Fulbright & Jaworski l.l.p.
                   A Registered Limited Liability Partnership
                          666 Fifth Avenue, 31st Floor
                          New York, New York 10103-3198
                                www.fulbright.com


mkraines@fulbright.com                                 telephone: (212) 318-3000
direct dial:  (212) 318-3261                           facsimile: (212) 318-3400


                                December 22, 2006



VIA EDGAR AND FEDERAL EXPRESS

Mr. Jeffrey P. Riedler
Assistant Director
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Mail Stop 3561
Washington, D.C. 20549-3561

         Re:      Applied DNA Sciences, Inc.
                  Registration Statement on Form SB-2
                  Filed January 15, 2005
                  File No. 333-122848

Dear Mr. Riedler:

      On behalf of Applied DNA Sciences, Inc. (the "Company") and in response to
the Staff's  comment  letter dated  December 13, 2006 (the "Comment  Letter") in
connection  with Amendment No.8 to the Company's  above-referenced  Registration
Statement on Form SB-2 (the "Registration Statement"), we hereby submit proposed
changes to the financial statements for your review. We do not intend to file an
Amendment No.9 to the Registration  Statement until financial statements for the
Company's  fourth  quarter are  available  and the  Company's  responses  to the
Comment Letter have been approved. We hope this approach is satisfactory.

      All  responses to the  comments set forth in this letter are  submitted on
behalf of the Company at its request.  All responses to the accounting  comments
were prepared by the Company in consultation with its independent auditors.  The
following numbered paragraphs repeat the comments in the Comment Letter for your
convenience, followed by the Company's responses to those comments.

General

1.    Prior to requesting  acceleration for effectiveness,  please refer to Item
      310(g) of  Regulation  S-B and amend your  registration  statement on Form
      SB-2 to provide updated financial statements.

      RESPONSE:  Updated  financial  statements  shall be provided in accordance
      with Item 310 (g) of Regulation S-B prior to requesting effectiveness.

Condensed Consolidated Financial Statements

Statements of Stockholders' Deficit, page F-4


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 2

2.    Please revise your interim and annual statements of stockholders'  deficit
      to  retroactively  change  the par  value  of  your  common  stock  to the
      beginning  of the period  presented as a result of the change in par value
      from $0.50 to $.001 in March 2005.

      RESPONSE:  In March, 2005, the Company changed the par value of its common
      stock  from $.50 per share to $.001 per  share.  The  Company's  financial
      statements accounted for and disclosed the change in par value.  According
      to  generally  accepted  accounting  principles,  changes  in the  capital
      structure must be retroactively adjusted for stock dividends, stock splits
      or reverser splits.  Accounting  standards do not require an adjustment to
      the  capital  structure  for  changes  in par value of the  common  stock.
      Accordingly,  the Company  believes its  accounting  and disclosure of the
      change in par value of its common stock is  reasonable  and in  accordance
      with generally accepted accounting principles.

Notes to Condensed Consolidated Financial Information

Note A - Summary of Significant Accounting Policies, page F-20

Stock-Based Compensation, page F-23

3.    Please tell us why you have not yet adopted SFAS No. 123(R), for which the
      effective  date is as of the  beginning  of the  first  interim  or annual
      reporting  period that begins  after  December  15,  2005.  Alternatively,
      please revise your financial statements and related disclosures to reflect
      your adoption of SFAS No. 123(R).

      RESPONSE: The Company had no unvested employee stock options as of January
      1, 2006. We propose to include the following disclosure:

      NEW ACCOUNTING PRONOUNCEMENTS

      On January 1, 2006,  we adopted the fair value  recognition  provisions of
      Financial  Accounting  Standards  Board  ("FASB")  Statement  of Financial
      Accounting   Standards  ("SFAS")  No.  123,  Accounting  for  Stock  Based
      Compensation,  to account for  compensation  costs under our stock  option
      plans. We previously  utilized the intrinsic value method under Accounting
      Principles Board Opinion No. 25,  Accounting for Stock Issued to Employees
      (as amended) ("APB 25").  Under the intrinsic  value method  prescribed by
      APB 25, no  compensation  costs were  recognized  for our  employee  stock
      options  because the option exercise price equaled the market price on the
      date of the  grant.  Prior to January  1, 2006 we only  disclosed  the pro
      forma  effects on net income and  earnings  per share as if the fair value
      recognition provisions of SFAS 123(R) had been utilized.



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 3

      In adopting SFAS No.  123(R),  we elected to use the modified  prospective
      method to account for the  transition  from the intrinsic  value method to
      the fair value recognition method.  Under the modified prospective method,
      compensation cost is recognized from the adoption date forward for all new
      stock options  granted and for any  outstanding  unvested awards as if the
      fair value  method had been  applied to those awards as of the date of the
      grant. We had no outstanding unvested awards as of the adoption date.

Note I - Restatement of Quarterly Financial Statements, page F-45

4.    In general,  please revise this note substantially to explain why you made
      each  correction of an error.  The examples in the ensuing comment are not
      all  inclusive  of  the  revisions   that  we  believe  you  should  make;
      additionally,  please ensure that your revised  narrative  discussion  not
      only  discloses  the  amount of each  change  and the  affected  financial
      statement line item, but why each change occurred.

      RESPONSE: We propose to revise Footnote I as follows:

      The Company has restated its financial  statements  for the nine and three
      months ended June 30, 2005 and 2006 and for the period from  September 16,
      2002 (date of  inception)  through  June 30, 2006 by filing  amended  Form
      10-QSB's for the three month periods ended June 30, 2005 and June 30, 2006
      to correct the  following  errors in the financial  statements  previously
      filed:

      o     The  Company  erroneously  accounted  for and  recorded as a current
            period  expense  the cost of issuing its debt  aggregating  $390,000
            during the quarter ended March,  2006. The restatement  corrects the
            $390,000  capitalized  financing costs within the correct  reporting
            quarter.

      o     The Company erroneously accounted for and recorded the fair value of
            warrants issued in previous  quarters and corrected the year to date
            fair value increasing the selling,  general and administrative costs
            by $563,750 for the nine months ended June 30, 2006.

      o     The Company erroneously accounted for and recorded the fair value of
            non-debt  related  warrants in the amount of  $5,940,556 to interest
            expense  in  previous  quarter(s)  and  corrected  the  year to date
            interest  expense and related warrant  liability for the nine months
            ended June 30, 2006.

      o     The Company  erroneously  accounted for and recorded the net gain on
            change  in fair  value  warrants  in the  amount of  $1,156,698  and
            $4,355,942  for the  three  and nine  months  ended  June 30,  2006,
            respectively.


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 4

      The net effect of the corrections of these errors was to:

      o     Increase  the  Company's  profitability  by $766,698  from a loss of
            $5,611 to a profit of $761,087  for the three  months ended June 30,
            2006

      o     Increase the  Company's  net income by  $2,148,264  from a profit of
            $3,458,485 to $5,606,849 for the nine months ended June 30, 2006.

      o     Increase the  Company's  net loss by $136,400  from  $84,181,303  to
            $84,317,703  from  the  period  from  September  16,  2002  (date of
            inception) through June 30, 2006.

      The result of the  Consolidated  Balance Sheet  restatement  is to reflect
      the:

      o     Increase in additional paid in capital by $136,400 from  $81,860,606
            as of June 30, 2006 to $81,997,006.

      o     Increase in deficit accumulated during development stage by $136,400
            from $84,181,303 as of June 30, 2006 to $84,317,703.

