UNITED STATES
                        SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                   FORM 10-Q


[X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934

    For the quarterly period ended March 31, 2013

[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
    EXCHANGE ACT OF 1934

    For the transition period from ___________ to ___________


                       Commission File No. 333-192374


                             SIGNAL ADVANCE, INC.
             (Exact name of registrant as specified in its charter)



                                    Texas
         (State or Other Jurisdiction of Incorporation or Organization)

                                     8731
             (Primary Standard Industrial Classification Number)

                                  76-0373052
                     (IRS Employer Identification Number)

                             2520 County Road 81
                            Rosharon, Texas 77583
                               (713) 510-7445
          (Address and telephone number of principal executive offices)


Securities registered pursuant to Section 12(b) of the Act:  None

Securities registered pursuant to Section 12(g) of the Act:  None
















                                         1


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for shorter period that the registrant as required
to file such reports), and (2) has been subject to such filing requirements for
the past 90 days.  Yes [X] No [ ]

Indicate by check mark whether the registrant has submitted electronically and
posted on its corporate Web site, if any, every Interactive Data File required
to be submitted and posted pursuant to Rule 405 of Regulation S-T (Sec. 232.405
of this chapter) during the preceding 12 months (or for such shorter period that
the registrant was required to submit and post such files).  Yes [X] No [ ]

Indicate by check mark whether the registrant is a large accelerated filer, an
accelerated filer, or a non-accelerated filer. See definition of "accelerated
filer and large accelerated filer" in Rule 12b-2 of the Exchange Act.(Check one)

      Large accelerated filer  [ ]          Accelerated filer          [ ]
      Non-accelerated filer    [ ]          Smaller reporting company  [X]

Indicate by check mark whether the registrant is a shell company (as defined
in Rule 12b-2 of the Act).  Yes [ ] No [X]

As of March 31, 2013, the registrant had 9,662,409 shares of common stock issued
and outstanding. No market value has been computed based upon the fact that no
active trading market has been established as of March 31, 2013.

































                                         2

                                 TABLE OF CONTENTS

                                      PART I

   ITEM  1     Financial Statements and Supplementary Data....................4

   ITEM  2     Management's Discussion and Analysis of Financial
                Condition and Results of Operations..........................15

   ITEM  3     Quantitative and Qualitative Disclosures about
                Market Risk..................................................19

   ITEM  4     Controls and Procedures.......................................19


                                      PART II

   ITEM  1     Legal Proceedings.............................................21

   ITEM  1A    Risk Factors..................................................21

   ITEM  2     Unregistered Sales of Equity Securities and Use of Proceeds...21

   ITEM  3     Defaults Upon Senior Securities...............................21

   ITEM  4     Mine Safety Disclosures.......................................21

   ITEM  5     Other Information.............................................21

   ITEM  6     Exhibits......................................................22





























                                         3

                                    PART I

ITEM 1.  Financial Statements and Supplementary Data


                               SIGNAL ADVANCE, INC.

                FINANCIAL STATEMENTS AND SUPPLEMENTARY INFORMATION

                 Interim Three Month Period Ended March 31, 2014


TABLE OF CONTENTS                                                       Page No.

ACCOUNTANT'S REPORT.......................................................F 1

FINANCIAL STATEMENTS

    Balance Sheet.........................................................F 2

    Statements of Income and Retained Earnings (Accumulated Deficit)......F 3

    Statement of Cash Flows...............................................F 4

    Notes to Financial Statements.......................................F 5-9

  SUPPLEMENTARY INFORMATION

    Schedule of General, Selling and Administrative Expenses.............F 10































                                         4

Bobby J. Hutton
Certified Public Accountant
4824 Courtside Drive
Fort Worth, TX 76133

             Report of Independent Registered Public Accounting Firm
             -------------------------------------------------------

The Board of Directors
Signal Advance, Inc.
2520 CR 81
Rosharon, TX  77583

We have reviewed the accompanying balance sheet of Signal Advance, Inc. (A Texas
Corporation) as of the interim three month period ended March 31, 2014 and, and
the related statements of income and retained earnings (accumulated deficit) and
cash flows the interim three month period ended March 31, 2014. The financial
statements are the responsibility of management.

We conducted our review in accordance with the standards of the Public Company
Accounting Oversight Board (United States). A review of interim financial
information consists principally of applying analytical procedures and making
inquiries of persons responsible for financial and accounting matters. It is
substantially less in scope than an audit conducted in accordance with the
standards of the Public Company Accounting Oversight Board, the objective of
which is the expression of an opinion regarding the financial statements taken
as a whole.  Accordingly we do not express such an opinion.

Based on our review, we are not aware of any material modifications that should
be made to the accompanying interim financial statements for them to be in
conformity with generally accepted accounting principles in the United States.

The accompanying financial statements have been prepared assuming that the
Company will continue as a going concern. As discussed in Note A in the
financial statements, the Company's operating losses raise substantial doubt
about its ability to continue as a going concern. The financial statements do
not include any adjustments that might result from this uncertainty.





