Fulbright & Jaworski l.l.p.
                 A Registered Limited Liability Partnership
                        666 Fifth Avenue, 31st Floor
                        New York, New York 10103-3198
                              www.fulbright.com

mkraines@fulbright.com                               telephone:   (212) 318-3000
direct dial:  (212) 318-3261                         facsimile:   (212) 318-3400

                                  March 6, 2007

VIA EDGAR AND FEDERAL EXPRESS

Mr. Jeffrey P. Riedler
Assistant Director
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Mail Stop 3561
Washington, D.C. 20549-3561

         Re:      Applied DNA Sciences, Inc.
                  Registration Statement on Form SB-2
                  Filed January 15, 2005
                  File No. 333-122848
                  -----------------------------------

Dear Mr. Riedler:

         On behalf of Applied DNA Sciences, Inc. (the "Company") and in response
to the Staff's  comment letter dated January 25, 2007 (the "Comment  Letter") in
connection  with Amendment No.8 to the Company's  above-referenced  Registration
Statement on Form SB-2 (the "Registration Statement"), we hereby submit proposed
changes to the financial statements for your review.

         All responses to the comments set forth in this letter are submitted on
behalf of the Company at its request.  All responses to the accounting  comments
were prepared by the Company in consultation with its independent auditors.  The
following numbered paragraphs repeat the comments in the Comment Letter for your
convenience, followed by the Company's responses to those comments.

Amendment No. 8 to Registration Statement on Form SB-2

General

1.       Prior to requesting  acceleration  for  effectiveness,  please refer to
         Item 310(g) of Regulation S-B and amend your registration  statement on
         Form SB-2 to provide updated financial statements.

         RESPONSE:  Updated financial statements shall be provided in accordance
         with Item 310(g) of Regulation S-B prior to requesting effectiveness of
         the Registration Statement.







Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 2


Notes to Condensed Consolidated Financial Information

Note A - Summary of Significant Accounting Policies, page F-20

Note I - Restatement of Quarterly Financial Statements, page F-45

2.       We  acknowledge  your  response  to comments 4, 5 and 7 and reissue our
         comments.   You  have  not  provided  us  with  sufficiently   detailed
         disclosure  that  substantially  revises your  restatement  footnote to
         explain why you made each correction of an error for the three and nine
         months ended June 30, 2006 and 2005 and the period from your  inception
         through June 30, 2006.  Please  revise Note I to not only  disclose the
         amount of each error and the  related  financial  statement  period and
         financial  statement line item affected,  but why each change occurred.
         That is,  describe  the  nature  of each  error  and the  corresponding
         financial  statement  line  items  that  it  affected;  tell us how you
         concluded  that  an  adjustment  was  necessary;  and  tell  us how you
         calculated that adjustment.  Additionally,  if a particular  adjustment
         affects,  for  example,  both  your  balance  sheet and  statements  of
         operations and cash flows for a particular  period,  you should clearly
         illustrate  that  correlation in your  description  of the error.  Your
         disclosure  should provide a clear  illustration  of how you progressed
         from each financial  statement line item "as reported" to "as adjusted"
         in each  period,  disaggregating  the total error  affecting  each line
         item,   preferably  in  tabular  format  with  corresponding   footnote
         disclosure.  Examples of items that we would like you to clarify  based
         on the  information  included in your  December  22, 2006  supplemental
         response follow;  however, you should provide this enhanced information
         for each error, as our list of examples is not exhaustive.

         o    It  is  unclear,   based  on  your   explanation   regarding   the
              capitalization of debt issuance costs, why you recorded a $390,000
              increase to selling, general and administrative (SG&A) expense for
              the three  months  ended  June 30,  2006  without a  corresponding
              decrease to your balance sheet. Please clarify.

         o    Explain why, in general, you would record the fair value effect of
              stock-based  compensation issued to  non-employees/consultants  to
              your interest expense or gain on fair value of debt derivative and
              wanrrant  liabilities  line items, as opposed to SG&A expense.  It
              appears that you recorded  various  adjustments of this nature for
              the nine months  ended June 30,  2006,  as well as the  cumulative
              period from your inception through June 30, 2006; for example, you
              recorded an increase in gain on fair value of debt  derivative and
              warrant liabilities of $ 1,156,598 for the three months ended June
              30, 2006 and a decrease in interest  expense of $5,940,556 for the
              nine months ended June 30, 2006.

         o    Tell us why the increase in "non-cash  income  attributable to the
              repricing of warrant and debt  derivatives"  of $4,131,604 in your
              narrative  explanation of the  adjustments  to your  statements of
              cash flows for the nine months  ended June 30, 2006 and the period
              from  your  inception  through June 30, 2006  does  not  correlate
              to the adjustment to the net gain on fair value of debt derivative
              and  warrant  liabilities  line  item on  page 6 of your  response
              letter (for both periods).





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 3



         o    Tell us why an error of  $1,365,000  occurred  in relation to your
              issuance of common  shares to settle  related party debt and where
              you recorded that error on your  statements of operations  for the
              nine  months  ended  June 30,  2005 and for the  period  from your
              inception  to June 30, 2006.  Similarly,  tell us why and where on
              your  statements of operations you recorded the other  adjustments
              to the "non-cash fair value of common stock issued in exchange for
              services"  that  you  have  outlined  on page 11 of your  response
              letter.

         RESPONSE:  We propose to amend the June 30,  2006  unaudited  financial
         statements to read as follows:

         The accompanying condensed consolidated financial statements as of June
         30,  2006 and the three and nine  months  ended June 30,  2006 and from
         September 16, 2002 (date of inception)  through June 30, 2006 have been
         restated to correct its  accounting for (a) the issuance of options and
         warrants in exchange for  compensation  and financing  activities,  (b)
         correcting the period reporting  capitalized  finance costs and current
         operating   expenses   and  (c)  errors  in  report   preparation   and
         miscellaneous   accounting   adjustments   appropriate   for  the  fair
         presentation of the financial statements.

         The effect of the adjustments in the restated  financial  statements is
         an increase in net loss of $136,401  from  September  16, 2002 (date of
         inception)  through  June 30,  2006 and an  increase  in net  income of
         $766,698 and $2,148,364 for the three and nine month periods ended June
         30,  2006,  respectively.  There  was no  effect  on total  cash  flows
         provided by (used in) operations, investing or financing activities.

