426 patents
Page 6 of 22
Utility
Methods of Enhancing MS Detection of Tagged Glycans
1 Dec 22
Methods for derivatization of biomolecules including glycans or other biopolymers with one or more fluorescent, MS active compounds by reductive amination or rapid tagging in order to produce derivatized glycan having a pKa >7 and between about 200 Å and about 1000 Å of nonpolar surface area are described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 2 May 22
Utility
Nickel-cobalt alloy material devices and components
29 Nov 22
Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors.
Jonathan L. Belanger, Hua Yang, Edouard S. P. Bouvier, Mathew DeLano, Raymond P. Fisk, Hillary B. Hewitson, Wade P. Leveille, Kevin Daniel Wyndham
Filed: 12 Aug 16
Utility
Equal Dispersion Split-flow Mixer
24 Nov 22
Disclosed is a liquid chromatography system and mixer for use therein that includes a first split connected to an inlet, the first split branching the flow of fluid from the inlet into a first path and a second path; a second split connected to an outlet of the first path, the second split branching the first path into a third path and a fourth path; and a third split connected to an outlet of the second path, the third split branching the second path into a fifth path and a sixth path.
Peter MacKinnon, Michael R. Jackson
Filed: 9 May 22
Utility
Rotary valve having bypass state
22 Nov 22
A rotary valve that includes a stator, a rotor and a plurality of sample channels.
Sylvain Gilles Cormier, Charles T. Murphy, Joseph D. Michienzi
Filed: 25 Jan 22
Utility
Hydrolytically Stable Zwitterionic Chromatographic Materials
17 Nov 22
In some aspects, the present disclosure pertains to chromatographic materials that comprise (a) a bulk material and (b) a zwitterionic polymer covalently linked to a surface of the bulk material, in which the zwitterionic polymer comprises one or more monomer residues that comprise an amide or urea moiety, a positively charged moiety, and a negatively charged moiety.
Nicole L. Lawrence, Darryl W. Brousmiche, Jessica Field, Daniel P. Walsh
Filed: 28 Apr 22
Utility
Variable thickness diaphragm pressure transducer and method
15 Nov 22
A diaphragm pressure transducer includes a body having an outer surface and a diaphragm, a strain gauge including a resistive element located on the outer surface, a fluidic inlet, and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet, the fluidic cavity having an upper surface.
Zongren Shang
Filed: 2 Apr 19
Utility
Compact Liquid Chromatography System Providing Thermal Management and Detection
10 Nov 22
The exemplary embodiments may provide liquid chromatography systems that are smaller in size and with reduced extra-column volume than conventional liquid chromatography systems.
Michael O. Fogwill, Fabrice Gritti
Filed: 4 May 22
Utility
Establishing Fluidic Connections Between Chromatography Components
10 Nov 22
A thermal module for pre-heating liquid flowing into a liquid chromatography column, includes a trough compartment with two ends, one of the two ends having an electrical socket, a first fluidic assembly, a second fluidic assembly, and a clamp assembly.
Peter Kirby, Marcos O. Peroza, Steven D. Trudeau, Ryan M. Hill, Raymond P. Fisk, Jonathan L. Belanger, Wade P. Leveille
Filed: 14 Jul 22
Utility
Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules and small molecules
25 Oct 22
The present disclosure relates to the determination of analytes in a sample using chromatography.
Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion, Melvin Blaze Muttikal Thomas, Thomas Walter
Filed: 14 Apr 20
Utility
Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution
25 Oct 22
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof.
Kevin D. Wyndham, Beatrice W. Muriithi
Filed: 13 Aug 18
Utility
System and method for detecting high pressure seal leaks in chromatographic pumps
18 Oct 22
The present disclosure relates to techniques for detecting leaks in a pump.
Michael O. Fogwill, Jason F. Hill
Filed: 18 Dec 19
Utility
High sample throughput differential scanning calorimeter
18 Oct 22
Described is a differential scanning calorimeter (DSC) instrument capable of performing analyses of multiple samples at the same time.
Donald J. Russell, David Serrell, Anthony E. Arnerich
Filed: 10 Oct 19
Utility
Solvent Delivery with a Reduced Volume Single Stroke Pumping Arrangement Providing Continuous Solvent Flow
6 Oct 22
The exemplary embodiments control solvent pumps so that system flow is constant.
Michael O. Fogwill, Sylvain G. Cormier
Filed: 30 Mar 22
Utility
Method of using chemical tags to improve the identification, quantification and spatial localization of components in a sample
4 Oct 22
The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture.
Giuseppe Astarita, Darryl W. Brousmiche
Filed: 17 Feb 17
Utility
Automated Semi-preparative Gradient Recycling Liquid Chromatography
29 Sep 22
The disclosure relates to a gradient twin column recycling chromatography method that is used to separate a mixture containing closely eluting compounds.
Fabrice Gritti
Filed: 21 Mar 22
Utility
Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
20 Sep 22
Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described.
Darryl W. Brousmiche, Ying-Qing Yu, Matthew Lauber
Filed: 5 Sep 19
Utility
Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material
13 Sep 22
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials.
Nicole L. Lawrence, Beatrice W. Muriithi, Kevin D Wyndham
Filed: 6 Mar 17
Utility
Sorbent Particles for Sample Treatment
8 Sep 22
Novel sorbents, devices, kits and methods useful for sample treatment are disclosed herein.
Darryl W. Brousmiche, Kevin D. Wyndham, Nicole L. Lawrence, Jacob N. Fairchild, Bonnie Alden
Filed: 23 May 22
Utility
Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules
6 Sep 22
The present disclosure relates to the determination of analytes in a sample using chromatography.
Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion
Filed: 28 Jan 19
Utility
Immobilized enzymatic reactor
6 Sep 22
An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi.
Joomi Ahn, Moon Chul Jung, Kevin D. Wyndham
Filed: 16 Dec 19