Exhibit 5.3 ZEVEN & ASSOCIATES - -------------------------------------------------------------------------------- Netherlands Antilles Lawyers Telephone: (212) 986-9595 1285 Avenue of the Americas Facsimile: (212) 986-0005 35th Floor E-mail: zeven@zeven.com New York, NY 10019-6028 Internet: www.zeven.com Frank P.C. Zeven December 12, 2003 Teva Pharmaceutical Industries Limited Teva Pharmaceutical Finance II, LLC Teva Pharmaceutical Finance III, LLC Teva Pharmaceutical Finance II B.V. Teva Pharmaceutical Finance III B.V. Teva Pharmaceuticals Finance Ireland Limited Teva Pharmaceuticals Finance Iceland I hf. Teva Pharmaceuticals Finance Iceland II hf. Orvet Pharmaceuticals Finance S.A. c/o Teva Pharmaceutical Industries Limited 5 Basel Street P.O. Box 3190 Petach Tikva 49131 Israel Re: Registration Statement on Form F-3 ---------------------------------- Ladies and Gentlemen: We are acting as Netherlands Antilles counsel for Teva Pharmaceutical Finance II, BV and Teva Pharmaceutical Finance III, BV ("Teva Finance II BV" and "Teva Finance III BV," respectively and together the "BVs"), each a Netherlands Antilles limited liability company, in connection with the preparation and filing of a Registration Statement on Form F-3 (the "Registration Statement") by Teva Pharmaceutical Industries Limited, an Israeli corporation ("Teva"), the BVs, Teva Pharmaceutical Finance II, LLC ("Teva Finance II LLC") and Teva Pharmaceutical Finance III, LLC ("Teva Finance III LLC" and, together with Teva Finance II LLC, the "LLCs"), each a Delaware limited liability company, Teva Pharmaceuticals Finance Ireland Limited ("Teva Finance Ireland"), an Irish limited liability company, Teva Pharmaceuticals Finance Iceland I hf ("Teva Finance I Iceland") and Teva Pharmaceuticals Finance Iceland II hf ("Teva Finance II Iceland" and together with Teva Finance I Iceland, the "Iceland Subsidiaries"), each an Icelandic limited liability company and Orvet Pharmaceuticals Finance S.A., a Luxembourg limited liability company, ("Orvet Finance" and together with the LLCs, the BVs, Teva Finance Ireland and the Iceland Subsidiaries, the "Finance Subsidiaries"), in connection with the preparation and filing of the Registration Statement by Teva and the Finance Subsidiaries with the Securities and Exchange Commission pursuant to the Securities Act of 1933, as amended (the "Act"), for the registration of the sale from time to time of up to US$ 2,000,000,000.00 aggregate principal amount of: (A) by Teva, (i) American Depositary Shares ("ADSs"), each representing one ordinary share, par value NIS 0.10 per share, of Teva (the "Ordinary Shares") and evidenced by American Depositary Receipts; (ii) senior debt securities - -------------------------------------------------------------------------------- ZEVEN & ASSOCIATES - -------------------------------------------------------------------------------- Teva Pharmaceutical Industries Limited and its Finance Subsidiaries December 12, 2003 Page 2 (the "Teva Senior Debt Securities"), which may be issued pursuant to an indenture (the "Teva Senior Indenture") to be executed by Teva and The Bank of New York; and subordinated debt securities (the "Teva Subordinated Debt Securities" and, together with the Teva Senior Debt Securities, the "Teva Debt Securities"), which may be issued pursuant to an indenture (the "Teva Subordinated Indenture" and, together with the Teva Senior Indenture, the "Teva Indentures") to be executed by Teva and The Bank of New York; (iii) warrants (the "Warrants") to purchase debt or equity securities of Teva, debt securities of the Finance Subsidiaries or securities of other parties or other rights; (iv) purchase contracts (the "Purchase Contracts") for the purchase or sale of Teva's securities or securities of third parties, a basket of such securities, an index or indices of such securities or any combination of the above; and (v) units (the "Units") consisting of one or more Purchase Contracts, Warrants, debt securities, ADSs, Ordinary Shares, other debt securities or any combination of such securities; and (B) by each of the Finance Subsidiaries, (i) senior debt securities (those issued by Teva Finance II BV, the "Teva Finance II BV Senior Debt Securities" and those issued by Teva Finance III BV, the "Teva Finance III BV Senior Debt Securities"), guaranteed by Teva, which may be issued pursuant to an indenture (when executed by Teva Finance II BV, a "Teva Finance II BV