Very truly yours,

/s/ Bobby J. Hutton

Bobby J. Hutton
Certified Public Accountant

Fort Worth, Texas
April 25, 2014







                                                                             F 1

                                         5

                               Signal Advance, Inc.
                                  Balance Sheets
                     As of March 31, 2014 and December 31, 2013
                                   (Unaudited)







Mar 31, 2014

Dec 31, 2013
                                                    ------------    ------------
ASSETS
  Current Assets
    Cash or Cash Equivalent
                              28,492          11,497
                                                    ------------    ------------
  Total Current Assets                                   28,492          11,497

  Fixed Assets
    Cost/Basis                                          126,467         125,807
    Depreciation                                       (122,299)       (121,884)
                                                    ------------    ------------
  Total Fixed Assets                                      4,169           3,924

  Other Assets
    Available for Sale Securities - Note C                    0              13
    Long-Term Investments                                21,438          21,438
                                                    ------------    ------------
  Total Other Assets                                     21,438          21,451
                                                    ------------    ------------
TOTAL ASSETS                                             54,099          36,871
                                                    ============    ============


LIABILITIES & EQUITY
  Liabilities


    Loan from Shareholder - Note F          36,807         118,406
                                                    ------------    ------------
  Total Liabilities                                      36,807         118,406

  Shareholders' Equity







    Common Stock - $0 par value
      - shares issued and outstanding
          9,662,409, as of Mar. 31, 2014
          9,520,409, as of Dec. 31, 2013

    Capital Investment
      Cash                                              709,101         667,101
      Services/Assets                                 3,609,732       3,509,732
                                                    ------------    ------------
    Total Capital Investment                          4,318,834       4,176,834

    Retained Earnings                                (4,258,368)     (3,057,220)
    Net Income                                          (43,174)     (1,201,149)
                                                    ------------    ------------
  Total Equity                                           17,292         (81,535)
                                                    ------------    ------------
TOTAL LIABILITIES & EQUITY                               54,099          36,871






                                         6

                  See Accompanying Notes and Accountant's Report             F 2


                               Signal Advance, Inc.
                  Statements of Income and Expense Distribution
            Interim Three Month Periods Ended March 31, 2014 and 2013
                                   (Unaudited)


                                                 Jan-Mar, 2014     Jan-Mar, 2013
                                                 -------------     -------------
  Ordinary Income/Expense
      Income
        Other Income
0                 0
                                                 -------------     -------------
      Total income                                          0                 0
                                                 -------------     -------------
    Gross Profit                                            0                 0
                                                 -------------     -------------

      Expense
        General, Selling & Administrative               8,642            13,788
        Intellectual Property Protection -Note B        7,418             5,575
        Professional Services                          22,686             1,846
        Research and Development                        4,000                 0
        Depreciation                                      415               677
                                                 -------------     -------------
      Total Expense                                    43,161            21,886
                                                 -------------     -------------
    Net Ordinary Income                               (43,161)          (21,886)

    Other Income/Expense
      Other Expense
        Available for Sale Securities - Note C
             13                 0
                                                 -------------     -------------
    Total Other Expense                                    13                 0
                                                 -------------     -------------
  Net Other Income                                        (13)                0
                                                 -------------     -------------
NET INCOME                                            (43,174)          (21,886)
                                                 =============     =============

















                                         7

                  See Accompanying Notes and Accountant's Report             F 3

                               Signal Advance, Inc.
                             Statements of Cash Flow
            Interim Three Month Periods Ended March 31, 2014 and 2013
                                   (Unaudited)

                                                 Jan-Mar, 2014     Jan-Mar, 2013
                                                 -------------     -------------
    OPERATING ACTIVITIES
      Net Income                                      (43,174)          (21,886)
      Adjustments to reconcile Net Income
      to net cash provided by operations:
        Depreciation                                      415               677
        Non-Cash Expenses:
          Services Rendered in
          Exchange for Equity                         100,000                 0
                                                 -------------     -------------
      Net cash provided by Operating Activities        57,241           (21,209)

    INVESTING ACTIVITIES
      Fixed Assets (Cost/Basis)                          (660)           (1,520)
      Available for Sale Securities                        13                 0
                                                 -------------     -------------
    Net cash provided by Investing Activities            (648)           (1,520)

    FINANCING ACTIVITIES
      Capital Investment (Sale of Common Stock)        42,000                 0
      Loan from Shareholder                           (81,599)           64,655
                                                 -------------     -------------
    Net cash provided by Financing Activities         (39,599)           64,655

  Net cash increase for period                         16,995            41,925

  Cash at beginning of period                          11,497             8,110
                                                 -------------     -------------
Cash at end of period                                  28,492            50,035


Supplemental Disclosure

  Interest Expense                                        898             2,343

















                                         8

                   See Accompanying Notes and Accountant's Report            F 4

NOTE A - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

NATURE OF OPERATIONS AND ORGANIZATION:  Signal Advance, Inc. (the Company) is
currently conducting operations. Signal Advance, Inc., incorporated in Texas on
June 4, 1992, is an engineering product and procedure development and consulting
firm focused on the development of applications for emerging technologies. The
Company has significant experience in computer technology, distributed
information systems, and data acquisition and analysis systems, as well as,
medical education, intellectual property protection and medical-legal litigation
support. The Company has focused its resources on the improvement of signal
detection systems through the development and refinement of its proprietary
"Signal Advance" technology which has potential application in a wide range of
medical applications, as well as applications outside of biomedicine.

CASH AND CASH EQUIVALENTS: The Company considers all highly liquid investments
purchased with an original maturity of three months or less to be cash
equivalents.