      Following  are  reconciliations  of  the  Company's   restatement  of  the
      Consolidated Balance Sheet as of June 30, 2006:



                                                                 June 30, 2006
                                                        -------------------------------
                                                        (As Restated)     (As Reported)
                                                        ------------       ------------
                                                                     
      ASSETS                                            $ 11,693,826       $ 11,693,826
                                                        ============       ============

      LIABILITIES AND  DEFICIENCY IN
      STOCKHOLDERS' EQUITY
      Accounts payable and accrued liabilities             4,680,849          4,680,849
      Note payable - Related Party                           410,429            410,429
                                                        ------------       ------------
      Total Current Liabilities                            5,091,278          5,091,278

      Convertible Note Payable, net of
      unamortized discount                                 3,306,371          3,306,371
      Debt Derivative and Note Liability                   5,698,286          5,698,286
      Deficiency in Stockholders' Equity:
      Preferred Stock                                              6                  6
      Common Stock                                           118,582            118,582
      Common stock subscribed                               (200,000)          (200,000)
      Additional Paid-In-Capital                          81,997,006         81,860,606
      Deficit Accumulated During Development Stage       (84,317,703)       (84,181,303)
                                                        ------------       ------------
      Total  Deficiency in Stockholders' Equity           (2,402,109)        (2,402,109)
      Total Liabilities and Deficiency in
      Stockholders' Equity                              $ 11,693,826       $ 11,693,826
                                                        ============       ============



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 5

      The result of the  Consolidated  Statement of Income (Losses)  restatement
      for the three and nine months  ended June 30, 2006 and for the period from
      September 16, 2002 (date of inception) through June 30, 2006 is:

      o     Increase in selling,  general and  administrative  expenses  for the
            three  months  ended June 30, 2006 by $390,000  from  $1,190,967  to
            $1,580,967.   The  increase  is  to  correct  into  the  appropriate
            reporting quarter the  reclassification  of previously expensed debt
            issuance costs from selling, general and administrative expenses.

      o     Reduction in selling,  general and  administrative  expenses for the
            nine  months  ended June 30,  2006 by $563,750  from  $4,955,055  to
            $4,391,305 for the nine months ended June 30, 2006. The reduction is
            a result of an error in recognizing  and recording the fair value of
            warrants issued to non-employees and consultants.

      o     Increase in selling and  administrative  expenses from September 16,
            2002  (date  of  inception)  to June  30,  2006 by  $5,838,514  from
            $70,072,368 to $75,910,882.  The increase is a cumulative  result of
            an error in  recognizing  and  recording  the fair value of warrants
            issued to non-employees and consultants, an error in recognizing and
            recording at fair value common  stock issued in  settlement  of debt
            and recognizing and recording additional compensation expenses.

      o     Increase  in net gain in fair value of debt  derivative  and warrant
            liabilities  by $1,156,698  from  $2,337,263  to $3,493,961  for the
            three  months  ended June 30,  2006.  The increase is a result of an
            error in recognizing  and recording fair value of non-debt  warrants
            issued to non-employees and consultants  leading to a revised change
            in reported gain in the current reporting period.

      o     Decrease  in net gain in fair value of debt  derivative  and warrant
            liabilities by $4,355,942  from  $18,606,563 to $14,250,621  for the
            nine  months  ended June 30,  2006.  The  decrease is a result of an
            error  in  recognizing  and  recording  the fair  value of  non-debt
            related  warrants to  non-employees  and  consultants  of $5,940,556
            erroneously charged to interest expense, net with the correction and
            an error in fair value  adjustment of non-debt  related  warrants of
            $1,584,614.

      o     Decrease  in net gain in fair value of debt  derivative  and warrant
            liabilities by $4,355,942  from  $35,307,553 to $30,951,611  for the
            period from September 16, 2002 (date of inception)  through June 30,
            2006.  The  decrease  is a result  of an error  in  recognizing  and
            recording   the  fair  value  of   non-debt   related   warrants  to
            non-employees and consultants of $5,940,556  erroneously  charged to
            interest expense, net with the correction and an error in fair value
            adjustment of non-debt related warrants of $1,584,614.

      o     Decrease  in  interest  expense by  $5,940,556  from  $9,117,785  to
            $3,177,229 for the nine months ended June 30, 2006. This decrease is
            a result of an error in  recognizing  and recording the initial fair
            value of  non-debt  related  warrants  issued to  non-employees  and
            consultants.

      o     Decrease in interest  expense by  $10,580,055  from  $47,119,730  to
            $37,061,675  for  the  period  from  September  16,  2002  (date  of
            inception)   through  ended  June  30,  2006.  This  decrease  is  a
            cumulative  result  of an error in  recognizing  and  recording  the
            initial  fair  value  of  non-debt   related   warrants   issued  to
            non-employees and consultants.



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 6

         The  following  chart  sets  forth  reconciliations  of  the  Company's
         restatement of the  Consolidated  Statement of Income  (Losses) for the
         three  and  nine  months  ended  June  30,  2006 as well as the  period
         September 16, 2002 (date of inception) through June 30, 2006.



                                                                                             For the Period September 16,
                                                                                              2002 (date of Inception of
                               Three Months Ended                Nine Months Ended            Development Stage) through
                                  June 30, 2006                    June 30, 2006                     June 30, 2006
                         ------------------------------    ------------------------------    ------------------------------

                              (As              (As              (As             (As              (As              (As
                            Restated)        Reported)       Restated)        Reported)        Restated)        Reported)
                         -------------    -------------    -------------    -------------    -------------    -------------
                                                                                            
Sales                    $      18,900    $      18,900    $      18,900    $      18,900    $      18,900           18,900
Cost of sales                   15,639           15,639           15,639           15,639           15,639           15,639
                         -------------    -------------    -------------    -------------    -------------    -------------
Gross Profit                     3,261            3,261            3,261            3,261            3,261            3,261
Operating Expenses:
Selling, General &
Administrative               1,580,967        1,190,967        4,391,305        4,955,055       75,910,882       70,072,368
Research and
Development                       --               --             75,276           75,276          968,711          968,711
Depreciation and
Amortization                   336,824          336,824        1,021,199        1,021,199        1,380,626        1,380,626
                         -------------    -------------    -------------    -------------    -------------    -------------
Total Operating
Expenses                     1,917,791        1,527,791        5,487,780        6,051,530       78,260,219      (72,421,705)
                         -------------    -------------    -------------    -------------    -------------    -------------
Operating Income
(Loss)                      (1,914,530)      (1,524,530)      (5,484,519)      (6,048,269)     (78,256,958)     (72,418,444)
Net gain  (loss)  in
fair  value of debt
derivative and
warrant
liabilities                  3,493,961        2,337,263       14,250,621       18,606,563       30,951,611       35,307,553
                         -------------    -------------    -------------    -------------    -------------    -------------
Other income (expense)           8,483            8,483           17,976           17,876           49,319           49,318
Interest income
(expense)                     (826,827)        (826,827)      (3,177,229)      (9,117,785)     (37,061,675)     (47,119,730)
                         -------------    -------------    -------------    -------------    -------------    -------------
Net income (loss)
before provision for
income taxes                   761,087           (5,611)       5,606,849        3,458,485      (84,317,703)     (84,181,303)
Provision for income
taxes                             --               --               --               --               --               --
                         -------------    -------------    -------------    -------------    -------------    -------------
Net Income (Loss)        $     761,087    $      (5,611)   $   5,606,849    $   3,458,485    $ (84,317,703)   $ (84,181,303)
                         =============    =============    =============    =============    =============    =============
Net income ( loss)
per common share-
basic                    $        0.01    $       (0.01)   $        0.05    $        0.03
                         -------------    -------------    -------------    -------------
Net income ( loss)
per common share-
fully diluted                     0.01                              0.03    $        0.02
Weighted average
shares outstanding         118,582,385      118,582,385      115,852,521      115,852,521
Basic
Diluted                    177,501,849                       181,716,985      181,716,985




Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 7

      The result of the  Consolidated  Statement of Income (Losses)  restatement
      for the three and nine months ended June 30, 2005 is:

      o     Decrease in selling, general and administrative expenses of $794,096
            from  $2,659,727 to  $1,865,631  for the three months ended June 30,
            2005.  The  reduction  is a result  of an error in  recognizing  and
            recording  the fair value of  non-debt  related  warrants  issued to
            non-employees and consultants.

      o     Increase  in  selling,   general  and  administrative   expenses  of
            $1,952,275 from $22,236,607 to $24,550,027 for the nine months ended
            June 30,  2005.  The  result is from an error in  recording  at fair
            value  common  stock  issued to a former  Director in exchange for a
            previously incurred debt of $1,365,000 and an error in recording the
            fair  value  of  non-debt  related  warrants  to  non-employees  and
            consultants of $587,275.

