EXHIBIT 4.1 kpmg Consolidated Financial Statements of NEUROCHEM INC. (A DEVELOPMENT STAGE COMPANY) Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (KPMG LOGO) KPMG LLP Telephone (514) 840-2100 Chartered Accountants Telefax (514) 840-2187 2000 McGill College Avenue http://www.kpmg.ca Suite 1900 Montreal (Quebec) H3A 3H8 AUDITORS' REPORT TO THE SHAREHOLDERS We have audited the consolidated balance sheets of Neurochem Inc. as at June 30, 2003 and 2002 and the consolidated statements of operations, deficit and cash flows for each of the years in the three-year period ended June 30, 2003 and for the period from inception (June 17, 1993) to June 30, 2003. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with Canadian generally accepted auditing standards. Those standards require that we plan and perform an audit to obtain reasonable assurance whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. In our opinion, these consolidated financial statements present fairly, in all material respects, the financial position of the Company as at June 30, 2003 and 2002 and the results of its operations and its cash flows for each of the years in the three-year period ended June 30, 2003 and for the period from inception (June 17, 1993) to June 30, 2003 in accordance with Canadian generally accepted accounting principles. (Signed) KPMG LLP Chartered Accountants Montreal, Canada August 8, 2003 (except note 18 (b), which is as of August 12, 2003) KPMG LLP, a Canadian owned limited liability partnership established under the laws of Ontario, is a member firm of KPMG International, a Swiss association. NEUROCHEM INC. Consolidated Financial Statements Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 FINANCIAL STATEMENTS Consolidated Balance Sheets........................... 1 Consolidated Statements of Operations................. 2 Consolidated Statements of Deficit.................... 3 Consolidated Statements of Cash Flows................. 4 Notes to Consolidated Financial Statements............ 5 NEUROCHEM INC. Consolidated Balance Sheets June 30, 2003 and 2002 (in thousands of Canadian dollars) (in accordance with Canadian GAAP) ================================================================================ <Table> <Caption> 2003 2003 2002 ----------- -------- -------- (US$ - (Cdn$) (Cdn$) note 2 (l)) Assets Current assets: Cash and cash equivalents $ 4,759 $ 6,450 $ 1,149 Marketable securities 7,292 9,884 23,013 Grants receivable (note 3) 390 529 1,017 Sales taxes and other receivables 651 882 405 Research tax credits receivable 866 1,174 718 Prepaid expenses and deposits 685 928 249 -------- -------- -------- 14,643 19,847 26,551 Long-term security deposits (note 9 (e)) 174 236 226 Long-term investment (note 4) 3,262 4,421 -- Property and equipment (note 5) 3,003 4,070 3,750 Patent costs (note 6) 1,908 2,586 2,206 -------- -------- -------- $ 22,990 $ 31,160 $ 32,733 ======== ======== ======== Liabilities and Shareholders' Equity Current liabilities: Accounts payable $ 2,253 $ 3,054 $ 2,216 Accrued liabilities 1,741 2,359 2,044 Current portion of obligations under capital leases (note 7) 303 411 552 -------- -------- -------- 4,297 5,824 4,812 Obligations under capital leases (note 7) 467 633 1,044 -------- -------- -------- 4,764 6,457 5,856 Shareholders' equity: Share capital (note 8) 64,544 87,482 69,501 Deficit (46,318) (62,779) (42,624) -------- -------- -------- 18,226 24,703 26,877 Commitments and contingencies (notes 3 (a) and 9)) Subsequent events (note 18) -------- -------- -------- $ 22,990 $ 31,160 $ 32,733 ======== ======== ======== </Table> See accompanying notes to consolidated financial statements. On behalf of the Board of Directors by: (Signed) John Molloy (Signed) Colin Bier, Ph.D. Director Director -1- NEUROCHEM INC. Consolidated Statements of Operations Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) (in accordance with Canadian GAAP) ================================================================================ <Table> <Caption> Cumulative since inception of 2003 2003 2002 2001 operations ----------- -------- -------- -------- ------------ (US$ - (Cdn$) (Cdn$) (Cdn$) (Cdn$) note 2 (l)) Revenues: Research contracts $ -- $ -- $ 2,271 $ 6,370 $ 9,216 License fees -- -- -- -- 1,106 -------- -------- -------- -------- -------- -- -- 2,271 6,370 10,322 Expenses: Research and development 13,857 18,782 15,304 9,926 68,108 Research tax credits (1,040) (1,410) (1,048) (752) (9,376) Research grants and other (1,398) (1,895) (2,071) (1,837) (7,608) -------- -------- -------- -------- -------- 11,419 15,477 12,185 7,337 51,124 General and administrative 5,300 7,184 3,698 3,189 22,221 Depreciation of property and equipment 752 1,019 758 348 3,035 Amortization of patent costs 131 178 130 74 541 Interest and bank charges 106 144 232 127 862 -------- -------- -------- -------- -------- 17,708 24,002 17,003 11,075 77,783 -------- -------- -------- -------- -------- Net loss before undernoted items (17,708) (24,002) (14,732) (4,705) (67,461) Investment and other income: Interest income 590 800 1,144 1,979 4,964 Foreign exchange 74 100 113 39 248 Gain on disposal of intellectual property (note 4) 2,570 3,484 -- -- 3,484 -------- -------- -------- -------- -------- 3,234 4,384 1,257 2,018 8,696 -------- -------- -------- -------- -------- Net loss before income taxes (14,474) (19,618) (13,475) (2,687) (58,765) Income taxes: Quebec credit for losses -- -- -- -- 700 -------- -------- -------- -------- -------- Net loss $(14,474) $(19,618) $(13,475) $ (2,687) $(58,065) ======== ======== ======== ======== ======== Net loss per share (note 12): Basic and diluted $ (0.66) $ (0.90) $ (0.75) $ (0.15) ======== ======== ======== ======== </Table> See accompanying notes to consolidated financial statements. -2- NEUROCHEM INC. Consolidated Statements of Deficit Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars) (in accordance with Canadian GAAP) ================================================================================ <Table> <Caption> Cumulative since inception of 2003 2003 2002 2001 operations ----------- -------- -------- -------- ------------ (US$ - (Cdn$) (Cdn$) (Cdn$) (Cdn$) note 2 (l)) Deficit, beginning of year $(31,448) $(42,624) $(29,149) $(25,897) $ -- Net loss (14,474) (19,618) (13,475) (2,687) (58,065) Share issue costs (396) (537) -- (565) (4,714) -------- -------- -------- -------- -------- Deficit, end of year $(46,318) $(62,779) $(42,624) $(29,149) $(62,779) ======== ======== ======== ======== ======== </Table> See accompanying notes to consolidated financial statements. -3- NEUROCHEM INC. Consolidated Statements of Cash Flows Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars) (in accordance with Canadian GAAP) ================================================================================ <Table> <Caption> Cumulative since inception of 2003 2003 2002 2001 operations ----------- -------- -------- -------- ------------ (US$ - (Cdn$) (Cdn$) (Cdn$) (Cdn$) note 2 (l)) Cash flows from operating activities: Net loss $(14,474) $(19,618) $(13,475) $ (2,687) $(58,065) Adjustments for: Gain on disposal of intellectual property (2,570) (3,484) -- -- (3,484) Depreciation and amortization 883 1,197 888 422 3,576 Write-off of patents -- -- 119 -- 119 Share issued for services -- -- -- -- 41 Changes in operating assets and liabilities: Grants receivable 360 488 (37) (370) (529) Sales taxes and other receivables (352) (477) 12 (64) (882) Research tax credits receivable (336) (456) 34 536 (1,174) Prepaid expenses and deposits (508) (689) (31) (72) (1,163) Accounts payable and accrued liabilities 801 1,086 1,565 116 5,448 -------- -------- -------- -------- -------- (16,196) (21,953) (10,925) (2,119) (56,113) Cash flows from financing activities: Proceeds from issue of share capital 13,266 17,981 11 8,891 87,440 Share issue costs (396) (537) -- (565) (4,714) Proceeds from sale-leaseback -- -- 1,649 -- 2,168 Repayment of obligations under capital lease (407) (552) (618) (443) (2,118) -------- -------- -------- -------- -------- 12,463 16,892 1,042 7,883 82,776 Cash flows from investing activities: Additions to property and equipment (1,209) (1,638) (946) (2,122) (6,280) Additions to patent costs (397) (538) (1,156) (424) (3,458) Long-term investment (436) (591) -- -- (591) Investment in marketable securities -- -- -- -- (31,000) Proceeds from maturity of marketable securities 9,686 13,129 7,045 942 21,116 -------- -------- -------- -------- -------- 7,644 10,362 4,943 (1,604) (20,213) -------- -------- -------- -------- -------- Net (decrease) increase in cash and cash equivalents 3,911 5,301 (4,940) 4,160 6,450 Cash and cash equivalents, beginning of year 848 1,149 6,089 1,929 -- -------- -------- -------- -------- -------- Cash and cash equivalents, end of year $ 4,759 $ 6,450 $ 1,149 $ 6,089 $ 6,450 ======== ======== ======== ======== ======== </Table> Supplemental disclosures to cash flow statements (note 13) See accompanying notes to consolidated financial statements. -4- NEUROCHEM INC. Notes to Consolidated Financial Statements Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 1. ORGANIZATION AND BUSINESS ACTIVITIES: Neurochem Inc. (the "Company" or "Neurochem"), incorporated under the Canada Business Corporations Act in 1993, is a Canadian biopharmaceutical company focused on the development and commercialization of innovative therapeutics for neurological disorders. Since inception, the business activities of the Company have been devoted principally to research and development of the