IMPAIRMENT: The Company anticipates amortizing intangible assets over their
estimated useful lives unless such lives are deemed indefinite. Amortized in-
tangible assets are tested for impairment based on undiscounted cash flows, and,
if impaired, written down to fair value based on either discounted cash flows or
appraised values. Intangible assets with indefinite lives are tested annually
for impairment and written down to fair value as required. No impairment of
intangible assets has been identified during any of the periods presented.

USE OF ESTIMATES IN FINANCIAL STATEMENT PREPARATION: The preparation of the
financial statements in conformity with accounting principles generally accepted
in the United States of America requires the use of estimates and assumptions
that affect the reported amounts of assets and liabilities, the disclosure of
contingent assets and liabilities at the date of the financial statements, and
the reported amounts of revenues and expenses during the reporting period. The
Company's financial statements include amounts and all adjustments that, in the
opinion of management and based on management's best estimates and judgments,
are necessary to make the financial statement not misleading. Actual results
could differ from those estimates.

AVAILABLE FOR SALE SECURITIES: The Company holds certain investments that are
treated as available-for-sale securities (FASB ASC 320-10-25) and stated at
their fair market values. All investments are available for current operations
and are classified as other assets in the balance sheet. Unrealized holding
gains and losses are included as a component of other comprehensive income
(loss) until realized (FASB ASC 320-35-1). Realized gains and losses are
determined by the specific identification method and are included in 'Other
Income (Loss)' in the income statement.

RESEARCH AND DEVELOPMENT: Research and development costs are expensed as
incurred until technological feasibility can be determined (FASB ASC 730-10-25).
Upfront and milestone payments made to third parties in connection with research
and development collaborations are expensed as incurred up to the point of
regulatory approval, marketability, licensing, lease, or sale when the net
present value and useful life is able to be determined. Payments made to third
parties subsequent to the aforementioned events will be capitalized. Amounts
capitalized for such payments will be included in other intangibles, less the
net of the accumulated amortization, once their useful lives can be determined.

                                         9

      Accompanying Notes are an Integral Part of the Financial Statements    F 5

REVENUE RECOGNITION: The Company revenues are generated by: 1) Providing
consulting services; 2) Licensing intellectual property; and 3) Providing
consulting services to licensees to facilitate implementation. Revenue is not
recognized until it is realized or realizable and earned (FASB Concepts State-
ment No. 5, Recognition and Measurement in Financial Statements of Business
Enterprises, paragraphs 83-84). In accordance with ASC 605, 'Revenue Recogni-
tion,' the Company recognizes as revenue the fees charged clients as referenced
below because 1) persuasive evidence of an arrangement exists, 2) the fees
charged as royalties and/or for services are substantially fixed or determinable
during the period in which services are provided or royalties are collected, 3)
the company and its clients understand the specific nature and terms of the
agreed upon transactions, and 4) collectability is reasonable assured after
services have been rendered, or according to a royalty payment schedule.

Consulting Revenue - For revenues generated by providing engineering, scientific
and medical/legal consulting services. Services are charged at an hourly rate
and clients are charged and revenue is recognized monthly.

License Revenue - As part of the Company's business model and as a result of the
company's on-going investment in research and development, the company plans to
license and sell the rights to certain of its intellectual property (IP)
including internally developed patents, trade secrets and technological know-
how. The typical license will call for a non-refundable initiation fee,
escalating minimum royalties to be paid before a given product is marketed, and
continuing royalties based on gross sales once marketing has begun, confirmed by
annual audits. The license will also include a set amount of time for
consulting. Licensees will also be required to participate in patent maintenance
and defense.

Certain transfers of IP to third parties may be licensing/royalty-based,
transaction-based, or other forms of transfer. Licensing/royalty-based fees
involve transfers in which the company earns the income over time, as a lump-sum
payment or the amount of income is not fixed or determinable until the licensee
sells future related products (i.e., variable royalty, based upon licensee's
revenue). Accordingly, following delivery and or legal conveyance of rights to
the aforementioned IP to the client, and following inception of the license
term, revenue is recognized in a manner consistent with the nature of the
transaction and the earnings process.

Combined License/Consulting Revenue - in certain circumstances the license
agreement will also include consulting services to facilitate the use of the
Company's IP, in which case the arrangement may include multiple deliverables.
If the client is dependent on the consulting services of the Company to bring
value to the license then the license and consulting services will be considered
a single unit of accounting. If, however, the license has value to the client,
independent of the consulting services provided by the Company, then each
deliverable has value on a standalone basis. As such each delivered item or
items shall be considered a separate unit of accounting (FASB ASC 605-25).

Alternatively, license terms may contain a citation of milestones of achievement
by the licensee. Each milestone may be tied to an increase in the minimum royal-
ty. For example, biomedical milestones may include completion of animal trials,
submission and then approval of 510K applications or pre-market approval by the
FDA. Each licensee pursuing a biomedical application will be expected to develop
its own clinical data to secure such pre-market notification (510k) or approval.
Under these circumstances, the deliverable, or unit of accounting, consideration

                                        10

     Accompanying Notes are an Integral Part of the Financial Statements     F 6

may be contingent on the substantive achievement of one or more milestones. As
such, revenue is recognized in its entirety in the period in which the milestone
is achieved (FASB ASC 605-28).

During the Interim three month periods ended March 31, 2013 and the year ended
December 31, 2013, the Company recognized no revenue.

