FIRST TRUST SERIES FUND
                       120 EAST LIBERTY DRIVE, SUITE 400
                            WHEATON, ILLINOIS 60187



                               December 22, 2010


Securities and Exchange Commission
100 F Street, N.E.
Washington, DC 20549

Re:            First Trust Preferred Securities and Income Fund;
             First Trust/Confluence Small-Cap Value Fund  (the"Funds")
             ---------------------------------------------------------

Ladies and Gentlemen:

    The  undersigned, First Trust Series Fund (the "Registrant") and First Trust
Portfolios  L.P.,  the  principal  underwriter  of  the  Funds,  pursuant to the
provisions of Rule 461 of the General Rules and Conditions of the Securities and
Exchange  Commission  (the  "Commission")  under  the Securities Act of 1933, as
amended,  hereby  respectfully request that the Commission grant acceleration of
the  effectiveness  of  Pre-Effective  Amendment  No.  1  to  the  Registrant's
Registration  Statement  on  Form  N-1A  (Registration No. 333-168727), filed on
December  22,  2010, so that the same may become effective at 3:00 p.m., Eastern
Time  on  December  29,  2010  or  as  soon  thereafter  as  practicable.

                                 Very truly yours,

                                 First Trust Series Fund


                                 By: /s/ W. Scott Jardine
                                     ----------------------------
                                     W. Scott Jardine, Secretary


                                 First Trust Portfolios L.P.

                                 By: /s/ W. Scott Jardine
                                     ----------------------------
                                     W. Scott Jardine, Secretary