Company's core technology platform, amyloid inhibitors, which focuses on the design and synthesis of chemical compounds that inhibit the formation, deposition and toxicity of amyloid fibrils implicated as the underlying causes of certain diseases. The Company's therapeutic focus is on developing treatments for a number of important disease indications characterized by the presence of toxic deposits of amyloid protein. The diseases currently targeted by the Company include Alzheimer's Disease, Hemorrhagic Stroke due to Cerebril Amyloid Angiopathy ("CAA"), and certain Systemic Amyloidosis disorders. In addition, the Company is also conducting research and development work for other neurological disorders principally Epileptic Seizures induced by Traumatic Brain Injury. In 2003, the Company disposed of its intellectual property and lead compounds for Diabetes Type II (see note 4). The status of the Company's principal product candidates are as follows: <Table> <Caption> Disease indication Product candidates Stage of development ------------------ ------------------ -------------------- Amyloid A (AA) Amyloidosis Fibrillex(TM) Phase II/III clinical trial Alzheimer's Disease Alzhemed(TM) Phase III clinical trials in design Hemorrhagic Stroke due to CAA Cerebril(TM) Phase II clinical trial Epileptic Seizures induced by Traumatic Brain Injury Lead compound NC-1461 Pre-clinical testing </Table> Neurochem is considered to be in the development stage, with a significant emphasis in clinical trials for three of its product candidates. Substantially all of the Company's research and development expenditures, and all revenues from milestone payments and research contracts, since inception, relate to the Company's core technology platform. The Company's capital expenditures since inception, including costs incurred to secure patents, relate principally to the Company's core technology platform. -5- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 2. SIGNIFICANT ACCOUNTING POLICIES: The consolidated financial statements, which have been prepared in accordance with Canadian generally accepted accounting principles ("GAAP"), would differ in some respects from those prepared in the United States. A reconciliation of the net loss and shareholders' equity reported in accordance with Canadian GAAP with US GAAP is presented in note 16. (a) Principles of consolidation: The consolidated financial statements include the accounts of the Company and its subsidiaries. All significant intercompany balances and transactions have been eliminated on consolidation. (b) Cash and cash equivalents: The Company considers all investments with maturities of three months or less that are highly liquid and readily convertible into cash to be cash equivalents. (c) Marketable securities: Marketable securities are investments with maturities greater than three months and less than a year, and consist principally of corporate bonds and commercial paper. Interest bearing financial assets are intended to be held to maturity and are carried at amortized cost. Interest is recognized on an effective yield basis. These investments are written down to their estimated fair market value when this amount is less than amortized cost, unless the Company has reason to believe it will be able to recover the carrying amount. Estimated fair market value is based on quoted or market prices. (d) Long-term investment: The long-term investment is recorded at cost. When, in the opinion of management, a permanent decline in value has occurred, the investment is written down to its estimated realizable value. In determining the estimated realizable value, management relies on its judgment and knowledge of the investment as well as assumptions of general business and economic conditions that prevail and are expected to prevail. These assumptions are limited due to the uncertainty of predictions concerning future events. -6- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 2. SIGNIFICANT ACCOUNTING POLICIES (CONTINUED): (e) Property and equipment: Property and equipment are stated at cost. Equipment under capital leases are stated at the present value of minimum lease payments. Depreciation and amortization are provided at the following annual rates: <Table> <Caption> Asset Basis Rate/period ----- ----- ----------- Research equipment Declining balance 20% Office equipment Declining balance 20% Computer hardware Declining balance 30% Computer software Straight-line 100% Equipment under capital leases Declining balance 20-30% Leasehold improvements Straight-line Over the term of the lease </Table> The Company performs a review for the impairment of its property and equipment whenever events or changes in circumstances indicate that the carrying amount of property and equipment may not be recoverable. An impairment loss would be recognized when estimates of non-discounted future cash flows expected to result from the use of such property and equipment and its eventual disposition are less than its carrying amount. No impairment losses have been identified by the Company for the years ended June 30, 2003, 2002 and 2001. (f) Patent costs: Patents are stated at cost and are amortized using the straight-line method over the life of the patent ranging from 17 to 20 years. The capitalized amount with respect to patents relates to direct costs incurred in connection with securing the patents. The cost of the patents does not necessarily reflect their present or future value and the amount ultimately recoverable is dependent upon the continued development and successful commercialization of the related products. Management reviews the unamortized balance of patent costs on an annual basis, or whenever events or changes in circumstances indicate that the carrying amount may not be recoverable, and recognizes any impairment in carrying values in the year of impairment. An impairment would be recognized when estimates of non-discounted future cash flows expected to result from the use of the asset and its eventual disposition are less then the carrying amount. In 2003, the Company recorded nil in write-downs in patent costs for which no future benefits were expected (2002 - $119; 2001 - nil). -7- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 2. SIGNIFICANT ACCOUNTING POLICIES (CONTINUED): (g) Goodwill and other intangible assets: Effective July 1, 2002, the Company adopted the new recommendations of the Canadian Institute of Chartered Accountants (CICA), Handbook Section 3062, with respect to the accounting for goodwill and other intangible assets. The standard changes the accounting for goodwill from an amortization method to an impairment-only approach. In addition, the standard requires acquired intangible assets to be separately recognized if the benefit of the intangible assets is obtained through contractual or other legal right, or if the intangible assets can be sold, transferred, licensed, rented or exchanged. There was no impact on the Company's financial position, results of operations and cash flows as a result of adopting these recommendations. In addition, there has been no change in the estimated useful life of the patent costs which continue to be amortized. (h) Revenue recognition: Revenue from research contracts is recognized when services to be provided are rendered and all conditions under the terms of the underlying agreement are met. Revenue subject to the achievement of milestones is recorded only when the specified events have occurred and collectibility is assured. Up-front payments and initial technology access fees are deferred and recognized as revenue on a systematic basis over the period that the related products or services are delivered and all obligations are performed. License fees are recorded when conditions and events under the license agreement have occurred and collectibility is reasonably assured. (i) Research and development: Research expenditures are expensed as incurred. Development expenditures, if any, are capitalized when they meet the criteria for capitalization in accordance with Canadian generally accepted accounting principles and the future benefits could be regarded as being reasonably certain. At June 30, 2003 and 2002, no development costs were deferred. (j) Government assistance: Government assistance, consisting of grants and research tax credits, is recorded as a reduction of the related expense or the cost of the asset acquired. Government assistance is recorded in the accounts when reasonable assurance exists that the Company has complied with the terms and conditions of the approved grant program or, for tax credits, when there is reasonable assurance that they will be realized. -8- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 2. SIGNIFICANT ACCOUNTING POLICIES (CONTINUED): (k) Foreign exchange: Monetary assets and liabilities denominated in foreign currencies are translated at year-end exchange rates. Other balance sheet items denominated in foreign currencies are translated at rates of exchange in effect at the transaction date. Income and expenses denominated in foreign currencies are translated at average rates prevailing during the year. Translation gains and losses are included in income. The Company's foreign subsidiaries are considered to be integrated foreign operations and their accounts have been translated using the temporal method with translation gains and losses included in the consolidated statements of operations. (l) Translation of convenience: The Company's functional currency is the Canadian