426 patents
Page 18 of 22
Utility
Method and Apparatus for High Pressure Sealing
18 Nov 20
The present technology generally relates to devices, systems and methods for providing robust sealing between surfaces in a pressurized system, such as a chromatography system.
Emily J. Berg, Joshua A. Shreve
Filed: 12 May 20
Utility
Catalytic oxidation of polar modifiers in chromatographic mobile phases
9 Nov 20
The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases.
Michael O. Fogwill, Joseph D. Michienzi, James P. Murphy
Filed: 20 Nov 18
Utility
Gas liquid separator and associated methods
2 Nov 20
Exemplary embodiments are directed to a gas liquid separator that includes a chamber for receiving a fluid mixture, a fluid mixture inlet, a solvent outlet, and a gas outlet.
Joshua A. Shreve
Filed: 23 Oct 17
Utility
Techniques for mass analyzing a complex sample based on nominal mass and mass defect information
2 Nov 20
Techniques and apparatus for analyzing mass spectrometry data are described.
Scott J. Geromanos, Curt Devlin, Steven J. Ciavarini
Filed: 20 Nov 17
Utility
Acid labile surfactants
2 Nov 20
This invention relates to an acid labile surfactant.
Darryl W. Brousmiche
Filed: 25 Feb 19
Utility
Modifier stream elution of trap column for multidimensional compressible fluid-based chromatography
2 Nov 20
A method of performing a chromatographic separation includes modulating a portion of a flowstream to a trap column to retain at least one analyte from the flowstream on the trap column.
Michael O. Fogwill, Isabelle François
Filed: 20 Dec 17
Utility
Systems, methods, and devices for providing pressurized solvent flow
2 Nov 20
The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.
Wade P. Leveille, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder, Joseph Michienzi, Keith Fadgen, Kevin Wyndham, Xiangjin Song
Filed: 18 Dec 17
Utility
Pressure related hysteresis manipulation in a pressurized flow system
2 Nov 20
Exemplary embodiments of the present disclosure are directed to manipulating pressure-related hysteresis in a pressurized flow system by setting the pressure of the system to a predetermined location in the hysteresis band to advantageously minimize an effect of the pressure related hysteresis on the pressure of the system or to advantageously benefit from the effects of the hysteresis on the pressure of the system.
Joshua A. Shreve, Paul Keenan, Steven J. Ciavarini
Filed: 12 Apr 18
Utility
Charged Surface Reversed Phase Chromatographic Materials Method for Analysis of Glycans Modified with Amphipathic, Strongly Basic Moieties
21 Oct 20
The present invention provides novel methods for the chromatographic analysis of glycans using high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier and a labeling reagent which is capable of providing amphipathic and strongly basic labeling moieties to a sample to be analyzed.
Matthew A. Lauber, Scott A. McCall, Babajide Okandeji, Pamela C. Iraneta
Filed: 20 Apr 17
Utility
Matching Thermally Modulated Variable Restrictors to Chromatography Separation Columns
21 Oct 20
Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column.
Michael O. Fogwill, Joseph D. Michienzi, Geoff Gerhardt, James P. Murphy
Filed: 29 Jun 20
Utility
Multi-dimensional chromatographic system for analyzing multiple sample components
12 Oct 20
A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments.
Amanda B. Dlugasch, Thomas E. Wheat, Daniel Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
Filed: 24 Jan 17
Utility
Methods, compositions, devices, and kits, for performing phospholipid separation
12 Oct 20
Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media.
Pamela C. Iraneta, Thomas H. Walter, Xin Zhang, Daniel P. Walsh, Kevin D. Wyndham, Raymond P. Fisk
Filed: 29 Mar 18
Utility
Online dilution for a liquid chromatography system using a sample metering pump
12 Oct 20
An apparatus for diluting a sample in a liquid chromatography system includes a metering pump, a sample needle and a sample valve.
Joshua A. Burnett, John M. Auclair
Filed: 12 Jun 18
Utility
Chromatography column assembly
12 Oct 20
Described is a chromatographic column assembly that includes an outer tube comprising a metal, a first conduit disposed within the outer tube, a second conduit disposed within the outer tube, and a first joint located between the first conduit and the second conduit.
Joseph D. Michienzi, Keith Fadgen, Wade P. Leveille, Raymond P. Fisk, Frank John Marszalkowski, Jr.
Filed: 24 May 18
Utility
Gas liquid separator for chromatography applications
5 Oct 20
Examples of gas liquid separators include a chamber, a fluid mixture inlet, a gas outlet and a liquid outlet.
Emily J. Berg, Joshua A. Shreve, Edwin H. Denecke
Filed: 23 Oct 17
Utility
Systems, devices, and methods for threshold analyte calibration and quantitation using threshold analyte calibration
5 Oct 20
Provided herein are definitive screening techniques for qualitatively and quantitatively detecting analytes in biological specimens.
Thomas G. Rosano, Michelle Wood
Filed: 15 Mar 16
Utility
Dual Mode Sample Manager
30 Sep 20
Described is a dual mode sample manager for a liquid chromatography system.
Sylvain Gilles Cormier, Joseph D. Michienzi
Filed: 22 Mar 20
Utility
Solvent preheating system for liquid chromatography
28 Sep 20
A heater assembly used in chromatography includes a thermally conductive base having a chamber extending fully through the base with an opening at a first side of the base and at a second side of the base, and a cavity with an opening at the second side of the base.
Joshua A. Shreve, Greg Kheyfets, Paul Keenan, Paul E. Linderson
Filed: 3 Feb 16
Utility
Apparatus for controlling sample position in a liquid chromatography system
28 Sep 20
Described is an apparatus for controlling a position of a sample in a liquid chromatography system.
Joshua A. Burnett, James E. Usowicz, Marc Lemelin
Filed: 10 Jan 11
Utility
Systems, Methods and Devices for Reducing Band Dispersion In Chromatography
23 Sep 20
Reduced column loading of a sample onto a chromatographic column may be mitigated by excluding diffuse portions of the sample from introduction to the column.
Abhijit Tarafder, Pamela C. Iraneta
Filed: 6 Mar 17