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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

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                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

       Date of Report (Date of earliest event reported): October 27, 2005

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                          MOLECULAR DEVICES CORPORATION
             (Exact name of registrant as specified in its charter)

                                    Delaware
                 (State or other jurisdiction of incorporation)

                 0-27316                               94-2914362
        (Commission File Number)            (IRS Employer Identification No.)

                               1311 Orleans Drive
                               Sunnyvale, CA 94089
          (Address of principal executive offices, including Zip Code)

       Registrant's telephone number, including area code: (408) 747-1700

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Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]  Written communications pursuant to Rule 425 under the Securities
     Act (17 CFR 230.425)

[ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange
     Act (17 CFR 240.14a-12)

[ ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

[ ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))

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ITEM 2.02.     RESULTS OF OPERATIONS AND FINANCIAL CONDITION.

On October 27, 2005, Molecular Devices Corporation ("Molecular Devices")
reported its financial results for the quarter ended September 30, 2005. A copy
of the press release issued by Molecular Devices on October 27, 2005 concerning
the foregoing results is furnished herewith as Exhibit 99.1 and is incorporated
herein by reference.

The information in this report, including the exhibit hereto, shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934, as amended, or otherwise subject to the liabilities of that Section or
Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The
information contained herein and in the accompanying exhibit shall not be
incorporated by reference into any filing with the U.S. Securities and Exchange
Commission made by Molecular Devices, whether made before or after the date
hereof, regardless of any general incorporation language in such filing.

ITEM 9.01.     FINANCIAL STATEMENTS AND EXHIBITS.

(d)   Exhibits

NUMBER                                  DESCRIPTION
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 99.1      Press release, dated October 27, 2005, entitled "Molecular Devices
           Reports Record Revenues and Earnings for Third Quarter of 2005,"
           issued by Molecular Devices.

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                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                                MOLECULAR DEVICES CORPORATION

Dated: October 27, 2005                         By:  /s/ TIMOTHY A. HARKNESS
                                                     ---------------------------
                                                     Timothy A. Harkness
                                                     Chief Financial Officer and
                                                     Senior Vice President
                                                     Finance and Operations

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                                  EXHIBIT INDEX

NUMBER                                  DESCRIPTION
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99.1       Press release, dated October 27, 2005, entitled "Molecular Devices
           Reports Record Revenues and Earnings for Third Quarter of 2005,"
           issued by Molecular Devices.

                                        4