dollar. As a convenience to certain users, the Company has also presented the 2003 consolidated financial statements in US dollars using the convenience translation method whereby all Canadian dollar amounts were converted into US dollars at the noon exchange rate quoted by the Bank of Canada at June 30, 2003, which was $0.7378 US dollar per Canadian dollar. The information in US dollars is presented only for the convenience of some readers and thus has limited usefulness. This translation should not be viewed as a representation that such Canadian dollar amounts actually represent such US dollar amounts or could be or would have been converted into US dollars at the rate indicated. (m) Stock-based compensation plan: Effective July 1, 2002, the Company adopted prospectively the new recommendations of the CICA, Handbook Section 3870, with respect to the accounting for stock-based compensation and other stock-based payments. The new recommendations require that all stock-based payments to non-employees, and employee awards that are direct awards of stock, call for settlement in cash or other assets, or are stock appreciation rights that call for settlement by the issuance of equity instruments, granted on or after July 1, 2002, be accounted for using the fair value method. For all other stock-based employee compensation awards, the new standards permit the Company to continue to follow its existing policy of using the settlement date method of accounting. Under this method, no compensation expense is recognized when stock options are issued to employees. Any consideration received from the plan participants upon exercise of stock options is credited to share capital. -9- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 2. SIGNIFICANT ACCOUNTING POLICIES (CONTINUED): (m) Stock-based compensation plan (continued): The new standard requires that the Company disclose the pro forma effect of accounting for all stock-based awards granted during the year ended June 30, 2003 under the fair value-based method (refer to note 12). In the first year of application, comparative disclosures need not be provided for prior periods. (n) Income taxes: The Company utilizes the asset and liability method for accounting for income taxes. Under this method, future income tax assets and liabilities are determined based on "temporary differences" (differences between the accounting basis and the tax basis of the assets and liabilities), and are measured using the currently enacted, or substantively enacted, tax rates and laws expected to apply when these differences reverse. A valuation allowance is recorded against any future tax asset if it is more likely than not that the asset will not be realized. (o) Earnings per share: Basic earnings per share are determined using the weighted average number of common shares outstanding during the period. Diluted earnings per share are computed in a manner consistent with basic earnings per share except that the weighted average shares outstanding are increased to include additional shares from the assumed exercise of options and warrants, if dilutive. The number of additional shares is calculated by assuming that outstanding options and warrants were exercised and that the proceeds from such exercises were used to acquire shares of common stock at the average market price during the reporting period. (p) Use of estimates: The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting periods. Significant areas requiring the use of management estimates include estimating the useful lives of long-lived assets, including property and equipment and patent costs, as well as assessing the recoverability of the long-term investment, research tax credits and future tax assets. The reported amounts and note disclosures are determined to reflect the most probable set of economic conditions and planned course of actions. Actual results could differ from these estimates. -10- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 3. GRANTS RECEIVABLE: (a) Technology Partnerships Canada Program: During the year ended June 30, 2000, the Company signed an agreement with the federal Ministry of Industry under its Technology Partnerships Canada Program (the "Agreement"). Under the Agreement, the Company is entitled to a financial contribution based on eligible expenditures incurred by the Company with respect to a project for the development of effective oral therapeutics for Alzheimer's Disease. The contributions were earned over a period of four years ended March 31, 2003. The Company submitted total claims under the Agreement in the amount of $1,498 in 2003, $2,019 in 2002, $1,777 in 2001 and $1,443 in 2000 for a cumulative amount of $6,737. The Company recorded $1,405 in 2003, $1,657 in 2002, $1,413 in 2001 in "research grants and other" in the consolidated statements of operations and $93 in 2003, $362 in 2002 and $364 in 2001 against property and equipment. Under the Agreement, the Company is committed to pay the federal government royalties equal to 7.24% of gross revenues realized from the commercialization of effective orally-administered therapeutics for the treatment of Alzheimer's Disease until June 30, 2010. After June 30, 2010, the Company may have to continue to pay royalties until such time as the aggregate amount of royalties paid pursuant to the Agreement reaches $20,540. (b) Food and Drug Administration: During the year ended June 30, 2002, the Company was awarded a $1,400 grant from the US Food and Drug Administration for certain direct costs to be incurred by the Company for a Phase II/III trial of Fibrillex(TM). Funds under the grant are expected to be received by the Company in equal quarterly instalments over a period of three years. Included in "research grants and other" on the statement of operations for the twelve-month period ended June 30, 2003 is an amount of $460 (2002 - $356) received under this agreement. -11- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 4. LONG-TERM INVESTMENT: In May 2003, the Company entered into the following transactions with respect to its Diabetes Type II pre-clinical program: (i) the Company disposed of its intellectual property rights relating to the pre-clinical diabetes program, including an exclusive perpetual, royalty-free, worldwide license to Innodia Inc. ("Innodia"), a privately held Canadian biopharmaceutical company. The carrying value of these rights, which amount to $346, were exchanged for 1,904,464 Innodia common shares having a fair market value of $5,400. The fair market value of the Innodia common shares was determined based on the pricing of a $7,000 private placement financing completed by Innodia concurrent with this transaction. Since the Company transferred its ownership of a controlled productive asset to Innodia in exchange for a non-controlling equity interest of 31% in Innodia, the Company accounted for this transaction as a partial sale and recognized a gain on the transaction only to the extent of the interest of the other shareholders in Innodia. Accordingly, the gain on sale of intellectual property rights of $3,484 included in the 2003 statement of operations represents approximately 69% of the total gain of $5,054 on the transaction; (ii) the Company subscribed for 176,339 Class A1 preferred shares of Innodia as part of a private placement for a cash consideration of $500, plus related costs of $91. In June 2003, the Company transferred its 31% interest in Innodia to a holding company which is controlled indirectly by a shareholder. As consideration for this transfer, Neurochem received 176,339 non-voting Class A1 preferred shares, 1,904,464 non-voting, participating Class A common shares and 352,537 voting, non-participating Class V preferred shares. The Class A1 preferred shares are convertible into common shares on a one-for-one basis at any time at the option of the holder and automatically convertible under specified circumstances. At June 30, 2003, the Company's long-term investment represents voting rights of approximately 12% and equity ownership of approximately 70% in the holding company, which represents the same economic interest as that held directly in Innodia prior to the transfer. -12- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 5. PROPERTY AND EQUIPMENT: <Table> <Caption> 2003 ----------------------------------------------------------- Accumulated depreciation Net book Cost and amortization value ------------- ---------------- ------------- Research equipment $ 2,484 $ 1,253 $ 1,231 Computer hardware and software 1,331 750 581 Office equipment 560 187 373 Equipment under capital leases 1,198 429 769 Leasehold improvements 1,532 416 1,116 ------------- ------------- ------------- $ 7,105 $ 3,035 $ 4,070 ============= ============= ============= </Table> <Table> <Caption> 2002 ----------------------------------------------------------- Accumulated depreciation Net book Cost and amortization value ------------- ---------------- ------------- Research equipment $ 1,694 $ 822 $ 872 Computer hardware and software 587 376 211 Office equipment 357 126 231 Equipment under capital leases 1,782 429 1,353 Leasehold improvements 1,346 263 1,083 ------------- ------------- ------------- $ 5,766 $ 2,016 $ 3,750 ============= ============= ============= </Table> Included in "depreciation of property and equipment" in the consolidated statements of operations is depreciation of equipment under capital lease of $251 (2002 - $245). -13- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 6. PATENT COSTS: <Table> <Caption> 2003 2002 ------ ------ Cost $2,946 $2,562 Accumulated amortization 360 356 ------ ------ $2,586 $2,206 ====== ====== </Table> The remaining weighted average amortization period of patents at June 30, 2003 is 15.4 years (2002 - 16.2 years). The estimated amortization expense for each of the next five years is approximately $196 per annum or $980 in the aggregate. 