      o     Increase in fair value of debt derivative and warrant liabilities of
            $5,679,175  from $-0- to $5,679,175  for the three months ended June
            30, 2005. The increase is a result of an error in accounting for the
            issuance of warrants subject to a registration rights agreement that
            provides  for the payment of  liquidated  damages if the  stipulated
            registration  deadlines  were not met. In  accordance  with SFAS 133
            "Accounting for Derivative  Instruments and Hedging Activities," the
            Company revalued the warrants issued subject to registration  rights
            as of June 30,  2005 (see Note G). The  difference  between the fair
            value of the warrants as of June 30, 2005 and the previous valuation
            has been recorded as a gain on revaluation of warrant liability.

      o     Increase in fair value of debt derivative and warrant liabilities of
            $16,454,928  from $-0- to $16,454,928 for the nine months ended June
            30, 2005. The increase is a result of an error in accounting for the
            issuance of warrants subject to a registration rights agreement that
            provides  for the payment of  liquidated  damages if the  stipulated
            registration  deadlines  were not met. In  accordance  with SFAS 133
            "Accounting for Derivative  Instruments and Hedging Activities," the
            Company revalued the warrants issued subject to registration  rights
            as of June 30,  2005 (see Note G). The  difference  between the fair
            value of the warrants as of June 30, 2005 and the previous valuation
            has been recorded as a gain on revaluation of warrant liability.

Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 8

      o     Increase in  interest  expense of  $23,148,214  from  $9,224,929  to
            $32,373,143 for the nine months ended June 30, 2005. The increase is
            a result of an error in recording and  recognizing  the recording of
            the  initial  valuation  of  warrants  issued  in  conjunction  with
            financing as a liability subject to registration  rights [as of June
            30, 2005 (see Note G). The difference  between the fair value of the
            warrants  as of June  30,  2005  of  $16,454,928  and  the  previous
            valuation  has been  recorded  as a gain on  revaluation  of warrant
            liability.

      The  following   chart  sets  forth   reconciliations   of  the  Company's
      restatement of the Consolidated Statement of Income (Losses) for the three
      and nine month ended June 30, 2005.



                                     Three Months Ended                  Nine Months Ended
                                        June 30, 2005                      June 30, 2005
                              -------------------------------     -------------------------------
                              (As Restated)     (As Reported)     (As Restated)     (As Reported)
                              -------------     -------------     -------------     -------------
                                                                        
      Sales                   $        --                --       $        --                --
      Cost of sales                    --                --                --                --
                              -------------     -------------     -------------     -------------
      Gross Profit                     --                --                --                --
      Operating Expenses:
      Selling general and
      administrative              1,865,631         2,659,727        24,188,882        22,236,607
      Research and
      Development                    88,870            88,870           345,958           345,958
      Depreciation and
      amortization                    3,160             3,160            15,187            15,187
                              -------------     -------------     -------------     -------------
      Total Operating
      Expenses                    1,957,661         2,751,757        24,550,027        22,597,752
                              -------------     -------------                       -------------
      Operating Loss             (1,957,661)       (2,751,757)      (24,550,027)      (22,597,752)
      Net gain  (loss)  in
      fair  value of debt
      derivative and
      warrant
      liabilities                 5,679,175              --          16,454,928              --
      Other income
      (expense)                         241               241             3,415             3,415
      Interest income
      (expense)                     (21,557)          (21,557)      (32,373,143)       (9,224,929)
      Net income (loss)
      before provision for
      income taxes                3,700,190        (2,773,073)      (40,464,827)      (31,819,266)
      Provision for income
      taxes                            --                --                --                --
                              -------------     -------------     -------------     -------------
      Net Income (Loss)       $   3,700,190     $  (2,773,073)    $ (40,464,827)    $ (31,819,266)
                              =============     =============     =============     =============
      Net loss per common
      share - basic           $         .06     $       (0.04)    $       (0.83)    $       (0.65)
                              -------------     -------------     -------------     -------------
      Net income ( loss)
      per common share-
      fully diluted           $         .04                NA
                              -------------     -------------
      Weighted average
      shares outstanding
      Basic                      66,308,115        66,298,115        48,810,599        48,810,599
      Diluted                   109,223,832                                N/A
      Weighted average
      shares outstanding



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 9

      Following  are  reconciliations  of  the  Company's   restatement  of  the
      Statement  of Cash Flows for the nine months  ended June 30, 2006 and 2005
      as well as the  period  from  September  16,  2002 (date of  inception  of
      development stage) through June 30, 2006.

      Cash Flows from Operating Activities:

      o     Increase in net loss from $3,458,485 to $5,606,849 or $2,148,364 for
            the nine months ended June 30, 2006  resulting from the items listed
            above.

      o     Increase in net loss from  $31,819,266  to $40,464,827 or $8,645,561
            for the nine  months  ended June 30, 2006  resulting  from the items
            listed above.

      o     Increase in net loss from $84,181,303 to $84,317,703 or $136,400 for
            the period from September 16, 2002 (date of inception)  through June
            30, 2006 resulting from the items listed above.

      o     Decrease  in  amortization  and  depreciation   from  $1,374,467  to
            $1,368,711 or $5,756 for the period from September 16, 2002 (date of
            inception)  through June 30,  2006.  The  resulting  decrease is the
            result of a classification error within the cash flow statement.

      o     Decrease in non-cash value of warrants  issued to  consultants  from
            $606,850 to $43,100 or $563,750  for the nine months  ended June 30,
            2006.  The  reduction  is a result  of an error in  recognizing  and
            recording  the fair value of  non-debt  related  warrants  issued to
            non-employees and consultants.

      o     Increase in the  non-cash  value of warrants  issued to  consultants
            from  $1,243,744 to  $3,241,068  or  $1,997,324  for the nine months
            ended  June  30,  2005.  The  increase  is a  result  of an error in
            recognizing  and  recording  the  fair  value  of  non-debt  related
            warrants issued to non-employees and consultants.

      o     Increase in the  non-cash  value of warrants  issued to  consultants
            from  $3,583,016 to  $9,421,530  or  $5,838,514  for the period from
            September  16,  2002  (date  of  inception)  to June 30,  2006.  The
            increase is a result of an error in  recognizing  and  recording the
            fair  value  of  non-debt  related  warrants  to  non-employees  and
            consultants.



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 10

      o     Increase in the non-cash income attributable to repricing of warrant
            and  debt  derivatives   from   $(10,118,917)  to  $(14,250,521)  or
            $4,131,604  for the nine months ended June 30, 2006. The increase is
            the result of an error in recognizing and recording the initial fair
            value of non-debt related warrants to non-employees and consultants.

      o     Increase in the non-cash income attributable to repricing of warrant
            and debt  derivatives  from $-0- to $(16,454,929) or $16,454,929 for
            the nine months ended June 30,  2005.  The increase is the result of
            an error in  recognizing  and  recording  the initial  valuation  of
            warrants issued in conjunction with financing as a liability subject
            to registration rights.

      o     Increase in the non-cash income attributable to repricing of warrant
            and  debt  derivatives   from   $(26,819,908)  to  $(30,951,611)  or
            $4,131,604   for  the  period  from  September  16,  2002  (date  of
            inception)  through June 30, 2006.  The increase is the result of an
            error  in  recognizing  and  recording  the  initial  fair  value of
            non-debt related warrants to non-employees and consultants.

      o     Increase in non-cash  financing  costs  attributable  to issuance of
            warrants from $-0- to  $2,271,000 or $2,271,000  for the nine months
            ended  June 30,  2006.  The  increase  is the  result of an error in
            recognizing  and recording the initial  valuation of warrants issued
            in conjunction with financing as a liability subject to registration
            rights.

      o     Increase in non-cash  financing  costs  attributable  to issuance of
            warrants from $-0- to $23,148,214 or $23,148,214 for the nine months
            ended  June 30,  2005.  The  increase  is the  result of an error in
            recognizing  and recording the initial  valuation of warrants issued
            in conjunction with financing as a liability subject to registration
            rights.

      o     Decrease in non-cash  financing  costs  attributable  to issuance of
            warrants from  $27,265,174  to  $25,418,674  or  $1,846,500  for the
            period from September 16, 2006 (date of inception)  through June 30,
            2005.  The  decrease  is the result of an error in  recognizing  and
            recording the initial  valuation of warrants  issued in  conjunction
            with financing as a liability subject to registration rights.

      o     Increase in non-cash  amortization of debt discount  attributable to
            convertible  notes from $-0- to $276,090  or  $276,090  for the nine
            months ended June 30, 2006.  The increase is a result of an error in
            recognizing and recording convertible debt discounts associated with
            debt financing.

      o     Increase in non-cash  amortization of debt discount  attributable to
            convertible  notes from $-0- to $276,090 or $276,090  for the period
            from  September 16, 2002 (date of inception)  through June 30, 2006.
            The increase is a result of an error in  recognizing  and  recording
            convertible debt discounts associated with debt financing.



