UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: March 31, 2013 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: Twin Focus Capital Partners LLC Address: 75 Park Plaza Boston, MA 02116 13F File Number: 028-15420 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Paul Karger Title: Chief Compliance Officer Phone: (617) 720-4500 Signature, Place, and Date of Signing: /s/ Paul Karger Boston, MA May 15, 2013 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 0 Form 13F Information Table Entry Total: 77 Form 13F Information Table Value Total: $111,606 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. NONE FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- AFFILIATED MANAGERS GROUP COM 008252108 461 3000 SH SOLE 0 0 3000 ALLIANCEBERNSTEIN HOLDING LP UNIT LTD PARTN 01881G106 219 10000 SH SOLE 0 0 10000 ASIA PAC FD INC COM 044901106 819 76133 SH SOLE 0 0 76133 BARCLAYS PLC ADR 06738E204 67 15061 SH SOLE 0 0 15061 BHP BILLITON LTD SPONSORED ADR 088606108 268 3915 SH SOLE 0 0 3915 BIOGEN IDEC INC COM 09062X103 245 1273 SH SOLE 0 0 1273 BLACKROCK ENHANCED EQT DIV T COM 09251A104 119 15185 SH SOLE 0 0 15185 BLACKROCK INC COM 09247X101 552 2150 SH SOLE 0 0 2150 CANADIAN PAC RY LTD COM 13645T100 364 2790 SH SOLE 0 0 2790 COPANO ENERGY L L C COM UNITS 217202100 204 5040 SH SOLE 0 0 5040 CURRENCYSHARES AUSTRALIAN DL AUSTRALIAN DOL 23129U101 296 2836 SH SOLE 0 0 2836 CURRENCYSHARES CDN DLR TR CDN DOLLAR SHS 23129X105 268 2735 SH SOLE 0 0 2735 DIAGEO P L C SPON ADR NEW 25243Q205 201 1595 SH SOLE 0 0 1595 DWS GLOBAL HIGH INCOME FD COM 23338W104 180 20000 SH SOLE 0 0 20000 EATON VANCE CORP COM NON VTG 278265103 209 5000 SH SOLE 0 0 5000 EATON VANCE TX ADV GLBL DIV COM 27828S101 375 23629 SH SOLE 0 0 23629 ENDOCYTE INC COM 29269A102 574 46110 SH SOLE 0 0 46110 ENERGY TRANSFER EQUITY L P COM UT LTD PTN 29273V100 360 6161 SH SOLE 0 0 6161 ENTERPRISE PRODS PARTNERS L COM 293792107 312 5182 SH SOLE 0 0 5182 ETFS PLATINUM TR SH BEN INT 26922V101 1047 6788 SH SOLE 0 0 6788 EXXON MOBIL CORP COM 30231G102 274 3041 SH SOLE 0 0 3041 FACEBOOK INC CL A 30303M102 8076 315734 SH SOLE 0 0 315734 FORD MTR CO DEL COM PAR $0.01 345370860 702 53421 SH SOLE 0 0 53421 GALECTIN THERAPEUTICS INC COM NEW 363225202 662 184277 SH SOLE 0 0 184277 GANNETT INC COM 364730101 3059 139891 SH SOLE 0 0 139891 GENERAL ELECTRIC CO COM 369604103 268 11572 SH SOLE 0 0 11572 HARTFORD FINL SVCS GROUP INC COM 416515104 387 15000 SH SOLE 0 0 15000 IMMUNOGEN INC COM 45253H101 3214 200000 SH SOLE 0 0 200000 INTERNATIONAL BUSINESS MACHS COM 459200101 251 1175 SH SOLE 0 0 1175 ISHARES GOLD TRUST ISHARES 464285105 506 32583 SH SOLE 0 0 32583 ISHARES INC MSCI PAC J IDX 464286665 583 11727 SH SOLE 0 0 11727 ISHARES TR LRGE GRW INDX 464287119 575 7032 SH SOLE 0 0 7032 ISHARES TR BARCLYS TIPS BD 464287176 687 5662 SH SOLE 0 0 5662 ISHARES TR MSCI EMERG MKT 464287234 3609 84380 SH SOLE 0 0 84380 ISHARES TR BARCLYS 20+ YR 464287432 947 8043 SH