August 14, 2017

Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C.  20549


          Re: Guggenheim Defined Portfolios, Series 1619 (the "Fund")
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Ladies and Gentlemen:

      Enclosed please find a copy of Amendment No. 1 to the Registration
Statement on Form S-6 for the registration under the Securities Act of 1933 of
units representing the ownership of interests in the subject Fund. This
Amendment No. 1 to the Registration Statement is filed on June 2, 2017, on
behalf of Guggenheim Funds Distributors, LLC (the "Sponsor").

      Inasmuch as the Fund is not yet operative, no filings have been required
under any of the acts administered by the Commission. Therefore, for purposes of
Securities Act Release No. 5196 there are no delinquencies to be reported or
other references to be made to filings under the 1934 Act.

      No notification of registration or Registration Statement under the
Investment Company Act of 1940 is currently being submitted to the Commission,
as the filings under the 1940 Act (File No. 811-03763) are intended to apply not
only to that series of the Fund, but to all "subsequent series" as well.

      The Fund is expected to be comprised of the following unit investment
trust: NDR Thematic Opportunities Portfolio, Series 1 (the "Trust"). The Trust
will invest in a portfolio of common stocks. We ask that the Commission review
the Trust as a result of the staff of the Commission's request that the first
series of a strategy be reviewed.

      We are advised that the Sponsor proposes to deposit securities and to
activate the subject Fund on August 23, 2017.

      In the event that you may have any questions with regard hereto or if
there is any way which we can be of assistance, please do not hesitate to
telephone Eric F. Fess collect at (312) 845-3781 or Morrison C. Warren at (312)
845-3484.

                                                               Very truly yours,

                                                      /s/ Chapman and Cutler LLP
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                                                          CHAPMAN AND CUTLER LLP