Delisting Determination, The Nasdaq Stock Market, LLC, August 20, 2009,
Advanced Life Sciences Holdings, Inc..  The Nasdaq Stock Market, LLC
(the Exchange) has determined to remove from listing the common stock of
Advanced Life Sciences Holdings, Inc. (the Company), effective at the
open of business on August 31, 2009.  Based on a review of information
provided by the Company,Nasdaq Staff determined that the Company no longer
qualified for listing on the Exchange as it failed to comply with Rule
5505(b)(2).  (Rule 5505(b)(2) was enumerated as Rule 4310(c)(2)(B)
at the time of the determination.)  The Company was notified of the Staffs
determination on October 1, 2008. On November 5, 2008, after review of the
Companys compliance plan, staff notified the Company that its shares would
be delisted unless it requested a hearing. On November 12, 2008, the
Company excercised its right to appeal the Exchange Staffs determination
to the Listing Qualifications Hearings Panel (Panel) pursuant to Rule
5815(a)(1)(A).  Upon review of the information provided by the Company,
the Panel determined to grant an extension to the Company until May 4,
2009.  On April 22, 2009, the Company requested that the Panel grant it an
extension to June 16, 2009.  On April 28, 2009, the Panel issued a decision
affirming its February 2, 2009 decision.  On May 4, 2009, the Company
exercised its right to appeal the April 28, 2009 Panel decision to the
Nasdaq Listing and Hearing Review Council (the Council) pursuant to Rule
5820(a). Pursuant to the Panel decisions, the Companys securities were
suspended from trading at the open of trading on May 5, 2009.  On June 24,
2009, the Council affirmed the Panel decision to delist the companys
securities.