         The following tables summarize the effects of these  adjustments on the
         Company's  condensed  consolidated  balance  sheet as of June 30, 2006,
         condensed  consolidated  statements  of  losses  for the three and nine
         months ended June 30, 2006 and for the period from  September  16, 2002
         (date  of   inception)   through  June  30,  2006  and  the   condensed
         consolidated  statements  of cash flows for the nine months  ended June
         30, 2006 and for the period from September 16, 2002 (date of inception)
         through June 30, 2006:





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 4




                                                 Condensed Consolidated Balance Sheet
                                                             June 30, 2006

                                                         As Previously
                                                           Reported                    Adjustment   Reference       As Restated
                                            --------------------------------------   --------------------------  -------------------
                                                                                                     
Cash                                        $                            1,931,173   $                           $        1,931,173
Accounts receivable, net                    $                               18,900   $                           $           18,900
Advances and other receivables              $                               11,611   $                           $           11,611
Prepaid expenses                            $                              146,667   $                           $          146,667
Total current assets                        $                            2,108,351   $                           $        2,108,351
Property, plant and equipment, net          $                               38,286   $                           $           38,286
Deposits                                    $                                8,322   $                           $            8,322
Capitalized finance costs                   $                            1,437,862   $                           $        1,437,862
Patents, net                                $                               17,376   $                           $           17,376
Intellectual property, net                  $                            8,083,629   $                           $       8,083,629
total assets                                $                           11,693,826   $                           $       11,693,826
Accounts payable and accrued liabilities    $                            4,680,849   $                           $        4,680,849
Notes payable, related party                $                              410,429   $                           $          410,429
Total current liabilities                   $                            5,091,278   $                           $        5,091,278
Convertible notes payable, net              $                            3,306,371   $                           $        3,306,371
Debt derivative and warrant liability       $                            5,698,286   $                           $        5,698,286
Total liabilities                           $                           14,095,935   $                           $       14,095,935
Preferred stock                             $                                    6   $                           $                6
Common stock                                $                              118,582   $                           $          118,582
Common stock subscription                   $                             (200,000)  $                           $         (200,000)
Additional paid in capital                  $                           81,860,606   $       136,400    a        $       81,997,006
Accumulated deficit                         $                          (84,181,303)  $      (136,400)   a        $      (84,317,703)
Total deficiency in stockholders' equity    $                           (2,402,109)  $                           $       (2,402,109)
Total liabilities and Deficiency in
   Stockholders' equity                     $                           11,693,826   $                           $       11,693,826






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 5




                                          Condensed Consolidated Statement of Income (Losses)
                                               For the Three Months Ended June 30, 2006
                                                                                                       
Sales                                                    $        18,900   $                                       $         18,900
Cost of sales                                            $        15,639   $                                       $         15,639
Gross margin                                             $         3,261   $                                       $          3,261
Selling, general & administrative                        $     1,190,967   $       390,000              b          $      1,580,967
Research and development                                 $             -   $                                                      -
Depreciation and amortization                            $       336,824   $                                       $        336,824
Total operating expenses                                 $     1,527,791   $       390,000              b          $      1,917,791
Net loss from operations                                 $    (1,524,530)  $      (390,000)             b          $     (1,914,530)
Net gain (loss) in fair value of debt derivative and
   warrant liability                                     $     2,337,263   $     1,156,698              c          $      3,493,961
Other income (expense)                                   $         8,483   $                                       $          8,483
Interest income (expense)                                $      (826,827)  $                                       $       (826,827)
Net income (loss)                                        $        (5,611)  $       766,698             b,c         $        761,087
Net income (loss) per share-basic                        $         (0.00)             0.01                         $           0.01
Net income (loss) per share-fully diluted                             NA              0.01                         $           0.01




                                          Condensed Consolidated Statement of Income (Losses)
                                                For the Nine Months Ended June 30, 2006
                                                                                                       
Sales                                                 $           18,900   $                                       $        18,900
Cost of sales                                         $           15,639   $                                       $        15,639
Gross margin                                          $            3,261   $                                       $         3,261
Selling, general & administrative                     $        4,955,055   $      (563,750)             d          $     4,391,305
Research and development                              $           75,276   $                                                75,276
Depreciation and amortization                         $        1,021,199   $                                       $     1,021,199
Total operating expenses                              $        6,051,530   $      (563,750)             d          $     5,487,780
Net loss from operations                              $       (6,048,269)  $      (563,750)             d          $    (5,484,519)
Net gain (loss) in fair value of debt derivative and
   warrant liability                                  $       18,606,563   $    (4,355,942)             e          $    14,250,621
Other income (expense)                                $           17,976   $                                       $        17,976

                                                                                  (136,400)             a
                                                                                  (563,750)             d
                                                                                 6,640,706              e
                                                                           ---------------
Interest income (expense)                             $       (9,117,785)  $     5,940,556                         $    (3,177,229)
Net income (loss)                                     $         3,458,485  $     2,148,364                         $     5,606,849
Net income (loss) per share-basic                     $              0.03             0.02                         $          0.05
Net income (loss) per share-fully diluted                            0.02             0.01                         $          0.03






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 6




                                        Condensed  Consolidated  Statement  of Income (Losses)
                                From September 16, 2002 (date of inception) through June 30, 2006
                                                                                                       
Sales                                                 $           18,900   $                                       $         18,900
Cost of sales                                         $           15,639   $                                       $         15,639
Gross margin                                          $            3,261   $                                       $          3,261
Selling, general & administrative                     $       70,072,368   $    5,838,514               f          $     75,910,882
Research and development                              $          968,711   $                                                968,711
Depreciation and amortization                         $        1,380,626   $                                       $      1,380,626
Total operating expenses                              $       72,421,705   $    5,838,514                          $     78,260,219
Net loss from operations                              $      (72,418,444)  $   (5,838,514)                         $    (78,256,958)
Net gain (loss) in fair value of debt derivative and
   warrant liability                                  $       35,307,553   $   (4,355,942)              e          $     30,951,611
Other income (expense)                                $           49,318   $                                       $         49,318
Interest income (expense)                             $      (47,119,730)  $   10,058,055               e          $    (37,061,675)
Net income (loss)                                     $      (84,181,303)  $     (136,401)                         $    (84,317,703)




                                            Condensed Consolidated Statement of Cash Flows
                                                For the Nine Months Ended June 30, 2006
                                                                                                      
