UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                    Form 13F

                              Form 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: March 31, 2013

Check here if Amendment [  ]; Amendment Number:
This Amendment (Check only one.): [  ] is a restatement.
                                  [  ] adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:    Twin Focus Capital Partners LLC
Address: 75 Park Plaza
         Boston, MA  02116

13F File Number:  028-15420

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:

Name:      Paul Karger
Title:     Chief Compliance Officer
Phone:     (617) 720-4500

Signature, Place, and Date of Signing:

 /s/  Paul Karger     Boston, MA     May 15, 2013

Report Type (Check only one.):

[ X]         13F HOLDINGS REPORT.

[  ]         13F NOTICE.

[  ]         13F COMBINATION REPORT.



                              FORM 13F SUMMARY PAGE

Report Summary:

Number of Other Included Managers:         0

Form 13F Information Table Entry Total:    77

Form 13F Information Table Value Total:    $111,606 (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional managers with respect to which this report is filed, other
than the manager filing this report.

NONE



                                    
                                                     FORM 13F INFORMATION TABLE
                                                             VALUE  SHARES/ SH/ PUT/ INVSTMT  OTHER            VOTING AUTHORITY
NAME OF ISSUER                 TITLE OF CLASS   CUSIP     (x$1000)  PRN AMT PRN CALL DSCRETN MANAGERS         SOLE   SHARED     NONE
------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- --------
AFFILIATED MANAGERS GROUP      COM              008252108      461     3000 SH       SOLE                        0        0     3000
ALLIANCEBERNSTEIN HOLDING LP   UNIT LTD PARTN   01881G106      219    10000 SH       SOLE                        0        0    10000
ASIA PAC FD INC                COM              044901106      819    76133 SH       SOLE                        0        0    76133
BARCLAYS PLC                   ADR              06738E204       67    15061 SH       SOLE                        0        0    15061
BHP BILLITON LTD               SPONSORED ADR    088606108      268     3915 SH       SOLE                        0        0     3915
BIOGEN IDEC INC                COM              09062X103      245     1273 SH       SOLE                        0        0     1273
BLACKROCK ENHANCED EQT DIV T   COM              09251A104      119    15185 SH       SOLE                        0        0    15185
BLACKROCK INC                  COM              09247X101      552     2150 SH       SOLE                        0        0     2150
CANADIAN PAC RY LTD            COM              13645T100      364     2790 SH       SOLE                        0        0     2790
COPANO ENERGY L L C            COM UNITS        217202100      204     5040 SH       SOLE                        0        0     5040
CURRENCYSHARES AUSTRALIAN DL   AUSTRALIAN DOL   23129U101      296     2836 SH       SOLE                        0        0     2836
CURRENCYSHARES CDN DLR TR      CDN DOLLAR SHS   23129X105      268     2735 SH       SOLE                        0        0     2735
DIAGEO P L C                   SPON ADR NEW     25243Q205      201     1595 SH       SOLE                        0        0     1595
DWS GLOBAL HIGH INCOME FD      COM              23338W104      180    20000 SH       SOLE                        0        0    20000
EATON VANCE CORP               COM NON VTG      278265103      209     5000 SH       SOLE                        0        0     5000
EATON VANCE TX ADV GLBL DIV    COM              27828S101      375    23629 SH       SOLE                        0        0    23629
ENDOCYTE INC                   COM              29269A102      574    46110 SH       SOLE                        0        0    46110
ENERGY TRANSFER EQUITY L P     COM UT LTD PTN   29273V100      360     6161 SH       SOLE                        0        0     6161
ENTERPRISE PRODS PARTNERS L    COM              293792107      312     5182 SH       SOLE                        0        0     5182
ETFS PLATINUM TR               SH BEN INT       26922V101     1047     6788 SH       SOLE                        0        0     6788
EXXON MOBIL CORP               COM              30231G102      274     3041 SH       SOLE                        0        0     3041
FACEBOOK INC                   CL A             30303M102     8076   315734 SH       SOLE                        0        0   315734
FORD MTR CO DEL                COM PAR $0.01    345370860      702    53421 SH       SOLE                        0        0    53421
GALECTIN THERAPEUTICS INC      COM NEW          363225202      662   184277 SH       SOLE                        0        0   184277
GANNETT INC                    COM              364730101     3059   139891 SH       SOLE                        0        0   139891
GENERAL ELECTRIC CO            COM              369604103      268    11572 SH       SOLE                        0        0    11572
HARTFORD FINL SVCS GROUP INC   COM              416515104      387    15000 SH       SOLE                        0        0    15000
IMMUNOGEN INC                  COM              45253H101     3214   200000 SH       SOLE                        0        0   200000
INTERNATIONAL BUSINESS MACHS   COM              459200101      251     1175 SH       SOLE                        0        0     1175
ISHARES GOLD TRUST             ISHARES          464285105      506    32583 SH       SOLE                        0        0    32583
ISHARES INC                    MSCI PAC J IDX   464286665      583    11727 SH       SOLE                        0        0    11727
ISHARES TR                     LRGE GRW INDX    464287119      575     7032 SH       SOLE                        0        0     7032