7. OBLIGATIONS UNDER CAPITAL LEASES: Minimum lease payments under capital leases expiring in 2006 are as follows: <Table> <Caption> 2003 2002 --------- --------- 2003 $ -- $ 645 2004 470 470 2005 470 470 2006 196 196 --------- --------- 1,136 1,781 Less amount representing interest at rates ranging from 6.88% to 9.75% 92 185 --------- --------- 1,044 1,596 Less current portion 411 552 --------- --------- $ 633 $ 1,044 ========= ========= </Table> Interest expense related to obligations under capital leases was $92 in 2003 (2002 - $80; 2001 - $50) and is included in "interest and bank charges" in the consolidated statements of operations. In December 2001, the Company entered into a sale-leaseback agreement with a Canadian chartered bank to sell previously acquired research equipment and concurrently leased the same property back over a four-year period. The Company received proceeds from the sale in the amount of $1,649. -14- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 8. SHARE CAPITAL: (a) The authorized share capital of the Company consists of: o an unlimited number of voting common shares o an unlimited number of non-voting preferred shares, issuable in one or more series (b) Issued and outstanding: The issued and outstanding share capital consists of: <Table> <Caption> 2003 2002 -------------- -------------- 23,483,024 common shares (2002 - 18,028,344 common shares) $ 87,482 $ 69,501 ============== ============== </Table> Changes in the issued and outstanding common shares for the past three fiscal periods were as follows: <Table> <Caption> Number Dollars ---------- ------- Balance, June 30, 2000 16,623,481 $60,599 Exercise of over allotment option (i) 581,818 4,800 Issued for cash from private placement (ii) 321,035 3,807 Exercise of options 435,438 205 Exercise of warrants 34,447 79 ---------- ------- Balance, June 30, 2001 17,996,219 69,490 Exercise of options 32,125 11 ---------- ------- Balance, June 30, 2002 18,028,344 69,501 Issued for cash from private placement (iii) 4,000,000 15,148 Exercise of warrants 836,644 1,904 Exercise of options 618,036 929 ---------- ------- Balance, June 30, 2003 23,483,024 $87,482 ========== ======= </Table> -15- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 8. SHARE CAPITAL (CONTINUED): (b) Issued and outstanding (continued): Fiscal 2001: (i) In August 2000, the underwriters fully exercised their over-allotment option issued in connection with the Company's 2000 initial public offering to purchase an additional 581,818 common shares for a cash consideration of $4,800. (ii) In January 2001, the Company issued 321,035 common shares to a shareholder for a cash consideration of $3,807. Fiscal 2003: (iii) On July 25, 2002 and February 18, 2003, the Company completed equity financing agreements with Picchio Pharma Inc. In July 2002, the Company issued 2.8 million units at a cost of $2.50 per unit, and received aggregate proceeds of $7,000. The units were comprised of one common share and one warrant exercisable any time within a three-year period at the exercise price of $3.13, which represents a premium of 25% over the issue price of the unit. The warrants expire on July 25, 2005. In February 2003, the Company issued 1.2 million units at a cost of $6.79 per unit and received aggregate proceeds of $8,148. The units were comprised of one common share and one warrant exercisable any time within a three-year period at an exercise price of $7.81, which represents a premium of 15% over the issue price of the unit. The warrants expire on February 18, 2006. Share issue costs related to these transactions were charged to the deficit. (c) Stock option plan: Under its stock option plan, the Company may grant options to purchase common shares to key employees, directors, officers, consultants and members of the Scientific Advisory Board of the Company. The terms, number of common shares covered by each option as well as the permitted frequency of the exercise of such options is determined by the Board of Directors. In general, options vest over periods ranging from one to five years. The total number of common shares which may be issued pursuant to the plan is 3,196,973 shares. The maximum number of common shares which may be optioned in favor of any single individual shall not exceed 5% of the issued and outstanding common shares of the Company. The option price per share will, in no circumstances, be lower than the fair market value of the common shares at the date of the grant of the option, less any discount permitted by any regulatory authority. In no event may the term of any option exceed ten years from the date of the grant of the option. -16- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 8. SHARE CAPITAL (CONTINUED): (c) Stock option plan (continued): Changes in outstanding options issued under the stock option plan for the past three fiscal periods were as follows: <Table> <Caption> Weighted average Number exercise price --------- -------------- Options outstanding, June 30, 2000 1,489,725 $ 1.73 Exercised (186,438) 0.37 Cancelled or expired (2,562) 0.41 --------- -------- Options outstanding, June 30, 2001 1,300,725 1.93 Granted 704,400 3.00 Exercised (22,125) 0.36 Cancelled or expired (19,500) 3.13 --------- -------- Options outstanding, June 30, 2002 1,963,500 2.32 Granted 909,000 7.22 Exercised (577,036) 1.59 Cancelled or expired (3,620) 3.25 --------- -------- Options outstanding, June 30, 2003 2,291,844 $ 4.48 ========= ======== </Table> -17- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 8. SHARE CAPITAL (CONTINUED): (c) Stock option plan (continued): The following table summarizes information about options outstanding and exercisable at June 30, 2003: <Table> <Caption> Weighted average remaining Options Options contractual life Exercise price/share outstanding exercisable (years) -------------------- ----------- ----------- ---------------- $ 0.36 - $ 0.65 272,500 272,500 3.8 $ 2.99 - $ 3.75 1,116,011 684,595 7.5 $ 5.30 - $ 6.79 377,333 98,708 9.3 $ 8.11 - $ 9.85 526,000 41,000 9.6 --------- --------- --- 2,291,844 1,096,803 7.8 ========= ========= === </Table> (d) Other outstanding options at June 30, 2003: The Company had previously issued 400,000 options to purchase common shares at prices ranging from US$0.20 to US$2.50 per share which are not covered by the stock option plan. In the fiscal period ended June 30, 2003, 41,000 (10,000 in 2002; 249,000 in 2001) of these options were exercised for gross proceeds of $12 ($3 in 2002; $135 in 2001). The remaining 100,000 outstanding options are detailed as follows: <Table> <Caption> Options Options Exercise price/share outstanding exercisable Expiry -------------------- ----------- ----------- ------ US$ 2.50 100,000 100,000 2004 ======= ======= ==== </Table> -18- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 8. SHARE CAPITAL (CONTINUED): (e) Outstanding warrants at June 30, 2003: Each warrant entitles the holder to purchase one common share. Changes in outstanding warrants issued in connection with various private placements for the past three fiscal periods were as follows: <Table> <Caption> Weighted average Number exercise price --------- -------------- Warrants outstanding, June 30, 2000 977,876 $ 2.22 Exercised (34,447) 2.31 --------- -------- Warrants outstanding, June 30, 2001 and 2002 943,429 2.22 Issued in connection with private placement (note 8 (b) (iii)) 4,000,000 4.53 Exercised (836,644) 2.28 --------- -------- Warrants outstanding, June 30, 2003 4,106,785 $ 4.46 ========= ======== </Table> The following table summarizes information about outstanding warrants at June 30, 2003: <Table> <Caption> Warrants Exercise price Expiry -------- -------------- ------ 106,785 $ 1.80 April 2005 2,800,000 $ 3.13 July 2005 1,200,000 $ 7.81 February 2006 --------- -------- 4,106,785 $ 4.46 ========= ======== </Table> -19- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 9. COMMITMENTS: (a) Operating leases: Minimum annual lease payments for the next five years and thereafter under operating leases relating to premises are as follows: <Table> 2004 $ 574 2005 479 2006 400 2007 323 2008 196 Thereafter 717 -------- $ 2,689 ======== </Table> In addition, the Company is also responsible for operating costs and taxes under the operating leases. (b) License agreements and research collaborations: Effective January 1, 1994, the Company entered into a number of license agreements (the "License Agreements") with Parteq Research and Development Innovations ("Parteq"), the commercialization arm and exclusive worldwide licensee of Queen's University. Pursuant to these agreements, the Company was granted the worldwide exclusive license to use, market and sublicense certain technologies, patents and patent applications developed and belonging to Queen's University. While the title and interest in the intellectual property rights remain the property of Queen's University, the Company will be the owner of all intellectual property rights in and to all improvements to the intellectual property rights developed, invented or acquired by the Company. Pursuant to the terms of the License Agreements, the Company has agreed to pay