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 11

      o     Increase in non-cash  fair value of common  stock  issued to related
            party in excess of  previously  incurred debt from $0- to $1,365,000
            or $1,365,000  for the nine months ended June 30, 2005. The increase
            is the result of an error in  recording  at fair value  common stock
            issued in settlement of a previously incurred debt.

      o     Increase  in the  non-cash  fair  value of  common  stock  issued to
            related  party in excess  of  previously  incurred  debt from $0- to
            $1,365,000  or  $1,365,000  for the period from  September  16, 2002
            (date of inception) through ended June 30, 2006. The increase is the
            result of an error in recording at fair value common stock issued in
            settlement of a previously incurred debt.

      o     Increase  in the  non-cash  fair  value of  common  stock  issued in
            exchange for services from  $12,471,727  to  $13,396,202 or $924,475
            for the nine months ended June 30, 2005.  The increase is the result
            of an error in  recording  at fair  value  common  stock  issued  in
            exchange for services.

      o     Decrease in non-cash common stock canceled for previously issued for
            services  rendered from $(642,098) to $(181,928) or $460,170 for the
            nine months  ended June 30,  2005.  The decrease is the result of an
            error in classification of common stock issued/cancelled.

      Cash Flows from Financing Activities:

      o     Decrease in proceeds from sale of common stock from  $10,481,055  to
            $-0- or  $10,481,055  for the nine months ended June 30,  2005.  The
            decrease  is the  result of an error in  reclassification  of common
            stock issued in settlement of convertible debt.

      o     Increase  in  proceeds  from  issuance  of  convertible  notes  from
            $1,575,000 to  $9,079,000  or  $7,504,000  for the nine months ended
            June  30,  2005.   The  increase  is  the  result  of  an  error  in
            classification  of  proceeds  received,  net of  related  costs,  in
            conjunction with issuance of convertible debentures.

      o     Increase in proceeds  from  exercise  of warrants  and options  from
            $70,750 to $102,750  or $32,000  for the nine months  ended June 30,
            2005.  The  increase  is the result of an error in  recognizing  and
            recording cancellation of previously issued options.

      Following  are  reconciliations  of  the  Company's   restatement  of  the
      Consolidated  Statement  of Cash Flows for the three and nine months ended
      June 30, 2006,  and 2005 and for the period from  September 16, 2002 (date
      of inception) to June 30, 2006.



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 12



                                                                                           For the Period September 16, 2002
                               Nine Months Ended                Nine Months Ended          (date of Inception of Development
                                 June 30, 2006                     June 30, 2005              Stage) through June 30, 2006
                         -----------------------------     -----------------------------     -----------------------------
                         (As Restated)   (As Reported)     (As Restated)   (As Reported)     (As Restated)   (As Reported)
                         ------------     ------------     ------------     ------------     ------------     ------------
                                                                                            
Cash flows from
Operating Activities:
Net income (loss)        $  5,606,849     $  3,458,485     $(40,464,827)    $(31,819,266)    $(84,317,703)    $(84,181,303)
Adjustment to
reconcile net loss to
net cash used in
operating activities:
Amortization and
depreciation                1,021,199        1,021,199           15,187           15,187        1,368,711        1,374,467
Organization expenses
                                 --               --               --               --             88,500           88,500
Preferred shares
issued in exchange
for services                     --               --               --               --          1,500,000        1,500,000
Warrants issued to
consultants                    43,100          606,850        3,241,068        1,243,744        9,421,530        3,583,016
Income attributable
to repricing of
warrant and debt
derivatives               (14,250,621)     (10,118,917)     (16,454,929)            --        (30,951,611)     (26,819,908)
Financing costs
attributable to
issuance of warrants        2,271,000             --         23,148,214             --         25,418,674       27,265,174
Amortization of
beneficial conversion
feature- convertible
notes                            --               --          8,836,000        8,836,000       10,461,000       10,461,000
Amortization of
capitalized financing
costs                         247,238          247,238             --               --            247,238          247,238
Amortization of debt
discount
attributable to
convertible notes             276,090             --               --               --            276,090             --
Fair value of common
stock issued to
related party in
excess of previously
incurred debt                    --               --          1,365,000             --          1,365,000        1,365,000
Common stock issued
in exchange for
services                      710,200          710,200       13,396,202       12,471,727       31,284,573       31,284,573




Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 13



                                                                                            

Common stock issued
in exchange for
intellectual property
in connection with
costs of acquiring
intangible assets                --               --               --               --         14,689,100       14,689,100
Common stock issued
as penalty in
connection with
financing                     773,958          773,958             --               --          1,550,487        1,550,487
Common stock
canceled- previously
issued for services
rendered                     (480,000)        (480,000)        (181,928)        (642,098)      (1,343,845)      (1,343,845)
Change in assets and
liabilities :
Increase in accounts
receivable                    (18,900)         (18,900)            --            (18,900)         (18,900)            --
Increase in prepaid
assets and deposits          (145,849)        (145,849)         (33,921)         (33,921)        (163,472)        (163,472)
Decrease in other
assets                          5,940            5,940             --               --             (3,128)          (3,128)
Decrease in due
related parties               (52,662)         (52,662)         (20,631)         (20,631)            --               --
Increase (decrease)
in accounts payable
and accrued
liabilities                 1,685,792        1,685,792         (833,465)        (983,197)       4,085,745        4,079,990
                         ------------     ------------     ------------     ------------     ------------     ------------
New cash used in
operating activities       (2,306,666)      (2,306,666)      (7,986,770)     (10,932,455)     (15,042,011)     (15,042,011)
Cash flows from
investing activities:
Payments foe patent
filing                           --               --             (4,347)          (4,347)         (25,698)         (25,698)
Capital expenditures
                              (35,851)         (35,851)            --               --            (48,602)         (48,602)
                         ------------     ------------     ------------     ------------     ------------     ------------
Net cash used in
investing activities          (35,851)         (35,851)          (4,347)          (4,347)         (74,300)         (74,300)
                         ------------     ------------     ------------     ------------
Cash Flows From
Financing Activities:
Proceeds from sale of
common stock, net of
costs                            --              --                --         10,481,055          432,000          432,000




Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 14




                                                                                            
Proceeds from
issuance of
convertible notes           4,242,500        4,242,500        9,079,000        1,575,000       13,446,500       13,446,500
Proceeds from
exercise of warrants
and options                      --               --            102,750           70,750          343,750          343,750
Payment of debt                  --               --               --               --            (24,854)         (24,854)
Proceeds from loans              --               --               --               --          2,750,000        2,750,000
Advances from
shareholders                     --               --               --               --            100,088          100,088
                         ------------     ------------     ------------     ------------     ------------     ------------
Cash provided by
financing activities        4,242,500        4,242,500        9,181,750       12,126,805       17,047,484       17,047,484
Net (decrease)
increase in cash            1,899,983        1,899,983        1,190,633        1,190,633        1,931,173        1,931,173
Cash, beginning of
period                         31,190           31,190            1,832            1,832             --               --
                         ------------     ------------     ------------     ------------     ------------     ------------
Cash, end of period      $  1,931,173     $  1,931,173     $  1,192,465     $  1,192,465     $  1,931,173     $  1,931,173
                         ============     ============     ============     ============     ============     ============


