Address of Principal Executive Offices/Zip Code)


                                 (818) 709-1244
              (Registrant's telephone number, including area code)


         Check the  appropriate  box below if the Form 8-K filing is intended to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (SEE General Instruction A.2. below):

         |_|      Written   communications   pursuant  to  Rule  425  under  the
                  Securities Act (17 CFR 230.425)

         |_|      Soliciting material pursuant to Rule 14a-12 under the Exchange
                  Act (17 CFR 240.14a-12)

         |_|      Pre-commencement  communications  pursuant  to  Rule  14d-2(b)
                  under the Exchange ct (17 CFR 240.14d-2(b))

         |_|      Pre-commencement  communications  pursuant  to Rule  13e-4(c))
                  under the Exchange Act (17 CFR 240.13e-4c))





ITEM 2.02 - RESULTS OF OPERATION AND FINANCIAL CONDITION

         On March 2, 2006,  we issued a press release  announcing  our financial
results for the fourth quarter and twelve months ended December 31, 2005. A copy
of the press  release is  attached  hereto as Exhibit  99.1 and is  incorporated
herein by this reference.

         We will host a conference call on March 2, 2006, at 11:30 a.m.  Eastern
time to review our  financial  results for the fourth  quarter and twelve months
ended  December 31, 2005.  The call may be accessed via a live audio web cast on
our web site at  www.proiris.com  or at  www.vcall.com,  or  through  a  dial-in
telephone   number  at   1-800-289-0569.   International   callers  should  dial
913-981-5542.

         The  information  in this Item 2.02 of this Current  Report on Form 8-K
and  Exhibit  99.1  attached  hereto  shall not be deemed to be "filed"  for the
purposes of Section 18 of the  Securities  Exchange  Act of 1934 (the  "Exchange
Act"), or otherwise  subject to the liabilities of such section,  nor shall such
information or exhibit be deemed  incorporated  by reference in any filing under
the Securities Act of 1933 or the Exchange Act, except as shall be expressly set
forth by specific reference in such a filing.


ITEM 9.01 - FINANCIAL STATEMENTS AND EXHIBITS

         (c)      Exhibits.

                  The following exhibits are filed herewith:

                  EXHIBIT
                  NUMBER   DESCRIPTION
                  -------  -----------

                  99.1     Press Release dated March 2, 2006,  published by IRIS
                           International, Inc.


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                                    SIGNATURE

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                       IRIS INTERNATIONAL, INC.



Date:    March 2, 2006                 By:      /s/ Martin G. Paravato
                                           -------------------------------------
                                                Martin G. Paravato
                                                Chief Financial Officer


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                                  EXHIBIT INDEX

EXHIBIT
NUMBER         DESCRIPTION
- -------        -----------

99.1           Press   Release   dated   March  2,  2006,   published   by  IRIS
               International, Inc.


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