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PROFORMA INVOICE/QUOTATION                                                                   PROFORMA INV/QUOTATION#
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SOLD TO:      IMMUNEREGEN BIOSCIENCES, INC.                                                        20593694
                                                                                         ---------------------------------
              4021 N. 75TH ST/ STE 201           SIGMA-ALDRICH                                        DATE
                                                                                         ---------------------------------
              SCOTTSDALE AZ  85251-4569          INQUIRIES TO:                                     4/7/2005
                                                                                         ---------------------------------
                                                 SIGMA-ALDRICH INC                                 VALID UNTIL
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SHIP TO:      PATWELL PHARMACEUTICAL             3050 SPRUCE ST                                    5/7/2005
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              SOLUTIONS, LLC                     SAINT LOUIS  MO  63103  US                  SOLD TO CUSTOMER NUMBER
                                                                                         ---------------------------------
              ATTN:  David P. Popplewell                                                           49671794
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              555 FOX CHASE/STE 102              Phone:     888-289-8454                      CUSTOMER REFERENCE NUMBER
                                                                                         ---------------------------------
              COATESVILLE  PA  19320             Fax:       888-289-8449
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                                                 Email:     SAFINECHEM@SIAL.COM                    INCO TERMS
                                                                                         ---------------------------------
CONTACT:      MICHAEL WILHELM                                                                    FCA/SHIPPING POINT
                                                                                         ---------------------------------
TELEPHONE:    480-922-3926
FAX:          NOT AVAILABLE

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 LINE   MATERIAL NUMBER             DESCRIPTION                   QUANTITY   UOM   UNIT PRICE EXTENDED PRICE PROPOSED ROUTE
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 001   SAFC-QC-BIO  Analytical Method Transfer & Testing     56.00    EA    135.00   7560.00
                    Others                                                                     Shipped from SAINT LOUIS


 002   SAFC-RD-BIO  Technology Transfers & Estimated Labor   136.00   EA    175.00  23800.00   Shipped From SAINT LOUIS
                    Others


 003   S8693-SPEC   (SAR, MET(02)11-SUBSTANCE P CUSTOM       100.00   MG    836.40  83640.00   AIRBORNE OVERNIGHT
                    NON-HAZARDOUS / Dry Ice Required                                           Shipped From SAINT LOUIS
                                                                                               Items Total            115,000.00 USD
                                                                                               Trans/Handling              35.53 USD
                                                                                               Total Tax                 6902.13 USD
                                                                                               Total Due              121,937.66 USD







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