PROPERTY, PLANT AND EQUIPMENT:  Fixed Assets (land, buildings and equipment) are
carried at cost less accumulated depreciation. Depreciation is based on the
estimated service lives of depreciable assets and is provided using the Modified
Accelerated Cost Recovery System (MACRS) method. In the case of disposals,
assets and related depreciation are removed from the accounts, and the net
amounts, less proceeds from disposal, are included in income.

INCOME TAXES:  The Company takes an asset and liability approach to financial
accounting and reporting for income taxes. The difference between the financial
statement and tax basis of assets and liabilities is determined annually.
Deferred income tax assets and liabilities are computed for those differences
that have future tax consequences using the currently enacted tax laws and rates
that apply to the periods in which they are expected to affect taxable income.
Valuation allowances are established, if necessary, to reduce the deferred tax
asset to the amount that will assure full realization (FASB ASC 740). As of
December 31, 2012, the Company recorded a valuation allowance that reduced its
deferred tax assets to zero.

CONCENTRATIONS OF CREDIT RISK: Financial instruments which potentially subject
the Company to significant concentrations of credit risk consist primarily of
investment securities. Investment securities are exposed to various risks, such
as interest rate, market and credit risks. Due to the level of risk associated
with certain investment securities, it is reasonably possible that changes in
the values of investment securities can occur in the near term and that each
change could materially affect the amounts reported in the financial statement.

GOING CONCERN: The Company is currently conducting operations. However, it has
not yet generated sufficient operating revenue to fund its development
activities to date. As such, the Company has relied on funding by the Company's
President and the sale of its common stock. There is a substantial doubt that
the Company will generate sufficient revenues in future years to meet its
operating cash requirements. Accordingly, the Company's ability to continue
operations in the short-term depends on its success in obtaining equity or debt
financing in an amount sufficient to support its operations. This could raise
doubt as to its ability to continue as a going concern. The financial state-
ments do not include any adjustments that might result from this uncertainty.

NOTE B - INTELLECTUAL PROPERTY

Intellectual property protection is being pursued for the specifically identifi-
able intellectual property (IP) termed Signal Advance technology. The following
table lists the patent applications, issued patents and their respective status:
            Patent Office      Patent or Appl. No.  Status
            -----------------  -------------------  -----------------
            United States      8452544              Issued May 2013
            China              ZL 200880015288.2    Issued Nov. 2012
            Europe             EP 08 75 4879.8      Under examination
            Mexico             MX/A/2009/00921      Claims Allowed
            India              3465/KOLNP/2009      Not yet examined

                                        11

      Accompanying Notes are an Integral Part of the Financial Statements    F 7

Additional patent submissions related to specific applications, SA circuit
configurations, and signal processing techniques are in preparation.

The IP derives from an assignment of the IP in the form of a patent application
filed with the USPTO as well as any patents which issue as a result of U.S. and
related international patent applications.

As ASSIGNEE, the Company is responsible for:

1) funding and executing activities required for any regulatory approval,
   development, implementation and commercialization;
2) introducing assigned products which incorporate the patent pending or
   patented technology to the commercial market;
3) make its best efforts to:
     a) develop and market assigned products and services, and
     b) increase and extend the commercialization of assigned products, and
4) commence the advertising and marketing assigned products not later than 24
   months following the granting of the patent.

The assignment was privately negotiated between the Company's President, Dr.
Hymel (Assignor) and the remaining members of the board of directors for the
Company (Assignee). Consideration to acquire the IP rights, in the form of
equity (specifically 1,525,000 shares of SAI common stock, to date) was expensed
as the assignment is considered a transaction between entities under common
control (FASB ASC 805-50-30-5,6). The value of the common stock issued in ex-
change for the equity was based on the most recent private sales of stock (FASB
ASC 505-50-30-6). In addition, royalties are payable to Assignor on net sales
and/or license fees as follows: a) <$10M: 6%; b) $10-$25M: 8%, and c)>$25M: 10%.
Assignor's remedy for non-payment is the termination of the assignment.

The costs incurred in acquiring the assignment of the Signal Advance IP as well
as the pursuit of domestic and international patent and trademark protection are
expensed (included as "Intellectual Property" under expenses on the Statements
of Income and Retained Earnings (Accumulated Deficit)) for the the interim three
month periods ended March 31, 2014, and 2013. These costs include expenses to
prepare and prosecute patent applications and protect the IP, include filing and
issuance fees, fees for consultants, experts, advisors, patent attorneys,
including foreign associates, patent applications, claims and other amendments,
responses to office actions, etc. Any patent infringement case may hinder the
Company's ability to generate revenues.

NOTE C - AVAILABLE FOR SALE SECURITIES

Cost and fair value of available for sale securities (acquired Jan. 10, 2011) as
of March 31, 2014 are as follows:
                                         Cost     Gross Gain(Loss)    Fair Value
                                        -------   ----------------    ----------
Equity Securities Available for Sale    $25,000
      (25,000)             -0-

NOTE D - EQUIPMENT

Property and equipment as of March 31, 2104 and December 31, 2013 are summarized
as follows:




                                        12

     Accompanying Notes are an Integral Part of the Financial Statements    F 8

                                    Mar. 31, 2014    Dec. 31, 2013
                                    -------------    -------------
           Cost/Basis                   126,467          125,807
           Depreciation                (122,299)        (121,884)
                                    -------------    -------------
           Total Fixed Assets             4,169            3,924

Depreciation expense during the interim periods ended March 31, 2014 and 2013
were $415 and $677, respectively.

