Exhibit 12.1

CERTIFICATION ON THE EFFECTIVENESS OF DISCLOSURE CONTROLS AND PROCEDURES
IN FORM 20-F FOR 2004

In the Form 20-F for 2004 I have certified that:

1.   I have reviewed this annual report on Form 20-F of Novo Nordisk;

2.   Based on my knowledge, this report does not contain any untrue statement of
     a material  fact or omit to state a  material fact  necessary  to make the
     statements made, in light of the circumstances  under which such statements
     were made,  not  misleading  with  respect to the  period  covered by this
     report;

3.   Based on my knowledge,  the financial statements,  and  other  financial
     information  included  in  this  report,  fairly  present  in all  material
     respects the financial condition,  results of operations and cash flows of
     the company as of, and for, the periods presented in this report;

4.   The  company's  other  certifying officer(s) and  I are  responsible for
     establishing and maintaining disclosure controls and procedures (as defined
     in Exchange Act Rules  13a-15(e) and 15d-15(e))  and internal  control over
     financial  reporting (as  defined  in  Exchange  Act Rules  13a-15(f) and
     15d-15(f) for the company and have:

          (a) Designed such disclosure  controls and procedures, or caused such
     disclosure controls and procedures to be designed under our supervision, to
     ensure that  material  information relating to the company, including its
     consolidated  subsidiaries,  is made  known to us by  others  within  those
     entities,  particularly  during the period in which this report is being
     prepared;

          (b) Designed such internal control over financial reporting, or caused
     such internal control over  financial reporting to be designed  under our
     supervision, to provide reasonable  assurance regarding the reliability of
     financial reporting  and  the  preparation of  financial  statements  for
     external purposes  in  accordance  with  generally   accepted   accounting
     principles;

NOVO NORDISK A/S    Novo Alle           Telephone:         Internet:
                    2880 Bagssvaerd     +45 4444 8888      www.novonordisk.com
                    Denmark                                CVR Number:
                                                           24 25 67 90


          (c) Evaluated the effectiveness of the company's disclosure  controls
     and  procedures  and  presented  in this report our  conclusions  about the
     effectiveness of the disclosure controls and procedures, as of the end of
     the period covered by this report based on such evaluation; and

          (d)  Disclosed in this  report any change in the  company's  internal
     control over financial reporting that occurred during the period covered by
     the annual report that has materially affected, or is reasonably likely to
     materially affect, the company's internal control over financial reporting;
     and

5.   The company's other  certifying  officer(s) and I have disclosed,  based on
     our most recent evaluation of internal control over financial reporting, to
     the company's auditors and the audit committee of the company's  board of
     directors (or persons performing the equivalent functions):

          (a) All significant deficiencies and material weaknesses in the design
     or  operation  of  internal  control  over  financial  reporting  which are
     reasonably  likely to adversely affect the registrant's  ability to record,
     process, summarize and report financial information; and

          (b) Any fraud,  whether or not material,  that involves  management or
     other  employees  who have a  significant  role in the  company's  internal
     control over financial reporting.

Date: 21 February 2005

/s/ Lars Rebien Sorensen
- ------------------------
[Lars Rebien Sorensen]
[President and CEO]