5.    Please  revise  your note  disclosure  regarding  the errors  and  related
      financial  statement  adjustments for the three and nine months ended June
      30, 2006. For example, please clarify items that follow.


      o     Explain what you mean by "...reclass fair value of previously issued
            warrants from interest expense to additional  paid-in  capital." Per
            your June 30, 2006 statement of shareholders'  deficit on page F-17,
            it  appears  that you  actually  reclassified  the  $1,584,614  from
            additional  paid-in capital to liabilities,  which is not consistent
            with your note disclosure.

      o     Explain  what you mean by  "...adjust  for  fair  value of  warrants
            issued to additional paid-in capital."

      o     Explain what you mean by "...adjust for effect of warrant  valuation
            change of $4,355,942."

      o     Explain  why you  reclassified  the "fair  value of  warrants"  from
            interest expense to additional paid-in capital.

      o     Explain  the  nature  of  the  error   adjustment   to  selling  and
            administrative expenses.

      o     Explain why your  statement  of cash flows for the nine months ended
            June 30, 2006 reflects the adjustment of $1,584,614. It appears this
            cash flow statement  adjustment  somehow  relates to the amount that
            you reclassified from additional  paid-in capital to liabilities and
            not to your net loss.



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 15

      RESPONSE: Please see response to comment 4.

6.    Please  separately detail the amounts included within the line item "other
      operating  activities-see cash flow statement for full details" and, in so
      doing,  ensure  that the  effect of each error on your  statement  of cash
      flows  is   readily   determinable.   Additionally,   please   provide  an
      accompanying  narrative  discussion  regarding  your cash  flow  statement
      adjustments.  Finally,  revise your  statement  of cash flows for the nine
      months  ended June 30,  2005 and Note M for the year ended  September  30,
      2005 as applicable.

      RESPONSE: Please see response to comments 4 and 10.

7.    Please  clarify  the  nature of the  errors/adjustments  recorded  to your
      financial  statements  for the three and nine months  ended June 30, 2005,
      ensuring  that your  narrative  discussion of those errors agrees with the
      amounts reflected in the accompanying  table. For example,  please clarify
      the items that follow.

      o     The increase in your selling,  general,  and administrative  expense
            line item of $54,951 does not agree with the  increase  shown in the
            table for either the three or nine months  ended June 30,  2005.  In
            addition,  the net income amount of  $2,851,151  does not agree with
            the table.

      o     Tell us and disclose why your interest  expense line item  increased
            by approximately $23.1 million.

      o     Clarify why the table reflects a $16.5 million change to "fair value
            of warrants" when your narrative  discussion reflects a $6.6 million
            change.

      o     Tell us how you derived the $12,086,901 warrant valuation adjustment
            reflected on your statement of cash flows,  as it does not appear to
            correlate to your related narrative discussion.

      o     Tell us and disclose why you appear to have  adjusted  subscriptions
            receivable,  common stock and additional  paid-in capital.  If these
            adjustments relate to a change in how you recorded the amount of the
            common stock that you issued in exchange for debt, clarify that fact
            and detail the  adjustment  amounts that resulted from recording the
            common stock issued at fair value.

      o     Please clarify the nature of the $749,640 change in "cash flows from
            financing   activities,"  as  the  adjustment   disclosed  does  not
            correspond to the change in the accompanying table.

      RESPONSE: Please see response to comment 4.

8.    Please  clarify  to us  and  in  the  filing  why  you  believe  that  you
      appropriately  classified certain error corrections within interest income
      (expense)  for all periods  presented in Note I of your interim  financial
      statements and Note M of your annual financial statements.


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 16

      RESPONSE:  The Company  determined  the fair value of warrants  and equity
      issued  to note  holders  was a  financing  cost  and in  addition  to the
      beneficial  conversion  feature  embedded  in the  convertible  notes  has
      classified the amounts as interest expense.

      Please see responses to comments 4 and 10, respectively.

      The Company  believes its policy for accounting for interest is reasonable
      and in accordance with generally accepted accounting principles.

Notes to (Audited) Consolidated Financial Statements (Restated)

Note D - Private Placement of Convertible Notes, page F-78

9.    We acknowledge your response to comment 8 of our letter dated May 1, 2006.
      We are aware that the EITF has not reached a consensus on the registration
      rights/liquidating  damages issue contemplated under EITF No. 05-4. Please
      revise the  disclosure  in your Form SB-2 to indicate  how you account for
      your  various   registration  rights  agreements  pursuant  to  the  views
      presented in Issue Summary No. 1 to EITF No. 05-4.

      RESPONSE:  We propose to include the following disclosure in Note D to the
      financial statements:

      In June 2005, the Financial  Accounting  Standards  Board Emerging  Issues
      Task Force issued EITF 05-04,  "The Effect of a Liquidated  Damages Clause
      on a Freestanding  Financial  Instrument  Subject to EITF Issue No. 00-19,
      Accounting  for   Derivative   Financial   Instruments   Indexed  to,  and
      Potentially  Settled  in,  a  Company's  Own  Stock".  Under  EITF  05-04,
      liquidated   damages  clauses  may  qualify  as   freestanding   financial
      instruments  for treatment as a derivative  liability.  Furthermore,  EITF
      05-04  addresses the question of whether a registration  rights  agreement
      should be combined as a unit with the underlying financial instruments and
      be evaluated as a single instrument. EITF 05-04 does not reach a consensus
      on this  question and allows for treatment as a combined unit (Views A and
      B) as well as separate  freestanding  financial  instruments  (View C). On
      September 15, 2005, the FASB staff  postponed  further  discussion of EITF
      05-04. As of June 30, 2006, the FASB has still not rescheduled  EITF 05-04
      for discussion.

      In  connection  with the  issuance  of the  convertible  notes and related
      warrants  (see  Note G),  we  granted  liquidated  damages  pursuant  to a
      separate registration rights agreement. The Company adopted View C of EITF
      05-04.  Accordingly,  the liquidated damages pursuant to this registration
      right agreement were evaluated as a stand alone financial instrument. This
      treatment did not have a significant  different effect than if the Company
      had adopted View A or B because the warrants were classified as derivative
      liabilities.  The  Company  believes  that if the  FASB  staff  reached  a
      consensus on EITF 05-04 and select  combined  treatment (View A or B), the
      warrants would have to be evaluated as a combined unit with the liquidated
      damages pursuant to the registration rights agreement, and accordingly, be
      evaluated as derivative liabilities. The Company does not believe that its
      measurement  of the  derivative  liabilities  under View A or View B would
      significantly  differ from its  measurement of the derivative  liabilities
      under View C in these circumstances.


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 17

Note M - Restatement of Financial Statements, page F-91

10.   Please  revise your  disclosure  to detail the nature of each  restatement
      line item; in so doing,  ensure that the changes in the various  financial
      statement  line items  correlate  to your the  narrative  discussion.  For
      example,  clarify why selling,  general,  and  administrative  expense and
      interest income  (expense)  changed  significantly.  Additionally,  please
      address  our  above  comments  with  respect  to  your  interim  financial
      statements as necessary.

      RESPONSE: We propose to amend Note M as follows:

      The Company  has  restated  its  financial  statements  for the year ended
      September  30,  2005 and the  period  from  September  16,  2002  (date of
      inception) through September 30, 2005 by filing an amended Form 10-KSB for
      the fiscal year ended  September 30, 2005 to correct the following  errors
      in the financial statements previously filed:

      o     The  Company  did not  recognize  and  record  as a  current  period
            expense,  warrants issued to consultants and non-employees  having a
            fair value of $7,358,568 (see Note G).

      o     The Company  erroneously  recorded  the value of shares  issued to a
            former  Director  in  exchange  for  previously   incurred  debt  of
            $1,365,000 (see Note E).

      o     The  Company  did record the fair value of  warrants  issued to note
            holders and consultants having registration  rights,  $23,148,214 in
            the  aggregate,  as a  charge  of  operations  and  a  liability  in
            accordance with EITF 00-19 (see Note D).

      o     The Company did not record the gain of  $16,700,991  on  revaluation
            for the warrant liability as of September 30, 2005 (see Note D).