NOTE E - INCOME TAXES

Operating Loss Carry-Forwards:  As of December 31, 2013, the Company has a net
operating tax loss carry-forward of $1,201,149. Other loss carry-forwards from
previous periods may be offset against future federal income taxes. If not used,
loss carry-forwards will expire as indicated in the following table:

        Year
   Operating Losses

     Year
   Operating Losses
        ----   ----------------      ----   ----------------
        2022        108,119          2028      1,443,756
        2023        104,123          2029        306,926
        2024        114,901          2030         32,146
        2025         52,988          2031        160,674
        2026        218,176          2032        179,372
        2027        256,471          2033      1,201,149

Deferred Tax Asset:  A valuation allowance was not recognized for the full
amount of the deferred tax asset because, based on the weight of available
evidence, it is more likely than not that some portion or the entire deferred
tax asset will not be realized.

Tax Depreciation:  The Company uses the Modified Accelerated Cost Recovery
System (MACRS) for depreciation of property for tax purposes.

Note F - SHORT TERM LOAN

The President has loaned funds to the Company under the terms of a Line of
Credit Promissory Note negotiated with, and approved by, the Board of Directors.

NOTE G - FACILITIES LEASE

The Company currently leases office space, from its president, on a month to
month basis at a rate of $700 per month. The following is a schedule of future
minimum payments for 4 years under the above operating lease as of the year
ended December 2013.
                           Year      Amount
                          ------    -------
                           2014     $ 8,400
                           2015       8,400
                           2016       8,400
                           2017       8,400
                          ------    -------
                          Total:    $33,600

Rental expense amounted to $2,100 for the interim three month periods ended
March 31, 2014 and 2013.

                                        13

      Accompanying Notes are an Integral Part of the Financial Statements    F 9


SUPPLEMENTAL INFORMATION

                               Signal Advance, Inc.
             Schedules of General, Selling and Administrative Expenses
             Interim Three Month Periods Ended March 31, 2014 and 2013
                                  (Unaudited)


                                            Jan-Mar, 2014   Jan-Mar, 2013
                                            -------------   -------------
             Automobile Expense                      0           3,085
             Bank Service Charges                  106              35
             Employee Benefits                   1,641               0
             Fees/Licenses                         300               0
             Insurance                             215             300
             Interest Expense                      898           2,343
             Maintenance and Repairs                94              39
             Marketing/Advertising                 250             250
             Meals/Entertainment                   381             111
             Office Supplies                        47             401
             Postage and Delivery                  128              79
             Rent - Note G                       2,100           2,100
             Telephone                             300             450
             Travel                              1,219           3,280
             Utilities                             962           1,316
                                            -------------   -------------
             Total Expense                       8,642          13,788





























                                        14

                  See Accompanying Notes and Accountant's Report            F 10

Item 2. Management's Discussion and Analysis of Financial Condition
        and Results of Operations

FORWARD-LOOKING STATEMENTS

The following discussion should be read in conjunction with our financial state-
ments, including the notes thereto, appearing elsewhere in this annual report.
This report may contain forward-looking statements which relate to future events
or our future financial performance. These statements often can be identified by
the use of terms such as "may," "will," "expect," "believe," "anticipate,"
"estimate," "plan," "approximate" or "continue," or the negative  thereof. We
intend that such forward-looking statements be subject to the safe harbors for
such statements. We wish to caution readers not to place undue reliance on any
such forward-looking statements, which speak only as of the date made. Any
forward-looking statements represent management's best judgment as to what may
occur in the future. However, forward-looking statements are subject to risks,
uncertainties and important factors beyond our control that could cause actual
results and events to differ materially from historical results of operations
and events and those presently anticipated or projected. We disclaim any
obligation subsequently to revise any forward-looking statements to reflect
events or circumstances after the date of such statement or to reflect the
occurrence of anticipated or unanticipated events. Unless the context requires
otherwise, the terms 'Company,' 'SAI,' 'SA,' 'we,' 'our,' and 'us' refer to
Signal Advance Inc., a Texas corporation formed on June 4, 1992. Our audited
financial statements are stated in United States Dollars and are prepared in
accordance with U.S. Generally Accepted Accounting Principles.


                            RESULTS OF OPERATIONS

We have incurred recurring losses to date. Our financial statements have been
prepared assuming that we will continue as a going concern and, accordingly, do
not include adjustments relating to the recoverability and realization of
assets and classification of liabilities that might be necessary should we be
unable to continue in operation.

Our auditors have issued a going concern opinion as the Company has generated
insufficient revenues to fund planned R&D, marketing and intellectual protec-
tion in the near-term. SAI will continue to rely on capital investment to cover
the projected costs to execute the Company's business plan and commercialize
its proprietary signal advance technology. We expect we will require additional
capital to meet our long term operating requirements. We anticipate raising
additional capital through, among other things, the sale of equity or debt
securities. There is no assurance that the Company will be able to raise the
required capital which would result in operations being scaled back accordingly.

The majority of the Company's resources are devoted to technology development
and protection of its proprietary technology aa well as raising the required
capital to execute our business plan.

INCOME:  In the interim three month period ended March 31, 2014 and 2013, the
Company recognized no revenue.







