POWER OF ATTORNEY


I, the undersigned, hereby authorize and designate Anne Marie Cook (SVP,
General Counsel), Kimi Iguchi (Chief Financial Officer) and Erin Lanciani
(SVP, People and Organizational Strategy), for as long as they remain
employees of Sage Therapeutics, Inc., and Laurie Burlingame of Goodwin Procter,
each acting singly, or their successors in role, to take the following actions,
acting as my agent and attorney-in-fact, with full power of substitution:

          (1)  to prepare and sign on my behalf any Form 4 or Form 5 pursuant
to Section 16 of the Securities Exchange Act of 1934, as amended, and to file
the same with the Securities and Exchange Commission, NASDAQ, NYSE, and each
stock exchange on which shares of Common Stock or other securities of Sage
Therapeutics, Inc. are listed, as required by law;

          (2)  to prepare and sign on my behalf any Form 144  pursuant to the
Securities Act of 1933, as amended, and to file the same with the Securities
and Exchange Commission, NASDAQ, NYSE, and each stock exchange on which shares
of Common Stock or other securities of Sage Therapeutics, Inc. are listed, as
required by law; and

          (3)  take any other action necessary or proper in connection with
the foregoing.

Unless earlier revoked under the next sentence, this Power of Attorney shall
remain in effect as long as I am an executive officer or director of Sage
Therapeutics, Inc., and shall not be affected by my subsequent disability
or incompetence.  I may revoke this Power of Attorney by written notice
delivered, in person or by nationally recognized courier, to the attention
of the SVP, General Counsel of Sage Therapeutics, Inc.



                    /s/ Michael Cola
                    ____________________________________________________
                    (Signature of Executive Officer or Director)


                    Name:  Michael Cola

                    Date:    06/22/2016