certain fees (including milestone payments) and royalties, and to assume all expenses related to the protection of the intellectual property rights. Each of the License Agreements will terminate upon the later of (i) the expiry date of the last-to-expire of the licensed patents or (ii) ten years after its first sales of products that use the license, should no patent be issued. -20- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 9. COMMITMENTS (CONTINUED): (b) License agreements and research collaborations (continued): The Company is a party to research and license agreements under which it has obtained rights to use certain technologies to develop certain of its product candidates. These agreements impose various milestones, commercialization, sublicensing, royalty and other payment, insurance, indemnification and other obligations and are subject to certain reservations of rights. (c) Agreement with H. Lundbeck A/S: In 1999, the Company entered into a Collaborative Research and License Agreement and a Master Private Placement and Stock Option Agreement (the "Agreements") with H. Lundbeck A/S ("Lundbeck"), a European pharmaceutical company specializing in the research, development, production and marketing of drugs for treating diseases of the central nervous system. Pursuant to the Agreements, the parties agreed to collaborate on the development of compounds (GAG and GAG mimetic) useful in treating Alzheimer's Disease. In October 2000, the Company achieved a research and development objective under its Agreements. In 2001, as a result of the determination of "proof of concept" in connection with the research program, the Company received a milestone payment in the amount of $3,807 (US$2,500). In addition, the Company received research funding of $1,933 (US$1,250) ($1,912 (US$1,250) in 2001) under a research program that commenced January 2001 under the Agreements and $338 ($651 in 2001) under other research agreements with Lundbeck. In October 2001, the Company and Lundbeck mutually agreed to terminate the Agreements and, as a result, the Company regained ownership and control of its anti-amyloid drug molecules program for Alzheimer's Disease at no cost to the Company. Consequently, the Company received the last payments from Lundbeck under the Agreements in October 2001. -21- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 9. COMMITMENTS (CONTINUED): (d) Management services agreement: Payments under a management services agreement with a shareholder-affiliated entity (see note 10 (d)) are as follows: 2004 - $960; 2005 - $640. (e) Guarantees: On January 1, 2003, the Company adopted the new recommendations of the CICA, accounting Guideline 14, Disclosure of Guarantees, which clarifies disclosure requirements for certain guarantees. The guideline does not provide guidance on nor require the measurement and recognition of a guarantor's liability for obligations under guarantees. The guideline defines a guarantee to be a contract (including an indemnity) that contingently requires the Company to make payments to a third party based on (i) changes in an underlying interest rate, foreign exchange rate, equity or commodity instrument, index or other variable, that is related to an asset, a liability or an equity security of the counterparty, (ii) failure of another party to perform under an obligating agreement or (iii) failure of another party to pay its indebtedness when due. At June 30, 2003, the Company is contingently liable for a letter of guarantee granted in favor of a landlord in the amount of $200. A long-term security deposit of $200 is pledged under the letter of guarantee. In addition, the Company has granted a movable hypothec in the amount of $100 under a lease agreement covering the universality of movable property at a leased location. -22- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 10. RELATED PARTY TRANSACTIONS: (a) Included in revenues are amounts received under various agreements with Lundbeck, a shareholder, of nil in 2003, $2,271 in 2002 and $6,370 in 2001. (b) Included in research and development are the following amounts paid to Queen's University at Kingston, a shareholder, under various research agreements: <Table> 2003 $ 5 2002 295 2001 137 </Table> (c) The Company paid Parteq Research and Development Innovations, a shareholder, the following amounts for patent fees in the normal course of operations: <Table> 2003 $ 10 2002 16 2001 -- </Table> (d) Under the terms of a management services agreement entered into in March 2003 with Picchio International Inc., a company controlled by a shareholder, the Company recorded a management fee of $320 for the year ended June 30, 2003. In addition, the Company reimbursed this company for $209 of expenses incurred prior to the date of the management services agreement. (e) Accounts payable and accrued liabilities include balances due to shareholders of $13 (2002 and 2001 - $47). These transactions are in the normal course of operations and are measured at the exchange amount, which is the amount of consideration established and agreed to by the related parties. -23- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 11. INCOME TAXES: (a) Details of the components of income taxes are as follows: <Table> <Caption> 2003 2002 2001 ---------- ---------- ---------- Loss before income taxes: Canadian operations $ (18,559) $ (13,475) $ (2,687) Foreign operations (1,059) -- -- ---------- ---------- ---------- (19,618) (13,475) (2,687) Basic income tax rate 34% 36% 38% ---------- ---------- ---------- Computed income tax recovery (6,670) (4,851) (1,021) Adjustment in income taxes resulting from: Non-recognition of losses and other unclaimed deductions 2,403 4,851 1,021 Reduction of future tax assets due to differences in tax rates with foreign subsidiaries 4,592 -- -- Permanent differences (325) -- -- ---------- ---------- ---------- $ -- $ -- $ -- ========== ========== ========== </Table> (b) Future income taxes: The temporary differences that give rise to future tax assets and liabilities at June 30, 2003 and 2002 are as follows: <Table> <Caption> 2003 2002 ---------- ---------- Future tax assets: Patent costs $ 10,053 $ -- Unclaimed scientific research and experimental development expenditures for tax purposes 5,750 9,546 Share issue costs 376 522 Non-capital losses carried forward -- 2,669 Long-term investment 271 -- Cumulative eligible capital 6 33 ---------- ---------- 16,456 12,770 Less: valuation allowance (15,621) (12,178) ---------- ---------- 835 592 Future tax liabilities: Property and equipment, and patent costs (835) (592) ---------- ---------- Net future tax assets $ -- $ -- ========== ========== </Table> -24- Intentionally Left Blank -25- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 11. INCOME TAXES (CONTINUED): (b) Future income taxes (continued): In assessing the realizability of future tax assets, management considers whether it is more likely than not that some portion or all of the future income tax assets will be realized. The ultimate realization of future tax assets is dependent upon the generation of future taxable income and/or tax planning strategies. Since the Company is a development stage enterprise, the generation of future taxable income is dependent on the successful commercialization of its products and technologies. (c) The Company has the following unclaimed deductions available to reduce future taxable income in Canada: <Table> <Caption> Federal Quebec ------------ ----------- Research expenditure pool (no expiry) $ 26,093 $ 149 ============ =========== </Table> The Company also has approximately $3,685 in federal research investment tax credits that can be used to reduce future federal taxes payable and which expire as follows: <Table> 2012 $1,434 2013 2,251 ------ $3,685 ====== </Table> -26- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 12. EARNINGS PER SHARE: (a) Basic and diluted earnings per share: The reconciliation between basic and diluted earnings per share is as follows: <Table> <Caption> 2003 2002 2001 ------------ ------------ ------------ Basic: Basic weighted average number of common shares outstanding 21,770,541 18,007,392 17,436,716 ============ ============ ============ Basic net loss per share $ (0.90) $ (0.75) $ (0.15) ============ ============ ============ Diluted: Basic weighted average number of common shares outstanding 21,770,541 18,007,392 17,436,716 Plus impact of stock options and warrants (1) 2,858,010 1,239,910 1,976,280 ------------ ------------ ------------ Diluted common shares 24,628,551 19,247,302 19,412,996 ============ ============ ============ Diluted net loss per share (1) $ (0.90) $ (0.75) $ (0.15) ============ ============ ============ </Table> (1) The impact of stock options and warrants is anti-dilutive because the Company incurred losses in 2003, 2002 and 2001. All outstanding options and warrants included in this computation could potentially be dilutive in the future. -27- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 12. EARNINGS PER SHARE (CONTINUED): (b) Stock-based compensation: Effective July 1, 2002, the Company adopted prospectively the new recommendations with respect to the accounting for stock-based compensation and other stock-based payments (see note 2 (m)). If the fair value-based accounting method had been used to account for and measure stock-based compensation costs relating to exempt options granted to employees after July 1, 2002, the net earnings and related earnings per share figures would have been as follows: <Table> Reported net loss $ (19,618) Pro forma adjustments to compensation expense (718) ------------ Pro forma net loss $ (20,336) ============ Pro forma loss per share: Basic $ (0.93) Diluted (0.93) ============ </Table> The weighted average fair value of each option granted is estimated on the date of grant using the Black-Scholes pricing model with the following assumptions: <Table> Risk free interest rate 4.68% Expected volatility 61% Expected life in years 7 Expected dividend yield nil </Table> -28- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 12. EARNINGS PER SHARE (CONTINUED): (b) Stock-based compensation (continued): The following table summarizes the weighted average grant-date fair value per share for options granted during the year ended June 30, 2003: <Table> <Caption> Weighted average grant-date Number of fair value options per share ------------ ------------ Exercise price per share equal to market 909,000 $ 4.66 ============ ============ </Table> Dividend yield was excluded from the calculation since it is the present policy of the Company to retain all earnings to finance operations. 