                                        15

EXPENSES:  Expenses are classified into the following four broad categories:
Depreciation, Intellectual Property Protection, Professional Services, R&D, and
General, Selling and Administrative. SAI has engaged consultants to accomplish
its goals over the last two years. Given sufficient capital, the majority of
these consultants have expressed interest in working for us full-time.
Professional Services includes expenses for accounting, legal, transfer agent
and director's fees. The increase seen in expenses during the interin three
month period ended March 31, 2014 and 2013 for Professional Services reflect
expenses related to the registration of securities and fulfillment of reporting
requirements with the Securities and Exchange Commission as well as intellectual
property (IP) protection. Research and Development expenses reflect on-going
efforts related to in scientific, technical and commercial validation, business
development and investigation into specific applications for our propietary
technology.

Expenses for the interim three month period ended March 31, 2014 and 2013, were
as follows:
                                             Jan-Mar, 2014     Jan-Mar, 2013
                                             -------------     -------------
  General, Selling & Administrative                 8,642            13,788
  Intellectual Property Protection                  7,418             5,575
  Professional Services                            22,686             1,846
  Research and Development                          4,000                 0
  Depreciation                                        415               677
                                             -------------     -------------
                                                   43,161            21,886

OTHER EXPENSE:  Other Expense included and impairment "write-down" related to
"Available for Sales Securities" in the amount of $13 in the interim three month
period ended March 31, 2014.

                        LIQUIDITY AND CAPITAL ASSETS

CURRENT ASSETS:  As of March 31, 2014 and December 31, 2013, the Company had
cash and cash equivalents of $28,492 and $11,497. These assets are used as
working capital to execute the Company's business plan. The Company requires
additional capital through debt or equity financing to fund operations.

Fixed assets (office/laboratory equipment) were $4,169 as March 31, 2014 and
$3,924 as of December 31, 2013.

OTHER ASSETS:  During the interim three month period ended March 31, 2014 and
2013, significant resources continued to be applied to intellectual property
(IP) and protection. This includes 1) responses to preliminary searches and
initial office actions resulting from the international filings, 2) preparation/
submission of amendments, additional disclosures 3) reviews of, and responses
to, office actions to the European and Mexican patent offices and 4) issuance
and annual renewal fees. Patents have issued in China (Nov. 2012) and in the US
(May 2013) and the patent claims have been allowed in Mexico.

All costs associated with IP protection have been expensed. IP protection costs
totaled $7,418 and $5,575, respectively, during the interim three month periods
ended March 31, 2014 and 2013, Further discussion regarding the intellectual
property can be found in Note B - Intellectual Property, starting on page (F7
of the Financial Statements and Supplementary Information).

Results from a single long term investment were discussed previously under
'Other Expense'. Available for sale securities lost the remaining value ($13)
by March 31, 2014.

                                        16

LIABILITIES:  Liabilities include a short-term loan from its President which was
reduced to $36,807 by March 31, 2013 from $118,406 as of December 31, 2013 as
the Company President converted $100,000 of the short-term debt into equity.

SHAREHOLDERS' EQUITY:  Accumulated deficit totaled $4,301,542 and $4,258,368 on
March 31, 2014 and December 31, 2913, respectively. The shares issued and
outstanding as of March 31, 2014 and December 31, 2913, totaled 9,662,409 and
9,520,409,respectively.

OFF-BALANCE SHEET TRANSACTIONS:  There are no off-balance sheet items, all
transactions are in U.S. dollars, and SAI is not currently subject to currency
fluctuations or similar market risks.

                       SIGNIFICANT ACCOUNTING POLICIES

CASH AND CASH EQUIVALENTS:  The Company considers highly liquid investments pur-
chased with an original maturity of three months or less to be cash equivalents.

AVAILABLE FOR SALE SECURITIES:  The Company holds certain investments that are
treated as available-for-sale securities and stated at their fair market values.
All investments are available for current operations and are classified as other
assets in the balance sheet. Realized gains and losses are determined by the
specific identification method and are included in 'Other Income (Loss)' in the
income statement.

RESEARCH AND DEVELOPMENT:  Research and development expenses are expensed as
incurred until technological feasibility can be determined. Upfront and mile-
stone payments made to third parties in connection with research and development
collaborations are expensed as incurred up to the point of regulatory approval,
marketability, licensing, lease, or sale when the net present value and useful
life is able to be determined. Costs associated with intellectual property
protection have been expensed until such time as the useful can be determined,
at which time, amounts capitalized will be included in intangible property, less
the net of accumulated amortization.

REVENUE RECOGNITION:  Revenue is not be recognized until it is realized or
realizable and earned. An extended discussion regarding the sources of revenue
expected as well as how revenue from these sources will be recognized can be
found under 'Revenue Recognition' beginning on F6 of the Financial Statements
and Supplementary Information).

PROPERTY, PLANT AND EQUIPMENT:  Fixed Assets (land, buildings and equipment) are
carried at cost less accumulated depreciation. Depreciation is based on the
estimated service lives of depreciable assets and is provided using the Modified
Accelerated Cost Recovery System (MACRS) method. In the case of disposals,
assets and related depreciation are removed from the accounts, and the net
amounts, less proceeds from disposal, are included in income.

INCOME TAXES:  The Company takes an asset and liability approach to financial
accounting and reporting for income taxes. Differences between the financial
statement and tax basis of assets and liabilities is determined annually.
Deferred income tax assets and liabilities are computed for those differences
that have future tax consequences using the currently enacted tax laws and rates
that apply to the periods in which they are expected to affect taxable income.
Valuation allowances are established, if necessary, to reduce the deferred tax
asset to the amount that will assure full realization. As of December 31, 2013,
the Company recorded a valuation allowance that reduced its deferred tax assets
to zero.