Cash flows from operating activities
Net income (loss)                                      $        3,458,485   $    2,148,364                        $       5,606,849
Adjustments to reconcile to net used in operating
   activities
Depreciation and amortization                          $        1,021,199   $                                     $       1,021,199
Organization expenses                                  $                    $
Preferred shares issued in exchange for services       $                    $                                     $               -
Warrants issued to consultants                         $          606,850   $     (563,750)             d         $          43,100
Income attributable to repricing of warrants and debt
   derivatives                                         $      (10,118,917)  $   (4,131,704)             g         $     (14,250,621)
Financing costs attributable to issuance of warrants   $                    $    2,271,000              h         $       2,271,000
Amortization of beneficial conversion feature
   -convertible notes                                  $                -   $                                     $               -
Amortization of capitalized finance costs              $          247,238   $                                     $         247,238
Amortization of debt discount attributable to
   convertible debenture                               $                -   $      276,090              k         $         276,090
Fair value of common stock issued to related party in
   excess of debt                                      $                -   $                                     $               -
Common stock issued in exchange for services           $          710,200   $                                     $         710,200
Common stock issued in exchange for intellectual
   property                                            $                -   $                                     $               -
Common stock issued as penalty in connection with
   financing                                           $          773,958   $                                     $         773,958
Common stock canceled-previously issued for services
   rendered                                            $         (480,000)  $                                     $        (480,000)
Change in assets and liabilities:
Increase in accounts receivable                        $          (18,900)  $                                     $        (18,900)
Increase in prepaid expenses and deposits              $         (145,849)  $                                     $        (145,849)
Decrease in other assets                               $            5,940   $                                     $           5,940
Decrease in due related parties                        $          (52,662)  $                                     $         (52,662)
Increase (decrease) in accounts payable and accrued
   liabilities                                         $        1,685,792   $                                     $       1,685,792
Net cash used in operating activities                  $       (2,306,666)  $                                     $      (2,306,666)
Cash flows from investing activities:
Payments for patent filing                             $                -
Capital expenditures                                   $          (35,851)  $                                     $         (35,851)
Net cash used in investing activities                  $          (35,851)  $                                     $         (35,851)
Cash flows from financing activities
Proceeds from sales of common stock, net               $                -   $                                     $
Proceeds from issuance of convertible notes            $        4,242,500   $                                     $       4,242,500
Proceeds from exercise of options and warrants         $                -   $                                     $               -
Payment of debt                                        $                -   $                                     $               -
Proceeds from loans                                    $                -   $                                     $               -
Advances from shareholders                             $                -   $                                     $               -
Net cash provided by financing activities              $        4,242,500   $                                     $       4,242,500
Net increase in cash and cash equivalents              $        1,899,983   $                                     $       1,899,983
Cash and cash equivalents at beginning of period       $           31,190   $                                     $          31,190
Cash and cash equivalents at end of period             $        1,931,173   $                                     $       1,931,173






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 7




                                         Condensed  Consolidated Statement of Cash Flows
                                From  September  16, 2002 (date of inception) through June 30, 2006
                                                                                                      
Cash flows from operating activities
Net income (loss)                                      $      (84,181,303)  $     (136,400)             a         $     (84,317,703)
Adjustments to reconcile to net used in operating
   activities
Depreciation and amortization                          $        1,374,467   $       (5,756)             j         $       1,368,711
Organization expenses                                  $           88,500   $                                                88,500
Preferred shares issued in exchange for services       $        1,500,000   $                                     $       1,500,000
Warrants issued to consultants                         $        3,583,016   $    5,838,514              f         $       9,421,530
Income attributable to repricing of warrants and debt
   derivatives                                         $      (26,819,908)  $   (4,131,703)             g         $     (30,951,611)
Financing costs attributable to issuance of warrants   $       27,265,174   $   (1,846,500)             k         $      25,418,674
Amortization of beneficial conversion feature
   -convertible notes                                  $       10,461,000   $                                     $      10,461,000
Amortization of capitalized finance costs              $          247,238   $                                     $         247,238
Amortization of debt discount attributable to
   convertible debenture                               $                -   $      276,090              k         $         276,090
Fair value of common stock issued to related party in
   excess of debt                                      $        1,365,000   $                                     $       1,365,000
Common stock issued in exchange for services           $       31,284,573   $                                     $      31,284,573
Common stock issued in exchange for intellectual
   property                                            $       14,689,100   $                                     $      14,689,100
Common stock issued as penalty in connection with
   financing                                           $        1,550,487   $                                     $       1,550,487
Common stock canceled-previously issued for services
   rendered                                            $       (1,343,845)  $                                     $      (1,343,845)
Change in assets and liabilities:
Increase in accounts receivable                        $          (18,900)  $                                     $         (18,900)
Increase in prepaid expenses and deposits              $         (163,472)  $                                     $        (163,472)
Decrease in other assets                               $           (3,128)  $                                     $          (3,128)
Decrease in due related parties                        $                -   $                                     $               -
Increase (decrease) in accounts payable and accrued
   liabilities                                         $        4,079,990   $        5,755              j         $       4,085,745
Net cash used in operating activities                  $      (15,042,011)  $                                     $     (15,042,011)
Cash flows from investing activities:
Payments for patent filing                             $          (25,698)  $                                     $         (25,698)
Capital expenditures                                   $          (48,602)  $                                     $         (48,602)
Net cash used in investing activities                  $          (74,300)  $                                     $         (74,300)
Cash flows from financing activities
Proceeds from sales of common stock, net               $          432,000   $                                     $         432,000
Proceeds from issuance of convertible notes            $       13,446,500   $                                            13,446,500
Proceeds from exercise of options and warrants         $          343,750   $                                     $         343,750
Payment of debt                                        $          (24,854)  $                                     $         (24,854)
Proceeds from loans                                    $        2,750,000   $                                     $       2,750,000
Advances from shareholders                             $          100,088   $                                     $         100,088
Net cash provided by financing activities              $       17,047,484   $                                     $      17,047,484
Net increase in cash and cash equivalents              $        1,931,173   $                                     $       1,931,173
Cash and cash equivalents at beginning of period       $                -   $                                     $               -
Cash and cash equivalents at end of period             $        1,931,173   $                                     $       1,931,173






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 8


         (a)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments  during the nine month  period  ended  June 30,  2006,  the
         Company  determined  that  certain  warrants to acquire  the  Company's
         common stock, which were issued to non-employees in connection with the
         Company's financing activities, were not valued in accordance with SFAS
         No. 123R.  The Company  corrected the valuation of these  warrants as a
         net  charge to  interest  expense  and a credit to  additional  paid in
         capital in the amount of $136,400.

         (b) During its review of the issuance  and  valuation of the March 2006
         debt instruments during the three month period ended June 30, 2006, the
         Company  determined that $390,000,  the cost related to the issuance of
         these debt  instruments,  was charged in error to selling,  general and
         administrative  expenses  instead of  capitalized  debt issuance  costs
         interest expense in the previous reporting quarter. The Company reduced
         the amounts recorded to selling general and administrative expenses for
         the three month period ended June 2006.  The  correction is intended to
         reflect the  adjustment  to  capitalize  financing  costs in the proper
         reporting period.  The net effect of this adjustment on the three month
         period  ended  June  30,  2006 is to  increase  operating  expenses  by
         $390,000. The adjustment as a result of the correction of the error has
         no net effect on operating  expenses during the nine month period ended
         June  30,  2006  and the  period  from  September  16,  2002  (date  of
         inception) to June 30, 2006.

         (c) During the Company's review of the outstanding warrants and options
         to acquire the  Company's  common stock,  it  determined  that the debt
         instruments  should be  reclassified  as  derivative  liabilities  as a
         result  of   distributing   convertible   notes   containing   embedded
         derivatives (see Note C). After further review,  the Company determined
         that as of June 30, 2006,  the  derivatives  were valued in error.  The
         warrants were initially  valued at $933,117.  The correct  valuation is
         $2,089,814, an increase of $1,156,698.