SOLE 0 0 8043 ISHARES TR MSCI EAFE INDEX 464287465 2654 45004 SH SOLE 0 0 45004 ISHARES TR RUSSELL 2000 464287655 357 3779 SH SOLE 0 0 3779 ISHARES TR FTSE CHINA ETF 464288190 344 7428 SH SOLE 0 0 7428 JOHNSON & JOHNSON COM 478160104 262 3215 SH SOLE 0 0 3215 KINDER MORGAN ENERGY PARTNER UT LTD PARTNER 494550106 223 2480 SH SOLE 0 0 2480 KINDER MORGAN MANAGEMENT LLC SHS 49455U100 2271 25850 SH SOLE 0 0 25850 MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 404 7560 SH SOLE 0 0 7560 MARKET VECTORS ETF TR GOLD MINER ETF 57060U100 1014 26783 SH SOLE 0 0 26783 MARKET VECTORS ETF TR AGRIBUS ETF 57060U605 2291 42300 SH SOLE 0 0 42300 MARKET VECTORS ETF TR BRAZL SMCP ETF 57060U613 406 10060 SH SOLE 0 0 10060 MERCK & CO INC NEW COM 58933Y105 240 5438 SH SOLE 0 0 5438 NOBLE CORPORATION BAAR NAMEN -AKT H5833N103 259 6780 SH SOLE 0 0 6780 NUVEEN MASS PREM INCOME MUN COM 67061E104 456 29997 SH SOLE 0 0 29997 NUVEEN NY AMT-FREE MUN INCOM COM 670656107 148 10233 SH SOLE 0 0 10233 NYSE EURONEXT COM 629491101 1236 32000 SH SOLE 0 0 32000 PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105 357 6312 SH SOLE 0 0 6312 POTASH CORP SASK INC COM 73755L107 290 7390 SH SOLE 0 0 7390 POWERSHARES DB CMDTY IDX TRA UNIT BEN INT 73935S105 2644 96808 SH SOLE 0 0 96808 PRICE T ROWE GROUP INC COM 74144T108 599 8000 SH SOLE 0 0 8000 PROCTER & GAMBLE CO COM 742718109 299 3880 SH SOLE 0 0 3880 PROSHARES TR PSHS ULTSH 20YRS 74347B201 854 13000 SH SOLE 0 0 13000 PUTNAM MANAGED MUN INCOM TR COM 746823103 189 23993 SH SOLE 0 0 23993 PUTNAM MUN OPPORTUNITIES TR SH BEN INT 746922103 394 31294 SH SOLE 0 0 31294 RIO TINTO PLC SPONSORED ADR 767204100 225 4780 SH SOLE 0 0 4780 SCHLUMBERGER LTD COM 806857108 396 5294 SH SOLE 0 0 5294 SPDR GOLD TRUST GOLD SHS 78463V107 31028 200867 SH SOLE 0 0 200867 SPDR INDEX SHS FDS S&P CHINA ETF 78463X400 1564 22364 SH SOLE 0 0 22364 SPDR INDEX SHS FDS S&P EM MKT DIV 78463X533 2829 62677 SH SOLE 0 0 62677 SPDR INDEX SHS FDS S&P EMKTSC ETF 78463X756 333 6951 SH SOLE 0 0 6951 SPDR S&P 500 ETF TR TR UNIT 78462F103 4021 25668 SH SOLE 0 0 25668 SPDR SERIES TRUST BARC SHT TR CP 78464A474 506 16460 SH SOLE 0 0 16460 SPDR SERIES TRUST S&P OILGAS EXP 78464A730 3727 61617 SH SOLE 0 0 61617 SPDR SERIES TRUST S&P DIVID ETF 78464A763 1042 15793 SH SOLE 0 0 15793 VALE S A ADR 91912E105 198 11445 SH SOLE 0 0 11445 VANGUARD BD INDEX FD INC TOTAL BND MRKT 921937835 274 3271 SH SOLE 0 0 3271 VANGUARD INDEX FDS S&P 500 ETF SH 922908413 330 4608 SH SOLE 0 0 4608 VANGUARD INDEX FDS TOTAL STK MKT 922908769 10400 128460 SH SOLE 0 0 128460 VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 1914 44618 SH SOLE 0 0 44618 VANGUARD SPECIALIZED PORTFOL DIV APP ETF 921908844 2842 43250 SH SOLE 0 0 43250 VANGUARD TAX MANAGED INTL FD MSCI EAFE ETF 921943858 282 7737 SH SOLE 0 0 7737 VANGUARD WHITEHALL FDS INC HIGH DIV YLD 921946406 439 8010 SH SOLE 0 0 8010 WEATHERFORD INTERNATIONAL LT REG SHS H27013103 125 10310 SH SOLE 0 0 10310