AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 1, 2016

                                                          1933 ACT FILE NO. 333-
                                                    1940 ACT FILE NO. 811- 03763
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            _______________________

                           REGISTRATION STATEMENT ON
                                    FORM S-6

                            ________________________

              FOR REGISTRATION UNDER THE SECURITIES ACT OF 1933 OF
                      SECURITIES OF UNIT INVESTMENT TRUSTS
                           REGISTERED ON FORM N-8B-2

     A.   EXACT NAME OF TRUST: GUGGENHEIM DEFINED PORTFOLIOS, SERIES 1449

     B.   NAME OF DEPOSITOR: GUGGENHEIM FUNDS DISTRIBUTORS, LLC

     C.   COMPLETE ADDRESS OF DEPOSITOR'S PRINCIPAL EXECUTIVE OFFICES:

                       Guggenheim Funds Distributors, LLC
                           2455 Corporate West Drive
                             Lisle, Illinois 60532

     D.   NAME AND COMPLETE ADDRESS OF AGENT FOR SERVICE:

Copies to:

    AMY LEE, ESQ.                                   ERIC F. FESS, ESQ.
    Vice President and Secretary                    Chapman and Cutler LLP
    Guggenheim Funds Distributors, LLC              111 West Monroe Street
    2455 Corporate West Drive                       Chicago, Illinois 60603
    Lisle, Illinois  60532                          (312) 845-3000
    (630) 505-3700

It is proposed that this filing will become effective (check appropriate box)

    [_]   immediately upon filing pursuant to paragraph (b)

    [_]   on (date) pursuant to paragraph (b)

    [_]   60 days after filing pursuant to paragraph (a)(1)

    [_]   on (date) pursuant to paragraph (a)(1) of rule 485

    [_]   This post-effective amendment designates a new effective date for a
          previously filed post-effective amendment.

     E.   TITLE OF SECURITIES BEING REGISTERED: Units of fractional undivided
          beneficial interest.

     F.   APPROXIMATE DATE OF PROPOSED SALE TO PUBLIC: As soon as practicable
          after the effective date of the Registration Statement.

    [_]   Check box if it is proposed that this filing will become effective on
          (date) at (time) pursuant to Rule 487.

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      The registration hereby amends this Registration Statement on such date or
dates as may be necessary to delay its effective date until the registrant shall
file a further amendment which specifically states that this Registration
Statement shall thereafter become effective in accordance with Section 8(a) of
the Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a)
may determine.


                   PRELIMINARY PROSPECTUS DATED MARCH 1, 2016

           GUGGENHEIM DEFINED PORTFOLIOS, SERIES 1449 (the "Series")

        S&P Dividend Aristocrats Select 25 Strategy Portfolio, Series 3
           (the "S&P Dividend Aristocrats Select 25 Strategy Trust")
                       Global Growth Portfolio, Series 5
                          (the "Global Growth Trust")
                  US 50 Dividend Strategy Portfolio, Series 8
                     (the "US 50 Dividend Strategy Trust")
                Rising Rate Defensive Equity Portfolio, Series 5
                   (the "Rising Rate Defensive Equity Trust")

                           (A Unit Investment Trust)

      The above-referenced Series is comprised of the S&P Dividend Aristocrats
Select 25 Strategy Portfolio, Series 3, Global Growth Portfolio, Series 5, US 50
Dividend Strategy Portfolio, Series 8 and Rising Rate Defensive Equity
Portfolio, Series 5 (each, a "trust" and together, the "trusts").

      The attached final prospectuses for the prior series of the trusts are
hereby used as the preliminary prospectus for the above-referenced Series. The
narrative information and structure of the attached final prospectuses will be
substantially similar to that of the final prospectus for this Series.
Information with respect to pricing, the number of units, dates and summary
information regarding the characteristics of securities to be deposited in this
Series is not available as of this date and will be different because each
series has a unique portfolio. Accordingly, the information contained herein
with regard to the previous series should be considered as being included for
informational purposes only. Ratings of the securities in this Series are
expected to be comparable to those of the securities deposited in the previous
series.

