208 patents
Utility
Method of Operating a Liquid Chromatography Arrangement, a Liquid Chromatography Arrangement, and a Chromatography System
18 May 23
There is provided a method of operating a liquid chromatography arrangement, the liquid chromatography arrangement comprising: a solvent pump arranged to flow a liquid solvent over a liquid chromatography column; a restrictor arranged to restrict the liquid solvent from leaving the liquid chromatography column; and a liquid pump arranged to provide liquid flow between the liquid chromatography column and the restrictor, the method comprising: flowing the liquid solvent through the liquid chromatography column using the solvent pump; and controlling a liquid pressure within the liquid chromatography column by providing a liquid flow between the liquid chromatography column and the restrictor using the liquid pump.
Szabolcs Fekete, Michael O. Fogwill, Matthew A. Lauber
Filed: 16 Nov 22
Utility
Light-guiding Flow Cell Technologies
18 May 23
A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel.
Michael O. Fogwill, Joseph D. Michienzi, Sebastien Besner, Brett G. Cook, Peter O'Brien
Filed: 18 Nov 22
Utility
Chemical Denaturation for Oligonucleotide Analysis
4 May 23
The present disclosure provides compositions and methods for sample processing, particularly for oligonucleotide analysis e.g. analysis of formulated nucleic acid drugs.
Matthew A. Lauber, Jennifer M. Nguyen, Xiaoxiao Liu, Michael Donegan
Filed: 28 Oct 22
Utility
Methods for Anion-exchange Analysis of Nucleic Acids
27 Apr 23
The present invention relates to a method for separating a sample comprising a nucleic acid, the method comprising: (a) loading a sample comprising a nucleic acid onto an anion-exchange column; and (b) eluting the sample from the anion-exchange column using a salt gradient, wherein a mobile phase used in the eluting step comprises a mild ion-pairing cation, and wherein a column temperature of the anion-exchange column is greater than 30° C.
Matthew A. Lauber, Kevin Wyndham, Szabolcs Fekete, Hua Yang, Stephan Koza
Filed: 21 Oct 22
Utility
Reagents for Rapid Chiral Labeling and Analysis of Amine Containing Enantiomers
27 Apr 23
Provided herein chiral derivatization reagents for use in separating and detecting of amine containing enantiomers.
Matthew A. Lauber, Darryl W. Brousmiche, Jun Yang, Weiqiang Gu, Mingcheng Xu, Peng Chen
Filed: 21 Oct 22
Utility
Sample Preparation for LC-MS Based Sequence Mapping of Nucleic Acids
13 Apr 23
Methods for quenching a nuclease digestion of a target nucleic acid prior to downstream analysis of the target nucleic acid are disclosed herein.
Matthew A. Lauber, Xiaoxiao Liu
Filed: 6 Oct 22
Utility
Zone Box for a Differential Scanning Calorimeter
6 Apr 23
Described is a zone box for a differential scanning calorimeter.
Robert L. Danley
Filed: 29 Aug 22
Utility
Core-shell Particles with Organic Polymer Cores
30 Mar 23
In various embodiments, the present disclosure pertains to core-shell particles that comprise a porous hybrid organic-inorganic shell disposed on a surface-modified non-porous polymer particle core.
MingCheng Xu, Darryl W. Brousmiche, Daniel P. Walsh, Nicole L. Lawrence, Kevin D. Wyndham
Filed: 26 Aug 22
Utility
Sample Automation Manager
30 Mar 23
A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column.
Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, JR.
Filed: 29 Nov 22
Utility
Immobilized Enzymatic Reactor
23 Mar 23
An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi.
Joomi Ahn, Moon Chul Jung, Kevin D. Wyndham
Filed: 4 Aug 22
Utility
Rotary Coupling with Magnetic Preload
23 Mar 23
Described is a rotary coupling that includes a pair of coupling bodies having parallel (preferably coincident) rotation axes, two cylindrical elements and a preload mechanism.
Gurpreet Singh, Colin F. Fredette, Dan Sullivan, Neal Pugh
Filed: 2 Sep 22
Utility
Methods to Increase Sensitivity of LC/MS Analysis
16 Mar 23
The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy.
Paul Rainville, Kerri Smith
Filed: 18 Nov 22
Utility
Mixer for Chromatography System
16 Mar 23
Described is a mixer for a chromatography system.
Peyton C. Beals, Sylvain Gilles Cormier, Richard Wayne Andrews
Filed: 23 Nov 22
Utility
Superficially Porous Organic Polymer Particles
9 Mar 23
In various embodiments, the present disclosure pertains to organic polymer core-shell particles that comprise a non-porous organic polymer core (i.e., having a pore volume of less than 0.1 cc/g) and a porous organic polymer shell (i.e., having a pore volume of greater than 0.1 cc/g), in which the porous organic polymer shell has a pore size ranging from 100 Å to 3000 Å.
MingCheng Xu, Darryl W. Brousmiche, Kevin Wyndham, Daniel P. Walsh, Nicole L. Lawrence
Filed: 26 Aug 22
Utility
Superficially Porous Materials Comprising a Substantially Nonporous Hybrid Core Having Narrow Particle Size Distribution
9 Feb 23
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof.
Kevin D. Wyndham, Beatrice Muriithi
Filed: 16 Sep 22
Utility
Peristaltic Pump Having Temperature-compensated Volumetric Delivery
26 Jan 23
Described is a method for regulating a volume of liquid delivered by a peristaltic pump and a peristaltic pump system that can be used to perform the method.
Timothy M. Raymond, Sean Eric Anderson
Filed: 15 Jul 22
Utility
Method of Using Chemical Tags to Improve the Identification, Quantification and Spatial Localization of Components In a Sample
19 Jan 23
The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture.
Giuseppe Astarita, Darryl W. Brousmiche
Filed: 30 Aug 22
Utility
USE OF NEUTRAL pH MOBILE PHASES IN REVERSED PHASE CHROMATOGRAPHY OF ACIDIC PEPTIDES
12 Jan 23
The present disclosure discusses a method of separating and/or purifying acidic peptides by the use of a mobile phase having a pH greater than or about equal to the isoelectric point of one or more of the metal oxides in the flow path.
Samantha Ippoliti, Ying Qing Yu
Filed: 6 Jul 22
Utility
Passive Solvent Mixer for Liquid Chromatography
29 Dec 22
Described is a mixer for a liquid chromatography system.
Fabrice Gritti
Filed: 24 May 22
Utility
Fluorescence Tagging of Glycans and Other Biomolecules Through Reductive Amination for Enhanced MS Signals
29 Dec 22
Novel reagents comprising MS active, fluorescent compounds having an activated functionality for reaction with aldehydes and useful in labeling biomolecules such as glycans and methods of making the same are taught and described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 3 Jun 21