230 patents
Page 5 of 12
Utility
Compounds for Use In System Suitability Testing of Inert LC Systems and Columns
24 Mar 22
The present disclosure is directed to a kit for evaluating system inertness.
Amit Patel, Moon Chul Jung, Susan Rzewuski, Matthew A. Lauber, Thomas H. Walter, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
Filed: 10 Sep 21
Utility
Continuous Flow Mixer
24 Mar 22
A continuous flow mixer for use in a chromatography system includes a first channel structure located between a mixer inlet and a mixer outlet.
Sean Eric Anderson, Peter MacKinnon
Filed: 22 Sep 21
Utility
Techniques for System Suitability Testing of Inert Liquid Chromatography Systems and Columns
17 Mar 22
The present disclosure is directed to methods of characterizing a system containing a chromatographic column.
Amit Patel, Moon Chul Jung, Susan Rzewuski, Thomas H. Walter, Matthew A. Lauber, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
Filed: 10 Sep 21
Utility
Methods for the Evaluation of System Inertness
17 Mar 22
The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system.
Amit Patel, Moon Chul Jung, Susan Rzewuski, Thomas H. Walter, Matthew A. Lauber, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
Filed: 10 Sep 21
Utility
Silica-based Particle with Hydroxy-terminated Peg Bonding and Methoxy-terminated Peg Surface Modification
17 Mar 22
The present disclosure is directed to stationary phase materials for performing size exclusion chromatography.
Nicole L. Lawrence, Yeliz Tunc Sarisozen, Darryl W. Brousmiche, Matthew A. Lauber
Filed: 16 Sep 21
Utility
Sorbent Used to Improve Chromatographic Separations In Size Exclusion Chromatography Via Reduced Secondary Interactions
17 Mar 22
The present disclosure is directed to stationary phase materials (e.g., porous inorganic-organic hybrid particles) for performing size exclusion chromatography.
Yeliz Tunc Sarisozen, Nicole L. Lawrence, Darryl W. Brousmiche, Andrew Wyatt Schmudlach, Matthew A. Lauber
Filed: 16 Sep 21
Utility
Size Exclusion Chromatography Utilizing Low Concentration Amino Acids In Size Exclusion Chromatography Mobile Phase
17 Mar 22
The present disclosure is directed to methods for performing size exclusion chromatography.
Andrew Wyatt Schmudlach, Susan Rzewuski, Matthew A. Lauber, Yeliz Tunc Sarisozen, Nicole L. Lawrence, Darryl W. Brousmiche
Filed: 16 Sep 21
Utility
Multidimensional Chromatography Method for Analysis of Antibody-drug Conjugates
10 Mar 22
The present disclosure relates to a sensitive, multidimensional chromatography method for extraction, detection, and quantification of non-conjugated cytotoxic agents and associated linker molecules used in cysteine based antibody-drug-conjugate production.
Robert Birdsall
Filed: 24 Sep 21
Utility
Multiple Sample Differential Scanning Calorimeter
3 Mar 22
A heat flow rate measurement method for use with a differential scanning calorimeter sensor is provided.
Robert L. Danley
Filed: 10 Nov 21
Utility
Pressure Transducer, System and Method
3 Mar 22
Disclosed is a pressure transducer including a body made of a material having a first coefficient of thermal expansion, a fluidic inlet and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet.
Gary W. Bertone, Taylor J. Castagna, Robert J. Dumas
Filed: 9 Nov 21
Utility
Hybrid Calorimeter Cell
3 Mar 22
A calorimeter and method is also provided, including a sample cell, a reference cell, a thermostat in thermal communication with the sample cell and the reference cell, a first conductive wire, the first conductive wire having a first end connected to the thermostat and a second end connected to the sample cell, and a second conductive wire, the second conductive wire having a first end connected to the thermostat and a second end connected to the reference cell.
Donald J. Russell, Anthony E. Arnerich, David Serrell
Filed: 9 Nov 21
Utility
Dual Delivery Needle Wash System
17 Feb 22
Described herein are systems and methods used for washing needle assemblies with multiple needles.
Rose Solow, David A. Simpson, Colin F. Fredette, Marc E. Lemelin, Joshua A. Burnett
Filed: 16 Aug 21
Utility
Device for Solid Phase Extraction and Method for Use Thereof
3 Feb 22
Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis.
Pamela C. Iraneta, Xin Zhang, Frank John Marszalkowski, JR.
Filed: 13 Oct 21
Utility
Materials for Hydrophilic Interaction Chromatography and Processes for Preparation and Use Thereof for Analysis of Glycoproteins and Glycopeptides
3 Feb 22
The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans.
Matthew A. Lauber, Stephan M. Koza, Pamela C. Iraneta, Kevin D. Wyndham
Filed: 8 Jul 21
Utility
Haptic Feedback for Configuring Materials Testing Systems
27 Jan 22
Disclosed is a material testing system that includes an output shaft configured to be moved by operation of a motor, the output shaft coupleable to a test specimen such that movement of the output shaft imparts a mechanical force on the test specimen.
David L. Dingmann
Filed: 24 Jun 21
Utility
Compositions, Kits and Methods Useful for Separating Oligonucleotides from Matrix Components
20 Jan 22
The present disclosure relates to compositions, kits and methods that may be used for removal of matrix components, including proteins and lipids, from one or more oligonucleotides.
Michael Donegan, Martin Gilar, Darryl W. Brousmiche
Filed: 14 Jul 21
Utility
Compositions, Kits and Methods Useful for Separating Proteins from Surfactants
13 Jan 22
The present disclosure pertains to methods for separating proteins from surfactants that comprise (a) adding an amount of denaturing buffer to a mixture comprising a protein and a surfactant thereby forming a denatured solution wherein the protein is denatured and (b) filtering the denatured solution with a molecular weight cutoff filter, thereby separating the protein from the surfactant and the denaturing buffer.
Ximo Zhang
Filed: 2 Jul 21
Utility
Non-antibody High-affinity-based Sample Preparation, Sorbent, Devices and Methods
13 Jan 22
In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein.
Laks Iyer, Beatrice W. Muriithi
Filed: 24 Sep 21
Utility
Combination Mixer Arrangement for Noise Reduction In Liquid Chromatography
13 Jan 22
A mixer arrangement for use in a chromatography system includes a first frequency targeting mixer including a first flow channel coupled between an inlet and an outlet and a second flow channel coupled between the inlet and the outlet, the second flow channel including a volume offset region configured to delay fluid propagation through the second flow channel, wherein the volume offset region is configured to reduce or eliminate fluidic compositional oscillations in a compositional solvent stream that depart from a desired composition at a first target frequency, and a residual noise targeting mixer fluidically connected in series to the frequency targeting mixer, the residual noise targeting mixer configured to dampen aperiodic baseline noise in the compositional solvent stream.
Fabrice Gritti
Filed: 25 Jun 21
Utility
Mixer for Liquid Chromatography
13 Jan 22
Described is a mixer for a liquid chromatography system.
Fabrice Gritti
Filed: 25 Jun 21