      The registration statement relating to the units of this Series is not
complete, may be changed and is not yet effective. Information contained herein
is subject to completion or amendment. The units of this Series may neither be
sold nor may an offer to buy such units be accepted prior to the time the
registration statement becomes effective. This prospectus shall neither
constitute an offer to sell nor be considered a solicitation of an offer to buy
the units. There shall be no sale of the units in any state in which such offer,
solicitation or sale would be unlawful prior to registration or qualification
under the securities laws of any such state.

      For purposes of the S&P Dividend Aristocrats Select 25 Strategy Trust
incorporated herein by reference is the final prospectus for Guggenheim Defined
Portfolios, Series 1411 (Registration No. 333-208222) as filed on January 26,
2016, which shall be used as the preliminary prospectus for such S&P Dividend
Aristocrats Select 25 Strategy Trust. For purposes of the Global Growth Trust
and Rising Rate Defensive Equity Trust incorporated herein by reference are
portions of the final prospectus for Guggenheim Defined Portfolios, Series 1374
(Registration No. 333-206598) as filed on October 22, 2015, which shall be used
as the preliminary prospectus for such Global Growth Trust and Rising Rate
Defensive Equity Trust. For purposes of the US 50 Dividend Strategy Trust
incorporated herein by reference is the final prospectus for Guggenheim Defined
Portfolios, Series 1410 (Registration No. 333-208221) as filed on January 25,
2016 which shall be used as the preliminary prospectus for such US 50 Dividend
Strategy Trust.

                          UNDERTAKING TO FILE REPORTS

      Subject to the terms and conditions of Section 15(d) of the Securities
Exchange Act of 1934, the undersigned registrant hereby undertakes to file with
the Securities and Exchange Commission such supplementary and periodic
information, documents, and reports as may be prescribed by any rule or
regulation of the Commission heretofore or hereafter duly adopted pursuant to
authority conferred in that section.

                       CONTENTS OF REGISTRATION STATEMENT

     A.   Bonding Arrangements of Depositor:

     The Depositor has obtained the following Securities Dealer Blanket Bond for
its officers, directors and employees:

               INSURER/POLICY NO.                             AMOUNT

          National Union Fire Insurance
       Company of Pittsburgh, Pennsylvania
                     5692790                                $4,000,000

     This Registration Statement comprises the following papers and documents.

                 The Facing Sheet
                 The Prospectus
                 The Signatures
                 Consents of Counsel
                 Exhibits

     The following exhibits:

     1.1  Reference Trust Agreement (to be supplied by amendment).

   1.1.1  Standard Terms and Conditions of Trust (Reference is made to Exhibit
          1.1.1 to Amendment No. 2 to the Registration Statement on Form S-6 for
          Claymore Securities Defined Portfolios, Series 116 (File No.
          333-72828) filed on December 18, 2001).

     2.1  Code of Ethics (Reference is made to Exhibit 2.1 to the Registration
          Statement on Form S-6 for Claymore Securities Deferred Portfolios,
          Series 213 (File No. 333-122184) filed on February 9, 2005).

     3.1  Opinion of counsel as to legality of the securities being registered
          including a consent to the use of its name in the Registration
          Statement (to be supplied by amendment).

     3.2  Opinion of counsel as to Federal and New York Income tax status of the
          securities being registered including a consent to the use of its name
          in the Registration Statement (to be supplied by amendment).

     3.3  Opinion of counsel as to the Trustee and the Trust(s), including a
          consent to the use of its name in the Registration Statement (to be
          supplied by amendment).

