Exhibit 99.1350CERT

         Certification Pursuant to Section 906 of the Sarbanes Oxley Act

I, Robert C. Doll, Jr., Chief Executive Officer of Merrill Lynch Large Cap
Series Fund, Inc. and Master Large Cap Series Trust (together, the "Fund"),
certify that:

      1.    The N-CSR of the Fund (the "Report") fully complies with the
            requirements of Section 13(a) or 15(d) of the Securities Exchange
            Act of 1934; and

      2.    The information contained in the Report fairly presents, in all
            material respects, the financial condition and results of operations
            of the Fund.

Dated: June 22, 2006


                                                 /s/ Robert C. Doll, Jr.
                                                 -------------------------------
                                                 Robert C. Doll, Jr.,
                                                 Chief Executive Officer of
                                                 Merrill Lynch Large Cap Series
                                                 Fund, Inc. and Master Large Cap
                                                 Series Trust

A signed original of this written statement required by Section 906, or other
document authenticating, acknowledging, or otherwise adopting the signature that
appears in typed form within the electronic version of this written statement
required by Section 906, has been provided to Merrill Lynch Large Cap Series
Fund, Inc. and Master Large Cap Series Trust and will be retained by Merrill
Lynch Large Cap Series Fund, Inc. and Master Large Cap Series Trust and
furnished to the Securities and Exchange Commission or its staff upon request.



Exhibit 99.1350CERT

         Certification Pursuant to Section 906 of the Sarbanes Oxley Act

I, Donald C. Burke, Chief Financial Officer of Merrill Lynch Large Cap Series
Fund, Inc. and Master Large Cap Series Trust (together, the "Fund"), certify
that:

      1.    The N-CSR of the Fund (the "Report") fully complies with the
            requirements of Section 13(a) or 15(d) of the Securities Exchange
            Act of 1934; and

      2.    The information contained in the Report fairly presents, in all
            material respects, the financial condition and results of operations
            of the Fund.

Dated: June 22, 2006


                                                 /s/ Donald C. Burke
                                                 -------------------------------
                                                 Donald C. Burke,
                                                 Chief Financial Officer of
                                                 Merrill Lynch Large Cap Series
                                                 Fund, Inc. and Master Large Cap
                                                 Series Trust

A signed original of this written statement required by Section 906, or other
document authenticating, acknowledging, or otherwise adopting the signature that
appears in typed form within the electronic version of this written statement
required by Section 906, has been provided to Merrill Lynch Large Cap Series
Fund, Inc. and Master Large Cap Series Trust and will be retained by Merrill
Lynch Large Cap Series Fund, Inc. and Master Large Cap Series Trust and
furnished to the Securities and Exchange Commission or its staff upon request.