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 18

      The results of the correction of these errors include:

      o     Increase  in the  Company's  reported  net loss  for the year  ended
            September 30, 2005 by $14,499,139 from $52,610,380 to $67,109,529.

      o     Increase in the Company's  current  liabilities  as of September 30,
            2005 by $384,651 from $2,595,897 to $2,980,548.

o                 Increase  in the  Company's  other  liabilities,  representing
                  warranty liabilities,  as of September 30, 2005 by $13,673,574
                  from $0 to $13, 673,574.

      The result of the Consolidated Balance Sheet restatement is:

      o     Increase in accounts  payable and accrued  expenses as of  September
            30, 2005 from $2,185,468 to $2,570,119, or $384,651. The increase is
            a result of an error in recognizing, recording and accruing the fair
            value  of  warrants  issued  to  non-employees  and  consultants  of
            $384,651 as of September 30, 2005.

      o     Increase  in  warrant  liability  as of  September  30,  2005  $0 to
            $13,673,574.  The increase is a result of an error in accounting for
            the issuance of warrants subject to a registration  rights agreement
            that  provides  for  the  payment  of  liquidated   damages  if  the
            stipulated  registration  deadlines  were not met (see  Note D).  In
            accordance with SFAS 133 "Accounting for Derivative  Instruments and
            Hedging  Activities,"  the  Company  revalued  the  warrants  issued
            subject to  registration  rights as of September  30, 2005 (see Note
            G). The fair value of the  warrants  as of  September  30,  2005 was
            $13,673,574 and has been recorded as a warrant liability.

      The  following   chart  sets  forth   reconciliations   of  the  Company's
      restatement of the Consolidated Balance Sheet as of September 30, 2005.



                                                            September 30, 2005
                                                      -----------------------------
                                                      (As Restated)    (As Reported)
                                                      ------------     ------------
                                                                 
      ASSETS
      Current Assets:
      Cash                                            $     31,190     $     31,190
      Accounts receivable and advances                      12,429           12,429
                                                      ------------     ------------
      Total current assets                                  43,619           43,619

      Property, plant and equipment                         12,750           12,750
      Less: accumulated depreciation                        (4,686)          (4,686)
                                                             8,064            8,064
      Other Assets:
      Deposits                                              14,262           14,262
      Intangible assets :
      Patents , net of accumulated amortization             22,493           22,493
      Intellectual Property ,net of accumulated
      amortization                                       9,094,082        9,094,082
                                                      ------------     ------------
                                                         9,130,837        9,130,837
                                                      $  9,182,520     $  9,182,520
             LIABILITIES AND DEFICIENCY IN
                  STOCKHOLDERS' EQUITY
      Accounts payable and accrued liabilities        $  2,570,119     $  2,185,468
      Note payable - Related Party                         410,429          410,429
                                                      ------------     ------------
      Total Current Liabilities                          2,980,548        2,595,897

      Warrant liability                                 13,673,574             --

      Deficiency in Stockholders' Equity:
      Preferred Stock                                            6                6
      Common Stock                                         112,230          112,230
      Common stock subscribed                               20,000           20,000
      Additional Paid-In-Capital                        82,320,715       81,879,801
      Deficit Accumulated During Development Stage     (89,924,553)     (75,425,414)
                                                      ------------     ------------
      Total  (Deficiency)  in Stockholders'
      Equity                                            (7,471,602)       6,586,623
                                                      ------------     ------------
                                                      $  9,182,520     $  9,182,520
                                                      ============     ============


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 19

      The result of the Consolidated Statement of Losses restatement is:

      o     Increase in selling,  general and  administrative  expenses  for the
            year ended September 30, 2005 from  $42,662,152 to  $50,714,015,  or
            $8,051,863.  The increase is a result of an error in recognizing and
            recording  the fair value of warrants  issued to  non-employees  and
            consultants of $6,402,264, an error in recognizing and recording the
            fair value of stock issued in settlement  of debt of $1,365,000  and
            an  error  in  recognizing  and  recording  additional  compensation
            expense of $284,599.

      o     Increase in selling,  general and  administrative  expenses  for the
            period from September 16, 2002 (date of inception) through September
            30,  2005  from  $63,483,689  to  $71,535,604,  or  $8,051,915.  The
            increase is a result of an error in  recognizing  and  recording the
            fair value of warrants  issued to  non-employees  and consultants of
            $6,402,264,  an error in recognizing and recording the fair value of
            stock issued in  settlement  of debt of  $1,365,000  and an error in
            recognizing  and  recording of  additional  compensation  expense of
            $284,599.

      o     Increase in the net gain on the revaluation of warrant liability for
            the  year  ended  September  30,  2005  from $0 to  $16,700,990,  or
            $16,700,990.  The increase is a result of an error in accounting for
            the issuance of warrants subject to a registration  rights agreement
            that  provides  for  the  payment  of  liquidated   damages  if  the
            stipulated  registration  deadlines  were not met (see  Note D).  In
            accordance with SFAS 133 "Accounting for Derivative  Instruments and
            Hedging  Activities,"  the  Company  revalued  the  warrants  issued
            subject to  registration  rights as of September  30, 2005 (see Note
            G). The  difference  of  $16,700,991  between  the fair value of the
            warrants as of  September  30, 2005 and the previous  valuation  has
            been recorded as a gain on revaluation of warrant liability.

      o     Increase in the net gain on the revaluation of warrant liability for
            the period September 16, 2002 (date of inception)  through September
            30, 2005 from $0 to $16,700,990,  or $16,700,990.  The increase is a
            result  of an error  in  accounting  for the  issuance  of  warrants
            subject to a  registration  rights  agreement  that provides for the
            payment  of  liquidated  damages  if  the  stipulated   registration
            deadlines  were not met (see  Note D). In  accordance  with SFAS 133
            "Accounting for Derivative  Instruments and Hedging Activities," the
            Company revalued the warrants issued subject to registration  rights
            as of September 30, 2005 (see Note G). The difference of $16,700,991
            between the fair value of the warrants as of September  30, 2005 and
            the previous valuation has been recorded as a gain on revaluation of
            warrant liability.


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 20

      o     Increase in the interest  expense for the year ended  September  30,
            2005 from $8,958,046 to $32,106,310, or $23,148,264. The increase is
            a result of an error in recording and  recognizing  the recording of
            the  initial  valuation  of  warrants  issued  in  conjunction  with
            financing as a liability subject to registration rights.

      o     Increase in the interest  expense for the period  September 16, 2002
            (date of inception)  through  September 30, 2005 from $10,736,232 to
            $33,884,446, or $23,148,214. The increase is a result of an error in
            recording and recognizing  the initial  valuation of warrants issued
            in conjunction with financing as a liability subject to registration
            rights.

      The  following   chart  sets  forth   reconciliations   of  the  Company's
      restatement  of the  Consolidated  Statement  of Losses for the year ended
      September 30, 2005 as well as the period from  September 16, 2002 (date of
      inception of development stage) through September 30, 2005.