ISHARES TR                     BARCLYS TIPS BD  464287176      687     5662 SH       SOLE                        0        0     5662
ISHARES TR                     MSCI EMERG MKT   464287234     3609    84380 SH       SOLE                        0        0    84380
ISHARES TR                     BARCLYS 20+ YR   464287432      947     8043 SH       SOLE                        0        0     8043
ISHARES TR                     MSCI EAFE INDEX  464287465     2654    45004 SH       SOLE                        0        0    45004
ISHARES TR                     RUSSELL 2000     464287655      357     3779 SH       SOLE                        0        0     3779
ISHARES TR                     FTSE CHINA ETF   464288190      344     7428 SH       SOLE                        0        0     7428
JOHNSON & JOHNSON              COM              478160104      262     3215 SH       SOLE                        0        0     3215
KINDER MORGAN ENERGY PARTNER   UT LTD PARTNER   494550106      223     2480 SH       SOLE                        0        0     2480
KINDER MORGAN MANAGEMENT LLC   SHS              49455U100     2271    25850 SH       SOLE                        0        0    25850
MAGELLAN MIDSTREAM PRTNRS LP   COM UNIT RP LP   559080106      404     7560 SH       SOLE                        0        0     7560
MARKET VECTORS ETF TR          GOLD MINER ETF   57060U100     1014    26783 SH       SOLE                        0        0    26783
MARKET VECTORS ETF TR          AGRIBUS ETF      57060U605     2291    42300 SH       SOLE                        0        0    42300
MARKET VECTORS ETF TR          BRAZL SMCP ETF   57060U613      406    10060 SH       SOLE                        0        0    10060
MERCK & CO INC NEW             COM              58933Y105      240     5438 SH       SOLE                        0        0     5438
NOBLE CORPORATION BAAR         NAMEN -AKT       H5833N103      259     6780 SH       SOLE                        0        0     6780
NUVEEN MASS PREM INCOME MUN    COM              67061E104      456    29997 SH       SOLE                        0        0    29997
NUVEEN NY AMT-FREE MUN INCOM   COM              670656107      148    10233 SH       SOLE                        0        0    10233
NYSE EURONEXT                  COM              629491101     1236    32000 SH       SOLE                        0        0    32000
PLAINS ALL AMERN PIPELINE L    UNIT LTD PARTN   726503105      357     6312 SH       SOLE                        0        0     6312
POTASH CORP SASK INC           COM              73755L107      290     7390 SH       SOLE                        0        0     7390
POWERSHARES DB CMDTY IDX TRA   UNIT BEN INT     73935S105     2644    96808 SH       SOLE                        0        0    96808
PRICE T ROWE GROUP INC         COM              74144T108      599     8000 SH       SOLE                        0        0     8000
PROCTER & GAMBLE CO            COM              742718109      299     3880 SH       SOLE                        0        0     3880
PROSHARES TR                   PSHS ULTSH 20YRS 74347B201      854    13000 SH       SOLE                        0        0    13000
PUTNAM MANAGED MUN INCOM TR    COM              746823103      189    23993 SH       SOLE                        0        0    23993
PUTNAM MUN OPPORTUNITIES TR    SH BEN INT       746922103      394    31294 SH       SOLE                        0        0    31294
RIO TINTO PLC                  SPONSORED ADR    767204100      225     4780 SH       SOLE                        0        0     4780
SCHLUMBERGER LTD               COM              806857108      396     5294 SH       SOLE                        0        0     5294
SPDR GOLD TRUST                GOLD SHS         78463V107    31028   200867 SH       SOLE                        0        0   200867
SPDR INDEX SHS FDS             S&P CHINA ETF    78463X400     1564    22364 SH       SOLE                        0        0    22364
SPDR INDEX SHS FDS             S&P EM MKT DIV   78463X533     2829    62677 SH       SOLE                        0        0    62677
SPDR INDEX SHS FDS             S&P EMKTSC ETF   78463X756      333     6951 SH       SOLE                        0        0     6951
SPDR S&P 500 ETF TR            TR UNIT          78462F103     4021    25668 SH       SOLE                        0        0    25668
SPDR SERIES TRUST              BARC SHT TR CP   78464A474      506    16460 SH       SOLE                        0        0    16460
SPDR SERIES TRUST              S&P OILGAS EXP   78464A730     3727    61617 SH       SOLE                        0        0    61617
SPDR SERIES TRUST              S&P DIVID ETF    78464A763     1042    15793 SH       SOLE                        0        0    15793
VALE S A                       ADR              91912E105      198    11445 SH       SOLE                        0        0    11445
VANGUARD BD INDEX FD INC       TOTAL BND MRKT   921937835      274     3271 SH       SOLE                        0        0     3271
VANGUARD INDEX FDS             S&P 500 ETF SH   922908413      330     4608 SH       SOLE                        0        0     4608
VANGUARD INDEX FDS             TOTAL STK MKT    922908769    10400   128460 SH       SOLE                        0        0   128460
VANGUARD INTL EQUITY INDEX F   FTSE EMR MKT ETF 922042858     1914    44618 SH       SOLE                        0        0    44618
VANGUARD SPECIALIZED PORTFOL   DIV APP ETF      921908844     2842    43250 SH       SOLE                        0        0    43250
VANGUARD TAX MANAGED INTL FD   MSCI EAFE ETF    921943858      282     7737 SH       SOLE                        0        0     7737
VANGUARD WHITEHALL FDS INC     HIGH DIV YLD     921946406      439     8010 SH       SOLE                        0        0     8010
WEATHERFORD INTERNATIONAL LT   REG SHS          H27013103      125    10310 SH       SOLE                        0        0    10310