EXHIBIT 32.1


                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         Pursuant to 18 U.S.C.  Section 1350, as adopted pursuant to Section 906
of the  Sarbanes-Oxley  Act of 2002, in connection with the filing of the Annual
Report on Form 10-K for the year ended  September 30, 2008 (the "Report") by CNS
Response, Inc. (the "Registrant"), the undersigned hereby certifies that:

1.       the Report fully  complies  with the  requirements  of section 13(a) or
         15(d) of the Securities Exchange Act of 1934; and

2.       the  information  contained  in  the  Report  fairly  presents,  in all
         material respects, the financial condition and results of operations of
         the Registrant.



Date:  January 13, 2009               /S/ LEONARD BRANDT
                                      ---------------------------------
                                      Leonard J. Brandt
                                      Chief Executive Officer (Principal
                                      Executive and Financial Officer)