EXHIBIT 99.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report of Emisphere Technologies, Inc. (the
"Company") on Form 10-K for the year ended December 31, 2002 as filed with the
Securities and Exchange Commission on the date hereof (the "Report"), I, Michael
M. Goldberg, as Chief Executive Officer of the Company, certify, pursuant to and
for the purpose of 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of
the Sarbanes-Oxley Act of 2002, that:

      (1) The Report fully complies with the requirements of section 13(a) or
      15(d) of the Securities Exchange Act of 1934; and

      (2) The information contained in the Report fairly presents, in all
      material respects, the financial condition and results of operations of
      the Company.

                                        /s/ Michael M. Goldberg, M.D.

                                        Michael M. Goldberg, M.D.
                                        Chief Executive Officer
                                        March 31, 2003

      A signed original of this written statement required by Section 906 has
been provided to Emisphere Technologies, Inc. and will be retained by Emisphere
Technologies, Inc. and furnished to the Securities and Exchange Commission or
its staff upon request.


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