Exhibit 32.1

                            SECTION 906 CERTIFICATION


     I, Jeffrey F.  O'Donnell,  Chief Executive  Officer of PhotoMedex,  Inc., a
Delaware  corporation (the "Company"),  do hereby certify, in accordance with 18
U.S.C.  Section 1350, as created  pursuant to Section 906 of the  Sarbanes-Oxley
Act of 2002, that:

         (1) the accompanying  Quarterly Report on Form 10-Q of the Company
         for the three and six months  ended June 30,  2003 (the  "Report")
         fully complies with the requirements of Section 13(a) or 15(d), as
         applicable,  of the  Securities  Exchange Act of 1934, as amended;
         and

         (2) the information  contained in the Report fairly  presents,  in
         all material  respects,  the  financial  condition  and results of
         operations of the Company.


                                                                 PHOTOMEDEX INC.


Dated: August 14, 2003
                                                   By: /s/ Jeffrey F. O'Donnell
                                                       ------------------------
                                                         Jeffrey F. O'Donnell
                                                         Chief Executive Officer





         A signed original of this written statement  required by Section 906 of
the   Sarbanes-Oxley   Act  of  2002   ("Section   906"),   or  other   document
authenticating,  acknowledging, or otherwise adopting the signature that appears
in typed form within the electronic  version of this written statement  required
by Section 906, has been  provided to  PhotoMedex,  Inc. and will be retained by
PhotoMedex,  Inc. and furnished to the Securities and Exchange Commission or its
staff upon request.