Chapman and Cutler LLP 111 West Monroe Street Chicago, Illinois 60603 April 12, 2017 Mr. Edward Bartz Division of Investment Management Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Re: Guggenheim Defined Portfolios, Series 1596 Floating Rate & Dividend Growth Portfolio, Series 14 File Nos. 333-216604 and 811-03763 -------------------------------------------------------------------------------- Dear Mr. Bartz: This letter is in response to your comment given during a telephone conversation with our office regarding the registration statement on Form S-6 for Guggenheim Defined Portfolios, Series 1596, filed on March 10, 2017, with the Securities and Exchange Commission (the "Commission"). The registration statement proposes to offer the Floating Rate & Dividend Growth Portfolio, Series 14 (the "Trust"). PROSPECTUS Investment Summary -- Principal Risks 1. The duration example in the seventh bullet uses a duration of three years. Please confirm that the average weighted duration of the fixed-income securities held indirectly by the Trust is approximately three years or less. If not, please revise this example to reflect the average weighted duration of the fixed-income securities. Response: The sponsor confirm that the average weighted duration of the fixed-income securities held indirectly by the Trust is approximately three years or less and, therefore, the example does not need to be revised. We appreciate your prompt attention to this registration statement. If you have any questions or comments or would like to discuss our responses to your questions, please feel free to contact the undersigned at (312) 845-3484. Very truly yours, CHAPMAN AND CUTLER LLP By /s/ Morrison C. Warren ------------------------- Morrison C. Warren