EXHIBIT 4.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the reference to our firm under the caption "Experts-Independent Registered Public Accounting Firm" and to the use of our report dated May 2, 2016 in the Amendment No. 1 to the Registration Statement (File No. 333-210352) and related Prospectus of Guggenheim Defined Portfolios, Series 1450. /s/ Grant Thornton LLP ---------------------- GRANT THORNTON LLP Chicago, Illinois May 2, 2016