POWER OF ATTORNEY


     I, the undersigned, hereby authorize and designate Chris Benecchi
(Chief Operating Officer) and Brandon Marsh (Senior Director,
Corporate Counsel), for as long as they remain employees of Sage
Therapeutics, Inc., and Stuart Falber of WilmerHale, each acting
singly, or their successors in role, to take the following actions,
acting as my agent and attorney-in-fact, with full power of
substitution:

(1)	 to prepare and sign on my behalf any Form 4 or Form 5
pursuant to Section 16 of the Securities Exchange Act of 1934, as
amended, and to file the same with the Securities and Exchange
Commission, Nasdaq, NYSE, and each stock exchange on which shares of
Common Stock or other securities of Sage Therapeutics, Inc. are
listed, as required by law;
(2)	 to prepare and sign on my behalf any Form 144 pursuant to the
Securities Act of 1933, as amended, and to file the same with the
Securities and Exchange Commission, Nasdaq, NYSE, and each stock
exchange on which shares of Common Stock or other securities of Sage
Therapeutics, Inc. are listed, as required by law; and

(3)	 take any other action necessary or proper in connection with
the foregoing.
     Unless earlier revoked under the next sentence, this Power of
Attorney shall remain in effect as long as I am a director or
executive officer of Sage Therapeutics, Inc., and shall not be
affected by my subsequent disability or incompetence. I may revoke
this Power of Attorney by written notice delivered, in person or by
nationally recognized courier, to the attention of the Senior Vice
President, General Counsel of Sage Therapeutics, Inc.


/s/ Gregory L. Shiferman
Name: Gregory L. Shiferman
Date: November 1, 2024