     4.1  Consent of Independent Registered Public Accounting Firm (to be
          supplied by amendment).

     6.0  Powers of Attorney authorizing Amy Lee to execute the Registration
          Statement. (Reference is made to Exhibit 6.0 to the Registration
          Statement on Form S-6 for Guggenheim Defined Portfolios, Series 1401
          (File No. 333-208180) filed on November 23, 2015).

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant,
Guggenheim Defined Portfolios, Series 1449 has duly caused this Registration
Statement to be signed on its behalf by the undersigned thereunto duly
authorized, in the City of Lisle, and State of Illinois, on the 1st day of
March, 2016.

                          GUGGENHEIM DEFINED PORTFOLIOS, SERIES 1449, Registrant

                               By: GUGGENHEIM FUNDS DISTRIBUTORS, LLC, Depositor

                                                                 By: /s/ Amy Lee
                                                                 ---------------
                                                                         Amy Lee
                                                    Vice President and Secretary

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the date indicated:



     SIGNATURE*                          TITLE                                 DATE
                                                                         
                                                                           )
                                                                           )   By:    /s/ Amy Lee
                                                                           )          -----------
                                                                           )          Amy Lee
DONALD C. CACCIAPAGLIA*                  Chief Executive Officer and       )          Attorney-in-Fact*
                                         President of Guggenheim Funds     )
                                         Distributors, LLC                 )          March 1, 2016
                                                                           )
DOMINICK COGLIANDRO*                     Chief Operating Officer of        )          March 1, 2016
                                         Guggenheim Funds Distributors,    )
                                         LLC                               )
                                                                           )
JULIE JACQUES*                           Treasurer of Guggenheim Funds     )          March 1, 2016
                                         Distributors, LLC                 )
                                                                           )
JULIE JACQUES*                           Principal Financial Officer of    )          March 1, 2016
                                         Guggenheim Funds Distributors,    )
                                         LLC                               )

FARHAN SHARAFF                           Chief Investment Officer of
                                         Guggenheim Funds Distributors,
                                         LLC

/s/ Amy Lee                              Vice President and Secretary of              March 1, 2016
-----------                              Guggenheim Funds Distributors,
AMY LEE                                  LLC


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*    Executed copies of the related powers of attorney were filed as Exhibit 6.0
     to the Registration Statement of Guggenheim Defined Portfolios, Series 1401
     on November 23, 2015.



            CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

     The consent of Grant Thornton LLP to the use of its report and to the
reference to such firm in the Prospectus included in the Registration Statement
will be filed as Exhibit 4.1 to the Registration Statement.

                       CONSENT OF CHAPMAN AND CUTLER LLP

     The consent of Chapman and Cutler LLP to the use of its name in the
Prospectus included in the Registration Statement will be contained in its
opinion to be filed as Exhibits 3.1 and 3.2 to the Registration Statement.

                        CONSENT OF DORSEY & WHITNEY LLP

     The consent of Dorsey & Whitney LLP to the use of its name in the
Prospectus included in the Registration Statement will be contained in its
opinion to be filed as Exhibit 3.3 to the Registration Statement.

                                   MEMORANDUM

                 Re: Guggenheim Defined Portfolios, Series 1449

     The list of securities comprising the trust of the fund, the evaluation,
record and distribution dates and other changes pertaining specifically to the
new series, such as size and number of units of the trust in the fund and the
statement of financial condition of the new fund will be filed by amendment.

                                    1940 ACT

                             FORMS N-8A AND N-8B-2

     Form N-8A and Form N-8B-2 were filed in respect of Guggenheim Defined
Portfolios, Series 718 (and subsequent series) (File No. 333-169214).

                                    1933 ACT

                                 THE INDENTURE

     The form of the proposed Standard Terms and Conditions of Trust is expected
to be in all respects consistent with the form of the Standard Terms and
Conditions of Trust dated December 18, 2001 relative to Claymore Securities
Defined Portfolios, Series 116.

                                                          CHAPMAN AND CUTLER LLP

Chicago, Illinois
March 1, 2016