343 patents
Utility
Methodology for scaling methods between supercritical fluid chromatography systems
31 Jan 23
A methodology scales supercritical fluid chromatography (SFC) and/or carbon dioxide based chromatography methods between different system and/or column configurations.
Christopher J. Hudalla, Abhijit Tarafder
Filed: 12 Jun 14
Utility
Peristaltic Pump Having Temperature-compensated Volumetric Delivery
26 Jan 23
Described is a method for regulating a volume of liquid delivered by a peristaltic pump and a peristaltic pump system that can be used to perform the method.
Timothy M. Raymond, Sean Eric Anderson
Filed: 15 Jul 22
Utility
Apparatus for multi-specimen test instrument
24 Jan 23
Described are a test device, a multi-specimen test fixture star and a multi-specimen test fixture.
Jason L. Chinavare
Filed: 13 Dec 19
Utility
Method of Using Chemical Tags to Improve the Identification, Quantification and Spatial Localization of Components In a Sample
19 Jan 23
The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture.
Giuseppe Astarita, Darryl W. Brousmiche
Filed: 30 Aug 22
Utility
Method and apparatus for minimizing the chromatographic band distortion of a back pressure regulator
17 Jan 23
The technology generally relates to tailoring a back pressure regulator in a chromatographic system to reduce unswept volume within the back pressure regulator to achieve better sample detection and a reduction in chromatographic band distortion effects.
Michael O. Fogwill, Joseph D. Michienzi, Joshua A. Shreve, Scott Kelley, Emily J. Berg
Filed: 13 May 20
Utility
Haptic feedback for configuring materials testing systems
17 Jan 23
Disclosed is a material testing system that includes an output shaft configured to be moved by operation of a motor, the output shaft coupleable to a test specimen such that movement of the output shaft imparts a mechanical force on the test specimen.
David L. Dingmann
Filed: 24 Jun 21
Utility
Liquid chromatography thermal system with thermal status detection
17 Jan 23
A liquid chromatography system including a solvent delivery system, a sample delivery system in fluidic communication with solvent delivery system, a liquid chromatography column located downstream from the solvent delivery system and the sample delivery system, a detector located downstream from the liquid chromatography column, a thermal chamber housing at least one of the solvent delivery system, the sample delivery system, the liquid chromatography column and the detector, an engine configured to control the temperature in the thermal chamber, a heatsink operably connected to the engine, a first temperature sensor in the thermal chamber, a second temperature sensor, and a computer system configured to receive temperature information from each of the first and second temperature sensors, and implement a method for controlling temperature in the thermal chamber.
David A. Simpson, Cameron Chaput, Miguel M. Soares
Filed: 19 Jul 19
Utility
Mixer for chromatography system
17 Jan 23
Described is a mixer for a chromatography system.
Peyton C. Beals, Sylvain Gilles Cormier, Richard Wayne Andrews
Filed: 10 Aug 20
Utility
USE OF NEUTRAL pH MOBILE PHASES IN REVERSED PHASE CHROMATOGRAPHY OF ACIDIC PEPTIDES
12 Jan 23
The present disclosure discusses a method of separating and/or purifying acidic peptides by the use of a mobile phase having a pH greater than or about equal to the isoelectric point of one or more of the metal oxides in the flow path.
Samantha Ippoliti, Ying Qing Yu
Filed: 6 Jul 22
Utility
Heat flow rate determination for a single sample differential scanning calorimeter
3 Jan 23
A method and a calorimeter system for reducing error in a measured sample heat flow rate due to interpan heat exchange are described.
Robert L. Danley
Filed: 24 Nov 20
Utility
Passive Solvent Mixer for Liquid Chromatography
29 Dec 22
Described is a mixer for a liquid chromatography system.
Fabrice Gritti
Filed: 24 May 22
Utility
Fluorescence Tagging of Glycans and Other Biomolecules Through Reductive Amination for Enhanced MS Signals
29 Dec 22
Novel reagents comprising MS active, fluorescent compounds having an activated functionality for reaction with aldehydes and useful in labeling biomolecules such as glycans and methods of making the same are taught and described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 3 Jun 21
Utility
High Sample Throughput Differential Scanning Calorimeter
22 Dec 22
Described is a differential scanning calorimeter (DSC) instrument capable of performing analyses of multiple samples at the same time.
Donald J. Russell, David Serrell, Anthony E. Arnerich
Filed: 23 Aug 22
Utility
Techniques for Mass Spectrometry Peak List Computation Using Parallel Processing
22 Dec 22
Described are techniques for processing data.
Jose DE CORRAL
Filed: 28 Feb 22
Utility
Methods to increase sensitivity of LC/MS analysis
20 Dec 22
The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy.
Paul Rainville, Kerri Smith
Filed: 15 Jan 21
Utility
Separation of Nucleic Acid Component Compounds on Zwitterionic Stationary Phases
8 Dec 22
The present disclosure pertains to methods of separating nucleic acid component compounds from one another.
Kenneth Berthelette
Filed: 3 Jun 22
Utility
Check Valve Having a Spherical Loading Element
1 Dec 22
Described is a check valve having a valve housing, a valve seat, a ball and a spherical loading element.
Christopher Walden
Filed: 6 May 22
Utility
Methods of Enhancing MS Detection of Tagged Glycans
1 Dec 22
Methods for derivatization of biomolecules including glycans or other biopolymers with one or more fluorescent, MS active compounds by reductive amination or rapid tagging in order to produce derivatized glycan having a pKa >7 and between about 200 Å and about 1000 Å of nonpolar surface area are described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 2 May 22
Utility
Nickel-cobalt alloy material devices and components
29 Nov 22
Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors.
Jonathan L. Belanger, Hua Yang, Edouard S. P. Bouvier, Mathew DeLano, Raymond P. Fisk, Hillary B. Hewitson, Wade P. Leveille, Kevin Daniel Wyndham
Filed: 12 Aug 16
Utility
Equal Dispersion Split-flow Mixer
24 Nov 22
Disclosed is a liquid chromatography system and mixer for use therein that includes a first split connected to an inlet, the first split branching the flow of fluid from the inlet into a first path and a second path; a second split connected to an outlet of the first path, the second split branching the first path into a third path and a fourth path; and a third split connected to an outlet of the second path, the third split branching the second path into a fifth path and a sixth path.
Peter MacKinnon, Michael R. Jackson
Filed: 9 May 22