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 9


         (d)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments,  the Company determined that $563,750, the cost related to
         the issuance of certain warrants to acquire the Company's common stock,
         which were issued  during the nine month  period ended June 30, 2006 to
         non-employees  in connection with the Company's  financing  activities,
         was recorded in error as selling,  general and administrative  expenses
         instead  of  interest  expense.  The  Company  corrected  the  error by
         reclassifying the amount of $563,750 to interest expense.

         (e)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments,  the Company  determined that certain  warrants to acquire
         the Company's common stock,  which were issued to non-employees  during
         the year ended  September  30, 2005 in  connection  with the  Company's
         financing  activities,  were erroneously recorded as having been issued
         during the nine month  period  ended June 30,  2006.  The effect of the
         error was an  overstatement  of  $4,355,942 in the net gain in the fair
         value of the debt derivative and warrant liability and an overstatement
         of  $6,640,706  in the net  interest  expense in the  original  filing,
         resulting in a net increase of $2,284,764 in income for the nine months
         ended June 30,  2006.  This amount of  $2,284,764  is  comprised of the
         corrections  of errors in the  recording and valuation of the following
         warrants:



                                          Original amount     Revised Amount    Increase/(decrease)
                                                                              
Warrants issued in December 2004                $ 394,698        $ 3,169,052           $ 2,774,354
Warrants issued in February 2005                        -             72,017                72,017
Warrants issued in June 2005 (Company
determined warrants were not properly
authorized and issued)                            849,047                  -              (849,047)
Warrants previously cancelled, later
determined issued                                (287,440)                 -               287,440
                                                ----------       ------------          ------------
                                                $ 956,305        $ 3,241,069           $ 2,284,764
                                                ==========       ============          ============






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 10


         The  adjustment of $2,284,764,  net of the additional  cost of warrants
         issued (see Note A above) of $136,400, results in an aggregate increase
         of  $2,148,364  in net income for the nine month  period ended June 30,
         2006, from $3,458,485 to $5,606,849.

         (f)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments,  the Company determined that $5,838,514, the fair value of
         certain warrants to acquire the Company's common stock that were issued
         to  non-employees  during the period from  September  16, 2002 (date of
         inception)  through  June  30,  2006 in  connection  with  payment  for
         services rendered to the Company,  was erroneously recorded as interest
         expenses instead of selling, general and administrative expenses.

         (g)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments, the Company reclassified the amortization of debt discount
         attributable  to  the  issuance  of  $4,131,704  of  convertible   debt
         separately  from the income  attributable  to repricing of warrants and
         debt derivatives, as set forth below:


                                                                            
Reclassification of initial warrant valuations relating to financing from
interest to separate line item in cash flow statement:                         $2,271,000
Change in non warrant valuations as described in (a) above:                     1,584,614
Reclassification of amortization of debt discount to separate cash flow
line item                                                                         276,090
                                                                               ----------
Total:                                                                         $4,131,704
                                                                               ==========


         (h)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments,   the   Company   separately   reclassified   from  income
         attributable to repricing of warrants and debt  derivatives,  the value
         of warrants  issued in  connection  with the  issuance of debt having a
         fair value of $2,271,000.

         (i)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments, the Company reclassified the amortization of debt discount
         attributable to the issuance of convertible debt of $276,090 separately
         from income attributable to repricing of warrants and debt derivatives.

         (j) During its review of capital  expenditures and related depreciation
         and  amortization,  the  Company  corrected a  classification  error of
         $5,756 between the depreciation and amortization expenses line item and
         accounts payable within the cash used in operating expenses.

         (k)  During  its  review  of  the  issuance  and  valuation  of  equity
         instruments,  the Company determined that $1,846,500, the fair value of
         certain  warrants  to acquire  the  Company's  common  stock  issued to
         non-employees  in connection with payment for services  rendered to the
         Company,  was charged in error to interest  expense instead of selling,
         general and administrative expenses.





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 11



3.       Refer to  comment  number  5 and your  reference  to your  response  to
         comment 4. It is not clear from your  response to comment 4 whether you
         have made any adjustments to additional  paid-in capital,  as initially
         described in Note I of the financial  statements in amendment  number 8
         to your Form  SB-2.  Please  explain  to us and  clarify  in the filing
         whether you made any adjustments to additional paid-in capital and tell
         us the basis  for those  adjustments.  If the  explanations  previously
         provided in Note I (as filed) were in error, please clarify.

         RESPONSE: The Company charged selling, general and administrative costs
         and increased  additional  paid in capital in the amount of $136,400 in
         connection  with that  correction of errors in the  accounting  for and
         recording of the issuance of warrants to acquire the  Company's  common
         stock to non-employees  during the nine months ended June 30, 2006. The
         warrants were not valued in accordance  with SFAS No. 123R. The Company
         corrected the valuation of warrants  issued as a net charge to interest
         expense  and a credit to  additional  paid in  capital in the amount of
         $136,400.

4.       We  acknowledge  your  response to comment 8 and  reissue our  comment.
         Please  clarify  for us and in your  filing  why you  believe  that you
         appropriately  classified  certain  error  corrections  related  to the
         valuation of your warrant liabilities pursuant to EITF No, 00-19 within
         interest income  (expense) for all periods  presented in Note I of your
         interim  financial  statements  and  Note M of  your  annual  financial
         statements.  We  specifically  refer you to the  material  increase  in
         "non-cash  financing costs attributable to the issuance of warrants" of
         approximately  $23.1  million for the nine  months  ended June 30, 2005
         discussed on page 10 of your  response,  which  appears to correlate to
         the increase in interest expense that we have noted above in comment 2.
         Additionally,  provide us with a detailed  analysis of each  correction
         that  aggregates to the $23.1  million and explain how each  connection
         relates to one of your various financing transactions.

         RESPONSE:  In connection  with the issuance of  convertible  promissory
         notes in 2005, the Company issued warrants with registration rights for
         the underlying  shares. As the registration  rights agreement  provides
         for  the  delivery  of  registered  shares  and  the  delivery  of  the
         registered  shares is not  controlled by the Company,  pursuant to EITF
         00-19, "Accounting for Derivative Financial Instruments Indexed to, and
         Potentially  Settled in, a Company's  Own Stock",  the net value of the
         warrants at the date of issuance was recorded as a warrant liability on
         the balance  sheet  $23,148,214  and charged to  operations as interest
         expense. Upon the registration statement being declared effective,  the
         fair value of the warrant on that date will be  reclassified as equity.
         The  Company  initially  valued the  warrants  using the  Black-Scholes
         pricing model with the following  assumptions:  (1) a dividend yield of
         0%; (2) an expected  volatility  of 152.59%,  (3) a risk-free  interest
         rate of 3.67%, and (4) an expected life of 5 years.