Senior Indenture" and when executed by Teva Finance III BV, a "Teva Finance III BV Senior Indenture") to be executed by the applicable Subsidiary, Teva and The Bank of New York; and (ii) subordinated debt securities (those issued by Teva Finance II BV, the "Teva Finance II BV Subordinated Debt Securities" and, together with the Teva Finance II BV Senior Debt Securities, the "Teva Finance II BV Debt Securities," and those issued by Teva Finance III BV, the "Teva Finance III BV Subordinated Debt Securities," and together with the Teva Finance III BV Senior Debt Securities, the "Teva Finance III BV Debt Securities"), guaranteed by Teva, which may be issued pursuant to an indenture (when executed by Teva Finance II BV, a "Teva Finance II BV Subordinated Indenture," and together with the Teva Finance II BV Senior Indentures, the "Teva Finance II BV Indentures," and when executed by Teva Finance III BV, a "Teva Finance III BV Subordinated Indenture," and together with the Teva Finance III BV Senior Indentures, the "Teva Finance III BV Indentures") to be executed by the applicable Subsidiary, Teva and The Bank of New York. In this capacity, we have examined copies of the following documents: (a) the Registration Statement; and (b) the forms of the Teva Finance II BV Indentures and the Teva Finance III BV Indentures. ZEVEN & ASSOCIATES - -------------------------------------------------------------------------------- Teva Pharmaceutical Industries Limited and its Finance Subsidiaries December 12, 2003 Page 3 Terms and expressions defined or referred to in the Registration Statement and the forms of the Teva Finance II BV Indentures and the Teva Finance III BV Indentures, which are not otherwise defined herein, shall have the same meaning herein. We have also examined originals or copies of the following corporate documents of the Company: (a) a copy of the Articles of Incorporation of each of the BVs as in effect as at the date hereof (together the "Articles of Incorporation"); (b) an extract from the registration of each of the BVs with the Commercial Register of the Chamber of Commerce and Industry at Curacao, each dated December 11, 2003; (c) resolutions of the Board of Managing Directors of each of the BVs, both dated December 10, 2003 (the "Resolutions"), authorizing the authorizing the execution, delivery of the Registration Statement by the BVs; and (d) a Power of Attorney dated December 11, 2003, issued for and on behalf of each of the BVs in favor of Steven Melkman, Th. J. Andriessen and William A. Fletcher and each of them (the "Powers of Attorney"). In our examination of the documents referred to above and in expressing our opinion, we have assumed without independent verification of any kind: (1) the genuineness of all signatures on all documents we have reviewed; (2) the authenticity of all such documents submitted to us as originals; (3) the conformity with the originals of all documents submitted to us as copies; (4) that the Teva Finance II BV Indentures and the Teva Finance III BV Indentures will constitute the legal, valid and binding obligations of the parties thereto other than the BVs, enforceable against the said parties in accordance with their respective terms; (5) that the Teva Finance II BV Indentures and the Teva Finance III BV Indentures will be legal, valid, binding and enforceable under the laws under which they are expressed to be construed and by which they are expressed to be governed; and ZEVEN & ASSOCIATES - -------------------------------------------------------------------------------- Teva Pharmaceutical Industries Limited and its Finance Subsidiaries December 12,2003 Page 4 (6) that the Resolutions and the Powers of Attorney have not been revoked or amended in any way. As to any facts material to the opinions expressed herein which were not independently established or verified, we have relied upon written or oral statements and representations of officers and other representatives of the Company. Any reference in this opinion to our "knowledge", "awareness" or the equivalent, means the conscious awareness of facts or other information by any lawyer of Zeven & Associates that gave attention to the matters addressed in this opinion, and does not include constructive notice of matters in public records, among other things. In rendering the following opinion, we are opining on the matters hereinafter referred to, only insofar as they are governed by the laws of