426 patents
Page 10 of 22
Utility
Systems and methods for refractive index detection
8 Mar 22
The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors.
Anthony C. Jeannotte, Mark Basile, Senthil Bala, Colin Fredette
Filed: 13 Apr 18
Utility
Multiple Sample Differential Scanning Calorimeter
3 Mar 22
A heat flow rate measurement method for use with a differential scanning calorimeter sensor is provided.
Robert L. Danley
Filed: 10 Nov 21
Utility
Hybrid Calorimeter Cell
3 Mar 22
A calorimeter and method is also provided, including a sample cell, a reference cell, a thermostat in thermal communication with the sample cell and the reference cell, a first conductive wire, the first conductive wire having a first end connected to the thermostat and a second end connected to the sample cell, and a second conductive wire, the second conductive wire having a first end connected to the thermostat and a second end connected to the reference cell.
Donald J. Russell, Anthony E. Arnerich, David Serrell
Filed: 9 Nov 21
Utility
Pressure Transducer, System and Method
3 Mar 22
Disclosed is a pressure transducer including a body made of a material having a first coefficient of thermal expansion, a fluidic inlet and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet.
Gary W. Bertone, Taylor J. Castagna, Robert J. Dumas
Filed: 9 Nov 21
Utility
Dual Delivery Needle Wash System
17 Feb 22
Described herein are systems and methods used for washing needle assemblies with multiple needles.
Rose Solow, David A. Simpson, Colin F. Fredette, Marc E. Lemelin, Joshua A. Burnett
Filed: 16 Aug 21
Utility
Continuously variable output liquid chromatography pump drive
8 Feb 22
A liquid chromatography solvent pump includes at least one motor, a first piston, a second piston, and a continuously variable output drive system coupling the at least one motor to at least one of the first and second pistons.
Jeffrey Musacchio, Michael Eggertson, Joseph Michienzi
Filed: 17 Sep 19
Utility
Solvent reservoir filters, systems and methods
8 Feb 22
A solvent reservoir filter for a liquid chromatograph system includes a first screen extending in a first plane, the first screen configured to filter solvent received through the first screen, a second screen extending in a second plane that is parallel to the first plane, the second screen configured to filter solvent received through the second screen, a main body extending between and connecting the first screen and the second screen, and a fluid outlet configured to expel solvent filtered by the first and second screens from the solvent reservoir filter.
Mark W. Moeller, William B. Clark
Filed: 24 Jun 19
Utility
Device for Solid Phase Extraction and Method for Use Thereof
3 Feb 22
Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis.
Pamela C. Iraneta, Xin Zhang, Frank John Marszalkowski, JR.
Filed: 13 Oct 21
Utility
Materials for Hydrophilic Interaction Chromatography and Processes for Preparation and Use Thereof for Analysis of Glycoproteins and Glycopeptides
3 Feb 22
The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans.
Matthew A. Lauber, Stephan M. Koza, Pamela C. Iraneta, Kevin D. Wyndham
Filed: 8 Jul 21
Utility
Chromatographic compositions
1 Feb 22
Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.
Matthew A. Lauber, Daniel P. Walsh
Filed: 26 Oct 20
Utility
Convectively controlled adiabatic column chamber for use in chromatographic systems
1 Feb 22
A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns.
Joshua A. Shreve, Kurt D. Joudrey
Filed: 10 Apr 15
Utility
Metabolic pathway and metabolite identification
1 Feb 22
The present disclosure relates to methods and apparatus for identifying metabolic pathways and metabolites in complex biological samples.
Giuseppe Astarita
Filed: 26 May 16
Utility
Haptic Feedback for Configuring Materials Testing Systems
27 Jan 22
Disclosed is a material testing system that includes an output shaft configured to be moved by operation of a motor, the output shaft coupleable to a test specimen such that movement of the output shaft imparts a mechanical force on the test specimen.
David L. Dingmann
Filed: 24 Jun 21
Utility
Compositions, Kits and Methods Useful for Separating Oligonucleotides from Matrix Components
20 Jan 22
The present disclosure relates to compositions, kits and methods that may be used for removal of matrix components, including proteins and lipids, from one or more oligonucleotides.
Michael Donegan, Martin Gilar, Darryl W. Brousmiche
Filed: 14 Jul 21
Utility
Non-antibody High-affinity-based Sample Preparation, Sorbent, Devices and Methods
13 Jan 22
In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein.
Laks Iyer, Beatrice W. Muriithi
Filed: 24 Sep 21
Utility
Compositions, Kits and Methods Useful for Separating Proteins from Surfactants
13 Jan 22
The present disclosure pertains to methods for separating proteins from surfactants that comprise (a) adding an amount of denaturing buffer to a mixture comprising a protein and a surfactant thereby forming a denatured solution wherein the protein is denatured and (b) filtering the denatured solution with a molecular weight cutoff filter, thereby separating the protein from the surfactant and the denaturing buffer.
Ximo Zhang
Filed: 2 Jul 21
Utility
Combination Mixer Arrangement for Noise Reduction In Liquid Chromatography
13 Jan 22
A mixer arrangement for use in a chromatography system includes a first frequency targeting mixer including a first flow channel coupled between an inlet and an outlet and a second flow channel coupled between the inlet and the outlet, the second flow channel including a volume offset region configured to delay fluid propagation through the second flow channel, wherein the volume offset region is configured to reduce or eliminate fluidic compositional oscillations in a compositional solvent stream that depart from a desired composition at a first target frequency, and a residual noise targeting mixer fluidically connected in series to the frequency targeting mixer, the residual noise targeting mixer configured to dampen aperiodic baseline noise in the compositional solvent stream.
Fabrice Gritti
Filed: 25 Jun 21
Utility
Mixer for Liquid Chromatography
13 Jan 22
Described is a mixer for a liquid chromatography system.
Fabrice Gritti
Filed: 25 Jun 21
Utility
Hybrid calorimeter cell
11 Jan 22
A calorimeter cell of a calorimetry system is provided, having a cell body having an internal region for receiving a first substance, the cell body being comprised of a chemically inert material, and a thermally conductive layer at least partially surrounding the chemically inert cell body.
Donald J. Russell, Anthony E. Arnerich, David Serrell
Filed: 20 Jul 18
Utility
Chromatographic Dimension Selection In Multidimensional Liquid Chromatography
30 Dec 21
A system capable of performing both single and multidimensional liquid chromatography includes a solvent delivery system, a sample injection system, a first dimension column path configured to perform a separation process in a first dimension, a second dimension column path configured to perform a separation process in a second dimension that is different than the first dimension, a valve system; and a sample injection system fluidically connected to the valve system.
Michael O. Fogwill
Filed: 28 Jun 21