Exhibit 32.1:  Certification of Chief Executive Officer and Chief Financial
               Officer under Section 1350 as Adopted Pursuant Section 906 of
               the Sarbanes-Oxley Act



               CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350
                           AS ADOPTED PURSUANT TO
                SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

The undersigned officer of Signal Advance, Inc. (the "Company"), hereby
certifies, to such officer's knowledge, that the Company's Quarterly Report
on Form 10-Q for the interim three month period ended March 31, 2014 (the
"Report") fully complies with the requirements of Section 13(a) of the
Securities Exchange Act of 1934 and that the information contained in the
Report fairly presents, in all material respects, the financial condition
and results of operations of the Company.



     /s/Chris M. Hymel

     Chris M. Hymel
     President/Treasurer


April 30, 2014