13. STATEMENT OF CASH FLOWS - SUPPLEMENTARY DISCLOSURE: (a) Cash and cash equivalents: Cash and cash equivalents consist of cash balances with banks and short-term investments: <Table> <Caption> 2003 2002 ------------ ------------ Cash balances with banks $ 2,462 $ 115 Short-term investments (yielding interest between 3.24% to 3.29% (2002: 1.3% to 2.7%) 3,988 1,034 ------------ ------------ $ 6,450 $ 1,149 ============ ============ </Table> (b) Interest and income taxes: <Table> <Caption> 2003 2002 ------------ ------------ Cash paid in the year for: Interest $ 92 $ 143 Income taxes -- -- </Table> -29- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 13. STATEMENT OF CASH FLOWS - SUPPLEMENTARY DISCLOSURE (CONTINUED): (c) Non-cash transactions: <Table> <Caption> 2003 2002 2001 ------------ ------------ ------------ Disposal of intellectual property to Innodia in exchange for an equity interest (note 4) $ 3,830 $ -- $ -- Additions to property and equipment and patent costs included in accounts payable and accrued liabilities at year-end 590 523 625 </Table> 14. SEGMENT DISCLOSURES: (a) Business segment: The Company operates in one business segment, namely the development and commercialization of innovative therapeutics for neurological disorders. The Company's operations are conducted principally in Canada. (b) Information about major customers: All of the Company's revenues in 2002 and 2001 were derived from one customer (see note 9 (c) and 10 (a)). (c) Property and equipment and intangible assets (patent costs) by geographic area are as follows: <Table> <Caption> 2003 2002 ------------ ------------ Canada $ 4,070 $ 5,956 Europe 2,586 -- ------------ ------------ $ 6,656 $ 5,956 ============ ============ </Table> -30- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 15. FINANCIAL INSTRUMENTS: (a) Fair value disclosure: Fair value estimates are made as of a specific point in time, using available information about the financial instrument. These estimates are subjective in nature and often cannot be determined with precision. The Company has determined that the carrying value of its short-term financial assets and liabilities, including cash and cash equivalents, grants receivable, sales taxes receivable, interest and other receivables, research tax credits receivable as well as accounts payable and accrued liabilities, approximates their fair value because of the relatively short periods to maturity of these instruments. Marketable securities are comprised of fixed income instruments with a high credit rating (not less than R1 (mid) rating). The weighted average effective interest rate of the marketable securities is approximately 3.25%. The fair market value of the marketable securities amounts to $9,947 as at June 30, 2003 ($22,976 in 2002). The fair value of obligations under capital leases, calculated at the present value of future contractual payments of principal and interest, discounted at the current market rates of interest available to the Company for debt instruments with similar terms and maturity, approximates their carrying value. (b) Credit risk: Credit risk results from the possibility that a loss may occur from the failure of another party to perform according to the terms of the contract. The Company regularly monitors the credit risk exposure and takes steps to mitigate the likelihood of these exposures from resulting in actual loss. Financial instruments that potentially subject the Company to significant concentrations of credit risk consist principally of marketable securities. The Company has investment policies that ensure the safety and preservation of principal, that ensure that the Company's liquidity needs are met and that optimize yields. Authorized investments include bankers' acceptances, bearer deposit notes, corporate and government bonds, certificates of deposit, commercial paper and treasury bills, and are limited to 10% per issuer. -31- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 15. FINANCIAL INSTRUMENTS (CONTINUED): (c) Foreign currency risk management: A substantial portion of the Company's revenues from research contracts and milestone payments in prior years, as well as expenses, are denominated in US dollars. This results in financial risk due to fluctuations in the value of the Canadian dollar relative to the US dollar. The Company does not use derivative financial instruments to reduce its foreign exchange exposure. Fluctuations in payments made for the Company's services could cause unanticipated fluctuations in the Company's operating results. (d) Interest rate risk: The Company's exposure to interest rate risk is as follows: Cash and cash equivalents Fixed interest rate Marketable securities Fixed interest rate Obligations under capital leases Fixed interest rate 16. CANADIAN/US REPORTING DIFFERENCES: (a) Consolidated statements of operations: The reconciliation of earnings reported in accordance with Canadian GAAP with US GAAP is as follows: <Table> <Caption> Cumulative since inception of 2003 2002 operations ------------ ------------ ------------ Net loss in accordance with Canadian GAAP $ (19,618) $ (13,475) $ (58,065) Adjustment for: Stock-based compensation costs (1) (83) (111) (1,967) ------------ ------------ ------------ Net loss in accordance with US GAAP $ (19,701) $ (13,586) $ (60,032) ============ ============ ============ Loss per share under US GAAP: Basic and diluted $ (0.90) $ (0.75) ============ ============ </Table> -32- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (a) Consolidated statements of operations (continued): The weighted average number of common shares outstanding for purposes of determining basic and diluted loss per share is the same amount as the one used for Canadian GAAP purposes. (b) Consolidated balance sheets: A reconciliation of balance sheet items in accordance with Canadian GAAP with US GAAP is as follows: (i) Share capital: <Table> <Caption> 2003 2002 ------------ ------------ Share capital, Canadian GAAP $ 87,482 $ 69,501 Adjustment for: Share issue costs (2) (4,714) (4,177) ------------ ------------ Share capital, US GAAP $ 82,768 $ 65,324 ============ ============ </Table> (ii) Additional paid-in capital: <Table> <Caption> 2003 2002 ------------ ------------ Additional paid-in capital, Canadian GAAP $ -- $ -- Adjustment for: Stock-based compensation (1): Current year 83 111 Cumulative effect of prior years 1,610 1,499 ------------ ------------ 1,693 1,610 ------------ ------------ Additional paid-in capital, US GAAP $ 1,693 $ 1,610 ============ ============ </Table> -33- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (b) Consolidated balance sheets (continued): (iii) Deficit: <Table> <Caption> 2003 2002 ------------ ------------ Deficit, Canadian GAAP $ (62,779) $ (42,624) Adjustment for: Stock-based compensation (1): Current year (83) (111) Cumulative effect of prior years (1,610) (1,499) ------------ ------------ (1,693) (1,610) Share issue expenses (2) 4,714 4,177 ------------ ------------ Deficit, US GAAP $ (59,758) $ (40,057) ============ ============ </Table> (1) Stock-based compensation: Employees For US GAAP purposes, the Company has elected to follow the intrinsic value method of Accounting Principles Board Opinion No. 25, "Accounting for Stock Issued to Employees" ("APB 25") in accounting for stock options granted to employees and directors. Under the intrinsic value method, compensation cost is recognized for the difference, if any, between the quoted market price of the stock as at the grant date and the amount the individual must pay to acquire the stock. The Company recorded compensation expense of $83 (2002 - $111) in respect of options granted to employees prior to the Company's initial public offering at prices other than the quoted market price at date of grant. Non-employees In accordance with FAS 123, Accounting for Stock-Based Compensation, compensation related to stock options granted to non-employees prior to July 1, 2002 is recorded in the accounts based on the fair value of the stock options at the grant date. For purposes of reconciliation to US GAAP, the Company recorded compensation expense of nil in respect of options granted to non-employees (2002 - nil). -34- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (b) Consolidated balance sheets (continued): (1) Stock-based compensation (continued): Fair value method Both Canadian and US GAAP require disclosure of