                                                                            For the Period September 16, 2002
                                          For the Year Ended                (date of Inception of Development
                                          September 30, 2005                Stage) through September 30, 2005
                                  ---------------------------------         ---------------------------------
                                  (As Restated)       (As Reported)         (As Restated)       (As Reported)
                                  ------------         ------------         ------------         ------------
                                                                                     
      Operating Expenses:
      Selling general and
      administrative              $ 50,714,017         $ 42,662,152         $ 71,535,604         $ 63,483,689
      Research and
      Development                      638,873              638,873              877,408              877,408
      Depreciation and
      amortization                     356,266              356,266              359,427              359,427
                                  ------------         ------------         ------------         ------------
      Total Operating
      Expenses                      51,709,156           43,657,291           72,772,439           64,720,524
                                  ------------         ------------         ------------         ------------
      Operating Income
      (Loss)                       (51,709,156)         (43,657,291)         (72,772,439)         (64,720,524)
      Net gain  (loss)  in
      fair  value of debt
      derivative and
      warrant liabilities           16,700,990                 --             16,700,990                 --
                                  ------------         ------------         ------------         ------------
      Other income
      (expense)                          4,957                 4957               31,342               31,342
      Interest income
      (expense)                    (32,106,310)          (8,958,046)         (33,884,446)         (10,736,232)
                                  ------------         ------------         ------------         ------------
      Provision for income
      taxes                               --                   --                   --                   --
                                  ------------         ------------         ------------         ------------
      Net Income (Loss)           $(67,109,569)        $(52,610,380)        $(89,924,553)        $(75,425,414)
                                  ============         ============         ============         ============
      Basic and diluted
      loss per common
      share                       $      (1.05)        $      (0.82)        $      (2.53)        $      (2.12)
                                  ------------         ------------         ------------         ------------
      Weighted average
      shares outstanding            63,517,009           63,517,009           35,590,871           35,570,559




Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 21

      The results of the restatement of the cash flow include:

      Cash Flows From Operating Activities

      o     Increase  in net loss for the year  ended  September  30,  2005 from
            $52,610,380 to  $67,109,519,  or  $14,499,139,  resulting from items
            listed above.

      o     Increase in net loss for the period from September 16, 2002 (date of
            inception)   through   September  30,  2005  from   $75,425,414   to
            $89,924,553, or $14,499,139 resulting from items listed above.

      o     Increase in the non-cash value of warrants issued to consultants for
            services  rendered  for the  year  ended  September  30,  2005  from
            $956,304 to 7,358,568, or $6,402,264. The increase is a result of an
            error in  recognizing  and  recording  the fair value of warrants to
            acquire our common stock issued to non-employees and consultants and
            charged to operations (see Note G).

      o     Increase in the non-cash value of warrants issued to consultants for
            services  rendered for the period from  September  16, 2002 (date of
            inception) through September 30, 2005 from $956,304 to 7,358,568, or
            $6,402,264.  The increase is a result of an error in recognizing and
            recording  the fair value of warrants  to acquire  our common  stock
            issued to  non-employees  and  consultants and charged to operations
            (see Note G).

      o     Increase in the  non-cash  income  attributable  to  re-pricing  the
            warrant  liability and debt derivatives for the year ended September
            30, 2005 from $0 to 16,700,991,  or  $16,700,991.  The increase is a
            result  of an error  in  accounting  for the  issuance  of  warrants
            subject to a  registration  rights  agreement  that provides for the
            payment  of  liquidated  damages  if  the  stipulated   registration
            deadlines  were not met (see  Note D). In  accordance  with SFAS 133
            "Accounting for Derivative  Instruments and Hedging Activities," the
            Company revalued the warrants issued subject to registration  rights
            as of September 30, 2005 (see Note G).

      o     Increase in the  non-cash  income  attributable  to  re-pricing  the
            warrant liability and debt derivatives for the period from September
            16, 2002 (date of inception)  through  September 30, 2005 from $0 to
            $16,700,991, or $16,700,991. The increase is a result of an error in
            accounting  for the issuance of warrants  subject to a  registration
            rights agreement that provides for the payment of liquidated damages
            if the stipulated  registration deadlines were not met (see Note D).
            In accordance with SFAS 133  "Accounting for Derivative  Instruments
            and Hedging  Activities,"  the Company  revalued the warrants issued
            subject to  registration  rights as of September  30, 2005 (see Note
            G).


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 22

      o     Increase  in  the  non-cash  financing  costs  attributable  to  the
            issuance of warrants for the year ended  September  30, 2005 from $0
            to $23,148,214, or $23,148,264. The increase is a result of an error
            in recording and recognizing the recording of the initial  valuation
            of warrants  issued in  conjunction  with  financing  as a liability
            subject to registration rights.

      o     Increase  in  the  non-cash  financing  costs  attributable  to  the
            issuance of warrants for the period from September 16, 2002 (date of
            inception)  through  September 30, 2005 from $0 to  $23,148,214,  or
            $23,148,214.  The increase is a result of an error in recording  and
            recognizing  the  recording  of the  initial  valuation  of warrants
            issued in  conjunction  with  financing  as a  liability  subject to
            registration rights.

      o     Increase  in the  non-cash  cost of the fair  value of common  stock
            issued to a related party in excess of previously  incurred debt for
            the  year  ended  September  30,  2005  from  $0 to  $1,365,000,  or
            $1,365,000.  The increase is a result of an error in  recording  and
            recognizing  the fair value of stock issued in settlement of debt of
            $1,365,000 to a former Director of the Company (See Note E).

      o     Increase  in the  non-cash  cost of the fair  value of common  stock
            issued to a related party in excess of previously  incurred debt for
            the period  from  September  16,  2002 (date of  inception)  through
            September  30,  2005  from  $0 to  $1,365,000,  or  $1,365,000.  The
            increase is a result of an error in recording  and  recognizing  the
            fair value of stock issued in  settlement of debt of $1,365,000 to a
            former Director of the Company (See Note E).

      o     Increase  in the  non-cash  cost of the fair  value of common  stock
            issued in exchange for services  for the period from  September  16,
            2002 (date of inception) through September 30, 2005 from $27,202,860
            to $30,574,373,  or $3,371,513. The increase is a result of an error
            in  recording  and  recognizing  the fair value of stock  issued for
            services  by  employees  and  non-employees  and a  reclassification
            common stock  previously  disclosed  as stock  issued  pursuant to a
            employee stock option plan (See Note F).

      o     Decrease  in  non-cash  cost of common  sock  issued  pursuant to an
            employee  stock  option plan for the year ended  September  30, 2005
            from  $3,960,000 to $0 , or $3,960,000.  The decrease is a result of
            reclassifying  common  stock  issued  pursuant to an employee  stock
            option plan to common stock  issued in exchange  for  services  (See
            Note F).

      o     Decrease  in  non-cash  cost of common  sock  issued  pursuant to an
            employee  stock option plan for the period from  September  16, 2002
            (date of inception)  through  September 30, 2005 from  $3,960,000 to
            $0, or $3,960,000.  The decrease is a result of reclassifying common
            stock  issued  pursuant to an employee  stock  option plan to common
            stock issued in exchange for services (See Note F).


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 23

      o     Decrease in non-cash cost of common sock cancelled-previously issued
            for  services  rendered for the year ended  September  30, 2005 from
            $1,078,270 to $578,270 , or $500,000. The decrease is a result of an
            error in recording  and  recognizing  the fair value of stock issued
            for services by employees and  non-employees  that was  subsequently
            cancelled (See Note F).

      o     Decrease in non-cash cost of common sock cancelled-previously issued
            for services  rendered for the period from  September 16, 2002 (date
            of  inception)  through  the year  ended  September  30,  2005  from
            $1,363,845 to $863,845, or $500,000.  The decrease is a result of an
            error in recording  and  recognizing  the fair value of stock issued
            for services by employees and  non-employees  that was  subsequently
            cancelled (See Note F).

      o     Decrease  in  cost  of  capital  expenditures  for  the  year  ended
            September 30, 2005 from $16,757 to $0, or $16,757. The decrease is a
            result  of   reclassifying   disbursement  for  the  acquisition  of
            equipment from operating activities to investing activities.

      o     Increase in the amount of net proceeds  from sale of  equipment  for
            the period from  September 16, 2002 (date of inception)  through the
            year ended  September 30, 2005 from $12,750 to $0 , or $12,750.  The
            increase is a result of reclassifying net proceeds received the sale
            of equipment from operating activities to investing activities.

      o     Increase in change of accounts  payable and accrued  liabilities for
            the year ended  September  30, 2005 from  $297,755 to  $663,748,  or
            $365,993.  The  increase  is a result  of an  error in  recognizing,
            recording  and  accruing  the  fair  value  of  warrants  issued  to
            non-employees and consultants as of September 30, 2005.

      o     Increase in change of accounts  payable and accrued  liabilities for
            the period  from  September  16,  2002 (date of  inception)  through
            September 30, 2005 from $2,053,464 to $2,419,457,  or $365,993.  The
            increase  is a  result  of an error in  recognizing,  recording  and
            accruing  the fair value of  warrants  issued to  non-employees  and
            consultants as of September 30, 2005.