the Netherlands Antilles as currently in effect and applied by the courts of the Netherlands Antilles. We have made no investigation of and express no opinion in relation to the laws of any jurisdiction other than the Netherlands Antilles. Based on and subject to the foregoing, we are of the opinion that: 1) Each of the BVs is a limited liability company in the form of a "besloten vennootschap" duly organized and existing under the laws of the Netherlands Antilles and has all requisite corporate power and authority to own its properties and to conduct its business as described in the Registration Statement and as set forth in the purpose clause (Article 2) of their respective articles of incorporation. Each of the BVs has been duly registered with the Chamber of Commerce and Industry at Curacao, Netherlands Antilles. 2) When the Teva Finance II BV Indentures have been duly authorized, executed and delivered by the parties thereto in accordance with the forms thereof that we have reviewed, and when the specific terms of a particular series of Teva Finance II BV Debt Securities have been duly authorized and established in accordance with the relevant Teva Finance II BV Indenture and such Teva Finance II BV Debt Securities have been duly authorized, executed, authenticated, issued and delivered in accordance with the relevant Teva Finance II BV Indenture and any applicable underwriting or other agreement, such Teva Finance II BV Debt Securities will constitute valid and binding obligations of Teva Finance II BV, enforceable against Teva Finance II BV in accordance with their terms provided, that the specific terms of the relevant particular series of Teva Finance II BV Debt Securities do not violate mandatory provisions of Netherlands Antilles law and the Articles of Incorporation. ZEVEN & ASSOCIATES - -------------------------------------------------------------------------------- Teva Pharmaceutical Industries Limited and its Finance Subsidiaries December 12, 2003 Page 5 3) When the Teva Finance III BV Indentures have been duly authorized, executed and delivered by the parties thereto in accordance with the forms thereof that we have reviewed, and when the specific terms of a particular series of Teva Finance III BV Debt Securities have been duly authorized and established in accordance with the relevant Teva Finance III BV Indenture and such Teva Finance III BV Debt Securities have been duly authorized, executed, authenticated, issued and delivered in accordance with the relevant Teva Finance III BV Indenture and any applicable underwriting or other agreement, such Teva Finance III BV Debt Securities will constitute valid and binding obligations of Teva Finance III BV, enforceable against Teva Finance III BV in accordance with its terms provided, that the specific terms of the relevant particular series of Teva Finance III BV Debt Securities do not violate mandatory provisions of Netherlands Antilles law and the Articles of Incorporation. 4) A competent Netherlands Antilles Court would respect the non-exclusive irrevocable submission by Teva Finance II BV and/or Teva Finance III BV to the jurisdiction of any of federal or state courts sitting in the State of New York regarding any matter arising out of or in relation to the obligations of Teva Finance II BV and Teva Finance III BV under the Teva Finance II BV Indentures and Teva Finance III BV Indentures, respectively, and such submission is binding upon Teva Finance II BV and Teva Finance III BV, respectively. 5) The United States and the Netherlands Antilles do not currently have a treaty providing for reciprocal recognition and enforcement of judgments in civil and commercial matters. Therefore, a final judgment for the payment of money rendered by any federal or state court in the United States based on civil liability, whether or not predicated solely upon the federal securities laws of the United States, would not be directly enforceable in the Netherlands Antilles. If the party in whose favor such a final judgment is rendered brings a new suit in a competent court in the Netherlands Antilles, that party may submit to the Netherlands Antilles court the final judgment that has been rendered in the United States. Since the laws of the State of New York have been chosen to govern the Teva Finance II BV Indentures and the Teva Finance III BV Indentures, Teva Finance II BV and Teva Finance III BV have in their free will submitted to the