Exhibit 32.1

                            SECTION 906 CERTIFICATION


          I, Jeffrey F. O'Donnell, Chief Executive Officer of PhotoMedex,  Inc.,
     a Delaware  corporation (the "Company"),  do hereby certify,  in accordance
     with 18 U.S.C.  Section  1350,  as created  pursuant  to Section 906 of the
     Sarbanes-Oxley Act of 2002, that:

              (1) the accompanying  Quarterly Report on Form 10-Q of the Company
              for the three  months  ended March 31, 2004 (the  "Report")  fully
              complies  with the  requirements  of  Section  13(a) or 15(d),  as
              applicable,  of the  Securities  Exchange Act of 1934, as amended;
              and

              (2) the information  contained in the Report fairly  presents,  in
              all material  respects,  the  financial  condition  and results of
              operations of the Company.


                                                              PHOTOMEDEX, INC.


Dated: May 10, 2004
                                                By: /s/ Jeffrey F. O'Donnell
                                                    -------------------------
                                                    Jeffrey F. O'Donnell
                                                    Chief Executive Officer



         A signed original of this written statement  required by Section 906 of
the   Sarbanes-Oxley   Act  of  2002   ("Section   906"),   or  other   document
authenticating,  acknowledging, or otherwise adopting the signature that appears
in typed form within the electronic  version of this written statement  required
by Section 906, has been  provided to  PhotoMedex,  Inc. and will be retained by
PhotoMedex,  Inc. and furnished to the Securities and Exchange Commission or its
staff upon request.