EXHIBIT 5.1
OPINION ON LEGALITY


                      The Law Offices of John Dean Harper
                   201 Las Vegas Boulevard South, Suite 200
                            Las Vegas, NV  89101

April 26, 2007

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549

     AngioGenex, Inc.
     Registration Statement on Form S-8

Gentlemen:

        We have acted as special counsel to AngioGenex, Inc., a Nevada
corporation (the "Company"), in connection with the preparation for filing
with the U. S. Securities and Exchange Commission of a Registration
Statement on Form S-8 ("Registration Statement") under the Securities Act
of 1933, as amended.  The Registration Statement relates to the
registration of 200,000 shares ("Shares") of the Company's common stock,
par value $.001 per share ("Common Stock"), for a Legal/Administrative
Option Plan ("Plan") dated January 31, 2007.

        We have examined the Plan and such corporate records, documents,
instruments and certificates of the Company, and have reviewed such other
documents as we have deemed relevant under the circumstances.  In such
examination, we have assumed without independent investigation the
authenticity of all documents submitted to us as originals, the
genuineness of all signatures, the legal capacity of all natural persons,
and the conformity of any documents submitted to us as copies to their
respective originals.  As to certain questions of fact material to this
opinion, we have relied without independent investigation upon statements
or certificates of public officials and officers of the Company.

     Based upon and subject to the foregoing, we are of the opinion that
the Shares, when issued in accordance with the Plan, will be legally
issued, fully paid and non-assessable.

     In connection with this opinion, we have examined the Registration
Statement, the Company's Articles of Incorporation and By-laws, and such
other documents as we have deemed necessary to enable us to render the
opinion hereinafter expressed.

     We render no opinion as to the laws of any jurisdiction other than the
internal laws of the State of Nevada.

     We hereby consent to the use of this opinion as an exhibit to the
Registration Statement and to the reference to our name under the caption
"Legal Opinions" in the prospectus included in the Registration Statement.

      This opinion is conditioned upon the compliance by the Company
with all applicable provisions of the Securities Act of 1933, as amended,
and such state securities rules, regulations and laws as may be
applicable.

Very truly yours,

/s/ John Dean Harper
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    John Dean Harper, Esq.