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 12


         See response to comment 5 (Note E), below.

Notes to (Audited) Consolidated Financial Statements (Restated)

Note M - Restatement of Financial Statements, page F-91

5.       We  acknowledge  your  response  to  comments 6 and 10 and  reissue our
         comments.   You  have  not  provided  us  with  sufficiently   detailed
         disclosure  that  substantially  revises your  restatement  footnote to
         explain  why you made each  correction  of an error for the year  ended
         September 30, 2005 and the period from your inception through September
         30, 2005.  Please revise Note M to not only disclose the amount of each
         error  and  the  related  financial   statement  period  and  financial
         statement line item affected,  but why each change  occurred.  That is,
         describe  the  nature  of each  error and the  corresponding  financial
         statement  line items that it affected;  tell us how you concluded that
         an  adjustment  was  necessary;  and  tell us how you  calculated  that
         adjustment.  Additionally,  if a  particular  adjustment  affects,  for
         example,  both your balance sheet and statements of operations and cash
         flows for a  particular  period,  you should  clearly  illustrate  that
         correlation in your  description of the error.  Your disclosure  should
         provide a clear  illustration of how you progressed from each financial
         statement  line item "as  reported"  to "as  adjusted"  in each period,
         disaggregating the total error affecting each line item,  preferably in
         tabular  format  with  footnote  disclosure.  Examples of items that we
         would like you to clarify  based on the  information  included  in your
         December 22, 2006  supplemental  response follow;  however,  you should
         provide enhanced information for each error, as our list of examples is
         not exhaustive.

         o    In  general,   your  use  of  the  term   "erroneously"  does  not
              sufficiently  tell  us how  you  determined  that  your  financial
              statements  were in error.  For example,  tell us what is meant by
              your "erroneous" recording of the $1,365,000 error related to your
              issuance of common  shares to a former  director  in exchange  for
              previously   incurred  debt.  Please  also  revise  your  proposed
              disclosures to Note I accordingly.

         o    Tell us why you recorded the $3,960,000 decrease in "non-cash cost
              of common stock issued  pursuant to an employee stock option plan"
              in your  statement of cash flows for the year ended  September 30,
              2005 and clarify the line items that this  adjustment  affected in
              your corresponding balance sheet and statement of operations.

         o    Tell  us why  you  recorded  the  $9,079,000  adjustment  to  your
              statement  of cash flows for the year ended  September  30,  2005,
              which you attribute to stock  subscription  proceeds.  Clarify the
              other   financial   statement  line  items  that  this  adjustment
              affected.

         RESPONSE:  We propose to amend our Footnote M to the September 30, 2005
         financial statements to read as follows:

         The accompanying  consolidated financial statements as of September 30,
         2005 for the year ended  September  30,  2005 and for the  period  from
         September 16, 2002 (date of inception)  through September 30, 2005 have
         been  restated  to  correct  the  accounting  for (a) the  issuance  of
         warrants in exchange for compensation and financing activities, (b) the
         valuation of stock issued in settlement of related party debt,  (c) the
         unrecorded   expense  accruals  relating  to  penalties  due  for  late
         registration,   and  (d)  the   errors   in  report   preparation   and
         miscellaneous   accounting   adjustments   appropriate   for  the  fair
         presentation of the financial statements.





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 13



         The  effect  of  these  adjustments  is an  increase  in  net  loss  of
         $14,499,139  for the period from September 16, 2002 (date of inception)
         through  September 30, 2006 and for the year ended  September 30, 2005.
         The effect on cash flows used in operations  was a reduction of $23,903
         for the year ended  September  30,  2005 and an increase of $5,604 from
         September 16, 2002 (date of inception) to September 30, 2005. Cash flow
         used in  investing  activities  increased by $16,757 for the year ended
         September  30,  2005 and  decreased  by  $12,750  for the  period  from
         September 16, 2002 (date of inception) through September 30, 2005. Cash
         flow from financing  activities  increased by $7,146 for the year ended
         September 30, 2005 and for the period from  September 16, 2002 (date of
         inception) through September 30, 2005.

         The following tables summarize the effects of these  adjustments on the
         Company's   consolidated  balance  sheet  as  of  September  30,  2005,
         consolidated  statements of operations for the year ended September 30,
         2005 and from September 16, 2002 (date of inception)  through September
         30,  2005 and the  consolidated  statements  of cash  flow for the year
         ended  September  30, 2005 and for the period from  September  16, 2002
         (date of inception) through September 30, 2005.



                                                 Condensed Consolidated Balance Sheet
                                                          September 30, 2005

                                                              As Previously
                                                                Reported          Adjustment      Reference  As Restated
                                                            ---------------------------------------------------------------
                                                                                                
Cash                                                        $          31,190    $                          $       31,190
Accounts receivables and advances                           $          12,429    $                          $       12,429
Total current assets                                        $          43,619    $                          $       43,619
Property, plant and equipment, net                          $           8,064    $                          $        8,064
Deposits                                                    $          14,262    $                          $       14,262
Patents, net                                                $          22,493    $                          $       22,493
Intellectual property, net                                  $       9,094,082    $                          $    9,094,082
Total assets                                                $       9,182,520    $                          $    9,182,520
Accounts payable and accrued liabilities                    $       2,185,468    $        331,989     a     $    2,517,457
Accounts and notes payable, related party                   $         410,429    $         52,662     a     $      463,091
Total current liabilities                                   $       2,595,897    $        384,651     a     $    2,980,548
Debt derivative and warrant liability                       $               -    $     13,673,574     b     $   13,673,574
Total liabilities                                           $       2,595,897    $     14,058,225    a,b    $   16,654,122
Preferred stock                                             $               6    $                          $            6
Common stock                                                $         112,230    $                          $      112,230
Common stock subscribed                                     $          20,000    $                          $       20,000
Additional paid in capital                                  $      81,879,801    $        440,914     c     $   82,320,715
Accumulated deficit                                         $     (75,425,414)   $    (14,499,139)          $  (89,924,553)
Total deficiency in stockholders' equity                    $       6,586,623    $    (14,058,225)          $   (7,471,602)
Total liabilities and Deficiency in Stockholders' equity    $       9,182,520    $                          $    9,182,520






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 14




                                              Condensed Consolidated Statement of Losses
                                                 For the Year Ended September 30, 2005
                                                                                           