the pro forma net loss using the fair value method of accounting for stock options granted to employees. The calculation under Canadian GAAP is presented in note 12 (b); the US GAAP calculation presented hereafter considers options granted prior to the effective date of the Canadian GAAP requirements. If the fair value based accounting method under FAS 123 had been used to account for stock-based compensation costs relating to options issued to employees, the net loss and related loss per share figures under US GAAP would have been as follows: <Table> <Caption> Cumulative since inception of 2003 2002 operations ------------ ------------ ------------ Reported net loss, US GAAP $ (19,701) $ (13,586) $ (60,032) Add: Stock-based employee compensation expense determined under the intrinsic value method included in reported net earnings, net of related taxes of $nil 83 111 1,967 Deduct: Total stock-based employee compensation expense determined under fair value based method for all awards, net of related taxes of $nil (1,115) (431) (3,820) ------------ ------------ ------------ Pro forma net loss, US GAAP $ (20,733) $ (13,906) $ (61,885) ============ ============ ============ </Table> -35- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (b) Consolidated balance sheets (continued): (1) Stock-based compensation (continued): <Table> <Caption> 2003 2002 ------------ ------------ Loss per share (US GAAP) Basic: As reported $ (0.90) $ (0.75) Pro forma (0.95) (0.77) Diluted: As reported (0.90) (0.75) Pro forma (0.95) (0.77) </Table> The weighted average fair value of each option granted is estimated on the date of grant using the Black-Scholes pricing model with the following weighted average assumptions: <Table> <Caption> 2003 2002 ------------ ------------ Risk-free interest rate 4.68% 5.19% Expected volatility 61% 54% Expected life in years 7 7 Expected dividend yield -- -- </Table> The following table summarizes the weighted average grant date fair value per shares for options granted: <Table> <Caption> Weighted average grant-date Number of fair value options per share ------------ ------------ 2003 909,000 $ 4.66 2002 704,400 1.54 </Table> -36- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (b) Consolidated balance sheets (continued): (2) Share issue costs: For US GAAP purposes, share issue costs are recorded as a reduction of the proceeds raised from the issuance of share capital. For Canadian GAAP purposes, share issue costs were charged to the deficit. (c) Consolidated comprehensive income: FAS 130, Reporting Comprehensive Income, requires the Company to report and display information related to comprehensive income for the Company. Comprehensive income consists of net income and all other changes in shareholders' equity that do not result from changes from transactions with shareholders, such as cumulative foreign currency translation adjustments and unrealized gains or losses on securities. There were no adjustments to the net loss, US GAAP, required to reconcile to the comprehensive loss. (d) Other disclosures required by US GAAP: (i) Debt and equity investments: In accordance with FAS 115, Accounting for Certain Investments in Debt and Equity Securities, the Company's marketable securities are classified as held-to-maturity and the amortized cost, gross unrealized holding gains, unrealized holding losses and fair value by security-type were as follows: At June 30, 2003 <Table> <Caption> Gross Gross unrealized unrealized Amortized holding holding Fair cost gains losses value ------------ ------------ ------------ ------------ Commercial paper $ 9,884 $ 63 $ -- $ 9,947 ============ ============ ============ ============ </Table> -37- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (d) Other disclosures required by US GAAP (continued): (i) Debt and equity investments (continued): At June 30, 2002 <Table> <Caption> Gross Gross unrealized unrealized Amortized holding holding Fair cost gains losses value ------------ ------------ ------------ ------------ Canadian money market securities $ 13,987 $ -- $ -- $ 13,987 Canadian corporate debt securities 9,026 -- (37) 8,989 ------------ ------------ ------------ ------------ $ 23,013 $ -- $ (37) $ 22,976 ============ ============ ============ ============ </Table> (ii) Supplementary information: Under US GAAP and SEC rules, separate disclosure is required for the following statement of operations item. There is not similar requirement under Canadian GAAP. <Table> <Caption> 2003 2002 -------------- -------------- Rental expense $ 485 $ 407 ============== ============== </Table> -38- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (d) Other disclosures required by US GAAP (continued): (iii) Development stage company (continued): The Company is a development stage enterprise as defined in FAS 7 and the following additional disclosures are provided. The statement of shareholders' equity since date of inception under US GAAP is presented below: <Table> <Caption> Common shares Class A shares 1st Preference ----------------------- ----------------------- ----------------------- Number Dollars Number Dollars Number Dollars ---------- ---------- ---------- ---------- ---------- ---------- Period ended October 14, 1994: Shares issued for cash 850,000 -- -- -- 400,000 546 Net loss -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- Balance, October 14, 1994 850,000 -- -- -- 400,000 546 Period ended September 30, 1995: Shares issued for cash -- -- -- -- 600,000 811 Net loss -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1995 850,000 -- -- -- 1,000,000 1,357 Year ended September 30, 1996: Shares issued for cash -- -- -- -- -- -- Shares issued for services 275,076 41 -- -- -- -- Share issue costs -- -- -- -- -- -- Net loss -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1996 1,125,076 41 -- -- 1,000,000 1,357 Year ended September 30, 1997: Net loss -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1997 1,125,076 41 -- -- 1,000,000 1,357 <Caption> Special shares Additional Total ----------------------- paid-in shareholders' Number Dollars capital Deficit equity ---------- ---------- ---------- ---------- ------------- Period ended October 14, 1994: Shares issued for cash -- -- $ -- $ -- $ 546 Net loss -- -- -- (551) (551) ---------- ---------- ---------- ---------- ---------- Balance, October 14, 1994 -- -- -- (551) (5) Period ended September 30, 1995: Shares issued for cash -- -- -- -- 811 Net loss -- -- -- (1,787) (1,787) ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1995 -- -- -- (2,338) (981) Year ended September 30, 1996: Shares issued for cash 5,595,001 10,071 -- -- 10,071 Shares issued for services -- -- -- -- 41 Share issue costs -- (217) -- -- (217) Net loss -- -- -- (2,169) (2,169) ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1996 5,595,001 9,854 -- (4,507) 6,745 Year ended September 30, 1997: Net loss -- -- -- (2,391) (2,391) ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1997 5,595,001 9,854 -- (6,898) 4,354 </Table> -39- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (d) Other disclosures required by US GAAP (continued): (iii) Development stage company (continued): The Company is a development stage enterprise as defined in FAS 7 and the following additional disclosures are provided (continued): The statement of shareholders' equity since date of inception under US GAAP is presented below (continued): <Table> <Caption> Common shares Class A shares 1st Preference ----------------------- ----------------------- ------------------------ Number Dollars Number Dollars Number Dollars ---------- ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1997 brought forward 1,125,076 41 -- -- 1,000,000 1,357 ---------- ---------- ---------- ---------- ---------- ---------- Year ended September 30, 1998: Conversion into Class A shares -- -- 6,595,001 11,211 (1,000,000) (1,357) Shares issued for cash -- -- 3,138,770 10,201 -- -- Exercise of options 5,500 2 -- -- -- -- Share issue costs -- -- -- (550) -- -- Net loss -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1998 1,130,576 43 9,733,771 20,862 -- -- Period ended June 30, 1999: Shares issued for cash -- -- 1,483,224 5,562 -- -- Exercise of options 29,314 11 -- -- -- -- Share issue costs -- -- -- (106) -- -- Net loss -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- Balance, June 30, 1999 1,159,890 54 11,216,995 26,318 -- -- <Caption> Special shares Additional Total ------------------------ paid-in shareholders' Number Dollars capital Deficit equity ---------- ---------- ---------- ---------- ------------- Balance, September 30, 1997 brought forward 5,595,001 9,854 $ -- $ (6,898) $ 4,354 ---------- ---------- ---------- ---------- ---------- Year ended September 30, 1998: Conversion into Class A shares (5,595,001) (9,854) -- -- -- Shares issued for cash -- -- -- -- 10,201 Exercise of options 5,500 -- -- -- 2 Share issue costs -- -- -- -- (550) Net loss -- -- 602 (6,824) (6,222) ---------- ---------- ---------- ---------- ---------- Balance, September 30, 1998 -- -- 602 (13,722) 7,785 Period ended June 30, 1999: Shares issued for cash -- -- -- -- 5,562 Exercise of options 29,314 -- -- -- 11 Share issue costs -- -- -- -- (106) Net loss -- -- 303 (3,887) (3,584) ---------- ---------- ---------- ---------- ---------- Balance, June 30, 1999 -- -- 905 (17,609) 9,668 </Table> -40- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (d) Other disclosures required by US GAAP (continued): (iv) Development stage company (continued): The Company is a development stage enterprise