LIMITED POWER OF ATTORNEY FOR SECTION 16 REPORTING OBLIGATIONS

      Know  all by these present, that the undersigned hereby makes, constitutes
and  appoints  each  of Mark Iwicki, Eric Trachtenberg and Mary Reumuth, signing
singly  and  each  acting  individually,  as  the  undersigned's true and lawful
attorney-in-fact with full power and authority as hereinafter described to:

      (1)  execute  for  and  on behalf of the undersigned, in the undersigned's
capacity as a director, officer and/or stockholder of Kala Pharmaceuticals, Inc.
(the  "Company"),  Forms  3,  4,  and  5  (including  any amendments thereto) in
accordance  with  Section  16(a)  of the Securities Exchange Act of 1934 and the
rules thereunder (the "Exchange Act");

      (2)  do  and perform any and all acts for and on behalf of the undersigned
which  may  be  necessary or desirable to prepare, complete and execute any such
Form  3,  4,  or  5,  prepare,  complete and execute any amendment or amendments
thereto, and timely deliver and file such form with the United States Securities
and Exchange Commission (the "SEC") and any stock exchange or similar authority,
including  without  limitation  the filing of a Form ID or any other application
materials to enable the undersigned to gain or maintain access to the Electronic
Data Gathering, Analysis and Retrieval system of the SEC;

      (3)  seek  or  obtain,  as  the  undersigned's  representative  and on the
undersigned's  behalf,  information  regarding  transactions  in  the  Company's
securities  from  any  third  party,  including  brokers,  employee benefit plan
administrators  and  trustees,  and  the  undersigned hereby authorizes any such
third-party   to   release   any   such  information  to  the  herein  appointed
attorney-in-fact and approves and ratifies any such release of information; and

      (4)  take  any  other action of any type whatsoever in connection with the
foregoing  which, in the opinion of such attorney-in-fact, may be of benefit to,
in  the  best  interest  of,  or  legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf of the
undersigned  pursuant  to this Power of Attorney shall be in such form and shall
contain  such  terms and conditions as such attorney-in-fact may approve in such
attorney-in-fact's discretion.

      The undersigned hereby grants to each such attorney-in-fact full power and
authority  to  do  and perform any and every act and thing whatsoever requisite,
necessary,  or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could  do  if personally present, with full power of substitution or revocation,
hereby  ratifying  and  confirming  all  that  such  attorney-in-fact,  or  such
attorney-in-fact's  substitute  or substitutes, shall lawfully do or cause to be
done  by  virtue  of  this  power  of  attorney and the rights and powers herein
granted.  The  undersigned acknowledges that the foregoing attorneys-in-fact, in
serving in such capacity at the request of the undersigned, are not assuming nor
relieving,  nor  is the Company assuming nor relieving, any of the undersigned's
responsibilities  to comply with Section 16 of the Exchange Act. The undersigned
acknowledges that neither the Company nor the foregoing attorneys-in-fact assume
(i)  any  liability  for  the  undersigned's  responsibility  to comply with the
requirement  of  the Exchange Act, (ii) any liability of the undersigned for any
failure  to  comply with such requirements, or (iii) any obligation or liability
of  the  undersigned for profit disgorgement under Section 16(b) of the Exchange
Act.

      This  Power  of  Attorney  shall remain in full force and effect until the
undersigned  is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's  holdings of and transactions in securities issued by the Company,
unless  earlier  revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

      IN  WITNESS  WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this 3rd day of January, 2019.

                                      /s/ Mary Reumuth
                                      ------------------------------------------
                                      Signature


                                      Mary Reumuth
                                      ------------------------------------------
                                      Print Name