Operating expenses:
Selling, general & administrative           $          42,662,152   $     8,051,865           d        $       50,714,017
Research and development                    $             638,873   $                                  $          638,873
Depreciation and amortization               $             356,266   $                                  $          356,266
Total operating expenses                    $          43,657,291   $     8,051,865           d        $       51,709,156
Net loss from operations                    $         (43,657,291)  $    (8,051,865)          d        $      (51,709,156)
Net gain (loss) in fair value of debt
   derivative and warrant liability         $                   -   $    16,700,990           e        $       16,700,990
Other income (expense)                      $               4,957   $                                  $            4,957
Interest income (expense)                   $          (8,958,046)  $   (23,148,264)          f        $      (32,106,310)
Net loss                                    $         (52,610,380)  $   (14,499,139)        d,e,f      $      (67,109,519)
Net loss per share-basic and fully diluted  $               (0.82)  $         (0.23)                   $            (1.05)




                                            Condensed Consolidated Statement of Losses
                                  From September 16, 2002 (date of inception) through September 30, 2005
                                                                                           
Operating expenses:
Selling, general & administrative               $     63,483,689   $       8,051,915          d        $      71,535,604
Research and development                        $        877,408   $                                             877,408
Depreciation and amortization                   $        359,427   $                                   $         359,427
Total operating expenses                        $     64,720,524   $       8,051,915          d        $      72,772,439
Net loss from operations                        $    (64,720,524)  $      (8,051,915)         d        $     (72,772,439)
Net gain (loss) in fair value of debt
   derivative and warrant liability             $              -   $      16,700,990          e        $      16,700,990
Other income (expense)                          $         31,342   $                                   $          31,342
Interest income (expense)                       $    (10,736,232)  $     (23,148,214)         f        $     (33,884,446)
Net loss                                        $    (75,425,414)  $     (14,499,139)       d,e,f      $     (89,924,553)
Net loss per share-basic and fully diluted      $          (2.12)              (0.41)                  $           (2.53)






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 15




                                            Condensed Consolidated Statement of Cash Flows
                                                 For the Year Ended September 30, 2005
                                                                                                    
Cash flows from operating activities
Net income (loss)                                      $      (52,610,380)  $     (14,499,139)      d,e,f       $      (67,109,519)
Adjustments to reconcile to net used in operating
   activities
Depreciation and amortization                          $          350,107   $                                   $          350,107
Organization expenses                                  $                    $
Preferred shares issued in exchange for services       $                -   $                                   $                -
Warrants issued to consultants                         $          956,304   $       6,402,264         d         $        7,358,568
Income attributable to repricing of warrants and debt
   derivatives                                         $                    $     (16,700,991)        e         $      (16,700,991)
Financing costs attributable to issuance of warrants   $                    $      23,148,214         f         $       23,148,214
Amortization of beneficial conversion feature
   -convertible notes                                  $        8,836,000   $                                   $        8,836,000
Fair value of common stock issued to related party in
   excess of debt                                      $                -   $       1,365,000         d         $        1,365,000
Common stock issued in exchange for services           $       14,805,128   $       3,371,513         g         $       18,176,641
Common stock issued in exchange for intellectual
   property                                            $       14,689,100   $                                   $       14,689,100
Common stock issued for ESOP                           $        3,960,000   $      (3,960,000)        g         $                -
Common stock issued as penalty in connection with
   financing                                           $          776,529   $                                   $          776,529
Common stock canceled-previously issued for services
   rendered                                            $       (1,078,270)  $         500,000         g         $         (578,270)
Change in assets and liabilities:
Increase in accounts receivable                        $                    $         (12,429)        g         $          (12,429)
Increase in other assets                               $          (12,429)  $          12,429         g         $                -
Decrease in security deposits                          $            9,297                                                    9,297
Capital expenditures                                   $           16,757   $         (16,757)        h         $                -
Increase (decrease) in accounts payable and accrued
   liabilities                                         $          297,755   $         365,993        a,i        $          663,748
Increase in due related parties                        $         (111,943)                                                (111,943)
Net cash used in operating activities                  $       (9,116,045)  $         (23,903)  a,d,e,f,g,h,i   $       (9,139,948)
Cash flows from investing activities:
Payments for patent filing                             $           (4,347)                                                  (4,347)
Capital expenditures                                   $                    $          16,757         h         $           16,757
Net cash used in investing activities                  $           (4,347)  $          16,757         h         $           12,410
Cash flows from financing activities
Proceeds from sales of common stock, net               $                -   $                                   $
Proceeds from subscription of common stock             $        9,079,000          (9,079,000)        j
Proceeds from issuance of convertible notes            $                    $       9,079,000         j         $        9,079,000
Proceeds from exercise of options and warrants         $           70,750   $          32,000         g         $          102,750
Payment of debt                                        $                -   $         (24,854)        i         $          (24,854)
Proceeds from loans                                    $                -   $                                   $                -
Advances from shareholders                             $                -   $                                   $                -
Net cash provided by financing activities              $        9,149,750   $           7,146       g,i,j       $        9,156,896
Net increase in cash and cash equivalents              $           29,358   $               -                   $           29,358
Cash and cash equivalents at beginning of period       $            1,832   $               -                   $            1,832
Cash and cash equivalents at end of period             $           31,190   $               -                   $           31,190






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 16




                                   Condensed Consolidated Statement of Cash Flows
                        From September 16, 2002 (date of inception) through September 30, 2005
                                                                                                      
Cash flows from operating activities
Net income (loss)                                     $     (75,425,414)   $       (14,499,139)      d,e,f        $     (89,924,553)
Adjustments to reconcile to net used in operating
   activities
Depreciation and amortization                         $         353,268    $                                      $         353,268
Organization expenses                                 $          88,500    $                                                 88,500
Preferred shares issued in exchange for services      $       1,500,000    $                                      $       1,500,000
Warrants issued to consultants                        $       2,976,166    $        6,402,264          d          $       9,378,430
Income attributable to repricing of warrants and
   debt derivatives                                   $               -    $      (16,700,991)         e          $     (16,700,991)
Financing costs attributable to issuance of warrants  $               -    $       23,148,214          f          $      23,148,214
Amortization of beneficial conversion feature
   -convertible notes                                 $      10,461,000    $                                      $      10,461,000
Fair value of common stock issued to related party
   in excess of debt                                  $               -    $        1,365,000          d          $       1,365,000
Common stock issued in exchange for services                                                           g
                                                      $      27,202,860    $        3,371,513                     $      30,574,373
Common stock issued for ESOP                          $       3,960,000    $       (3,960,000)         g          $
Common stock issued in exchange for intellectual
   property                                           $      14,689,100    $                                      $      14,689,100
Common stock issued as penalty in connection with
   financing                                          $         776,529    $                                      $         776,529
Common stock canceled-previously issued for services                                                   g
   rendered                                           $      (1,363,845)   $          500,000                     $        (863,845)
Change in assets and liabilities:
Increase in accounts receivable                       $               -    $          (12,429)         g          $         (12,429)
Increase other current assets                         $         (12,429)   $           12,429          g          $
Increase in security deposits                         $         (14,262)   $                                      $         (14,262)
Increase in capital expenditures                      $         (12,750)               12,750          h
Increase in other assets                              $         (13,890)   $                                      $         (13,890)
Increase in due related parties                       $          40,753    $                                      $          40,753
Increase (decrease) in accounts payable and accrued
   liabilities                                        $       2,053,464    $          365,993         a,i         $       2,419,457
Net cash used in operating activities                 $     (12,740,950)   $            5,604    a,d,e,f,g,h,i    $     (12,735,346)
Cash flows from investing activities:
Payments for patent filing                            $         (25,698)   $                                      $         (25,698)
Capital expenditures                                  $                    $          (12,750)         h          $         (12,750)
Net cash used in investing activities                 $         (25,698)   $          (12,750)         h          $         (38,448)
Cash flows from financing activities
Proceeds from sales of common stock, net              $         432,000    $                                      $         432,000
Proceeds from subscription of common stock            $       9,204,000    $       (9,204,000)         j          $
Proceeds from issuance of convertible notes           $               -    $        9,204,000          j                  9,204,000
Proceeds from exercise of options and warrants        $         311,750    $           32,000          g          $         343,750
Payment of debt                                       $                    $          (24,854)         i          $         (24,854)
Proceeds from loans                                   $       2,750,000    $                                      $       2,750,000
Advances from shareholders                            $         100,088    $                                      $         100,088
Net cash provided by financing activities             $      12,797,838    $            7,146        g.i,j        $      12,804,984
Net increase in cash and cash equivalents             $          31,190    $                -                     $          31,190
Cash and cash equivalents at beginning of period      $               -    $                                      $               -
Cash and cash equivalents at end of period            $          31,190    $                -                     $          31,190






