UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                   FORM 12b-25

                           NOTIFICATION OF LATE FILING

                                                        SEC File Number: 0-26285
                                                                         -------

         (Check one)

         [X] Form 10-K    [_] Form 20-F     [_] Form 11-K    [_] Form 10-Q

         [_] Form N-SAR   [_] Form N-CSR

         For period ended                SEPTEMBER 30, 2008
                         ----------------------------------------------

         ___ Transition Report on Form 10-K

         ___ Transition Report on Form 20-F

         ___ Transition Report on Form 11-K

         ___ Transition Report on Form 10-Q

         ___ Transition Report on Form N-SAR

         ___ Transition Report on Form N-CSR

         For the transition period ended ___________________________

         READ ATTACHED  INSTRUCTION SHEET BEFORE PREPARING FORM. PLEASE PRINT OR
TYPE.

         Nothing in this form shall be  construed  to imply that the  Commission
has verified any information contained herein.

         If the  notification  relates to a portion of the filing checked above,
identify the item(s) to which the notification relates: ________________________

________________________________________________________________________________


                                     PART I
                             REGISTRANT INFORMATION

Full name of registrant CNS RESPONSE, INC.

Former name if applicable
                          ------------------------------------------------------

Address of principal executive office (STREET AND NUMBER)   2755 BRISTOL STREET,
                                                          ----------------------
  SUITE 285
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City, state and zip code   COSTA MESA, CALIFORNIA, 92626
                          ------------------------------------------------------


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                                    PART II
                             RULE 12B-25(B) AND (C)

         If the subject report could not be filed without unreasonable effort or
expense  and  the  registrant  seeks  relief  pursuant  to Rule  12b-25(b),  the
following should be completed. (Check box if appropriate.)

          (a)      The reasons  described  in  reasonable  detail in Part III of
                   this form could not be eliminated without unreasonable effort
                   or expense;

          (b)      The subject annual  report,  semi-annual  report,  transition
                   report on Form 10-K, Form 20-F, Form 11-K, Form N-SAR or Form
                   N-CSR,  or  portion  thereof,  will be filed on or before the
                   15th calendar day following the  prescribed  due date; or the
 [X]               subject  quarterly report or transition  report on Form 10-Q,
                   or  subject  distribution  report on Form  10-D,  or  portion
                   thereof,  will be filed on of before the fifth  calendar  day
                   following the prescribed due date; and

          (c)      The accountant's  statement or other exhibit required by Rule
                   12b-25(c) has been attached if applicable.

                                    PART III
                                    NARRATIVE

         State below in reasonable  detail the reasons why Form 10-K, Form 20-F,
Form 11-K,  Form 10-Q,  Form N-SAR or Form N-CSR,  or the  transition  report or
portion thereof,  could not be filed within the prescribed time period.  (Attach
extra sheets if needed.)

                  The  Registrant's   Form  10-K,  for  the  fiscal  year  ended
         September  30,  2008,  could not be filed  within the  prescribed  time
         period because  certain  information and data relating to and necessary
         for  the  completion  of  the  Registrant's  financial  statements  and
         management's discussion and analysis of financial condition and results
         of  operations  could not be  obtained by  Registrant  within such time
         period without unreasonable effort or expense.

                                    PART IV
                                OTHER INFORMATION

(1)      Name and  telephone  number  of  person  to  contact  in regard to this
         notification.

     LEONARD BRANDT                      (714)                   545-3225
- --------------------------------------------------------------------------------
        (Name)                        (Area Code)           (Telephone Number)

(2)      Have all other periodic  reports  required under Section 13 or 15(d) or
         the  Securities  Exchange  Act of 1934 or Section 30 of the  Investment
         Company Act of 1940 during the  preceding 12 months or for such shorter
         period that the  registrant  was required to file such  report(s)  been
         filed? If the answer is no, identify report(s).    [X] Yes  [_] No


(3)      Is it anticipated that any significant  change in results of operations
         from  the  corresponding  period  for  the  last  fiscal  year  will be
         reflected  by the  earnings  statements  to be  included in the subject
         report or portion thereof?                         [X] Yes  [_] No


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If so attach an explanation of the  anticipated  change,  both  narratively  and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of the results cannot be made.


                               CNS RESPONSE, INC.
- --------------------------------------------------------------------------------
                  (Name of Registrant as Specified in Charter)

has  caused  this  notification  to be signed on its  behalf by the  undersigned
thereunto duly authorized.

Date:   DECEMBER 29, 2008      By:   /S/ LEONARD BRANDT
       ------------------            -------------------------------------------
                               Name:  Leonard Brandt
                               Title: Chief Executive Officer

         INSTRUCTION.  The form may be signed  by an  executive  officer  of the
registrant or by any other duly authorized representative. The name and title of
the person signing the form shall be typed or printed beneath the signature.  If
the  statement  is  signed  on  behalf  of  the   registrant  by  an  authorized
representative   (other   than   an   executive   officer),   evidence   of  the
representative's  authority to sign on behalf of the  registrant  shall be filed
with the form.

                                    ATTENTION

         Intentional  misstatements  or  omissions  of fact  constitute  federal
criminal violations (SEE 18 U.S.C. 1001).



PART IV - OTHER INFORMATION

(3)      EXPLANATION OF ANTICIPATED CHANGE

The Registrant expects to report revenues of approximately $773,500 for the year
ended  September 30, 2008; as compared to $238,400 for the year ended  September
30, 2007.

For the year ended  September 30, 2008, the  Registrant  expects to report a net
loss of $5.4  million as  compared  to a net loss of $3.3  million  for the same
period in 2007.


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