POWER OF ATTORNEY

The undersigned, as a Section 16 reporting person of Pacific
Biosciences of California, Inc. (the "Company"), hereby constitutes
and appoints Susan Kim, Brett Atkins, Michele Farmer and Andrew
Hoffman, and each of them, the undersigned's true and lawful
attorney-in-fact to:

1. complete and execute Forms 3, 4 and 5 and other forms and all
amendments thereto as such attorney-in-fact shall in his or her
discretion determine to be required or advisable pursuant to
Section 16 of the Securities Exchange Act of 1934 (as amended) and
the rules and regulations promulgated thereunder, or any successor
laws and regulations, as a consequence of the undersigned's
ownership, acquisition or disposition of securities of the Company;
and

2. do all acts necessary in order to file such forms with the U.S.
Securities and Exchange Commission, any securities exchange or
national association, the Company and such other person or agency
as the attorney-in-fact shall deem appropriate.

The undersigned hereby ratifies and confirms all that said
attorneys-in-fact and agents shall do or cause to be done by virtue
hereof. The undersigned acknowledges that the foregoing attorneys-
in-fact, in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company assuming, any of
the undersigned's responsibilities to comply with Section 16 of the
Securities Exchange Act of 1934 (as amended).

This Power of Attorney shall remain in full force and effect until
the undersigned is no longer required to file Forms 3, 4 and 5 with
respect to the undersigned's holdings of and transactions in
securities issued by the Company, unless earlier revoked by the
undersigned in a signed writing delivered to the Company and the
foregoing attorneys-in-fact.

IN WITNESS WHEREOF, the undersigned has caused this Power of
Attorney to be executed as of May 27, 2022.

Signature: /s/ David Botstein

Name: David Botstein