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 17


         (a) Accounts payable and accrued expenses:


                                  
         As previously reported      $ 2,185,468

         Adjustment, net                 331,989
                                     -----------
         As restated                 $ 2,517,457


         In connection with the placement of convertible promissory notes in the
         amount  of  $1,465,000  in  December  2004  and   $1,675,000  in  2003,
         aggregating $3,140,000, the Company was obligated pursuant to the terms
         of a registration rights agreement to pay liquidated damages of 3.5% of
         the aggregate convertible note financing amount each month in the event
         it failed  to have a  registration  statement  registering  the  shares
         underlying the  convertible  notes declared  effective by the specified
         deadline.  During its  comment  process on the  Company's  Registration
         Statement  on Form  SB-2,  as  amended,  the  Securities  and  Exchange
         Commission  requested that the Company  provide  additional  disclosure
         regarding  the  Company's  accounting policies in  connection  with the
         accounting for previously  issued common stock,  convertible  notes and
         warrants  issued pursuant to the  registration  rights  agreement.  The
         Company   initially  did  not  calculate  the  penalties   incurred  in
         connection  with its failure to meet the  deadline to file an effective
         registration  statement.  Following its review,  the Company  concluded
         that  such  penalties  should  be  calculated  as  3.5%  multiplied  by
         $3,140,000  multiplied by 3.5 months,  which resulted in an increase of
         $384,651.  The failure to properly account for such penalties  resulted
         in an  understatement  of  liquidated  damage  penalties  (included  in
         selling,   general  and  administrative  expense  in  the  accompanying
         restated  statement of losses) and an underestimate of accrued expenses
         as of September 30, 2005 aggregating $384,651.

         Separately,  the Company  reclassified  $52,662 of previously  incurred
         debt to an officer  from  accounts  payable  and  accrued  expenses  to
         accounts  and  notes  payable  -  related  parties.  As a result of the
         reclassification, accounts payable and accrued expenses were overstated
         by  $52,662  and  accounts  and notes  payable - related  parties  were
         understated  by  $52,662.  There  was no  adjustment  to the  Company's
         statement   of   operations   or  cash   flows  as  a  result   of  the
         reclassification of the liability.





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 18



         (b) In  conjunction  with  raising  capital  through  the  issuance  of
         convertible  promissory  notes,  the Company issued  warrants that have
         registration  rights for the underlying shares. As the contract must be
         settled by the  delivery of  registered  shares and the delivery of the
         registered  shares is not  controlled by the Company,  pursuant to EITF
         00-19, "Accounting for Derivative Financial Instruments Indexed to, and
         Potentially  Settled in, a Company's  Own Stock",  the net value of the
         warrants at the date of issuance was recorded as a warrant liability on
         the balance sheet charged to operations as interest  expense.  Upon the
         registration statement being declared effective,  the fair value of the
         warrants on that date will be reclassified  to equity.  The Company did
         not record the fair value of warrant  liability  of  $13,673,574  as of
         September  30,  2005 with the  original  filing.  The net effect of the
         adjustment is an increase in liabilities of $13,673,574 as of September
         30, 2005.

         (c) In  February,  2005 the  Company  issued  1,500,000  shares  of its
         restricted  common stock to a Company  officer and Director in exchange
         for $600,000 of previously incurred debt. The debt was in the form of a
         promissory note. The Company initially valued and recorded the issuance
         of the common  stock  based on the face value of the  promissory  note.
         Upon subsequent review the Company determined that the shares should be
         valued at $1.31 per share for a total of $1,965,000,  which  represents
         the  fair  value  of the  common  stock  on the  date of the  exchange.
         $1,365,000,  the difference  between the fair value of the common stock
         of  $1,965,000  and the face  value of the debt of  $600,000,  has been
         charged to current period selling,  general and administrative expense.
         The  Company  initially  recorded  the  value  of the  common  stock at
         $600,000. The net effect of the adjustment is an increase of $1,365,000
         in selling,  general and  administrative  expense during the year ended
         September 30, 2005.

         Separately,  the Company initially  recorded the fair value of warrants
         issued to non-employees in connection with its financing  activities as
         a charge to  interest  expense  with the offset to  additional  paid in
         capital.  Pursuant to EITF 00-19,  "Accounting for Derivative Financial
         Instruments  Indexed to, and  Potentially  Settled in, a Company's  Own
         Stock",  the net  value of the  warrants  at the date of  issuance  was
         recorded as a warrant liability on the balance sheet. The net effect of
         the adjustment is a decrease of $924,086 in interest expense during the
         year ended September 30, 2005.