      Cash Flows From Investing Activities:

      o     Increase in the cash  provided by the sale of equipment for the year
            ended  September  30,  2005  from $0 to  $16,757,  or  $16,757.  The
            increase  is a result of an error in properly  classifying  proceeds
            from the sale of equipment as an investing activity.

      o     Decrease  in the cash used in  capital  expenditures  for the period
            from  September 16, 2002 (date of inception)  through  September 30,
            2005 from $0 to $12,750, or $12,750.  The decrease is a result of an
            error in properly  classifying net  disbursements in connection with
            acquiring equipment as an investing activity.


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 24

      Cash Flows From Financing Activities:

      o     Increase in the cash used in repayment of  previously  incurred debt
            for the  year  ended  September  30,  2005  from $0 to  $24,854,  or
            $24,854.  The  increase  is a  result  of an  error  in  classifying
            repayment of debt as a financing activity.

      o     Increase in the cash used in repayment of  previously  incurred debt
            for the period from  September 16, 2002 (date of inception)  through
            September 30, 2005 from $0 to $24,854, or $24,854. The increase is a
            result of an error in properly  classifying  repayment  of debt as a
            financing activity.

      o     Increase  in  proceeds  from  the sale of  options  to  acquire  the
            Company's  common stock for the year ended  September  30, 2005 from
            $70,750 to  $102,750,  or  $32,000.  The  increase is a result of an
            error in  recognizing  and  recording  $32,000 of proceeds  from the
            exercise of options as issuance of common stock (see Note F).

      o     Increase  in  proceeds  from  the sale of  options  to  acquire  the
            Company's  common stock for the period from September 16, 2002 (date
            of inception)  through September 30, 2005 from $311,750 to $343,750,
            or $32,000.  The increase is a result of an error in recognizing and
            recording  $32,000  of  proceeds  from the  exercise  of  options as
            issuance of common stock (see Note F).

      o     Decrease in proceeds from  subscription of common stock for the year
            ended September 30, 2005 from  $9,079,000 to $0, or $9,079,000.  The
            decrease is a result of an error in  recognizing  and  recording the
            proceeds from the issuance of convertible  notes that were exchanged
            for the Company's common stock ( see Note D).

      o     Decrease  in  proceeds  from  subscription  of common  stock for the
            period September 16, 2002 (date of inception)  through September 30,
            2005 from $9,204,000 to $0, or $9,204,000.  The decrease is a result
            of an error in  recognizing  and  recording  the  proceeds  from the
            issuance of convertible  notes that were exchanged for the Company's
            common stock ( see Note D).

      The  following   chart  sets  forth   reconciliations   of  the  Company's
      restatement of the Consolidated Statement of Cash Flows for the year ended
      September  30,  2005 as well as the  period  September  16,  2002 (date of
      inception of development stage) through September 30, 2005.


Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 25



                                                                      For the Period September 16, 2002
                                       For the Year Ended             (date of Inception of Development
                                       September 30, 2005             Stage) through September 30, 2005
                                 -------------------------------      ---------------------------------

                                 (As Restated)     (As Reported)       (As Restated)     (As Reported)
                                 ------------       ------------       ------------       ------------
                                                                              
      Cash flows from
      Operating Activities:
      Net income (loss)           (67,109,519)       (52,610,380)       (89,924,553)       (75,425,414)
      Adjustment to
      reconcile net loss
      to net cash used in
      operating activities:
      Amortization and
      depreciation                    350,107            350,107            353,268            353,268
      Organization expenses              --                 --               88,500             88,500
      Preferred share
      issued in exchange
      for services                       --                 --            1,500,000          1,500,000
      Warrants issued to
      consultants in
      exchange for
      services rendered             7,358,568            956,304          9,378,430          2,976,166
      Income attributable
      to repricing of
      warrant and debt
      derivatives                 (16,700,991)              --          (16,700,991)              --
      Financing costs
      attributable to
      issuance of warrants         23,148,214               --           23,148,214               --
      Amortization of
      beneficial
      conversion feature-
      convertible notes             8,836,000          8,836,000         10,461,000         10,461,000
      Amortization of
      capitalized
      financing costs                    --                 --                 --                 --
      Amortization of debt
      discount
      attributable to
      convertible notes                  --                 --                 --                 --
      Fair value of common
      stock issued to
      related party in
      excess of previously
      incurred debt                 1,365,000               --            1,365,000               --
      Common stock issued
      in exchange for
      services                     18,176,641         14,805,128         30,574,373         27,202,860



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 26




                                                                              
      Common stock issued
      to ESOP                            --            3,960,000               --            3,960,000
      Common stock
      exchanged for
      intellectual
      property in
      connection with
      costs of acquiring
      intangible assets            14,689,100         14,689,100         14,689,100         14,689,100
      Common stock issued
      as penalty in
      connection with
      financing                       776,529            776,529            776,529            776,529
      Common stock
      canceled- previously
      issued for services
      rendered                       (578,270)        (1,078,270)          (863,845)        (1,363,845)
      Change in assets and
      liabilities :
      Increase in accounts
      receivable                      (12,429)           (12,429)           (12,429)           (12,429)
      Increase in prepaid
      assets and deposits               9,297              9,297            (14,262)           (14,262)
      Decrease in other
      assets                             --                 --              (13,890)           (13,890)
      Capital expenditures               --               16,757               --              (12,750)
      Increase (Decrease)
      in due related
      parties                        (111,943)          (111,943)            40,753             40,753
      Increase (decrease)
      in accounts payable
      and accrued
      liabilities                     663,748            297,755          2,419,457          2,053,464
                                 ------------       ------------       ------------       ------------
      Net cash used in
      operating activities         (9,139,948)        (9,116,045)       (12,735,346)       (12,740,950)
      Cash flows from
      investing
      activities:
      Payments for patent
      filing                           (4,347)            (4,347)           (25,689)           (25,698)
      Capital expenditures
      (disposals)                      16,757               --              (12,750)              --
                                 ------------       ------------       ------------       ------------



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 27




                                                                              

      Net cash used in
      investing activities             12,410             (4,347)           (38,448)           (25,689)
      Cash Flows From
      Financing
      Activities:
      Proceeds from sale
      of common stock ,
      net of costs                       --                 --              432,000            432,000
      Proceeds from
      subscription of
      common stock                       --            9,079,000               --            9,204,000
      Proceeds form
      issuance of
      convertible notes             9,079,000               --            9,204,000               --
      Proceeds from sale
      of  options                     102,750             70,750            343,750            311,750
      Payment of debt                 (24,854)              --              (24,854)              --
      Proceeds from loans                --                 --            2,750,000          2,750,000
      Advances from (to)
      shareholders                       --                 --              100,088            100,088
                                 ------------       ------------       ------------       ------------
      Cash provided by
      financing activities          9,156,896          9,149,750         12,804,984         12,797,838
      Net (decrease)
      increase in cash and
      cash equivalents                 29,358             29,358             31,190             31,190
      Cash, beginning of
      period                            1,832              1,832               --                 --
                                 ------------       ------------       ------------       ------------
      Cash and cash
      equivalents, end of
      period                     $     31,190       $     31,190       $     31,190       $     31,190
                                 ============       ============       ============       ============



Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
December 22, 2006
Page 28




      If you have any  additional  comments  or  questions,  please feel free to
contact the undersigned at (212) 318-3261

                                                          Very truly yours,

                                                          /s/Merrill M. Kraines

                                                          Merrill M. Kraines


Enclosures


cc:      Mr. John Krug, Senior Staff Attorney
         Mary Mast, Senior Accountant
         Amy Bruckner, Staff Accountant
         James A. Hayward, Applied DNA Sciences, Inc.