jurisdiction of the federal or state courts sitting in the State of New York in connection with disputes relating to the Teva Finance II BV Indentures and Teva Finance III BV Indentures, and to the Teva Finance II BV Debt Securities and Teva Finance III BV Debt Securities, respectively. The holders, by acquiring the Teva Finance II BV Debt Securities or Teva Finance III BV Debt Securities, have voluntarily accepted such choice of law and choice of forum. A judgment obtained in any such court will be considered and recognized by the competent courts of the Netherlands Antilles to be part of the Teva Finance II BV Debt Securities and Teva Finance III BV Debt Securities, and such courts would grant a judgment in accordance with a United States judgment that would be enforceable in the ZEVEN & ASSOCIATES - -------------------------------------------------------------------------------- Teva Pharmaceutical Industries Limited and its Finance Subsidiaries December 12,2003 Page 6 Netherlands Antilles generally, without any re-examination of the merits of the original judgment; provided that: . the judgment is final in the jurisdiction where rendered and was issued by a competent court; . the judgment is valid in the jurisdiction where rendered; . the judgment was issued following personal service of the summons upon the defendant or its agent and, in accordance with due process of law, an opportunity was provided for the defendant to defend against the foreign action; . the judgment does not violate any compulsory provisions of Netherlands Antilles law or principles of public policy; . the terms and conditions of the Teva Finance II BV Debt Securities, Teva Finance III BV Debt Securities, Teva Finance II BV Indentures and Teva Finance III BV Indentures, as applicable, do not violate any compulsory provisions of Netherlands Antilles law or principles of public policy; and . the judgment is not contrary to a prior or simultaneous judgment of a competent Netherlands Antilles court. Accordingly, there is doubt as to the enforceability in the Netherlands Antilles courts of judgments obtained in United States courts. Moreover, there is doubt as to the ability of a holder of Teva Finance II BV Debt Securities or Teva Finance III BV Debt Securities to bring an original action in the Netherlands Antilles predicated on the United States federal securities laws. The opinions set forth above are subject to the qualification that (a) the Teva Finance II BV Debt Securities and Teva Finance III BV Debt Securities are issued in denominations of at least US$ 100,000.00, or, in the alternative, apply for a license from the Central Bank of the Netherlands Antilles and be supervised by the Central Bank of the Netherlands Antilles; and (b) the BVs will be required to file for publishing with the Commercial Register of the Chamber of Commerce and Industry a certificate setting forth the particulars of the relevant Teva Finance II BV Debt Securities and Teva Finance III BV Debt Securities, a failure to so file such certificate would not affect the validity of the relevant Teva Finance II BV Debt Securities and Teva Finance III BV Debt Securities or the Registration Statement and the forms of the Teva Finance II BV Indentures and the Teva Finance III BV Indentures and other than the filing of such certificate, it is not ZEVEN & ASSOCIATES - -------------------------------------------------------------------------------- Teva Pharmaceutical Industries Limited and its Finance Subsidiaries December 12, 2003 Page 7 necessary to record or register or file the relevant Teva Finance II BV Debt Securities and Teva Finance III BV Debt Securities or the Registration Statement and the forms of the Teva Finance II BV Indentures and the Teva Finance III BV Indentures with any court or governmental body of the Netherlands Antilles or any political subdivision thereof. We hereby consent to the filing of this opinion as an exhibit to the Registration Statement. By giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations promulgated thereunder. This opinion is being delivered to you solely for your information in connection with the above matter. This letter addresses matters only as of the date hereof, may not be relied upon in any manner by any other person and is not to be used, circulated, quoted or otherwise referred to for any other purpose without our express written permission. Sincerely, /s/ Frank P. C. Zeven Frank P. C. Zeven