LIMITED POWER OF ATTORNEY
The undersigned hereby constitutes and appoints each of Tracey McCain,
Christopher Frankenfield, Xing Yan, Ariel Hurley and Michael Landsittel, and
each of them individually, and with full power of substitution, the
undersigned's true and lawful attorney-in-fact to:
(1) Complete and execute for and on behalf of the undersigned, in the
undersigned's capacity as an officer, director and/or ten percent
(10%) shareholder of Blueprint Medicines Corporation, a Delaware
corporation (the "Company"), any and all instruments, certificates
and documents required to be executed on behalf of the undersigned
as an individual or on behalf of the undersigned's company or
partnership, as the case may be, pursuant to Section 13 and Section
16 of the Securities Exchange Act of 1934, as amended (the "Exchange
Act") or the rules and regulations thereunder;
(2) Do and perform any and all acts for and on behalf of the undersigned
which may be necessary or desirable to complete and execute any such
instruments, certificates or documents required to be filed pursuant
to Sections 13 and 16 of the Exchange Act or the rules or
regulations thereunder and timely file such forms with the United
States Securities and Exchange Commission and any stock exchange or
similar authority; and
(3) Take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of
benefit to, in the best interest of, or legally required by, the
undersigned, it being understood that the documents executed by any
such attorney-in-fact on behalf of the undersigned pursuant to this
Power of Attorney shall be in such form and shall contain such terms
and conditions as such attorney-in-fact may approve in such
attorney-in-fact's discretion.
The undersigned hereby grants to each such attorney-in-fact, acting
singly, full power and authority to do and perform any and every act which is
necessary, proper or desirable to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that any such
attorney-in-fact, or any such attorney-in-fact's substitute or substitutes,
shall lawfully do or cause to be done by virtue of this Power of Attorney and
the rights and powers herein granted.
The undersigned acknowledges that each of the foregoing attorneys-in-fact,
in serving in such capacity at the request of the undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's responsibilities to comply
with Section 13 or Section 16 of the Exchange Act or the rules or regulations
thereunder. The undersigned hereby agrees to indemnify each attorney-in-fact and
the Company from and against any demand, damage, loss, cost or expense arising
from any false or misleading information provided by the undersigned to such
attorney-in fact.
This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file any instruments, certificates and
documents pursuant to Section 13 and 16 of the Exchange Act or the rules or
regulations thereunder with respect to the undersigned's holdings of and
transactions in securities issued by the Company, unless earlier revoked by the
undersigned in a signed writing delivered to the foregoing attorneys-in-fact.
IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of January 11, 2021.
By: /s/ Becker Hewes
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Name: L. Becker Hewes