POWER OF ATTORNEY

	Know all by these presents, that the undersigned hereby constitutes and
appoints Christopher Aker, Vice President, Legal Affairs of Regulus Therapeutics
Inc., signing individually, the undersigned's true and lawful attorney in fact
and agent to:
(1)	prepare, execute in the undersigned's name and on the undersigned's behalf,
and submit to the U.S. Securities and Exchange Commission (the "SEC") any
documents necessary or appropriate to obtain EDGAR codes and passwords enabling
the undersigned to make electronic filings of reports with the SEC; and
(2)		take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney in fact, may be of benefit, in
the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney in fact on behalf on
behalf of the undersigned pursuant to this Power of Attorney shall be in such
form and shall contain such terms and conditions as such attorney in fact may
approve in such attorney in fact's discretion.
	The undersigned hereby grants to such attorney in fact full power and authority
to do and perform any and every act and thing whatsoever requisite, necessary,
or proper to be done in the exercise of any of the rights and powers herein
granted, as fully to all intents and purposes as the undersigned might or could
do if personally present, with full power of substitution or revocation, hereby
ratifying and confirming all that such attorney in fact, or such attorney in
fact's substitute or substitutes, shall lawfully do or cause to be done by
virtue of this power of attorney and the rights and powers herein granted.
	IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of this 7th day of June, 2017.

/s/ Mark Deeg
_________________________
Mark Deeg