         The following summarizes the adjustments:





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 19



                                                                                           
         Summary:
         Adjustment for Fair value of stock issued in settlement of related party debt:       $   1,365,000
         Reclassification of fair value of financing warrants issued pursuant to EITF 00-19        (924,086)
                                                                                              --------------
         Net effect:                                                                          $     440,914


         (d) In July 2005,  the Company  entered into an agreement  with Trilogy
         Capital  Partners,  Inc. and Joff Pollon  ("Trilogy"  and  "Pollon") to
         provide  marketing  services  to the  Company  for a term of one  year,
         terminable  thereafter  by  either  party  upon 30 days  prior  written
         notice.  In connection  with the  agreement,  the Company agreed to pay
         Trilogy a monthly fee of $12,500.  The Company also issued  Trilogy and
         Pollon warrants to purchase an aggregate of 9,000,000  shares of common
         stock at $0.55 per share,  exercisable for a period of three years from
         issuance. As the contract must be settled by the delivery of registered
         shares and the delivery of the  registered  shares is not controlled by
         the  Company,  pursuant  to  EITF  00-19,  "Accounting  for  Derivative
         Financial  Instruments  Indexed  to,  and  Potentially  Settled  in,  a
         Company's  Own  Stock",  the  Company  recorded  the net  value  of the
         warrants at the date of issuance as a warrant  liability of  $4,117,500
         and charged to  operations as consulting  fees.  Upon the  registration
         statement being declared  effective,  the fair value of the warrants on
         that date will be reclassified to equity.  The Company initially valued
         the warrants using the  Black-Scholes  pricing model with the following
         assumptions:  (1) a dividend yield of 0%; (2) an expected volatility of
         155.3%,  (3) a risk-free  interest  rate of 3.82%,  and (4) an expected
         life of 3 years.

         During the  quarter  ended  December  31,  2004,  the  Company  granted
         warrants  to  purchase   6,063,500   shares  of  its  common  stock  to
         non-employees  in exchange  for services and  financing  expenses.  The
         estimated  fair  value  of the  compensatory  warrants  granted  to the
         non-employees  in exchange  for  services  and  financing  expenses was
         initially  determined  using the  Black-Scholes  pricing  model and the
         following assumptions:  a contractual term of 2 to 5 years, a risk free
         interest  rate  from  2.47%  to  3.53%,  a  dividend  yield of 0% and a
         volatility  from 65.7% to 148.7%.  The amount of the expense charged to
         operations for  compensatory  warrants granted in exchange for services
         and financing  expenses was  $3,169,052  for the quarter ended December
         31, 2004.

         During the quarter ended March 31, 2005, the Company  granted  warrants
         to  purchase  55,000  shares of its common  stock to  non-employees  in
         exchange for  services.  The estimated  fair value of the  compensatory
         warrants  granted to the  non-employees  in exchange  for  services was
         determined  using the  Black-Scholes  pricing  model with the following
         assumptions:  a contractual  term of 5 years, a risk free interest rate
         of 3.67%, a dividend yield of 0% and volatility of 152.59%.  The amount
         of the expense charged to operations for compensatory  warrants granted
         in exchange for  services  was $72,017 for the quarter  ended March 31,
         2005.





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 20



                                                                                          
         Summary:
         Total value of warrants described above:                                            $    7,358,569
         Less previously recorded                                                                  (956,305)
                                                                                             ---------------
         Net:                                                                                      6,402,264
         Adjustment  to fair value of common stock issued in  settlement  of related  party
         debt (see (b) above)                                                                     1,365,000
         Penalties accrued due to late registration (see (a) above)                                 384,651
         Correction in value of shares issued for services rendered                                (100,000)
                                                                                             ---------------
         Net effect:                                                                         $    8,051,915


         (e) In  conjunction  with  raising  capital  through  the  issuance  of
         convertible   promissory   notes,  the  Company  issued  warrants  with
         registration  rights for the underlying shares. As the contract must be
         settled by the  delivery of  registered  shares and the delivery of the
         registered  shares is not  controlled by the Company,  pursuant to EITF
         00-19, "Accounting for Derivative Financial Instruments Indexed to, and
         Potentially  Settled in, a Company's Own Stock",  the Company  recorded
         the net  value of the  warrants  at the date of  issuance  as a warrant
         liability of $23,148,214 and charged to operations as interest expense.
         Upon the  registration  statement  being declared  effective,  the fair
         value of the warrant on that date will be reclassified  to equity.  The
         Company initially valued the warrants using the  Black-Scholes  pricing
         model with the following  assumptions:  (1) a dividend yield of 0%; (2)
         an expected  volatility  of 152.59%,  (3) a risk-free  interest rate of
         3.67%, and (4) an expected life of 5 years.

         In accordance with SFAS 133 "Accounting for Derivative  Instruments and
         Hedging Activities",  the Company revalued the warrants with underlying
         shares  subject to  registration  rights as of September 30, 2005 using
         the Black-Scholes option pricing model. Assumptions regarding the life,
         the expected  dividend yield and volatility were left unchanged but the
         Company  applied a risk free  interest  rate of 4.18%,  a volatility of
         155.91% and a deemed fair value of common stock of $0.57, which was the
         closing price of the Company's  common stock on September 30, 2005. The
         difference of $16,700,991  between the fair value of the warrants as of
         September 30, 2005 and the previous valuation as of February,  2005 has
         been  recorded  as a gain  on  revaluation  of  warrant  liability  and
         included in the restated consolidated financial statements.

         (f) Please refer to paragraph 1(e) above.

         (g) The Company  misclassified  a number of line items  within the cash
         flow statement;  the adjustments to correct these line items are as set
         forth below:


                                                                                   
         1  Common stock issued for services                                          $        3,371,513
         2  Correction of shares issued originally labeled ESOP                               (3,960,000)
         3  Correction of amount of shares cancelled, previously issued for services             500,000
         4  Decrease in change in accounts receivable                                            (12,429)
         5  Increase in change in other assets                                                    12,429
         6  Correction of proceeds from exercise of options and warrants                          32,000
         7  Accounts payable correction                                                           56,487
                                                                                      -------------------
            Net effect:                                                               $                0






Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 21


         (h) The Company initially  classified capital  expenditures as usage in
         cash flow for  operations.  The correct  classification  of the capital
         expenditures is under the investing activity.

         (i)  The  correction  of  the  errors  affecting  accounts  payable  is
         summarized below:


                                                                            
         1  Recording of accrual for penalties as described in (a) above:      $       384,651
         2  Misclassification of debt payments                                         (24,854)
         3  Accrual adjustments                                                          6,196
                                                                               ----------------
            Net effect                                                         $       365,993


         (j) In connection  with its financing  activities,  the Company  issued
         convertible  debt,  which was converted to common stock within the same
         accounting  period.  The Company has  revised  its  description  of the
         financing as proceeds  received from the issuance of  convertible  debt
         instead of a sale of common stock.





Mr. Jeffrey P. Riedler
U.S. Securities and Exchange Commission
Division of Corporation Finance
March 6, 2007
Page 22


         If you have any additional  comments or questions,  please feel free to
contact the undersigned at (212) 318-3261.

                                                    Very truly yours,

                                                    /s/ Merrill M. Kraines

                                                    Merrill M. Kraines

Enclosures

cc:      Mr. John Krug, Senior Staff Attorney
         Mary Mast, Senior Accountant
         Amy Bruckner, Staff Accountant
         James A. Hayward, Applied DNA Sciences, Inc.