                                        17

CONCENTRATIONS OF CREDIT RISK:  Financial instruments which may subject the
Company to significant concentrations of credit risk consist primarily of in-
vestment securities. Investment securities are exposed to various risks, such as
interest rate, market and credit risks. Due to the level of risk associated with
certain investment securities, it is reasonably possible that changes in the
values of investment securities can occur in the near term and that such change
could materially affect the amounts reported in the financial statements.

IMPAIRMENT:  The Company amortizes intangible assets over their estimated useful
lives unless such lives are deemed indefinite. Amortized intangible assets are
tested for impairment based on undiscounted cash flows, and, if impaired,
written down to fair value based on either discounted cash flows or appraised
values. Intangible assets with indefinite lives are tested annually for
impairment and written down to fair value as required.

DEFERRED TAX ASSET:  A valuation allowance was not recognized for the full
amount of the deferred tax asset because, based on the weight of available
evidence, it is more likely than not that some portion or the entire deferred
tax asset will not be realized.

NET EARNINGS PER SHARE:  Basic earnings per share is computed by dividing net
income available to common shareholders by the weighted average number of
common shares outstanding for the period.

                       PLAN OF OPERATION AND FUNDING

We anticipate that required working capital will continue to be funded through
a combination of our existing funds and further issuances of securities. Working
capital requirements will likley to increase in line with the business growth.

Existing working capital, further advances, debt instruments, and firm
commitments are expected to be adequate to fund our operations over the next
three months. We have no lines of credit or other bank financing arrangements.
Generally, we have financed operations to date through the proceeds of the
private placement of equity and debt instruments. In connection with our
business plan, management anticipates additional increases in operating expenses
and capital expenditures relating to: i) technology development, ii) marketing
and commercialization, and iii) intellectual property protection. We intend to
finance these expenses with further issuances of securities, and debt issuances.
Thereafter, we expect we will need to raise additional capital and generate
revenues to meet long-term operating requirements.

Additional issuances of equity or convertible debt securities will result in
dilution to our current shareholders. Also, such securities may have rights,
preferences or privileges senior to our common stock. Additional financing may
not be available upon acceptable terms, or at all. If adequate funds are not
available or are not available on acceptable terms, we may not be able to take
advantage of prospective new business endeavors or opportunities, which  could
significantly and materially restrict our business operations.

MATERIAL COMMITMENTS:

Payments due by Period:   Total    <1 yr    1-3 yrs   3-5 yrs   >5 yrs
                          ------   ------   -------   -------   -------
 Office Lease (per year)  $8,400   $8,400

PURCHASE OF SIGNIFICANT EQUIPMENT: We do not intend to purchase any significant
equipment during the next six months.

                                        18

                                GOING CONCERN

The independent auditors' report accompanying our Financial Statements and
Supplementary Information for the interim three month period ended March 31,
2014 and fiscal year ended December 31, 2013, contains an explanatory paragraph
expressing substantial doubt about our ability to continue as a going concern.
The financial statements have been prepared "assuming that we will continue as
a going concern," which contemplates that we will realize our assets and satisfy
our liabilities and commitments in the ordinary course of business.


Item 3. Quantitative and Qualitative Disclosures about Market Risk

Not applicable to smaller reporting companies.


Item 4. Controls and Procedures

MANAGEMENT'S REPORT ON DISCLOSURE CONTROLS AND PROCEDURES:  Management is
responsible for establishing and maintaining adequate internal control over
financial reporting (as defined in Exchange Act Rule 13a-15(f)). Internal
control over financial reporting is a process designed to provide reasonable
assurance regarding the reliability of financial reporting and the preparation
of financial statements for external purposes in accordance with accounting
principles generally accepted in the United States of America. Because of its
inherent limitations, internal control over financial reporting may not prevent
or detect misstatements. Also, projections of any evaluation of effectiveness to
future periods are subject to the risk that controls may become inadequate
because of changes in conditions, or that compliance with the policies or
procedures may deteriorate. Management evaluated the effectiveness of the
Company's internal control over financial reporting as of December 31, 2013
using the criteria established in 'Internal Control - Integrated Framework'
issued by the Committee of Sponsoring Organizations of the Treadway Commission
("COSO").

A material weakness is a deficiency, or combination of deficiencies, in internal
control over financial reporting, such that there is a reasonable possibility
that a material misstatement of the Company's annual or interim financial state-
ments will not be prevented or detected on a timely basis. In its assessment of
the effectiveness of internal control over financial reporting as of October 31,
2013, based on the above referenced guidelines, the Company determined that
there were control deficiencies that constituted material weaknesses, as
described below.

1) We do not have an Audit Committee - While not being legally obligated to have
   an audit committee, it is the management's view that such a committee, in-
   cluding a financial expert member, is an important entity level control over
   the Company's financial statement. Currently the Board of Directors acts in
   the capacity of the Audit Committee, and does not include a member that is
   considered to be independent of management to provide the necessary oversight
   over management's activities.









                                        19

2) We did not maintain appropriate cash controls - As of December 31, 2013, the
   Company has not maintained sufficient internal controls over financial
   reporting for the cash process, including failure to segregate cash handling
   and accounting functions, and did not require dual signature on the Company's
   bank accounts. Alternatively, the effects of poor cash controls were
   mitigated by the fact that the Company had limited transactions in their
   bank accounts.