as defined in FAS 7 and the following additional disclosures are provided (continued): The statement of shareholders' equity since date of inception under US GAAP is presented below (continued): <Table> <Caption> Common shares Class A shares 1st Preference -------------------------- -------------------------- ------------------------- Number Dollars Number Dollars Number Dollars ----------- ----------- ----------- ----------- ----------- ----------- Balance, June 30, 1999 brought forward 1,159,890 54 11,216,995 26,318 -- -- Year ended June 30, 2000: Shares issued for cash 180,723 750 63,442 238 -- -- Exercise of options 12,177 4 -- -- -- -- Exercise of warrants - -- -- 111,467 362 -- -- Conversion of Class A shares 11,391,904 26,918 (11,391,904) (26,918) -- -- Initial public offering 3,878,787 32,000 -- -- -- -- Share issue costs -- (2,739) -- -- -- -- Net loss -- -- -- -- -- -- ----------- ----------- ----------- ----------- ----------- ----------- Balance June 30, 2000 16,623,481 56,987 -- -- -- -- Year ended June 30, 2001: Exercise of over- allotment option 581,818 4,800 -- -- -- -- Shares issued for cash 321,035 3,807 -- -- -- -- Exercise of options 435,438 205 -- -- -- -- Exercise of warrants 34,447 79 -- -- -- -- Share issue expenses -- (565) -- -- -- -- Net loss -- -- -- -- -- -- ----------- ----------- ----------- ----------- ----------- ----------- Balance, June 30, 2001 17,996,219 65,313 -- -- -- -- <Caption> Special shares Additional Total ------------------------- paid-in shareholders' Number Dollars capital Deficit equity ----------- ----------- ----------- ----------- ------------- Balance, June 30, 1999 brought forward -- -- $ 905 $ (17,609) $ 9,668 Year ended June 30, 2000: Shares issued for cash -- -- -- -- 988 Exercise of options -- -- -- -- 4 Exercise of warrants - -- -- -- -- 362 Conversion of Class A shares -- -- -- -- -- Initial public offering -- -- -- -- 32,000 Share issue costs -- -- -- -- (2,739) Net loss -- -- 334 (5,915) (5,581) ----------- ----------- ----------- ----------- ----------- Balance June 30, 2000 -- -- 1,239 (23,524) 34,702 Year ended June 30, 2001: Exercise of over- allotment option -- -- -- -- 4,800 Shares issued for cash -- -- -- -- 3,807 Exercise of options -- -- -- -- 205 Exercise of warrants -- -- -- -- 79 Share issue expenses -- -- -- -- (565) Net loss -- -- 260 (2,947) (2,687) ----------- ----------- ----------- ----------- ----------- Balance, June 30, 2001 -- -- 1,499 (26,471) 40,341 </Table> -41- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (d) Other disclosures required by US GAAP (continued): (iii) Development stage company (continued): The Company is a development stage enterprise as defined in FAS 7 and the following additional disclosures are provided (continued): The statement of shareholders' equity since date of inception under US GAAP is presented below (continued): <Table> <Caption> Common shares Class A shares 1st Preference Special shares ----------------------- ----------------------- ----------------------- ----------------------- Number Dollars Number Dollars Number Dollars Number Dollars ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- Balance, June 30, 2001 brought forward 17,996,219 65,313 -- -- -- -- -- -- Year ended June 30, 2002: Exercise of options 32,125 11 -- -- -- -- -- -- Net loss -- -- -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- Balance, June 30, 2002 18,028,344 65,324 -- -- -- -- -- -- Year ended June 30, 2003: Shares issued for cash 4,000,000 15,148 -- -- -- -- -- -- Exercise of warrants 836,644 1,904 -- -- -- -- -- -- Exercise of options 618,036 929 -- -- -- -- -- -- Share issue costs -- (537) -- -- -- -- -- -- Net loss -- -- -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- Balance, June 30, 2003 23,483,024 82,768 -- -- -- -- -- -- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- <Caption> Additional Total paid-in shareholders' capital Deficit equity ---------- ---------- ------------- Balance, June 30, 2001 brought forward $ 1,499 $ (26,471) $ 40,341 Year ended June 30, 2002: Exercise of options -- -- 11 Net loss 111 (13,586) (13,475) ---------- ---------- ---------- Balance, June 30, 2002 1,610 (40,057) 26,877 Year ended June 30, 2003: Shares issued for cash -- -- 15,148 Exercise of warrants -- -- 1,904 Exercise of options -- -- 929 Share issue costs -- -- (537) Net loss 83 (19,701) (19,618) ---------- ---------- ---------- Balance, June 30, 2003 $ 1,693 $ (59,758) $ 24,703 ---------- ---------- ---------- </Table> -42- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (d) Other disclosures required by US GAAP (continued): (iv) Recent accounting pronouncements: In April 2003, the Financial Accounting Standards Board ("FASB") issued FAS 149, Amendment of Statement 133 on Derivative Instruments and Hedging Activities, which is effective for contracts entered into or modified after June 30, 2003 and hedging relationships designated after June 30, 2003. In May 2003, FASB issued FAS 150, Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity. The provisions of this statement are effective for financial instruments entered into or modified after May 31, 2003. The Company does not expect FAS 149 and 150 to have a material impact on its financial statements. The Emerging Issues Task Force ("EITF") reached a consensus on issue 00-21, Revenue Arrangements with Multiple Deliverables. This consensus addresses issues related to separating and allocating value to the individual elements of a single customer arrangement involving obligations regarding multiple products, services, or rights which may be fulfilled at different points in time or over different periods of time. The EITF guidance is applicable for arrangements entered into in fiscal periods beginning after June 15, 2003. The Company does not expect this guidance to have a material impact on its financial statements. In December 2002, the Canadian Institute of Chartered Accountants ("CICA") issued Handbook Section 3063, Impairment or Disposal of Long-lived Assets and revised Section 3475, Disposal of Long-Lived Assets and Discontinued Operations. Together, these two Sections supersede the write-down and disposal provisions of Section 3061, Property, Plant and Equipment as well as Section 3475, Discontinued Operations. Section 3063 amends existing guidance on long-lived asset impairment measurement and establishes standards for the recognition, measurement and disclosure of the impairment of long-lived assets held for use by the Company. It requires that an impairment loss be recognized when the carrying amount of an asset to be held and used exceeds the sum of the undiscounted cash flows expected from its use and disposal; the impairment recognized is measured as the amount by which the carrying amount of the asset exceeds its fair value. Section 3475 provides a single accounting model for long-lived assets to be disposed of by sale. Section 3475 provides specified criteria for classifying an asset as held-for-sale to be measured at the lower of their carrying amounts or fair value, less costs to sell. -43- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 16. CANADIAN/US REPORTING DIFFERENCES (CONTINUED): (d) Other disclosures required by US GAAP (continued): (iv) Recent accounting pronouncements (continued): Section 3475 also broadens the scope of businesses that qualify for reporting as discontinued operations to include any disposals of a component of an entity, which comprises operations and cash flows that can be clearly distinguished from the rest of the Company, and changes the timing of recognizing losses on such operations. The new standards contained in Section 3063 on the impairment of long-lived assets held for use are applicable for years beginning on or after April 1, 2003. The revised standards contained in Section 3475 on disposal of long-lived assets and discontinued operations are applicable to disposal activities initiated by the Company's commitment to a plan on or after May 1, 2003. The Company does not expect that the adoption of these standards will have a material effect on its financial statements. 17. COMPARATIVE FIGURES: Certain of the comparative figures have been reclassified to conform to the presentation adopted in the current year. 18. SUBSEQUENT EVENTS: (a) Exercise of warrants and options: In July and August 2003, the Company issued 178,907 common shares pursuant to the exercise of 106,785 warrants and 72,122 options for an aggregate cash consideration of $400. -44- NEUROCHEM INC. Notes to Consolidated Financial Statements, Continued Years ended June 30, 2003, 2002 and 2001 and for the period from inception (June 17, 1993) to June 30, 2003 (in thousands of Canadian dollars, except per share data) ================================================================================ 18. SUBSEQUENT EVENTS (CONTINUED): (b) Litigation: The Company executed an agreement with Immtech International, Inc. ("Immtech") of Vernon Hills, Illinois in 2002 pursuant to which Immtech provided the Company with certain compounds for testing and granted the Company an option to license such compounds. On August 12, 2003, Immtech filed certain legal proceedings with the United States District Court with respect to a dispute regarding the agreement. The Company is vigorously defending these proceedings. In the opinion of management, none of the compounds involved in the dispute are relevant to the Company's product candidates and the Company does not believe these proceedings will have any material impact on its business. -45-