3) We did not implement appropriate information technology controls - As at
   December 31, 2013, the Company retains copies of all financial data and
   material agreements and periodically make backups of the Company's data;
   however there is no formal procedure or evidence of normal backup of the
   Company's data or off-site storage of data in the event of theft,
   misplacement, or loss due to unmitigated factors.

Accordingly, the Company concluded that these control deficiencies resulted in a
reasonable possibility that a material misstatement of the annual or interim
financial statements will not be prevented or detected on a timely basis by the
company's internal controls.  As a result of the material weaknesses described
above, management has concluded that the Company did not maintain effective
internal control over financial reporting as of March 31, 2013 based on criteria
established in Internal Control - Integrated Framework issued by COSO.

CHANGES IN INTERNAL CONTROL OVER FINANCIAL REPORTING:  There has been no change
in our internal control over financial reporting identified in connection with
our evaluation we conducted of the effectiveness of our internal control over
financial reporting as of March 31, 2013, that occurred subsequent to the
evaluation that has materially affected, or is reasonably likely to materially
affect, our internal control over financial reporting.

This annual report does not include an attestation report of the Company's
registered public accounting firm regarding internal control over financial
reporting. Management's report was not subject to attestation by the Company's
registered public accounting firm pursuant to rules of the SEC applicable to an
Emerging Growth Company  that permit the Company to provide only management's
report in this annual report.
























                                        20

                                     PART II

Item 1.  Legal Proceedings

We know of no legal proceedings to which we are a party or to which any of our
property is the subject which are pending, threatened or contemplated or any
unsatisfied judgments against us.


Item 1A. Risk Factors

Not applicable to smaller reporting companies.



Item 2.  Unregistered Sales of Equity Securities and Use of Proceeds

During the interim three month period ended March 31, 2914, the Company's
President converted $100,000 in short term debt into equity. In additon, three
individuals invested a total of $42,000 to acquire equity (Common stock) in the
Company. The proceeds were used to fund on-going operations.

These issuances of unregistered were exempt pursuant to Section 4(2) of the
Securities Act as these were privately negotiated transactions in which there
was no advertising and no commissions paid. Accordingly, the stock certificates
representing these shares were issued with restrictive legends indicating that
the shares have not been registered and may not be traded until registered or
otherwise exempt from registration.

Item 3.  Defaults Upon Senior Securities

Not Applicable


Item 4.  Mine Safety Disclosures

Not Applicable


Item 5.  Other Information

Not Applicable



















                                        21

Item 6. Exhibits

The following exhibits are filed as part of this Quarterly Report.

31.1:      Certification of Chief Executive Officer pursuant to Section 302(a)
           of the Sarbanes-Oxley Act

31.2:      Certification of Chief Financial Officer pursuant to Section 302(a)
           of the Sarbanes-Oxley Act

32.1:      Certification of Chief Executive Officer and Chief Financial Officer
           under Section 1350 as Adopted Pursuant Section 906 of the Sarbanes-
           Oxley Act

101.INS*   XBRL Instance Document

101.SCH*   XBRL Taxonomy Extension Schema Document

101.CAL*   XBRL Taxonomy Extension Calculation Linkbase Document

101.DEF*   XBRL Taxonomy Definition Linkbase Document

101.LAB*   XBRL Taxonomy Extension Label Linkbase Document

101.PRE*   XBRL Taxonomy Extension Presentation Linkbase Document

* Furnished herewith. XBRL (Extensible Business Reporting Language) information
  is furnished and not filed or a part of a registration statement or prospectus
  for purposes of Sections 11 or 12 of the Securities Act of 1933, is deemed not
  filed for purposes of Section 18 of the Securities Exchange Act of 1934, and
  otherwise is not subject to liability under these sections.




























                                        22

SIGNATURES

In accordance with the requirements of the Exchange Act, the registrant
caused this report to be signed on its behalf by the undersigned, thereunto
duly authorized.



Dated: April 30, 2014
SIGNAL ADVANCE, INC.



                                       By: /s/ Chris M. Hymel




                                         Chris M. Hymel, President/Treasurer

Pursuant to the requirements of the Securities Act of 1933, this Registration
Statement has been signed by the following persons in the capacities and as
of the dates indicated.

SIGNATURE                 TITLE                               DATE
-----------------------   -------------------------------     ---------------

/s/ Chris M. Hymel        Member: Board of Directors,         April 30, 2014
Chris M. Hymel            President and Treasurer
                          (Principal Executive, Financial
                           and Accounting Officer)


/s/ Malcolm H. Skolnick   Member: Board of Directors,         April 30, 2014
Malcolm H. Skolnick       Secretary


/s/ Richard C. Seltzer    Member: Board of Directors          April 30, 2014
Richard C. Seltzer





























                                        23

Supplemental Information to be Furnished With Reports Filed Pursuant to
Section 15(d) of the Act by Registrants Which Have Not Registered Securities
Pursuant to Section 12 of the Act


As of the date of filing of this report, no annual report or proxy material
has been sent to security holders. An annual report and/or proxy material
will be furnished to security holders subsequent to the filing of the annual
report of this Form and the registrant shall furnish copies of such material
to the Commission when it is sent to security holders.

















































                                        24